cheminform abstract: antiplasmodial and cytotoxicity evaluation of 3-functionalized 2-azetidinone...

ChemInform 2011, 42, issue 52 © 2011 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Triazole derivatives R 0280 DOI: 10.1002/chin.201152130 Antiplasmodial and Cytotoxicity Evaluation of 3-Functionalized 2-Azetidinone Derivatives. — 3-Azido, 3-amino- and 3-(1,2,3-triazol-1-yl)- β-lactams are synthesized using the Staudinger reaction to construct the desired azetidinone scaffold. The synthesized compounds are screened for their antiplasmodial activity and cytotoxicity. Best results are observed for derivative (VIa) having an N-cyclohexyl substituent in the β-lactam ring. — (KUMAR*, V.; et al.; Bioorg. Med. Chem. Lett. 21 (2011) 15, 4561-4563, http://dx.doi.org/10.1016/j.bmcl.2011.05.119 ; Dep. Chem., Guru Nanak Dev Univ., Amritsar 143 005, India; Eng.) — H. Toeppel 52- 130

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Page 1: ChemInform Abstract: Antiplasmodial and Cytotoxicity Evaluation of 3-Functionalized 2-Azetidinone Derivatives

Triazole derivativesR 0280 DOI: 10.1002/chin.201152130

Antiplasmodial and Cytotoxicity Evaluation of 3-Functionalized 2-Azetidinone Derivatives. — 3-Azido, 3-amino- and 3-(1,2,3-triazol-1-yl)-β-lactams are synthe-sized using the Staudinger reaction to construct the desired azetidinone scaffold. The synthesized compounds are screened for their antiplasmodial activity and cytotoxicity. Best results are observed for derivative (VIa) having an N-cyclohexyl substituent in the β-lactam ring. — (KUMAR*, V.; et al.; Bioorg. Med. Chem. Lett. 21 (2011) 15, 4561-4563, http://dx.doi.org/10.1016/j.bmcl.2011.05.119 ; Dep. Chem., Guru Nanak Dev Univ., Amritsar 143 005, India; Eng.) — H. Toeppel

52- 130

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