cheminform abstract: preparation of 6-iodo-n1,n3-dimethyluracil and 6-(2-acylvinyl)-n1,n3-...

1996 uracil derivatives uracil derivatives R 0520 44 - 156 Preparation of 6-Iodo-N1,N3-dimethyluracil and 6-(2-Acylvinyl)- N1,N3- dimethyluracils: The Correction of a Mistake and an Improved Synthesis. — The title compound (II) rather than the iodo analogue of compound (I) is formed by the reaction of the chlorouracil (I) with sodium iodide. The reaction mechanism is discussed. (II) serves as starting material for the synthesis of the uracils (IV) which show cytotoxic activities. — (DAS, P.; KUNDU, N. G.; J. Chem. Res., Synop. (1996) 6, 298-299; Dep. Org. Chem., Indian Assoc. Cult. Sci., Calcutta 700 032, India; EN) 1

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Page 1: ChemInform Abstract: Preparation of 6-Iodo-N1,N3-dimethyluracil and 6-(2-Acylvinyl)-N1,N3- dimethyluracils: The Correction of a Mistake and an Improved Synthesis

1996 uracil derivatives

uracil derivativesR 0520

44 - 156Preparation of 6-Iodo-N1,N3-dimethyluracil and 6-(2-Acylvinyl)-N1,N3- dimethyluracils: The Correction of a Mistake and anImproved Synthesis. — The title compound (II) rather than the iodoanalogue of compound (I) is formed by the reaction of the chlorouracil (I) withsodium iodide. The reaction mechanism is discussed. (II) serves as startingmaterial for the synthesis of the uracils (IV) which show cytotoxic activities.— (DAS, P.; KUNDU, N. G.; J. Chem. Res., Synop. (1996) 6, 298-299; Dep.Org. Chem., Indian Assoc. Cult. Sci., Calcutta 700 032, India; EN)

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