cheminform abstract: quinoxaline chemistry. part 11. 3-phenyl-2[phenoxy- and phenoxymethyl]-6(7) or...

1999 pyrazine derivatives pyrazine derivatives R 0550 09 - 182 Quinoxaline Chemistry. Part 11. 3-Phenyl-2[phenoxy- and phenoxymethyl]-6(7) or 6,8-Substituted Quinoxalines and N-[4-(6(7)- Substituted or 6,8-Disubstituted-3-phenylquinoxalin-2-yl)hydroxy or hydroxymethyl]benzoylglutamates. Synthesis and Evaluation of in vitro Anticancer Activity and Enzymatic Inhibitory Activity Against Dihydrofolate Reductase and Thymidylate Synthase. — The title compounds (I), (II), and (III) exhibit high values of percent tumor growth inhibition in all cancer cell lines tested. — (CORONA, PAOLA; VITALE, GABRIELLA; LORIGA, MARIO; PAGLIETTI, GIUSEPPE; COSTI, MARIA PAOLA; Farmaco 53 (1998) 7, 480-493; Ist. Chim. Farm. Tossicol., Univ. Sassari, I-07100 Sassari, Italy; EN) 1

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Page 1: ChemInform Abstract: Quinoxaline Chemistry. Part 11. 3-Phenyl-2[phenoxy- and phenoxymethyl]-6(7) or 6,8-Substituted Quinoxalines and N-[4-(6(7)-Substituted or 6,8-Disubstituted-3-phenylquinoxalin-2-yl)hydroxy

1999 pyrazine derivatives

pyrazine derivativesR 0550

09 - 182Quinoxaline Chemistry. Part 11. 3-Phenyl-2[phenoxy- andphenoxymethyl]-6(7) or 6,8-Substituted Quinoxalines and N-[4-(6(7)-Substituted or 6,8-Disubstituted-3-phenylquinoxalin-2-yl)hydroxy orhydroxymethyl]benzoylglutamates. Synthesis and Evaluation of invitro Anticancer Activity and Enzymatic Inhibitory Activity AgainstDihydrofolate Reductase and Thymidylate Synthase. — The titlecompounds (I), (II), and (III) exhibit high values of percent tumor growthinhibition in all cancer cell lines tested. — (CORONA, PAOLA; VITALE,GABRIELLA; LORIGA, MARIO; PAGLIETTI, GIUSEPPE; COSTI, MARIAPAOLA; Farmaco 53 (1998) 7, 480-493; Ist. Chim. Farm. Tossicol., Univ.Sassari, I-07100 Sassari, Italy; EN)

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