2001 benzimidazole derivatives

benzimidazole derivativesR 0200

15 - 130Synthesis and Antiparasitic Activity of 2-(Trifluoromethyl)benzimidazole Derivatives. — Title benzimidazolederivatives (IV) (7 samples) substituted at the 1-, 5-, and 6-positions areprepared in good yields and tested for their antiprotozoal and anthelminticactivity. All compounds are more active as antiprotozoal agents than thereference drugs albendazole and metronidazole. However, none of them inhibitstubulin polymerization. — (CASTILLO, RAFAEL; ET AL.; Bioorg. Med.Chem. Lett. 11 (2001) 2, 187-190; Dep. Farm., Fac. Quim., Univ. Natl. Auton.Mex., Coyoacan, 04510 Mexico, Mex.; EN)

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