CHEMISTRY IN INDUSTRY

A GUIDANCE TO BSC MSC GRADUATES IN

CHEMISTRY

Sudhir Sawant PhD (Chemistry)

DGM – Synthesis & Process Development

Enalteclabs Pharma, Ambernath

WHY MAKE IN INDIA?

Increasing overhead costs in Europe due to various economic reasons

and

Less availability of trained manpower.

European companies looking at India as an opportunity towards

establishing manufacturing sites in India….Why India?

well educated and trained man power, youngest average age about 30

years

Good english speaking population,

good communication skills – verbal & written

Flexible, systematic approach, talent pool.

Professional integrity and reliable professional

Government is encouraging direct foreign investments in SEZs in all

over India

PHARMACEUTICALS

Organic Chemistry

Named reactions:

Enantioselective synthesis [Chiral synthesis] Corey-Itsuno -

Dapoxetine.HCl

Wittig Reaction : Rosuvastatin

HOW WE DO WHAT WE DO? – GENERICS APIS

Project allotment

Literature survey

Laboratory experiments

Optimisation experiments

Scale up – Kilo lab, Pilot plant, Manufacturing plant

Validation campaign

Filing for USFDA approval

Commercialisation

DAPOXETINE.HCL

Retrosynthetic analysis

ENANTIOSELECTIVE SYNTHESIS

Corey−Itsuno Reduction of Ketones

MECHANISM – CHIRAL SYNTHESIS

Reference: Corey−Itsuno Reduction of Ketones: A Development of Safe and

Inexpensive Process for Synthesis of Some API Intermediates

Rajendra D. Mahale,* Sudhir P. Chaskar, Kiran E. Patil, Golak C. Maikap,* and

Mukund K. Gurjar, Organic Process Research & Development., 2012, 16,

710−713

DAPOXETINE SYNTHESIS – NAMED REACTIONS

Knoevenagel condensationReductive alkylation

Fischer Esterfication

Michael Addition

Reduction

ROSUVASTATIN – WITTIG REACTION

TEMPO OXIDATION

WITTIG REACTION

TPAP/ TEMPO OXIDATION

TEMPO OXIDATION MECHANISM

Proposed mechanism for the oxidation of primary alcohols under basic

conditions

M. Angelin, M. Hermansson, H. Dong, O. Ramström, Eur. J. Org. Chem., 2006,

4323-4326

ANALYTICAL CHEMISTRY

Wet chemistry

HPLC method development

HPLC/MS analysis

GC, GC/MS

Ion chromatography

Spectroscopic instrumental analysis: NMR, IR, MS, PXRD,

Single Crystal, DSC, TGA, Reaction Calorimetry

OPPORTUNITIES

Synthesis development

Analytical development*

Intellectual property management*

Quality assurance

Regulatory affairs*

Manufacturing: “Make in India” initiative

Industrial Safety & environment: Fire safety*

* post graduate courses offered

Consumer Health care : FMCG : Colgate Palmolive, HLL, Godrej,Femicare

Forensic Science Laboratory

Foods and Beverages industry : Cadbury, Nestle.

Speciality chemicals Industry : Ciba Vision,

Flavours and fragnances industry : IFF

Inorganic Chemicals industry : Tata Chemicals,

Agrochemical industry : Gharda Chemicals,

Veterinary medicines : Pfizer,

Petrochemical Industry: Reliance,

Construction / Ceramic chemicals :

Effluent treatment chemicals / Water treatment /softening chemicals

Textile industry:

OPPORTUNITIES

AN ADVICE

Prepare well for your final Exams!

All the best!

Do not forget your teachers after exams are

over.

Keep in touch with them for guidance and

career opportunities.