chicory root fiber inspires innovation to target globesity · 2019. 11. 28. · chicory root fiber...
TRANSCRIPT
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Chicory root fiber inspires innovation
to target globesity
Elaine E. Vaughan, PhDSensus (Royal Cosun), the Netherlands
17th Nov 2019, Food Matters Live, London
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Agro-industrial cooperative - established ~110 years ago by Dutch sugar beet growers
Sensus, in Royal Cosun Cooperative – plants powering people
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Sensus: introduction
• Sensus established in 1995
R&D with Cosun Innovation Centre
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We believe in inulin to contribute to consumer health
Because consumers will increasingly adopt healthier lifestyles and make
better food choices with ingredients from natural origin. These healthier food
products will be even more successful if they taste great.
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Sensus product portfolio
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Overweight, obesity, a global challenge
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SUGAR: Reinventing Sweetness
SUGAR is the new dietary baddie !
TOO MUCH
SUGAR
../Video/Habit Pioneers Personalized Nutrition Category.mp4
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Frutafit® inulin & Frutalose® FOS as sugar replacer
• Low caloric value (2 kcal / gram)
• Sweetness, up to 50% possible
• Low caloric bulking agent
• Combines well with High Intensity Sweeteners
Mask off and after taste
Synergistic effect
• Different types for each application, easy to use
• Low glycemic response - EC authorized health claim
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SUGAR
SUGAR Reinventing Sweetness Strategies
Albert Heijn, NL
30% sugar reduction Marshmallow
Reduce the Sugar
Make it Natural
Pure Indulgence
Sugar for energy
Milkybar Wowsomes, UK
30% less sugar
Fever-Tree, UK
Light tonic with 4-5g
per 100ml fructose
W.K. Kellogg, UK
plant-based, no-added-sugar cereal
Deliciously Ella, US
energy balls
DiamondPure, MY
milk with Manuka honey Fruitella, UK
30% sugar
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Inulin fermentation by gut microbiota - bifidobacteria - to SCFAs
Inulin → Short Chain Fatty Acids
Acetate 82%
Propionate 12%
Butyrate 6%
Bifidobacteria produce acetate
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Inulin & SCFAs beneficial for human metabolism & weight...
SCFAs, notably acetate, may play central role in inulin effect on metabolic health
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Project ENOF: chicory FOS for body weight ?
Treatment:
p=0.67
oligofructosecontrol
• FOS 16 g/d for 12 wk versus isoenergetic control
➢ Body weight, fat mass & body fat%, waist circumference
➢ Energy intake
➢ Appetite/satiety †Decreased HUNGER for FOS (p=0.04)
(microbiota effects? )
*FOS sign difference vs control (p
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Systematic review – Inulin Fructans & Weight Parameters (preliminary)
Inclusion Criteria
✓ randomised controlled trials
✓ only active
✓ satiety, energy intake, body weight
✓ human (≧2 yr)✓ single or repeated exposures
✓ quality (amount, type, timing defined)
❖ Huge variation studies (doses, matrices) → comparison difficult
❖ ½ show significant effect on satiety & body weight
What are the key mechanisms?
Satiety
12 studies
Effect, n=6
No effect, n=6
Body weightPrimary parameter 12 wk; Dose: ~10-30g/d
Effect, n=3
No effect, n=3
6 studies
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SCFA acetate in distal colon improved weight-related parameters
Can inulins increase SCFA/ acetate in the human distal colon
to improve metabolic parameters - in a pleasant manner ☺ ?
(Na)acetate anal infusion with catheter
Van der Beek & Canfora, et al. (2016) Clinical Science; Canfora et al. (2017) Scientific
Reports; Canfora & Van der Beek, et al. (2017) Gastroenterology
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Does inulin produce SCFAs/acetate in distal colon?
Hypothesis:
Microbiota ferment resistant starch (RS) first, so
Frutafit® inulin will be fermented in the distal colon
TIM Human Colon Model
Inulin + RS (single shot) increases acetate in in vitro distal colon of lean subjects
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Human study with inulin+RS
➢ Does inulin+RS improve metabolism in humans?
➢ Is there a difference between lean and obese insulin-resistant men?
❖ Randomised double blind, n=12 men
❖ ‘lean healthy’ versus ‘overweight pre-diabetic’
❖ +/- high fat meal
❖ Acute intake one day before measurements:
I = Frutafit® inulin 12 g
I+RS = Frutafit® inulin 12 g + resistant starch 7.5 g
C = control (maltodextrin)
C
Day -7 Day 0 washout Day 14 washout Day 28
I+RSI+RS I+RS
I
C
I
C
I
C
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Inulin+RS acute intake improves numerous metabolic parameters in lean men
Fat oxidation
Values: means SEM, *p
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Inulin+RS increases breadth H2 → fermentation in lean men
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Bifidobacteria
Inulin-type fructans …increase
bifidobacteria in overweight/obese adults –
12 week trial(Reimer et al 2017 AmJClinNut)
Longer term intervention required to modify microbiota of obese subjects
Bifidobacteria → acetate
Before & after
high fat mixed meal
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Chicory Inulin & FOS are Prebiotic
Prebiotic: A substrate that is selectively utilized by host microorganisms conferring a health benefit
Inulin selectively enhances bifidobacteria
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Perspectives: Chicory root fibers – supporting human health
Mental
health
Digestive health
Prebiotic
Immunity
Body
weight
Insulin
resistance
Calcium
absorption
Anti-Inflammation
• Dietary fiber
• Low caloric value, sugar replacement
• Low glycemic response (EC authorized claim)
• Prebiotic
• Inulin fibre fermentation - gut microbiota -
metabolites SCFAs - increasing evidence for
supporting weight management, besides other
benefits
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Emanuel Canfora
Ellen Blaak
Koen Venema
Mattea Müller
Monica Mars
Korrie Pol
Cees de Graaf
James Dower
Sabita Soedamah-Muthu
Els Siebelink
Acknowledgements
Diederick Meyer
All study volunteers
Gerben D.A. Hermes
Erwin G. Zoetendal
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Thank you!
Sensus at Food Matters LiveDiscover the benefits of inulin chicory root fibers
Visit us at Booth #E20