child with osa anesthetic considerations
DESCRIPTION
Presented at Pediatric Anesthesia Conference: www.egyptpac.orgTRANSCRIPT
Child with “OSA”Anesthetic Considerations
BY
Eid Ali GumaaAssist. Professor of Anesthesia
Faculty of Medicine
Zagazig University
2013
Milestones
1837: Charles Dickens, in the Posthumous Papers of the Pickwick Club,described an obese boy named Joe with excessive daytime somnolence.
Joe has become the prototype of the obesity-hypoventilation syndrome, and probably suffered from obstructive sleep apnea.
1918: Sir William Osler, was subsequently coined the word „Pickwickian‟ to describe such obese, hypersomnolent patients.
1928: Berger, Human EEG alpha waves.
1937: Loomis, EEG Sleep stages described.
Milestones
1965: Gastaut et al. documented the presence of repetitive obstructive apneas during polysomnographic recording of an obese Pickwickian patient.
The link between obesity, hypoventilation, daytime somnolence, and upper airway obstruction was now established.
1972: Guilleminault – coined the term OSA.
1990: International Classification of Sleep Disorders.
What is Sleep?
“a reversible behavioral state of
perceptual disengagement from and unresponsiveness to the environment”
75% in Non-REM sleep
25% REM sleep –muscle atonia,
autonomic activation
NREM sleep:
Normal muscle tone
Regular respiration
Four stages of NREM sleep based on EEG
Stage 1-small amplitude high frequency waves resembling awake state
Stage 4-large amplitude and lowest frequency waves approaching REM
REM sleep:
Rapid eye movements.
Generalized hypotonia of muscles.
Irregular rate and depth of respiration.
Marked suppression of hypothalamic regulation of homeostasis.
Sleep Disordered Breathing:
Sleep-Disordered Breathing (SDB):
Obstructive Sleep Apnea Syndrome (OSAS)
–Obstructive Sleep Hypopnea Syndrome (OSHS)
–Upper Airway Resistance Syndrome (UARS)
Heavy Snorers Disease (HSD):
Definitions:
OSAS: describe a person with specific symptoms and signs (daytime sleepiness, cognitive dysfunction, snoring, hypertension, and a narrow upper airway), and a polysomnogram showing upper airway obstruction.
associated symptoms have frequently been described, including gastro-esophageal reflux, nocturnal or unusually enuresis, abnormal motor activity, and sweating during sleep.
Definitions (Continue):
Apnea is cessation of airflow >10 sec, ends in arousal
OSA- apnea with continued respiratory efforts
Hypopnea –reduction in airflow of
50% with 4% desaturation, ends in arousal
Apnea / Hypopnea Index (AHI)
Syndromes:
OSAS: AHI >5/ h. on polysomnography.
UARS: AHI <5/ h., excessive daytime somnolence, elevated intra-thoracic pressure
Primary Snoring: no polysomnogram abnormalities
OSAS:
AHI SaO2 (%)
Mild 5–20 >85
Moderate 21–40 65–84
Severe >40 <65
OSA severity scoring
Severe OSAModerate OSAMild OSA
Mouth breathing,
markedly increased
respiratory effort, loud
snoring and „snorting‟,
disrupted sleep
Mouth breathing with
moderate increase in
respiratory effort, +/-
snoring or „snorting‟,
restless sleep
Mouth breathing, slight
increased respiratory
effort, +/- snoring,
sleeps quietly at night
Clinical signs
Frequent prolonged
episodes of paradoxical
breathing, frequent
prolonged desaturation
Normal baseline SpO2,
repeated desaturation to mid 80s
SpO2 in normal limits,
+/- minor dipsSleep study correlate
Control of Airway Patency:
Pathophysiology
Anatomy-Obesity
–Nasal Obstruction
–Pharyngeal Obstruction
Jaw
Tongue
Palate
Physiology–Failure of dilator muscles
–Excessive intra-thoracic pressure
Consequences of OSAS:
Hypertension
Ischemic heart disease
Myocardial dysfunction & arrhythmias
Cerebro-vascular disease
Mood, neurocognitive, behavioral
–Increased industrial/traffic accidents
Increased mortality.
Consequences of OSAS:
Consequences of OSAS:
Upper airway resistance syndrome:
A group of children with:
Symptoms of (OSAS) excessive daytime somnolence but
Without polygraphic apnea and hypopneas.
Rather repeated central nervous system arousals, during sleep
However, these children were found to have increased respiratory efforts during sleep.
Using esophageal manometry as a measure of respiratory effort, it was noted that such arousals were preceded by increased respiratory effort.
The typical presentation of UARS patients:
Daytime somnolence,
Not obese,
May or may not snore,
But typically has a narrowed upper airway anatomy.
particularly hypotension,Of interest, postural hypotension, seems to be a common finding in such patients, in contrast to OSAS where hypertension is the usual finding.
Clinical assessment:
Diagnosis may be wrong in 50 % cases
Loud snoring + witnessed apneas identified OSAHS with sensitivity 78% and specificity 67%
Neck circumference <37cm , >48 cm are associated with low and high risk of OSA
Obesity (BMI>30) independent risk factor but ~ 50% cases are not obese
Polysomnography:
EEG
EOG
EMG
ECG
Oronasal airflow
Pulse oximetry
Respiratory efforts
Snoring
Position
Leg movements
Normal Sleep Study:
Obstructive apnea: Complete cessation of airflow despite efforts to breathe
Desaturation
Obstructive apnea
Respiratory paradox
Snore
Hypopnea:Reduction in airflow compared to baseline, associated with desaturation:
Desaturation
Hypopnea
Progressively increasing respiratory effort
Pediatric OSAS:
2% of children
Boys = Girls
Peak at age 2:5 years
Peak OSA =Peak ATH
Pediatric OSAS:
Snoring- severity not predictive
Many are mouth breathers (Adenoid facies 15% have OSA)
Excessive daytime sleepiness
Obesity Vs. Fatty
Increased respiratory effort
Pediatric OSAS:
Impaired growth
* Possible impairment of release or end-organ response to GH
* Increased caloric effort with respiration
* Difficulty with eating
Cor pulmonal
Associated with GERD
Clinical features of OSA in children and adults
ObesityAdenotonsillar hypertrophy
Craniofacial disorders
Chromosomal abnormalities
Hypotonia
Causes
ObeseFailure to thriveWeight
CommonUncommonDaytime sleepiness
Cognitive impairment
Poor vigilance
Hyperactive
Poor school performance
Secondary enuresis
Neurobehavioural
Adults and Children
Type II OSA
Children
Type I OSA
Clinical features
Middle age2-6 yearsPeak age
Male>>femaleMale=femaleGender
Anesthesia Considerations:
High rate of comorbidity (COPD, CAD, etc)
Pre-op. CPAP/BiPAP
Short, obese neck / retrognathia –
setup for disaster unless prepared
Post-op. HTN
Post-obstructive pulmonary edema
Anesthesia Considerations:
Identification of children at high risk for complications after adenotonsillectomy
Age < 3 years or Weight < 15 Kg.
Severe OSA
Failure to thrive
Cardiac complications
Obesity
Prematurity
Recent URTI
Craniofacial abnormalities
Anesthesia Considerations:
Children with OSA with a cold should be postponed for 4 weeks.
Children with signs and symptoms suggestive of severe OSA with cardiac involvement need to be assessed by a cardiologist prior to surgery
The improvement is not immediate, but children are dramatically improved in the weeks after surgery.
Premedication:
Sedative premedication should be avoided for children with OSA.
Parents to accompany the child to the anaesthetic room to reduce the child‟s
anxiety.
Induction:
May be gaseous or intravenous, depending on the child and the preference of the anesthetist.
Immediately after induction” with the loss of pharyngeal tone “ airway almost
obstruct & may be relieved by jaw thrust and the application of CPAP.
As soon as the child is deep enough an oral airway should be inserted and effectively relieves the obstruction.
Induction (Continue):
Children with severe micrognathia (expected will not be easy to intubate) a cautious gas induction is sensible in this situation.
Intubation and electively ventilation of children with severe OSA, usually using a short acting non-depolarising NMBDs.
Intubation under deep anesthesia without muscle relaxant is unwise in this situation.
Suxamethonium should be used if non depolarising agents are not available.
Maintenance& Recovery:
Children with severe OSA have been estimated to require 50% less opioid than normal children due to increased opioid sensitivity.
Analgesia should be carefully titrated to effect, Simple analgesics should be used.
Awake Extubation at the end of surgery.Opioid analgesia should be kept to a minimum
in the postoperative period.Insertion of a nasopharyngeal prong airway
(NP airway) for these children at the end of surgery
Postoperative:
Airway obstruction is not relieved immediately after surgery in children undergoing adenotonsillectomy for severe OSA. This is mainly due to edema and swelling at the operation site, which improves in the first 24-48 hours after surgery.
The child is nursed on the high dependency area (HAD) with the NP airway in position for the first night at least – it is very important to regularly do suction the airway with soft suction catheter.
Careful overnight observation, using saturation monitoring as part of routine monitoring on the ward / HAD , but do not administer oxygen to those with severe OSA unless required.
Thank you………….