cholelithiasis anaphysio
TRANSCRIPT
Anatomy and Physiology
The Liver
• Digestive function produces bile• Hepatocytes secrete 800–1000 of bile per day
The Gallbladder• pear-shaped sac • posterior of liver• 3-4 in. long• stores and concentrate the bile produced by the liver (up to tenfold)• releases bile into the duodenum of small intestine• fat release of cholecystokinin (CCK) gallbladder contraction bile secretion
The BileComponents:• cholesterol• bile salts• bile pigments (e.g. bilirubin)• phospholipids (e.g. lecithin)• water and body salts (Na+, K+)• small amounts of copper and other metals
The Bile
• Yellowish brownish or olive-green liquid• Can pass directly from liver into duodenum or• Stored in the gallbladder (fasting state)• Alkaline to neutralize the acidic chyme (pH
7.6-8.6)• Function: Emulsifying agent– dietary fat fat droplets
How we degrade cholesterol
• 500 mg cholesterol converted to bile acid/day• As bile salt and bile acid excreted in feces– Bile acid- cholic and chenodeoxycholic acid– Bile salt- bile acid conjugated with taurine/glycine
• Secretion in the bile transported into intestine and eliminated
SYNTHESIS OF BILE SALTS
Where does the bile go?
Liver
Bile canaliculiBile ducts
Common hepatic duct
Common bile duct
Pancreatic duct
Hepatopancreatic ampulla
Duodenum
References
• Digestive Disorders Health Center (2010). WebMD. [Online]. Available at: http://www.cliffsnotes.com/study_guide/The-Liver-and-Gallbladder.topicArticleId-277792,articleId-277768.html [Accessed 11 October 2012].
• The Liver and Gallbladder (n.d.) CliffsNotes. [Online]. Available at http://www.cliffsnotes.com/study_guide/The-Liver-and-Gallbladder.topicArticleId-277792,articleId-277768.html [Accessed 11 October 2012].
• Champe PLEASE PAKI CITE NG MAAYOS KASI EBOOK UNG AKIN. Wala sya nung front page part. Thanks (222-24)