chromosome theory of inheritance. proposed in 1902 by walter sutton and theodor boveri noticed that...
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CHROMOSOME THEORY OF
INHERITANCE
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Proposed in 1902 by Walter Sutton and Theodor Boveri
Noticed that transmission of chromosomes closely parallels
Mendelian pattern
Theory states: chromosomes are the carriers of the genes
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Theory strongly supported after discovery of sex chromosomes
Female: homogameticMale: heterogametic
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Cruzamientos realizados por Morgan
F1: Toda de ojos rojos
Conclusion: Ojo Blanco es recesivo
Generación Parental
Parental femenino Parental masculino
OJOSROJOS
OJOSBLANCOS
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Morgan’s eye-color crosses
F1: All red-eyed
Conclusion? White eye is recessive
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Resultados de la F2
1/2 Hembras ojo rojo : 1/4 machos ojo rojo : 1/4 machos ojo blanco
Todas las hembras son de ojo rojo
En base a este resultado Morgan propone que el carácter ojo blanco debe estar asociado al cromosoma X
Cruzamientos realizados por Morgan
Generación F1
Fenotipos F1 OjosRojos
OjosRojos
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Morgan’s eye-color crosses
What was going on?
All the white-eyed flies were males!
White-eyed flies have lower viability than wild-type
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Morgan’s eye-color crosses
So, the ratio was probably really 3 : 1
On the basis of these results from crosses, Morgan proposed that w is on the X
Hypothesized the following model as an explanation:
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El macho tiene ojos blancos porque es hemicigoto.
Muestra el fenotipo de un alelo recesivo en simple dosis
Cruzamientos realizados por Morgan
Generación Parental
Genotipo Parentaldiploide
Gametoshaploides
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Cruzamientos realizados por Morgan
Gametos masculinos
Gametos femeninos
Generación F1
Genotipos F1
½ w+/w (o X+/Xw) ½ w+/Y (o X+/Y)
Fenotipos F1½ hembras ½ machosTodos de ojos rojos
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Morgan’s eye-color crosses
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Morgan’s eye-color crosses
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Morgan’s eye-color crosses
Morgan’s crosses showed a transmission pattern of:
Male P to Female F1 to Male F2
This pattern is called crisscross inheritance
It is indicative of X-linked recessives
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Morgan’s eye-color crossesReciprocal crosses:
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Morgan’s eye-color crosses
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Morgan’s eye-color crosses
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Morgan’s eye-color crosses
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Morgan’s eye-color crosses
The difference in the phenotypic ratios in the 2 sets of crosses is because of the sex
linkage
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Morgan’s eye-color crosses
When the results of reciprocal crosses are not the same,
Different ratios are seen for the sexes of the offspring
Sex-linkage is strongly suspected
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Morgan’s results strongly supported the chromosome theory of inheritance
The transmission pattern of the phenotypes neatly fit the pattern of the X
chromosome
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The theory is further supported by the parallel behavior between Mendelian traits and chromosomes in meiosis:
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