chronic stress and metabolic systems
DESCRIPTION
Chronic Stress and Metabolic Systems. Mark R. Bartlett Ph.D. Senior Scientist, Pharmanex. YIKES!. Yo quiero. anxiousness. stress. sadness. conflict. personality. bereavement. nervous system. endocrine system. immune system. HEALTH. Adrenal. stressors. Glucocorticoids Gluco=sugar. - PowerPoint PPT PresentationTRANSCRIPT
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Chronic Stress and Metabolic Systems
Mark R. Bartlett Ph.D.
Senior Scientist, Pharmanex
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YIKES!
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Yo quiero...
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HEALTH
endocrine systemnervous system
immune system
stress
sadness
anxiousness
conflict
personality bereavement
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Hypothalamus
stressors
Pituitary
Adrenal
GlucocorticoidsGluco=sugar
CRH
ACTH
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.
70503010-10-100
2
4
6
8
10
12
14
16
18
Cor
tisol
(µg/
100
ml)
Cortisol
0
10
20
30
40
50
AC
TH (p
g/m
l)
70503010-10-10
ACTH
70503010-10-100
100
200
300
400
500
600
700
800
900
1000
1100
1200
1300
1400
NE
(ng/
l)
Norepinephrine
Time (min)
stress stress stress
M. Altemus, Cornell University.Trier Social Stress Test(public speaking & arithmetic)
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The “normal” stress resonse
B. Stress ResponseBegins in Brain
(lots of chemistry)
C. Fight or flight
Why Zebras Don’t Get Ulcers…
Robert Sapolsky, PhDStanford stress
researcher A. Stress happens
D. Stress responseends. Stress hormones dissipate
Yikes!!!
Whew!
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But you are NOT a Zebra…
Yikes!!!
Same stress response begins in the brain(lots of chemistry)
Modern stressors do not permitfight or flight
Stress responsecontinues. Stresshormones lead to
tissue damage
Yikes!!!
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STRESS
ACUTE STRESS• brief• normal circadian rhythm• adaptive
CHRONIC STRESS• prolonged & repeated• disrupted circadian rhythm• maladaptive
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Hypothalamus
stressors
Pituitary
Adrenal
GlucocorticoidsGluco=sugar
CRH
ACTH
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Elevated Cortisol and Appetite• Women with high cortisol response (compared to
women with low cortisol response):• consumed more calories• ate significantly more sweet foods• had more negative moods
• High dietary restraint is associated with high urinary cortisol excretion
• Dietary Restraint = Consciously trying to limit food intake
to achieve or maintain a desired body weight1. Epel ES, et al. Psychoneuroendocrinology 2001;26:37-49.2. McLean JA, Barr SI, Prior JC. Am J Clin Nutr 2001;73:7-12.
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Abdominal Fat & Stress-Related Cortisol
Years in work
Abdominal Fat Stress-related cortisol
<10 <1011-20 >21 11-20 >2119
20
22
24
23
21
0
0.1
0.3
0.5
0.4
0.220.6±2.2
21.5±4.1
22.5±3.7
P<0.05
0.04±0.3
0.15±0.6
0.34±0.5
P<0.05
Rosmond, et al. Obes Res 2000;8:445-450.
nmol/Lcm
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Abdominal Fat Accumulation
High Stress / High Cortisol Normal Stress / Normal Cortisol
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% Change in Abdominal Fat
baseline post-tx (3 mo.) follow-up (6 mo.)
-2.5
-2.0
-1.5
-1.0
-0.5
0.0
0.5
1.0
Treatment Control
Abd
omin
al
Fat
(%
)
Time
TREATMENT
*
F=9.7, p< .008Epel et al. Psychosom Med 2000;62(5):623-32.
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– Stress– Lack of Sleep– Dieting / Restrained eating
Cortisol Levels Are Elevated In...
Adults who need to control cortisol levels are… • Frequently confronted with stressful situations• Getting less than 8 hours of sleep every night• Limiting caloric intake to lose weight
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Stress Management Techniques • Meditation, Coping strategies, etc…
Exercise– Daily, moderate aerobic and strength training
Nutrition
Supplements – Avoid ephedra and related stimulants– Cortisol-controlling supplements (PS, Beta-sitosterol...)– Relaxation supplements (Magnolia, Theanine…)
Evaluation (every month to see how you are doing)
You can control cortisol levels via:
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Magnolia bark • calming effects; non-sedating
Epimedium• reduces cortisol levels during high stress
L-Theanine• increase alpha brain wave production; promotes relaxed alertness and concentration; non-sedating
Phosphatidylserine• reduces cortisol levels following strenuous exercise; improves mental function and positive feelings
Beta-sitosterol• balances cortisol:DHEA ratio; supports immune
function
Scientific Substantiation
*References available upon request
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Cortitrol™ STRESS CONTROL FORMULA- Health Benefits -
• Enhances feelings of wellbeing and control in response to stressful situations
• Improves performance and increased vigor throughout the day
• Better mental concentration and focus
• Supports weight maintenance efforts
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The Right Approachto Weight Management
• Diet
• Exercise
• Supplements:– Cortitrol– Tegreen 97– CraveEase
Removes the metabolic road blocks to long-lasting results.
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