chronic wasting disease in montana · current research and understanding of the potential for....
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![Page 1: Chronic Wasting Disease in Montana · Current research and understanding of the potential for. Chronic Wasting Disease to infect humans . Brent Race D.V.M. Associate Scientist, Rocky](https://reader034.vdocument.in/reader034/viewer/2022050123/5f52da2b9126804705184fbf/html5/thumbnails/1.jpg)
Current research and understanding of the potential forChronic Wasting Disease to infect humans
Brent Race D.V.M.Associate Scientist, Rocky Mountain LaboratoriesHamilton, MT, USA
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Animal prion diseases and host species
Prion source Exposed species Transmission Result
Cattle BSE (mad cow) Cattle ++ BSE
Cattle BSE (mad cow) Human + (low incidence)
CWD Deer, Elk, Moose +++ CWD
CWD Human ?????
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Research progress so far….
• Human epidemiology
• In vitro (at the lab bench)
• In vivo (animal models)
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Summary of RML CWD transmission studiesSquirrel monkeys Cynomolgus macaques Transgenic mice
100% susceptible(25 / 25)
0% susceptible0 / 14
0% susceptible0 / 108*
Race B. et al. Vet Res. 2019AND five other laboratories!!
Race B. et al. J Virol. 2018 Race B. et al. Emerg Infect Dis. 2014 Race B. et al. Emerg Infect Dis. 2009
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Overall conclusions- No epidemiologic evidence for human transmission Scientific studies support a strong species barrier exists between deer and humans
Full review in: Waddell, L. et al. Current evidence on the transmissibility of chronicwasting disease prions to humans-A systematic review. Tranbound Emerg Dis. 2018:65:37-49.
Caveats/concerns:
Numbers game? Incubation period of CWD in people ?Will we recognize what CWD looks like in people (if it were to occur)?CWD strains- differences in transmission ability ?Human genetic diversity ?Intermediate hosts? (potential changes to the prion protein properties)