Chronomics: Chronomics: circadian effects of circadian effects of

magnetic storms in rabbits' magnetic storms in rabbits' circulation and transannual circulation and transannual

variations?variations?

Sergei Chibisov*, Sergei Chibisov*,

Germaine Cornélissen•, Germaine Cornélissen•,

Franz Halberg•Franz Halberg•Материалы третьей Межд. конф. «Болезни цивилизации в Материалы третьей Межд. конф. «Болезни цивилизации в

аспекте учения В.И.Вернадского» 10-12 октября 2005 г., С. 416-аспекте учения В.И.Вернадского» 10-12 октября 2005 г., С. 416-418418

BackgroundBackground

• Biological variables sampled mostly Biological variables sampled mostly daily with variable density (from half-daily with variable density (from half-hourly sampling to once or twice a day) hourly sampling to once or twice a day) for 6 or more (up to 36) years for 6 or more (up to 36) years longitudinally, on the same individual, longitudinally, on the same individual, exhibit reproducibly changing exhibit reproducibly changing chronomes (structures in time).chronomes (structures in time).

BackgroundBackground

• Chronomes consist of Chronomes consist of

1.1. probabilistic and other chaos, probabilistic and other chaos,

2.2. trends and trends and

3.3. a broad spectral element.a broad spectral element.

BackgroundBackground

• Components in the spectral region of Components in the spectral region of about 1.3 years correspond roughly about 1.3 years correspond roughly to the periodicity of about 1.3- and/or to the periodicity of about 1.3- and/or about 1.6-year length in the solar about 1.6-year length in the solar wind, herein called the transyear.wind, herein called the transyear.

BackgroundBackground

• Transyears are defined as spectral Transyears are defined as spectral components with 95% confidence components with 95% confidence intervals for the period between 1 intervals for the period between 1 and 2 years that overlap neither of and 2 years that overlap neither of these two trial periods, nor one these two trial periods, nor one another when there is more than one another when there is more than one transyear (such as in human urinary transyear (such as in human urinary 17-ketosteroid excretion).17-ketosteroid excretion).

BackgroundBackground

• Thus, there can be two or more Thus, there can be two or more distinct components in the about-distinct components in the about-yearly region of biological spectra, yearly region of biological spectra, one or several transyears and/or one or several transyears and/or another component of about 1-year another component of about 1-year length.length.

MethodsMethods

• The left and right ventricular pressures of The left and right ventricular pressures of rabbits were measured at intervals rabbits were measured at intervals around the clock in different seasons.around the clock in different seasons.

• The data were analyzed by linear-The data were analyzed by linear-nonlinear rhythmometry for an nonlinear rhythmometry for an assessment of any circadian, circannual assessment of any circadian, circannual and transyearly variations.and transyearly variations.

MethodsMethods

• We here summarize two kinds of information, one We here summarize two kinds of information, one event-related, the other cycle-related.event-related, the other cycle-related.

• The event-related findings consist of the The event-related findings consist of the statistically significant alteration of the circadian statistically significant alteration of the circadian acrophase of intracardiac pressure by magnetic acrophase of intracardiac pressure by magnetic storms.storms.

• The cycle-related findings consist of the detection The cycle-related findings consist of the detection of a transannual vs. circannual cycle in intracardiac of a transannual vs. circannual cycle in intracardiac pressure of different comparable groups of rabbits pressure of different comparable groups of rabbits sampled in four seasons under comparable sampled in four seasons under comparable conditions in the laboratory. conditions in the laboratory.

ResultsResults

• The circadian acrophase differs with The circadian acrophase differs with statistical significance, with a near-statistical significance, with a near-antiphase during a 3-day span with antiphase during a 3-day span with stormy geomagnetic activity versus stormy geomagnetic activity versus similar spans during relatively quiet similar spans during relatively quiet conditions in 3 other seasons as well as in conditions in 3 other seasons as well as in the same season 4 years earlier, when the same season 4 years earlier, when data collected over a single day also differ data collected over a single day also differ in terms of MESOR and circadian in terms of MESOR and circadian amplitude. amplitude.

ResultsResults

• Differences in MESOR and circadian Differences in MESOR and circadian amplitude from season to season are part amplitude from season to season are part of an about-yearly variation.of an about-yearly variation.

• Acrophases are numerically more tightly Acrophases are numerically more tightly clustered at the 1.3-year than at the 1.0-clustered at the 1.3-year than at the 1.0-year trial period, covering 36˚ vs. 46˚, year trial period, covering 36˚ vs. 46˚, respectively (360˚ being equated to each respectively (360˚ being equated to each of these periods).of these periods).

Rhythmometric Summaries

Trial period (years)Trial period (years)VariableVariable -------- 1.0 -------- 1.0

--------------------- 1.3 -------------- 1.3 -------

MESOMESOR R

± SE± SE

PRPR

(%)(%)AmplitudAmplitud

e e

±± SE SE

AcrophasAcrophase e

± SE± SE

PRPR

(%)(%)AmplitudAmplitude e ±± SE SE

Acrophase Acrophase ± SE± SE

MAP-LVMAP-LV 119.5 119.5 ±± 1.4 1.4

1212 15.1 15.1

±± 1.9 1.9-6-6°°

±± 7 71212 16.5 16.5

±± 1.8 1.8-324-324°°

±± 9 9

SBP-LVSBP-LV 199.3 199.3 ±± 1.3 1.3

99 12.6 12.6

±± 1.9 1.9-22 -22 °°

±± 8 866 10.8 10.8

±± 1.7 1.7-336-336°°

±± 13 13

MAP-MAP-RVRV

23.0 23.0

±± 0.2 0.299 2.0 2.0

±± 0.3 0.3-348 -348 °°

±± 9 999 2.5 2.5

±± 0.3 0.3-309-309°°

±± 8 8

SBP-RVSBP-RV 42.6 42.6

±± 0.4 0.41010 3.8 3.8

±± 0.5 0.5-336 -336 °°

±± 8 81010 4.9 4.9

±± 0.6 0.6-300-300°°

±± 7 7P<0.001 in all cases for zero-amplitude test of 1.0 and 1.3-year components.

DiscussionDiscussion

• Data collected over several years will be Data collected over several years will be needed to distinguish between the needed to distinguish between the circannual and transannual components, circannual and transannual components, notably since the tighter clustering of notably since the tighter clustering of acrophases of the transyear needs to be acrophases of the transyear needs to be qualified by a larger standard error as qualified by a larger standard error as compared to that of the calendar year. compared to that of the calendar year.

DiscussionDiscussion

• Associations of magnetic activity with the Associations of magnetic activity with the rabbits' circulation at the circadian and rabbits' circulation at the circadian and transannual frequencies have their precedent in transannual frequencies have their precedent in the circulation of babies and in human adults' the circulation of babies and in human adults' blood pressure and heart rate studied blood pressure and heart rate studied longitudinally by studies of cross-spectral longitudinally by studies of cross-spectral coherence.coherence.

• The results await scrutiny by time-varying The results await scrutiny by time-varying coherence and phase synchronization. coherence and phase synchronization.

ConclusionsConclusions

• The solar wind now and in an The solar wind now and in an evolutionary past competed with the evolutionary past competed with the seasons in the circulation of rabbits seasons in the circulation of rabbits and humans.and humans.

• Effects of the cosmos can be Effects of the cosmos can be quantified by chronomics.quantified by chronomics.