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Chulabhorn Graduate Institute

Environmental Toxicology Program

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Program Management Committee

Assoc. Prof. Dr. Jutamaad Satayavivad

Chairperson

Program Management Committee

Dr. Panida Navasumrit Dr. Piyajit WatcharasitDr. Daam Settachan

Dr. Jantamas KanitwithayanunDr. Nuchanart Rangkadilok

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Environmental Toxicology Overview

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Diploma (credits)

M.S.(credits)

Ph. D.(credits)

Required Courses 12* 9 12Elective Courses 12 15 12Thesis - 12 36

Total 24 36 60Duration 2 years 2-3 years 3-4

years

ET Curriculum - credits

* Basic science (3) + Environmental Toxicology (9) = 12

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• Principles of Toxicology (3 credits)• Environmental Toxicology (2 credits)• Seminar in Environmental Toxicology (2 credits)• Environmental and Health Risk Assessment and

Management of Toxic Chemicals (2 credits)• Detection of Environmental Pollutants and

Monitoring of Health Effects (3 credits)

ET Curriculum – core courses

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Nature of Courses/Teaching

Traditional lectures – highly technical, i.e. mechanistic:Principles of Toxicology; Immunotoxicology & Reproductive Toxicology; Environmental Toxicology

Lectures with practical component: Detection of Environmental Pollutants and Monitoring of Health Effects

Lectures that include policy components:Environmental and Health Risk Assessment and Management of Toxic Chemicals; Health, Development & Environment

Others: - Seminar in Environmental Toxicology- Case Studies in Applied Biosciences

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• Elucidate mechanisms through which chemical, physical & biological agents in the environment induce toxicity & pathogenesis, including cancer

• Understand effects of environmental pollutants & industrial chemicals as modifiers of physiological & pathological status, & influence of host factors such as nutritional status & disease states on toxicity & carcinogenicity of chemicals

• Develop new methods for detection of environmental toxicants

• Understand gene-environment interactions

ET Research Goals

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• Exposure & health impacts of urban air pollution, particularly carcinogenic compounds such as PAHs, benzene and 1,3-butadiene

• Cellular responses to chronic arsenic exposure in Southern Thailand

• Effects of vitamin B deficiency on toxicity of benzene• Biomarkers of exposure, effects & susceptibility in

environmentally & occupationally exposed people• Detection of environmental toxicants by

dielectrophoresis

Examples of ET Research

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Research Interests

Researcher Research Interests

Assoc. Prof. Dr. Jutamaad Satayavivad

Head, Laboratory of Pharmacology, CRI

• Metals and Pesticides: Effects on Environment & Health

• Non-neuronal cholinergic functions: Immunotoxicological aspects

• Nutraceuticals

• Pharmacological and Toxicological Studies of Selected Medicinal Plants

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Research Interests

Researcher Research Interests

Dr. Panida NavasumritLaboratory of

Environmental Toxicology, CRI

• Molecular mechanisms of environmental pollutants

• Molecular epidemiology

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Research Interests

Researcher Research Interests

Dr. Piyajit WatcharasitLaboratory of Pharmacology,

CRI

• Neurodegenerative diseases

• Cell Signaling

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Research Interests

Researcher Research Interests

Dr. Daam SettachanLaboratory of

Environmental Toxicology, CRI

• Development and refinement of whole-effluent toxicity testing with local indicator species as a monitoring tool for wastewater effluent quality

• Rodent models for inhalation toxicity testing to determine health effects from exposure to environmental toxicants

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Research Interests

Researcher Research Interests

Dr. Nuchanart RangkadilokLaboratory of Pharmacology,

CRI

• Contamination of toxic metals & pesticides in food & environmental samples

• Phytochemical analysis & pharmacological effects of selected medicinal plants

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Research InterestsResearcher Research Interests

Dr. Jantamas KanitwithayanunLaboratory of Pharmacology,

CRI

• Potential human health effects from exposure to environmental pollutants and industrial chemicals

• Evaluation of biomarkers of exposure, human health effects & individual susceptibility to carcinogenic pollutants

• Protective effects of selected medicinal plants against environmental pollutant-induced toxicity

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Thank you

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CB, ABS & ET

• ET is relatively narrow in focus - measuring exposures and effects, & understanding mechanisms of action & modifying factors

• ABS focuses on disease & covers other factors, including influence of environmental factors, e.g. climate change, etc…

• Drug development pulls all programs together – understanding target disease (ABS) to drug discovery (CB) to drug testing (ET)

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MS PhDCore: 13 13Elective: 11 11Thesis: 12 36Total: 36 60

• Principles of Applied Biosciences

• Experimental Strategies for Biological Problems

• Case Studies in Applied Biosciences

• Pathobiology & Analysis of Disease at the Organism

Level• Pathobiology & Analysis

of Disease at the Population Level

MS PhDCore: 9 12Elective: 15 12Thesis: 12 36Total: 36 60

• Principles of Toxicology• Environmental Toxicology

• Seminar in Environmental Toxicology

• Detection of Environmental Pollutants & Monitoring of Health

Effects• Environmental & Health

Risk Assessment & Management

Chemical Biology

Applied Biological Sciences:

Environmental Health

MS PhDCore: 15 15Elective: 9 9Thesis: 12 36Total: 36 60

• Principles of Applied Biosciences

• Experimental Strategies for Biological Problems

• Case Studies in Applied Biosciences

• Advanced Organic Chemistry

• Spectroscopic Methods for Organic Compounds &

Biomolecules• Drug Discovery &

Development

Environmental Toxicology