Tips to search the literatureExample with CRD

Patrice CHALON, MscKnowledge manager, Centre fédéral d'expertise des soins de santé (KCE)

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Approach

1. Identify your problem

2. Define a structured question

3. Find the best evidence

4. How valid is the study?

5. What are the results?

6. How should I apply the results to patient care?

Source: Guyatt G, Evidence-Based Medicine Working Group. Users' guides to the medical literature : a manual for evidence-based clinical practice. 2nd ed. New York: McGraw-Hill Medical; 2008.

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1. IDENTIFY YOUR PROBLEM

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Example

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2. DEFINE A STRUCTURED QUESTION

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Example

Source : Horsmans Y, Thiry N, le Polain M, Adler M, Colle I, Delwaide J, Michielsen P, Orlent H, Van Damme P, Hulstaert F. Rapport coût-efficacité du traitement antiviral de l’hépatite B chronique en Belgique. Partie 1: Examen de la littérature et résultats d’une étude nationale. Health Technology

Assessment (HTA). Bruxelles: Centre fédéral d’expertise des soins de santé (KCE). 2010. KCE Reports 127B. D/2010/10.2738/23.

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Example (cont.)

(CHB OR (Hepatitis B ADJ2 Chronic*))

AND

(NA OR (Nuclo?ide ADJ2 analogue) OR (Interferon ADJ3 therap*))

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3. FIND THE BEST EVIDENCE

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Databases for economic evaluations

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CRD DATABASESHTA DATABASE, NHS EED, DARE

http://www.crd.york.ac.uk/crdweb/

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CRD fact sheetProducer Centre for Reviews and Dissemination, University

of York (UK)Content DARE contains 15,000 abstracts of systematic reviews

including over 6,000 quality assessed reviews and details of all Cochrane reviews and protocols.

NHS EED contains 24,000 abstracts of health economics papers including over 7,000 quality assessed economic evaluations.

DARE and NHS EED include details of abstracts in the process of being written and these can be 'fast-tracked' on request.

HTA brings together details of over 8,000 completed and ongoing health technology assessments from around the world.

Indexation Medical Subject headings (MeSH), updated annually manual indexation based on full text reading

Source : http://www.crd.york.ac.uk/crdweb/

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Example

Source : Horsmans Y, Thiry N, le Polain M, Adler M, Colle I, Delwaide J, Michielsen P, Orlent H, Van Damme P, Hulstaert F. Rapport coût-efficacité du traitement antiviral de l’hépatite B chronique en Belgique. Partie 1: Examen de la littérature et résultats d’une étude nationale. Health Technology

Assessment (HTA). Bruxelles: Centre fédéral d’expertise des soins de santé (KCE). 2010. KCE Reports 127B. D/2010/10.2738/23.

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Search 1st concept (patient / pathology)

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Check MeSH term

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Results

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Search : 2nd concept (therapy)

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Strategies

Source : Horsmans Y, Thiry N, le Polain M, Adler M, Colle I, Delwaide J, Michielsen P, Orlent H, Van Damme P, Hulstaert F. Rapport coût-efficacité du traitement antiviral de l’hépatite B chronique en Belgique. Partie 1: Examen de la littérature et résultats d’une étude nationale. Health Technology

Assessment (HTA). Bruxelles: Centre fédéral d’expertise des soins de santé (KCE). 2010. KCE Reports 127B. D/2010/10.2738/23.

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Thank you!

Copyrights: This work is released under Creative Commons License

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