class routes of drug administration
TRANSCRIPT
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Dr. RAGHU PRASADA M SMBBS,MDASSISTANT PROFESSORDEPT. OF PHARMACOLOGYSSIMS & RC.
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Enteral routesOralSublingualRectal
Parentral routesIntra venousintra muscularintra peritonialIntrathecalintramedullaryIntra-arterialIntra-articularSubcutaneousIntracardiacEpidural
InhalationalTransdermal
Topical routeConjunctival, nasalAuditory, vaginalUrethralInunctionDermal
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1. Commonest, Convenient , Cost effective2. No Skill required, Self medication, Safest,
Sterilization is not required3. Acceptable, Less Adverse effects compared to
parenteral route4. Painless,5. Large volume (doses) can be givenBoth for systemic /local effects in G.I.T (All effects)For local effect e.g. neomycin (an aminoglycoside),
anthelmintics, antiamoebic.
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1. Absorption varies (delay, decrease, or increase )2. affected by food or drugs that affect GI motility
e.g. antimuscarinic, opioids )3. Dose may not accurately be delivered4. Irritation of gastric mucosa5. Patient compliance not ensured6. First pass metabolism/Presystemic elimination -
Metabolism of drug (to inactive form) afteradministration before it reaches the systemiccirculation.Greater the first pass effect, lesser will be the
bioavailability
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Not suitable for Unconscious patients, Vomitingpatients, Emergency --- (Slow onset of action)Following drugs can not be given by oral route:Drugs destroyed by Stomach pH -benzyl penicillin)Drugs destroyed by Intestinal enzymes (e.g., InsulinHydrophilic drugs which can not absorbed
(e.g. neomycin)Drug interaction: One drug can affect the absorptionof other drug e.g., antacids decrease the absorption of
tetracycline.
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Rapid onset of actionUseful in emergency- (glyceryl trinitrate, nifedipine &ergotamine), especially if tablet is crushed, giving greatersurface area for solutionEffect can be terminated by spitting out tabletNo sterilization required, No skill neededFirst pass hepatic metabolism Increase bioavailability
Not affected by gastric acidity or intestinal enzymes
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Inconvenient for frequent useIrritation of oral mucosa & excessive salivationPromotes swallowing, so losing the advantage of bypassing the first pass effectPatient compliance not ensuredNot suitable for large doses and vomiting patientsBitter, irritant drugs cannot be given
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Can be used for producing both the systemic effectsand local effectsDrugs that are irritant to stomach can be given bysuppository (aminophylline)Suitable in unconscious, vomiting , motion sickness,migraine or when a patient can not swallow, & whencooperation is lacking (sedation in children)
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Sterilization is not requiredMinimal skill is requiredAvoid 50% first pass hepatic metabolism (from
lower rectum)For local effect e.g. in proctitis or colitisDemerit-Psychological, patient may be embarrassedIrritation of mucosa & inflammation may occur
with repeated useAbsorption unreliable, especially if rectum is full of
faeces
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Rapid onset of actionUseful in emergencyNo first pass effect, 100% bioavailability,Dose more accurately delivered & give effective, &Highly predictable blood concentrationSuitable in vomiting , motion sickness, migraineUnconscious patients, or when a patient can not
swallow & when cooperation is lackingLarge volume (doses) of drug can be given
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Costly, Inconvenient, Local irritationMore chances of adverse effects,most dangerousMaximal Sterilization, Skill is requiredSelf-medication is not advisableDrugs that are too irritant(anticancer agents) to be givenby other routes
Chances of local venous thrombosisand infection with prolonged infusion
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Reliable and suitable for irritant drugs anddepot preparations (penicillin, neuroleptics,medroxyprogesterone) can be used at monthly
or longer intervalsAbsorption is more rapid than subcutaneous injectionor oral route (soluble preparations are absorbed within10 – 30 mins)
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DemeritsInconvenient
Painful especially for frequent useMore chances of adverse effects than oral route
Sterilization is requiredChances of infection are more
Skill required for administrationLocal irritation at site of administration
Not acceptable for self administrationIf any adverse effect occur that can not be
removed.
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Can be used for local and systemic effects bothReliable and acceptable for self administration
(e.g. diabetic patients taking Insulin)For local effect --- e.g. local anestheticsPoor absorption in peripheral circulatory failureRepeated injections at one site can cause
lipodystrophy, resulting in erraticabsorption (insulin)
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Small amount of drug can be givenSlow absorptionTuberculin syringeExample: BCG vaccine, diagnostic tests,
Allergic sensation testing
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Site: Lumen of arteryMerits: Greater concentration of the drug can bedeliveredDemerits: Expertise and asepsis is requiredExamples: Radiopaque contrast for coronaryangiography and cerebral angiography
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Site: Subarachanoid spaceMerits: Bypass blood brain barrier and blood CSF barrier-acts directly on meninges and spinal cordDemerits-Asepsis required, expertise is neededPainful and Risky Eg: Radio-opaque contrast media,Xylocaine inj, intrathecal injection of streptomycin in TBEpidural-Through vertebral interspace between dura andlining of spinal canal Eg: Xylocaine injection
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Site: Tibial or Sternal bone marrowThe needle is introduced into marrow cavity andeffects are similar to those following intravenousinjection. This route is used when veins are notavailable specially in children.Merit: onset of action very fastDemerits: Strict aseptic conditions,
Expertise and skill requiredPainful and risky
Examples: Bone Marrow transplantation
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Site: Injection directly into the joint space Merit: High concentration is obtained in localized area Demerits: sepsis, Joint damage, Pain Examples: Hydrocortisone, Gold chloride for
rheumatoid arthritisIntra Cardiac
In cardiac arrest intra-cardiac injection ofadrenaline is made for resuscitation.
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Drugs directly into the nose.Desmopressin is administered intranasally in theTreatment of diabetes insipidusSalmon calcitonin- osteoporosisGnRH analogues
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Site-Peritoneal spaceThe peritoneum offers a large absorbing surface areafrom which drugs enter circulation rapidly butprimarily by way of portal vein. Hence First-Pass effectnot avoided.Example: Dialyzing fluid-poisoning and renal failureIn lab animals
Merits-Rapid absorption-large surface areaDemerits-Painful, Risky, Adhesions, Peritonitis
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Drugs as gases can be rapidly taken up or eliminatedCan be used for both local & systemic effectsSelf administration is practicableAs gas General anaestheticsAs aerosolβ2 –adrenoceptor agonist bronchodilators
Aerosols & powders provide high localconcentration for action on bronchi, minimizingsystemic effects
Aerosols can also be used for systemic effect, e. gergotamine for migraineAs powder, e.g. sodium chromoglycate
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Special apparatus is neededDrug must be nonirritant.If the patient is unconsciousObstructed bronchi (mucus plugs in asthma) maycause therapy to fail
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Active ingredient is delivered across theskin for systemic distribution.Example: transdermal scopolamine, transdermalnitroglycerine
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Conjunctival, nasal and auditoryEye drops, Ointment, nasal drops, nasal spraysIsotonic aqueous solutions of drugs- sulfacetamide,chloramphenicol, gentamycinAtropine & β-adrenoceptor blocker to eyeVaginal and urethralSolutions, ointments, emulsions, foams, tablets,suppositories and pessaries -Antifungal agentsInunction and dermalRubbing the drug preparation on to the skin, dusting,spraying
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MeritsHigh local concentration can be usedwithout systemic effect
Demerit-Systemic effects can occur especially whenthere is tissue destruction e.g., adrenal steroids& neomycin to skinOnly small number of drugs can be used bythis route, Slow onset of action and localreactions can occur
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Intravenous 30-60 SecondsIntraosseous 30-60 SecondsEndotracheal 2-3 MinutesInhalation 2-3 MinutesSublingual 3-5 MinutesIntramuscular 10-20 MinutesSubcutaneous 15-30 MinutesRectal 5-30 MinutesIngestion 30-90 MinutesTransdermal (Topical) Variable (Minutes To Hours)
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“All substances are poisons;there is none which is not a poison.The right dose differentiates a poison from a remedy.”
Paracelsus (1493-1541)
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