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Classic Drug association in M

DR.SHERIF BADRAWY

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Psychosis

Dr. Sherif

Badrawy

Digitally

Sherif Ba

DN: cn=D

o=KKUH,

email=sh

hoo.com

Date: 201

+03'00'

8/19/2019 Classical Drug association

3/319

◥ levodopa

◥ corticosteroids

8/19/2019 Classical Drug association

4/319

Increased risk of  venous

thromboembolism

8/19/2019 Classical Drug association

5/319

◥ combined oral

contraceptive pill

◥ tamoxifen◥ antipsychotics

8/19/2019 Classical Drug association

6/319

increased risk of 

endometrial cance

8/19/2019 Classical Drug association

7/319

Tamoxifen

8/19/2019 Classical Drug association

8/319

Flushing

8/19/2019 Classical Drug association

9/319

◥ amlodipine◥ sildenafil

◥ tamoxifen

8/19/2019 Classical Drug association

10/319

Mucositis

8/19/2019 Classical Drug association

11/319

◥ methotrexate

◥ fluorouracil (5-FU

8/19/2019 Classical Drug association

12/319

Fluid retention

8/19/2019 Classical Drug association

13/319

◥ pioglitazone

◥ ciclosporin

◥ corticosteroids◥ hydralazine

8/19/2019 Classical Drug association

14/319

Peripheral

neuropathy 

8/19/2019 Classical Drug association

15/319

◥

 vincristine,vinblastine,cispla◥ isoniazid

◥ amiodarone◥ phenytoin

◥ etanercept

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16/319

haemorrhagic cystit

8/19/2019 Classical Drug association

17/319

Cyclophosphamide

8/19/2019 Classical Drug association

18/319

Carbimazole

8/19/2019 Classical Drug association

19/319

myelosuppression/agranulocyto

8/19/2019 Classical Drug association

20/319

Primaquine

8/19/2019 Classical Drug association

21/319

haemolysis inpatients with G6PD

deficiency 

8/19/2019 Classical Drug association

22/319

Toxicity in patients

 with thiopurine

methyltransferasedeficiency 

8/19/2019 Classical Drug association

23/319

azathioprine

8/19/2019 Classical Drug association

24/319

Thrombocytopaeni

8/19/2019 Classical Drug association

25/319

◥ heparin

◥ sodium valproate◥ thiazides

◥ valproic acid

◥ quinidine

8/19/2019 Classical Drug association

26/319

antagonist of the

P2Y12 adenosine

diphosphate (ADPreceptor

8/19/2019 Classical Drug association

27/319

Clopidogrel

8/19/2019 Classical Drug association

28/319

acetazolamide

8/19/2019 Classical Drug association

29/319

Normal anion gap

metabolic acidosis

8/19/2019 Classical Drug association

30/319

Sumatriptan -

contraindicated by

8/19/2019 Classical Drug association

31/319

ischaemic heart

disease

8/19/2019 Classical Drug association

32/319

tendon damage

8/19/2019 Classical Drug association

33/319

Ciprofloxacin

8/19/2019 Classical Drug association

34/319

acts as a decoy receptor for TNF-

alpha

8/19/2019 Classical Drug association

35/319

Etanercept

8/19/2019 Classical Drug association

36/319

Prevents microtubul

depolymerisation &

disassembly,decreasing free tubul

8/19/2019 Classical Drug association

37/319

docetaxel

8/19/2019 Classical Drug association

38/319

Inhibits formation o

microtubules

8/19/2019 Classical Drug association

39/319

 vincristine

8/19/2019 Classical Drug association

40/319

Intracranial

hypertension

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41/319

◥ isotretinoin

◥ corticosteroids

8/19/2019 Classical Drug association

42/319

Pulmonary,retroperitoneal and

cardiac fibrosis

8/19/2019 Classical Drug association

43/319

 bromocriptine

8/19/2019 Classical Drug association

44/319

glucagon-like

peptide-1 mimetic

8/19/2019 Classical Drug association

45/319

Exenatide

8/19/2019 Classical Drug association

46/319

increased risk of 

fractures

8/19/2019 Classical Drug association

47/319

◥ Pioglitazone

◥ heparin

◥ bisphosphonates◥ corticosteroids

8/19/2019 Classical Drug association

48/319

 Adenosine -

contraindicated by

8/19/2019 Classical Drug association

49/319

asthma

8/19/2019 Classical Drug association

50/319

 Weight gain

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51/319

◥ sodium valproate

◥ sulfonylureas◥ pioglitazone

◥ lithium◥ antipsychotics

◥ corticosteroids

8/19/2019 Classical Drug association

52/319

decreases IL-2release by inhibitin

calcineurin

8/19/2019 Classical Drug association

53/319

Ciclosporin -

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54/319

Causes cross-linkin

in DNA 

8/19/2019 Classical Drug association

55/319

cisplatin

8/19/2019 Classical Drug association

56/319

Oculogyric crisis

8/19/2019 Classical Drug association

57/319

◥ antipsychotics

◥ metoclopramide

8/19/2019 Classical Drug association

58/319

Metformin

Monitoring

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59/319

review if creatinine > 130, stop

metformin if > 150

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60/319

 ACE inhibitors

Monitoring

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61/319

 Acceptable↑ in serum

creatinine , up to 50% from baseline or up to 265

(whichever is smaller) & anincrease in potassium up to 5

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oesophagitis

8/19/2019 Classical Drug association

63/319

Bisphosphonates

8/19/2019 Classical Drug association

64/319

8/19/2019 Classical Drug association

65/319

Methotrexate

8/19/2019 Classical Drug association

66/319

5-HT3 antagonist

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67/319

Ondansetron -

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68/319

Increased risk of 

ischaemic stroke

8/19/2019 Classical Drug association

69/319

◥ combined oralcontraceptive pill

◥ antipsychotics

8/19/2019 Classical Drug association

70/319

Hypomagnesaemia

8/19/2019 Classical Drug association

71/319

cisplatin

8/19/2019 Classical Drug association

72/319

torticollis

8/19/2019 Classical Drug association

73/319

 Antipsychotics

8/19/2019 Classical Drug association

74/319

slate-grey appearan

8/19/2019 Classical Drug association

75/319

 Amiodarone

8/19/2019 Classical Drug association

76/319

 Anal ulceration

8/19/2019 Classical Drug association

77/319

nicorandil

8/19/2019 Classical Drug association

78/319

Increased risk of 

cervical cancer

8/19/2019 Classical Drug association

79/319

combined oral contraceptive p

8/19/2019 Classical Drug association

80/319

Sildenafil -

contraindicated by

8/19/2019 Classical Drug association

81/319

recent myocardial

infarction

8/19/2019 Classical Drug association

82/319

 Aspirin in

 breastfeeding

8/19/2019 Classical Drug association

83/319

must be avoided

8/19/2019 Classical Drug association

84/319

Corneal deposits

8/19/2019 Classical Drug association

85/319

◥ amiodarone

◥ antipsychotics

8/19/2019 Classical Drug association

86/319

irreversible blockad

of H+/K+ ATPase

8/19/2019 Classical Drug association

87/319

Omeprazole -

8/19/2019 Classical Drug association

88/319

Metformin -

contraindicated by

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89/319

recent myocardial

infarction

8/19/2019 Classical Drug association

90/319

Palpitations

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91/319

◥ levodopa◥ hydralazine

◥ adenosine

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92/319

 Akathisia (severe

restlessness)

8/19/2019 Classical Drug association

93/319

antipsychotics

8/19/2019 Classical Drug association

94/319

Red man syndrome

8/19/2019 Classical Drug association

95/319

 vancomycin

8/19/2019 Classical Drug association

96/319

Epistaxis

8/19/2019 Classical Drug association

97/319

◥ isotretinoin (dtdryness)

◥ warfarin

8/19/2019 Classical Drug association

98/319

Reactivation of 

tuberculosis

8/19/2019 Classical Drug association

99/319

◥ corticosteroids◥ infliximab

◥ etanercept

8/19/2019 Classical Drug association

100/319

8/19/2019 Classical Drug association

101/319

Rasburicase -

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102/319

Depression

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103/319

◥ isotretinoin◥ corticosteroids

◥ levodopa

8/19/2019 Classical Drug association

104/319

Hypertrichosis

8/19/2019 Classical Drug association

105/319

◥ ciclosporin

◥ minoxidil

8/19/2019 Classical Drug association

106/319

Cinchonism

8/19/2019 Classical Drug association

107/319

quinidine

8/19/2019 Classical Drug association

108/319

Thrombophlebitis

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109/319

◥ amiodarone

◥ vancomycin

8/19/2019 Classical Drug association

110/319

Impotence

8/19/2019 Classical Drug association

111/319

thiazides

 beta-blockers

8/19/2019 Classical Drug association

112/319

Pruritus

8/19/2019 Classical Drug association

113/319

◥ opioids

◥ fenofibrate

8/19/2019 Classical Drug association

114/319

Hypocalcaemia

8/19/2019 Classical Drug association

115/319

◥ loop diuretics◥

 foscarnet

8/19/2019 Classical Drug association

116/319

Skin necrosis

8/19/2019 Classical Drug association

117/319

 warfarin

8/19/2019 Classical Drug association

118/319

anticoagulant whicdon't cross-react é

HIT Abs

◥

8/19/2019 Classical Drug association

119/319

◥ Danaparoid◥ Lepirudin

◥ Argatroban

8/19/2019 Classical Drug association

120/319

Oligospermia

8/19/2019 Classical Drug association

121/319

sulphasalazine

8/19/2019 Classical Drug association

122/319

urinary retention

◥ Tricyclic

8/19/2019 Classical Drug association

123/319

antidepressants◥

 antipsychotics◥ chlorpheniramin

8/19/2019 Classical Drug association

124/319

Proximal myopathy

8/19/2019 Classical Drug association

125/319

corticosteroids

8/19/2019 Classical Drug association

126/319

Hypothyroidism

◥

8/19/2019 Classical Drug association

127/319

◥ amiodarone◥ lithium

◥ carbimazole

8/19/2019 Classical Drug association

128/319

Blocks T-type calciuchannels in thalami

neurons

8/19/2019 Classical Drug association

129/319

ethosuximide

Binds to TNF-alph

8/19/2019 Classical Drug association

130/319

and prevents it from

 binding with TNFreceptors

8/19/2019 Classical Drug association

131/319

infliximab

8/19/2019 Classical Drug association

132/319

 Anti-CD20

monoclonal antibod

8/19/2019 Classical Drug association

133/319

rituximab

Decreases absorptio

8/19/2019 Classical Drug association

134/319

Decreases absorptio

of fat-soluble

 vitamins

8/19/2019 Classical Drug association

135/319

cholestyramine

8/19/2019 Classical Drug association

136/319

Osteoporosis

◥ corticosteroids

8/19/2019 Classical Drug association

137/319

◥ corticosteroids

◥ heparin

◥ pioglitazone

8/19/2019 Classical Drug association

138/319

Mania

8/19/2019 Classical Drug association

139/319

corticosteroids

Competitive

8/19/2019 Classical Drug association

140/319

antagonist of nicotinacetylcholine

receptors

8/19/2019 Classical Drug association

141/319

atracurium

8/19/2019 Classical Drug association

142/319

Myalgia

8/19/2019 Classical Drug association

143/319

◥ statins◥ fenofibrate

8/19/2019 Classical Drug association

144/319

Dopamine receptoagonist

◥ ropinirole

8/19/2019 Classical Drug association

145/319

◥ apomorphine◥ bromocriptine

◥ cabergoline

8/19/2019 Classical Drug association

146/319

 Acetylcholinesterasinhibitor

◥ donepezil

8/19/2019 Classical Drug association

147/319

◥ pyridostigmine◥ galantamine

◥ rivastigmine◥ edrophonium

inhibits RANK ligand

8/19/2019 Classical Drug association

148/319

 which in turn inhibitthe maturation of 

osteoclasts

8/19/2019 Classical Drug association

149/319

Denosumab -

8/19/2019 Classical Drug association

150/319

Insomnia

8/19/2019 Classical Drug association

151/319

8/19/2019 Classical Drug association

152/319

Tachycardia

◥ isosorbide

8/19/2019 Classical Drug association

153/319

mononitrate◥ hydralazine

◥ minoxidil

8/19/2019 Classical Drug association

154/319

Neurolepticmalignant syndrom

8/19/2019 Classical Drug association

155/319

antipsychotics

8/19/2019 Classical Drug association

156/319

 Anorexia

◥ levodopa

8/19/2019 Classical Drug association

157/319

◥ digoxin

◥ interferon-alpha

8/19/2019 Classical Drug association

158/319

Optic neuritis

8/19/2019 Classical Drug association

159/319

ethambutol

8/19/2019 Classical Drug association

160/319

Non-arteritic anteriischaemic neuropath

8/19/2019 Classical Drug association

161/319

sildenafil

8/19/2019 Classical Drug association

162/319

coarsening of faciafeatures

8/19/2019 Classical Drug association

163/319

Phenytoin

8/19/2019 Classical Drug association

164/319

Pneumonitis

8/19/2019 Classical Drug association

165/319

◥ amiodarone◥ methotrexate

8/19/2019 Classical Drug association

166/319

Bronchospasm

b bl k

8/19/2019 Classical Drug association

167/319

◥ beta-blockers◥ adenosine

8/19/2019 Classical Drug association

168/319

Hypertension

i id

8/19/2019 Classical Drug association

169/319

◥ corticosteroids◥ ciclosporin

Inhibits microtubule

l i i b bi di

8/19/2019 Classical Drug association

170/319

polymerization by binding totubulin, interfering with

mitosis. Also inhibits

neutrophil motility and activ

l hi i

8/19/2019 Classical Drug association

171/319

colchicine

8/19/2019 Classical Drug association

172/319

hi i

8/19/2019 Classical Drug association

173/319

azathioprine

8/19/2019 Classical Drug association

174/319

Ni dil

8/19/2019 Classical Drug association

175/319

Nicorandil -

bi li di

8/19/2019 Classical Drug association

176/319

 bivalirudin

8/19/2019 Classical Drug association

177/319

 Activates antithrombin

III F l th

8/19/2019 Classical Drug association

178/319

III. Forms a complex thinhibits thrombin, facto

Xa, Ixa, Xia and XIIa

f ti t d

8/19/2019 Classical Drug association

179/319

unfractionatedheparin

Bl dd

8/19/2019 Classical Drug association

180/319

Bladder cancer

i lit

8/19/2019 Classical Drug association

181/319

pioglitazone

S i f

8/19/2019 Classical Drug association

182/319

Suppression of growth in children

ti t id

8/19/2019 Classical Drug association

183/319

corticosteroids

8/19/2019 Classical Drug association

184/319

◥ l t i i

8/19/2019 Classical Drug association

185/319

◥ lamotrigine◥ carbamazepine

I d i k f

8/19/2019 Classical Drug association

186/319

Increased risk of  breast cancer

combined oral contraceptive p

8/19/2019 Classical Drug association

187/319

combined oral contraceptive p

MAO B inhibitor

8/19/2019 Classical Drug association

188/319

MAO-B inhibitor

selegiline

8/19/2019 Classical Drug association

189/319

selegiline

COMT inhibitor

8/19/2019 Classical Drug association

190/319

COMT inhibitor

◥ entacapone

8/19/2019 Classical Drug association

191/319

◥ entacapone◥ tolcapone

Inhibits sodium

absorption at the

8/19/2019 Classical Drug association

192/319

absorption at the beginning of the dist

convoluted tubule

bendroflumethiazid

8/19/2019 Classical Drug association

193/319

 bendroflumethiazid

Blocks the action o

cyclooxygenase 1 an

8/19/2019 Classical Drug association

194/319

cyclooxygenase-1 an2 and thromboxane

 A2 formation

aspirin

8/19/2019 Classical Drug association

195/319

aspirin

Hyperprolactinaem

8/19/2019 Classical Drug association

196/319

Hyperprolactinaem

◥ antipsychotics

8/19/2019 Classical Drug association

197/319

◥ antipsychotics◥ metoclopramide

Enhance the effect of th

inhibitory

8/19/2019 Classical Drug association

198/319

inhibitory neurotransmitter gamm

aminobutyric acid (GAB

benzodiazepines

8/19/2019 Classical Drug association

199/319

 benzodiazepines

Alopecia

8/19/2019 Classical Drug association

200/319

 Alopecia

◥ sodium valproat

8/19/2019 Classical Drug association

201/319

◥ sodium valproat◥ valproic acid

Increased risk of

8/19/2019 Classical Drug association

202/319

Increased risk of myocardial infarctio

combined oral contraceptive p

8/19/2019 Classical Drug association

203/319

combined oral contraceptive p

Constipation

8/19/2019 Classical Drug association

204/319

Constipation

◥ antipsychotics

◥ verapamil

8/19/2019 Classical Drug association

205/319

◥ verapamil◥ tricyclic antidepressan

◥ opioids

Apomorphine

8/19/2019 Classical Drug association

206/319

 Apomorphine

dopamine receptor

8/19/2019 Classical Drug association

207/319

dopamine receptoragonist

Retinopathy

8/19/2019 Classical Drug association

208/319

Retinopathy 

hydroxychloroquin

8/19/2019 Classical Drug association

209/319

hydroxychloroquin

Slurred speech

8/19/2019 Classical Drug association

210/319

Slurred speech

◥ antipsychotics

◥ phenytoin

8/19/2019 Classical Drug association

211/319

◥ phenytoin

◥ amantadine

Gout

8/19/2019 Classical Drug association

212/319

Gout

◥ thiazides

◥ pyrazinamide

8/19/2019 Classical Drug association

213/319

◥ pyrazinamide◥ loop diuretics

◥ nicotinic acid

Blurred vision

8/19/2019 Classical Drug association

214/319

Blurred vision

◥ antipsychotics

◥ tricyclic antidepressani b di

8/19/2019 Classical Drug association

215/319

◥ tricyclic antidepressan◥ ivabradine

◥ chlorpheniramine

Gingival hyperplasi

8/19/2019 Classical Drug association

216/319

Gingival hyperplasi

◥ phenytoin◥ ciclosporin

◥ amlodipine

8/19/2019 Classical Drug association

217/319

◥ p

◥ diltiazem

◥ verapamil

8/19/2019 Classical Drug association

218/319

◥ levodopa

◥ antipsychotics

8/19/2019 Classical Drug association

219/319

◥ antipsychotics

◥ phenytoin

Photosensitivity

8/19/2019 Classical Drug association

220/319

Photosensitivity 

◥ amiodarone

◥ tetracyclines◥ i i i

8/19/2019 Classical Drug association

221/319

◥ tetracyclines◥ isotretinoin

◥ thiazides

Nasal congestion

8/19/2019 Classical Drug association

222/319

Nasal congestion

8/19/2019 Classical Drug association

223/319

Ototoxicity

8/19/2019 Classical Drug association

224/319

Ototoxicity 

◥ loop diuretics

◥ aminoglycosides

8/19/2019 Classical Drug association

225/319

◥ aminoglycosides

◥ vancomycin

Ataxia

8/19/2019 Classical Drug association

226/319

 Ataxia

◥ phenytoin

◥ sodium valproat◥ b i

8/19/2019 Classical Drug association

227/319

◥ sodium valproat◥ carbamazepine

◥ amantadine

Dry mouth

8/19/2019 Classical Drug association

228/319

Dry mouth

◥ isotretinoin◥ tricyclic antidepressan

◥ levodopa

8/19/2019 Classical Drug association

229/319

p◥ antipsychotics

◥ chlorpheniramine

Hypoglycaemia

8/19/2019 Classical Drug association

230/319

ypog ycae a

8/19/2019 Classical Drug association

231/319

Heart failure

8/19/2019 Classical Drug association

232/319

◥ verapamil◥ diltiazem

8/19/2019 Classical Drug association

233/319

◥ p◥ diltiazem

Dry skin

8/19/2019 Classical Drug association

234/319

y

isotretinoin

8/19/2019 Classical Drug association

235/319

Cartilage damage

8/19/2019 Classical Drug association

236/319

g g

ciprofloxacin

8/19/2019 Classical Drug association

237/319

p

pyrimidine analogue whi

induces cell cycle arrestand apoptosis by blockin

8/19/2019 Classical Drug association

238/319

and apoptosis by blockin

thymidylate synthase

Fluorouracil (5-FU)

8/19/2019 Classical Drug association

239/319

(5 )

discolouration of teeth

8/19/2019 Classical Drug association

240/319

teeth

Tetracyclines

8/19/2019 Classical Drug association

241/319

y

Osteonecrosis of thjaw

8/19/2019 Classical Drug association

242/319

 jaw 

 bisphosphonates

8/19/2019 Classical Drug association

243/319

p p

Blocks the release oacetylcholine

8/19/2019 Classical Drug association

244/319

acetylcholine

Botox

8/19/2019 Classical Drug association

245/319

Heart block 

8/19/2019 Classical Drug association

246/319

◥ verapamil◥ diltiazem

◥ ivabradine◥ d i

8/19/2019 Classical Drug association

247/319

◥ adenosine

◥ digoxin

8/19/2019 Classical Drug association

248/319

◥ phenytoin◥ corticosteroids

8/19/2019 Classical Drug association

249/319

◥ corticosteroids

8/19/2019 Classical Drug association

250/319

Pegvisomant -

8/19/2019 Classical Drug association

251/319

agonist of the A1

receptor in the AV

8/19/2019 Classical Drug association

252/319

node

 Adenosine -

8/19/2019 Classical Drug association

253/319

Hypokalaemia

8/19/2019 Classical Drug association

254/319

◥ thiazides

◥ loop diuretics

8/19/2019 Classical Drug association

255/319

◥ amphotericin B

Stimulates alphaadrenergic, dopaminerg

and serotonergic receptoresulting in uterine

8/19/2019 Classical Drug association

256/319

resulting in uterine

contractions

ergometrine

8/19/2019 Classical Drug association

257/319

Blocks the uptake o

dopamine,noradrenaline and

8/19/2019 Classical Drug association

258/319

noradrenaline and

serotonin

cocaine

8/19/2019 Classical Drug association

259/319

Crystallinenephropathy 

8/19/2019 Classical Drug association

260/319

p p y

aciclovir

8/19/2019 Classical Drug association

261/319

8/19/2019 Classical Drug association

262/319

◥ digoxin◥

 amantadine◥ phenytoin

8/19/2019 Classical Drug association

263/319

◥ p y

◥ metoclopramide

Haemolysis in

patients with G6PD

8/19/2019 Classical Drug association

264/319

deficiency 

◥ primaquine◥ ciprofloxacin

◥ sulphonamides◥ sulphasalazine

8/19/2019 Classical Drug association

265/319

◥ sulphasalazine

◥ sulfonylureas

Meglitinides MOA

8/19/2019 Classical Drug association

266/319

increase pancreatic

insulin secretion

8/19/2019 Classical Drug association

267/319

non-specificphosphodiesterase

inhibitor and decreasescellular uptake of

8/19/2019 Classical Drug association

268/319

cellular uptake of 

adenosine

Dipyridamole -

8/19/2019 Classical Drug association

269/319

Pancreatitis

8/19/2019 Classical Drug association

270/319

◥ corticosteroids◥ sodium valproat

◥ thiazides

8/19/2019 Classical Drug association

271/319

◥ valproic acid

Facilitate GABAA action by increasing th

duration of chloride

8/19/2019 Classical Drug association

272/319

channel opening

 barbiturates

8/19/2019 Classical Drug association

273/319

 Yellow-green vision

8/19/2019 Classical Drug association

274/319

digoxin

8/19/2019 Classical Drug association

275/319

 Arachidonic acid produc

causing vasoconstriction

increased platelet

8/19/2019 Classical Drug association

276/319

aggregation

TXA2

8/19/2019 Classical Drug association

277/319

Lymphadenopathy

8/19/2019 Classical Drug association

278/319

phenytoin

8/19/2019 Classical Drug association

279/319

Tremor

8/19/2019 Classical Drug association

280/319

◥ lithium◥ ciclosporin

◥ sodium valproat

8/19/2019 Classical Drug association

281/319

◥ antipsychotics

Sumatriptan -

contraindicated by

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282/319

cerebrovascular

disease

8/19/2019 Classical Drug association

283/319

Inhibits GABA 

transaminase

8/19/2019 Classical Drug association

284/319

 valproic acid

8/19/2019 Classical Drug association

285/319

Increased

susceptibility tosevere infection

8/19/2019 Classical Drug association

286/319

severe infection

◥ corticosteroids

◥ ciclosporin

8/19/2019 Classical Drug association

287/319

Hyponatraemia

8/19/2019 Classical Drug association

288/319

◥ thiazides◥ loop diuretics

◥ sulfonylureas◥ carbamazepine

8/19/2019 Classical Drug association

289/319

◥ sodium valproate

8/19/2019 Classical Drug association

290/319

theophylline

8/19/2019 Classical Drug association

291/319

Increases cGMP

leading to smoothmuscle relaxation

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292/319

muscle relaxation

◥ isosorbide

mononitrate◥ hydralazine

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293/319

◥ hydralazine

 Antagonises the

effects of vitamin K

8/19/2019 Classical Drug association

294/319

 warfarin

8/19/2019 Classical Drug association

295/319

Gynaecomastia

8/19/2019 Classical Drug association

296/319

spironolactone

8/19/2019 Classical Drug association

297/319

Drug-induced lupu

8/19/2019 Classical Drug association

298/319

◥ hydralazine

◥ procainamide

◥ hydralazine

◥ phenytoin◥ carbamazepine

◥ tetracyclines

8/19/2019 Classical Drug association

299/319

◥ tetracyclines

◥ isoniazid

Disulfiram-like

reaction with alcoho

8/19/2019 Classical Drug association

300/319

8/19/2019 Classical Drug association

301/319

Nephrotoxicity 

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302/319

◥ ciclosporin◥ aminoglycosides

◥ amphotericin B

◥ foscarnet

◥ vancomycin

8/19/2019 Classical Drug association

303/319

◥ loop diuretics

HER2/neu recepto

antagonist

8/19/2019 Classical Drug association

304/319

trastuzumab

8/19/2019 Classical Drug association

305/319

Respiratory 

depression

8/19/2019 Classical Drug association

306/319

◥ benzodiazepines

◥ opioids

8/19/2019 Classical Drug association

307/319

8/19/2019 Classical Drug association

308/319

◥ ciprofloxacin

◥ antipsychotics◥ foscarnet

8/19/2019 Classical Drug association

309/319

Dizziness

8/19/2019 Classical Drug association

310/319

◥ phenytoin◥ carbamazepine

◥ amantadine

8/19/2019 Classical Drug association

311/319

◥ nicorandil

Hyperlipidaemia

8/19/2019 Classical Drug association

312/319

◥ isotretinoin◥ corticosteroids

◥ ciclosporin◥ protease inhibitors

◥

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313/319

◥ antipsychotics

Lipodystrophy 

8/19/2019 Classical Drug association

314/319

◥ protease inhibitor

◥ corticosteroids

8/19/2019 Classical Drug association

315/319

Cholesterol gallston

8/19/2019 Classical Drug association

316/319

8/19/2019 Classical Drug association

317/319

Bradycardia

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318/319

◥ amiodarone

◥ beta-blockers

◥ digoxin

◥ verapamil

◥ diltiazem

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319/319

◥ ivabradine