clean-in-place: bhs meeting the requirements in the chemical, pharmaceutical … · 2019-08-05 ·...
TRANSCRIPT
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CLEAN-IN-PLACE:
BHS MEETING THE REQUIREMENTS
IN THE CHEMICAL, PHARMACEUTICAL
AND FOOD INDUSTRIES
Tim Ochel, Project Manager
Filtration Application Engineering
BHS-Sonthofen GmbH
Website: www.bhs-filtration.com
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BHS Rotary Pressure Filter:
Chemical, Pharmaceutical and Food
Applications
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© BHS-Sonthofen
BHS-Sonthofen GmbH Location
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© BHS-Sonthofen
BHS-Sonthofen GmbH
Divisions
Filtration
Technology
Mixing
Technology
Crushing
Technology
Recycling
Technology
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© BHS-Sonthofen
BHS-Filtration New Location
• New Location for
three divisions
• 14,000 ft2 Facility
Office, Laboratory
and Warehouse
• $1.3 million
Investment
BHS-Sonthofen Inc., Charlotte, NC
Filtration, Mixing & Recycling
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© BHS-Sonthofen
• Pressure & Vacuum Filtration
• Batch & Continuous Operation
• High Solids to Clarification
• Cake Washing & Drying
• Automatic Discharge
• Wet Cake
• Dry Cake
• Concentrated Slurry
BHS Technology Portfolio
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Candle Filter
Pressure Plate Filter
Autopress
Rotary Pressure Filter Indexing Belt Filter
Rubber Belt Filter
BHS Filtration Technology Portfolio
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SELECTION OF FILTRATION
TECHNOLOGY
CAKE STRUCTURE /PROCESS
PARAMETERS FROM LAB TESTING
• Filtration Pressure
• Cake Thickness
• Filter Media
• Cake Washing
• Cake Drying
• Cake Discharge
• Cycle Times
• Process Guarantees
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© BHS-Sonthofen
BHS-Filtration New Location BHS Laboratories:
Charlotte, NC / Sonthofen, Germany
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© BHS-Sonthofen
BHS Lab Testing
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BHS Lab Testing:
Pressure or Vacuum
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© BHS-Sonthofen
BHS Lab Testing:
Pressing – Drying for Vacuum
Air for
Pressing
For
Vacuum
Filtration
Air for Blowing
for Cake Drying
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BHS Lab Testing: Cake Structure
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BHS Rotary Pressure Filter (RPF)
BHS Rotary Pressure Filter (RPF) Page 14
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Main components
BHS Rotary Pressure Filter (RPF) Page 15
housing bearing shield control head drive drum
cake discharge separating elements filter cells
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Functional principle
BHS Rotary Pressure Filter (RPF) Page 16
BHS rotary pressure filter with center drive
“Three in one” machine: filtration, washing, drying
Hydraulic (gas free) filtration and washing
Multi step counter-current cake washing
Completely enclosed process room
Internal pressure release: cake discharge at ambient pressure
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Machine design
BHS Rotary Pressure Filter (RPF) Page 18
For toxic or hazardous media:
Second containment
Closed bearing shields
Leakage detection
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Applications
BHS Rotary Pressure Filter (RPF) Page 19
Agrochemicals
Pharmaceuticals
Organic chemicals
Intermediate plastic products
Natural extracts
Cellulose products
Dyes and pigments Food
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Clean-In-Place Requirements
BHS Rotary Pressure Filter (RPF) Page 20
Avoiding of potential contamination by solid deposit:
Cross contamination
micro-bacterial contamination
Requirement:
cGMP design and engineering of the installation
Effective, efficient and reliable cleaning procedure.
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Cleaning-in-place (CIP)
BHS Rotary Pressure Filter (RPF) Page 21
Fully or semi automated cleaning procedure without dismantling the system.
The five influencing factors:
Velocity
Temperature
Chemicals
Time
Technology
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CIP mechanism
BHS Rotary Pressure Filter (RPF) Page 22
Mechanical:
Removal of solids by impact with high pressure and
turbulent flow.
Chemical:
Removal of solids by chemical reaction with e.g. caustic
soda and/or phosphoric and nitric acids
Sterilization:
Disinfection with e.g. sodium hypochlorite
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Cleaning of the housing
BHS Rotary Pressure Filter (RPF) Page 23
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Hollow cone spray nozzles
BHS Rotary Pressure Filter (RPF) Page 24
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© BHS-Sonthofen
CIP devices
BHS Rotary Pressure Filter (RPF) Page 25
Housing and inlets
Drum and filter media
Cake discharge chute
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Design features
BHS Rotary Pressure Filter (RPF) Page 26
Materials and surface roughness
Good drainage philosophy (“self drain”)
less gaps and dead ends
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Riboflavin test
BHS Rotary Pressure Filter (RPF) Page 27
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Example: CIP in Food Application
BHS Rotary Pressure Filter (RPF) Page 28
Process step Time [min] Washing agent Recycling
Filter draining 3 - -
Pre-rinse 3 water no
Main cleaning 1 40 detergent yes
Main cleaning 2 80 detergent yes
Subsequent cleaning 20 water yes
Final rinse 3 water no
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Example: CIP in Food Application
BHS Rotary Pressure Filter (RPF) Page 29
Total rinsing consumption: approx. 4 m³
Max. temperature rinsing liquid: 60°C
Cleaning time: approx. 3 h
Cleaning period: weekly
Velocity filtrate pipes: approx. 2 m/s
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Pharma Applications
40 rotary pressure filters for active pharmaceutical products (API) within the last 15 years
FDA approved sealing material
ATEX rated machine design
Safe and tight process
High efficient multiple step cake washing and extraction
BHS Rotary Pressure Filter (RPF) Page 30
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Success story – Pharma
Application Product: antibiotics
Suspension: app. 2 m³/h,
solids in isopropanol
Filter area: 2,16 m²
Cake thickness: 12 mm
Production rate:
app. 130 kg/h incl. moisture
Process steps: filtration,
cake washing with water and
isopropanol, dewatering with
nitrogen
BHS Rotary Pressure Filter (RPF) Page 32
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Highlights review
BHS Rotary Pressure Filter (RPF) Page 34
Hydraulic (gas free) filtration
Counter current cake washing
Cake discharge at ambient pressure,
no lock system
Fully automatic cleaning-in-place system
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© BHS-Sonthofen
Tim Ochel, Project Manager
Filtration Application Engineering
BHS-Sonthofen GmbH
Website: www.bhs-filtration.com
Thank You!