clearing the bph path - the trendlines group
TRANSCRIPT
Clearing the BPH Path
Minimally Invasive Solution for BPH
Legal disclaimerIMPORTANT NOTICE
This presentation has been prepared by ProArc Medical Ltd. (the “Company”) solely for informational purposes. The information contained herein has been prepared to assist prospective investors in making their own evaluation of the Company and does not purport to be complete or to contain all of the information a prospective or existing investor may desire. In all cases, interested parties should conduct their own investigation and analysis of the Company and the data set forth in this information. The Company has prepared this presentation based on information available to it, including information derived from public sources that have not been independently verified. The Company makes no representation or warranty as to the accuracy or completeness of this information and shall not have any liability for any representations (expressed or implied) regarding information contained in, or for any errors omissions in, this presentation. This presentation includes certain statements and estimates provided by the Company with respect to the projected future performance of the Company. Such statements, estimates and projections reflect various assumptions by management concerning possible anticipated results, which assumptions may or may not be correct. No representations are made as to the accuracy of such statements, estimates or projections. This presentation may contain statements that are not historical facts, referred to as “forward looking statements.” The Company’s actual future results may differ materially from those suggested by such statements. No assurance can be given that future events will occur or that projections will be achieved. Past performance is not a reliable indication of future performance. This presentation is not, and nothing in it should be construed as, an offer, invitation or recommendation in respect of the Company’s securities, or an offer to sell, or a solicitation of an offer to buy, the Company’s securities in any jurisdiction. Neither this presentation nor anything in it shall form the basis of any contract or commitment. Prospective investors should not construe the contents of this presentation as business, legal, tax, investment or other advice. Each prospective investor should make his, her or its own inquiries and consult his, her or its own advisors as to the appropriateness and desirability of an investment in the Company and as to business, legal, tax and related matters concerning an investment in the Company.
An investment in the Company shall be allowed only to such number and category of investors in accordance with applicable laws and regulations and pursuant to a predetermined process. Accordingly, detailed information in connection with the investment shall be revealed and delivered only to a limited number of qualifying investors as provided by law.
Company Highlights
Team with
Track Record
Pre-Regulatory
Stage
Now Funding… Patents
granted/allowed
Scientific Publications
BPH Prostatetic Implant
CAGR 35%
Simple, Cost-Effective,
office procedure
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Enlarged Prostate (BPH) Symptoms
• Frequency of urination
• Urgency
• Feeling of incomplete
emptying
• Weak stream
• Nocturia
• Sexual dysfunction
Normal Prostate
Bladder
Open Urethra
Source: The Canadian Journal of Urology, International Supplement, October 2015
Enlarged Prostate
Bladder
Obstructed Urethra
Benign Prostatic Hyperplasia (enlarged prostate)
affects ~50% of men 50+ and 90% of men 80+
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Growing Costs
12 million men are
actively treated in
the US each year
Prevalence of BPH
is increasing with
aging population
$4 billion annually in direct
treatment costs in the US2
Source: (1) (2) The Canadian Journal of Urology, International Supplement, October 2015
Diagnosis and
treatment of BPH
represents the
largest segment of
urologic practice,
representing 23% of all office visits.1
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MedicationEffective in relieving
symptoms but expensive with
diminishing effect over time
SurgeryExpensive with steep
learning curve
Current Treatments Are Not Cost Effective
Dizziness, fainting,
fatigue, headache, nasal
congestion, retrograde
ejaculation and more
Pain, bleeding,
impotence,
incontinence, urethral
stricture (narrowing)
The market seeks
a simple,
cost-effective,
minimally invasive
BPH treatment
Do NothingSome patients accept their
condition and are reluctant to
undergo treatment
Risk of severe kidney
damage, acute urinary
retention, urinary
bleeding and more
Side Effects
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Fastest Growth: Sub-Surface Implants
Sub-Surface Prostatic
Urethral Lift Implant
35% CAGR
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TURP (mono or bipolar)
Thermal Ablation
Laser Surgery
Steam (Rezum)
Aquablation
Prostatic Artery Embolization
Sub-Surface Prostatic Urethral Lift Implant
Transurethral Resection/Ablation of the Prostate
Sub-surface prostatic urethral lift Implant
Sexual function preservation
Minor side effects
Reversible
Long procedure time 30-45 min
Irreversible
High probability of sexual dysfunction
Prostatic Urethral Lift
Our Solution: ClearRingTM
• Patented technology
• Office-based
• Easy to learn
• Fast & simple procedure
• Reversible procedure
ProArc Medical Animation Link
The ClearRingTM
implant is
positioned inside
the prostate just
under the surface
and reshapes the
prostatic urethra.
It provides 360º
support along the
urethra.
Sub-Surface Prostate Implant
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Scientific Publication in the EUROPEAN UROLOGY FOCUS
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Clinical Evidence
AfterBefore
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ClearRing Advantages
ClearRing has the
potential to be the
most financial
attractive solution
for urologists
ClearRing
• Safe: fully implantable inside the prostate;
• Economic incentive: With comparable effectiveness, ClearRing offers an
attractive financial incentive with a single Clearing Implant
• Simple: shorter procedure time; expected shorter learning curve;
expected use by more urologists
• ClearRing offers a 100% reversible treatment
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Executive Team & Scientific Advisors
David Nitsan, CEOIsrael
Yair Feld, MDFounder, Medical Director,
Israel
Gilad Heftman, R&D
Israel
Frank Mastandrea, MDFL, United States
Fernando Gomez Sancha, MD
Spain
Egils Vjiaters, MDLatvia
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