SPECIAL FEATURES

Highlights of This Issue 2019

CCR Translations

2021 Immune Exclusion-Wnt/CTNNB1 Class PredictsResistance to Immunotherapies in HCCRoser Pinyol, Daniela Sia, and Josep M. LlovetSee related article, p. 2116

2024 Mapping Physical Tumor Microenvironment andDrug DeliveryHadi T. Nia, Lance L. Munn, and Rakesh K. JainSee related article, p. 2136

2027 No Cell Left Unturned: Intraductal PapillaryMucinous Neoplasm HeterogeneityYasmin G. Hernandez-Barco, Nabeel Bardeesy, andDavid T. TingSee related article, p. 2194

2030 Circulating Tumor DNA in Advanced Anal Cancer:A Blood Biomarker Goes ViralVan K. MorrisSee related article, p. 2109

Reviews

2033 Advances inHER2-Targeted Therapy: Novel Agentsand Opportunities Beyond Breast and GastricCancerFunda Meric-Bernstam, Amber M. Johnson,Ecaterina E. Ileana Dumbrava, Kanwal Raghav,Kavitha Balaji, Michelle Bhatt, Rashmi K. Murthy,Jordi Rodon, and Sarina A. Piha-Paul

2042 Immunotherapy for Glioblastoma: Adoptive T-cellStrategiesBryan D. Choi, Marcela V. Maus, Carl H. June, andJohn H. Sampson

Perspectives

2049 Challenges with Novel Clinical Trial Designs:Master ProtocolsMichael Cecchini, Eric H. Rubin, Gideon M. Blumenthal,Kassa Ayalew, Howard A. Burris, Michele Russell-Einhorn,Hildy Dillon, H. Kim Lyerly, Gregory H. Reaman,Scott Boerner, and Patricia M. LoRusso

CLINICAL TRIAL BRIEF REPORTS

2058 Postprogression Outcomes for Osimertinib versusStandard-of-Care EGFR-TKI in Patients withPreviously Untreated EGFR-mutated AdvancedNon–Small Cell Lung CancerDavid Planchard, Michael J. Boyer, Jong-Seok Lee,Arunee Dechaphunkul, Parneet K. Cheema,Toshiaki Takahashi, Jhanelle E. Gray, Marcello Tiseo,Suresh S. Ramalingam, Alexander Todd, Astrid McKeown,Yuri Rukazenkov, and Yuichiro Ohe

2064 Immunologic Correlates of the Abscopal Effect ina SMARCB1/INI1-negative Poorly DifferentiatedChordoma after EZH2 Inhibition andRadiotherapyMrinal M. Gounder, Guo Zhu, Lev Roshal, Eric Lis,Scott R. Daigle, Steven J. Blakemore, Neil R. Michaud,Meera Hameed, and Travis J. Hollmann

CLINICAL TRIALS: TARGETED THERAPY

2072 Combination Paclitaxel and Palbociclib: Resultsof a Phase I Trial in Advanced Breast CancerAmy S. Clark, Nicholas P. McAndrew, Andrea Troxel,Michael Feldman, Priti Lal, Mark Rosen, Jessica Burrell,Colleen Redlinger, MaryannGallagher, Angela R. Bradbury,Susan M. Domchek, Kevin R. Fox, Peter J. O'Dwyer, andAngela M. DeMichele

2080 Autophagy Inhibition to Augment mTORInhibition: a Phase I/II Trial of Everolimus andHydroxychloroquine in Patients with PreviouslyTreated Renal Cell CarcinomaNaomi B. Haas, Leonard J. Appleman, Mark Stein,Maryann Redlinger, Melissa Wilks, Xiaowei Xu,Angelique Onorati, Anusha Kalavacharla, Taehyong Kim,Chao Jie Zhen, Sabah Kadri, Jeremy P. Segal,Phyllis A. Gimotty, Lisa E. Davis, and Ravi K. Amaravadi

CLINICAL TRIALS: IMMUNOTHERAPY

2088 Efficacy and Safety of the Biosimilar ABP 215Compared with Bevacizumab in Patients withAdvanced Nonsquamous Non–small Cell LungCancer (MAPLE): A Randomized, Double-blind,Phase III StudyNicholas Thatcher, Jerome H. Goldschmidt,Michael Thomas, Michael Schenker, Zhiying Pan,Luis Paz-Ares Rodriguez, Valery Breder, Gyula Ostoros, andVladimir Hanes

April 1, 2019 � Volume 25 � Number 7

Clinical Cancer Research

Table ofContents

iv

on June 25, 2020. © 2019 American Association for Cancer Research. clincancerres.aacrjournals.org Downloaded from

2096 A Pilot Trial of the Combination of TransgenicNY-ESO-1–reactive Adoptive Cellular Therapywith Dendritic Cell Vaccination with or withoutIpilimumabTheodore S. Nowicki, Beata Berent-Maoz,Gardenia Cheung-Lau, Rong Rong Huang,Xiaoyan Wang, Jennifer Tsoi, Paula Kaplan-Lefko,Paula Cabrera, Justin Tran, Jia Pang,Mignonette Macabali, Ivan Perez Garcilazo,Ignacio Baselga Carretero, Anusha Kalbasi,Alistair J. Cochran, Catherine S. Grasso,Siwen Hu-Lieskovan, Bartosz Chmielowski,Bego~na Comin-Anduix, Arun Singh, and Antoni Ribas

PRECISION MEDICINE AND IMAGING

2109 Clinical Validity of HPV Circulating Tumor DNAin Advanced Anal Carcinoma: An Ancillary Studyto the Epitopes-HPV02 TrialAlice Bernard-Tessier, Emmanuelle Jeannot,David Guenat, Alice Debernardi, Marc Michel,Charlotte Proudhon, Anne Vincent-Salomon, Ivan Bi�eche,Jean-Yves Pierga, Bruno Buecher, Aur�elia Meurisse,�Eric Francois, Romain Cohen, Marine Jary,V�eronique Vendrely, Emmanuelle Samalin, Farid El Hajbi,Nabil Baba-Hamed, Christophe Borg,Francois-Cl�ement Bidard, and Stefano KimSee related commentary, p. 2030

2116 Prospective Genotyping of HepatocellularCarcinoma: Clinical Implications of Next-Generation Sequencing for Matching Patients toTargeted and Immune TherapiesJames J. Harding, Subhiksha Nandakumar,Joshua Armenia, Danny N. Khalil, Melanie Albano,Michele Ly, Jinru Shia, Jaclyn F. Hechtman, Ritika Kundra,Imane El Dika, Richard K. Do, Yichao Sun,T. Peter Kingham, Michael I. D'Angelica, Michael F. Berger,David M. Hyman, William Jarnagin, David S. Klimstra,Yelena Y. Janjigian, David B. Solit, Nikolaus Schultz, andGhassan K. Abou-AlfaSee related commentary, p. 2021

2127 Methylation Biomarker Panel Performance inEsophaCap Cytology Samples for DiagnosingBarrett's Esophagus: A Prospective ValidationStudyZhixiong Wang, Swetha Kambhampati, Yulan Cheng,Ke Ma, Cem Simsek, Alan H. Tieu, John M. Abraham,Xi Liu, Vishnu Prasath, Mark Duncan, Alejandro Stark,Alexander Trick, Hua-Ling Tsai, Hao Wang, Yulong He,Mouen A. Khashab, Saowanee Ngamruengphong,Eun J. Shin, Tza-Huei Wang, and Stephen J. Meltzer

2136 Elastography Can Map the Local InverseRelationship between Shear Modulus and DrugDelivery within the Pancreatic DuctalAdenocarcinoma MicroenvironmentHexuan Wang, Reem Mislati, Rifat Ahmed,Phuong Vincent, Solumtochukwu F. Nwabunwanne,Jason R. Gunn, Brian W. Pogue, and Marvin M. DoyleySee related commentary, p. 2024

2144 The First-week Proliferative Response ofPeripheral Blood PD-1þCD8þ T Cells Predicts theResponse to Anti-PD-1 Therapy in Solid TumorsKyung Hwan Kim, Jinhyun Cho, Bo Mi Ku, Jiae Koh,Jong-Mu Sun, Se-Hoon Lee, Jin Seok Ahn,Jaekyung Cheon, Young Joo Min, Su-Hyung Park,Keunchil Park, Myung-Ju Ahn, and Eui-Cheol Shin

2155 Integrated Molecular Analysis of UndifferentiatedUterine Sarcomas Reveals Clinically RelevantMolecular SubtypesAmrei Binzer-Panchal, Elin Hardell, Bj€orn Viklund,Mehran Ghaderi, Tjalling Bosse, Marisa R. Nucci,Cheng-Han Lee, Nina Hollfelder, P�adraic Corcoran,Jordi Gonzalez-Molina, Lidia Moyano-Galceran,Debra A. Bell, John K. Schoolmeester, Anna Ma

�sb€ack,

Gunnar B. Kristensen, Ben Davidson, Kaisa Lehti,Anders Isaksson, and Joseph W. Carlson

2166 CirculatingmiRNAs and PD-L1 Tumor ExpressionAre Associated with Survival in AdvancedNSCLC Patients Treated with Immunotherapy:a Prospective StudyMattia Boeri, Massimo Milione, Claudia Proto,Diego Signorelli, Giuseppe Lo Russo, Carlotta Galeone,Carla Verri, Mavis Mensah, Giovanni Centonze,Antonia Martinetti, Elisa Sottotetti, Ugo Pastorino,Marina Chiara Garassino, and Gabriella Sozzi

2174 irRECIST for the Evaluation of CandidateBiomarkers of Response to Nivolumab inMetastatic Clear Cell Renal Cell Carcinoma:Analysis of a Phase II Prospective Clinical TrialJean-Christophe Pignon, Opeyemi Jegede,Sachet A. Shukla, David A. Braun, Christine E. Horak,Megan Wind-Rotolo, Yuko Ishii, Paul J. Catalano,Jonian Grosha, Abdallah Flaifel, Jesse S. Novak,Kathleen M. Mahoney, Gordon J. Freeman,Arlene H. Sharpe, F. Stephen Hodi, Robert J. Motzer,Toni K. Choueiri, Catherine J. Wu, Michael B. Atkins,David F. McDermott, and Sabina Signoretti

TRANSLATIONAL CANCER MECHANISMSAND THERAPY

2185 Genomic Landscape of PancreaticAdenocarcinoma in Younger versus OlderPatients: Does Age Matter?Irit Ben-Aharon, Moshe Elkabets, Raphael Pelossof,Kenneth H. Yu, Christine A. Iacubuzio-Donahue,Steven D. Leach, Maeve A. Lowery, Karyn A. Goodman,and Eileen M. O'Reilly

Table of Contents

v

on June 25, 2020. © 2019 American Association for Cancer Research. clincancerres.aacrjournals.org Downloaded from

2194 Single-Cell Transcriptomics of Pancreatic CancerPrecursors Demonstrates Epithelial andMicroenvironmental Heterogeneity as an EarlyEvent in Neoplastic ProgressionVincent Bernard, Alexander Semaan, Jonathan Huang,F. Anthony San Lucas, Feven C. Mulu, Bret M. Stephens,Paola A. Guerrero, Yanqing Huang, Jun Zhao,Nabiollah Kamyabi, Subrata Sen, Paul A. Scheet,Cullen M. Taniguchi, Michael P. Kim, Ching-Wei Tzeng,Matthew H. Katz, Aatur D. Singhi, Anirban Maitra, andHector A. AlvarezSee related commentary, p. 2027

2206 Arylsulfonamide 64B Inhibits Hypoxia/HIF-Induced Expression of c-Met and CXCR4 andReduces Primary Tumor Growth and Metastasisof Uveal MelanomaLei Dong, Shuo You, Qing Zhang, Satoru Osuka,Narra S. Devi, Stefan Kaluz, Jalisa H. Ferguson, Hua Yang,Guoliang Chen, Binghe Wang, Hans E. Grossniklaus, andErwin G. Van Meir

2219 Induction of Peripheral Effector CD8 T-cellProliferation by Combination of Paclitaxel,Carboplatin, and Bevacizumab in Non–small CellLung Cancer PatientsPauline L. de Goeje, Myrthe Poncin, Koen Bezemer,Margaretha E.H. Kaijen-Lambers, Harry J.M. Groen,Egbert F. Smit, Anne-Marie C. Dingemans, Andr�e Kunert,Rudi W. Hendriks, and Joachim G.J.V. Aerts

2228 Preclinical Efficacy of Endoglin-TargetingAntibody–Drug Conjugates for the Treatment ofEwing SarcomaPilar Puerto-Camacho, Ana Teresa Amaral,Salah-Eddine Lamhamedi-Cherradi, Brian A. Menegaz,Helena Castillo-Ecija, Jos�e Luis Ord�o~nez,Saioa Domínguez, Carmen Jordan-Perez,Juan Diaz-Martin, Laura Romero-P�erez,Maria Lopez-Alvarez, Gema Civantos-Jubera,María Jos�e Robles-Frías, Michele Biscuola, Cristina Ferrer,Jaume Mora, Branko Cuglievan, Keri Schadler,Oliver Seifert, Roland Kontermann, Klaus Pfizenmaier,

Laureano Sim�on, Myriam Fabre, �Angel M. Carcaboso,

Joseph A. Ludwig, and Enrique de �Alava

2241 Developing Allogeneic Double-Negative T Cellsas a Novel Off-the-Shelf Adoptive CellularTherapy for CancerJong Bok Lee, Hyeonjeong Kang, Linan Fang,Cheryl D'Souza, Oyedele Adeyi, and Li Zhang

2254 Low-pass Whole-genome Sequencing ofCirculating Cell-free DNA DemonstratesDynamic Changes in Genomic Copy Number in aSquamous Lung Cancer Clinical CohortXiaoji Chen, Ching-Wei Chang, Jill M. Spoerke,Kathryn E. Yoh, Vidushi Kapoor, Charles Baudo,Junko Aimi, Mamie Yu, May M.Y. Liang-Chu,Rebecca Suttmann, Ling-Yuh Huw, Steven Gendreau,Craig Cummings, and Mark R. Lackner

2264 YAP1-Mediated CDK6 Activation ConfersRadiation Resistance in Esophageal Cancer –Rationale for the Combination of YAP1 andCDK4/6 Inhibitors in Esophageal CancerFan Li, Yan Xu, Bovey Liu, Pankaj Kumar Singh, Wei Zhao,Jiankang Jin, Guangchun Han, Ailing W. Scott,Xiaochuan Dong, Longfei Huo, Lang Ma,Melissa Pool Pizzi, Ying Wang, Yuan Li, Kazuto Harada,Min Xie, Heath D. Skinner, Sheng Ding, Linghua Wang,Sunil Krishnan, Randy L. Johnson, Shumei Song, andJaffer A. Ajani

2278 Broad Spectrum Activity of the CheckpointKinase 1 Inhibitor Prexasertib as a Single Agent orChemopotentiator Across a Range of PreclinicalPediatric Tumor ModelsCaitlin D. Lowery, Michele Dowless, Matthew Renschler,Wayne Blosser, Alle B. VanWye, Jennifer R. Stephens,PhilipW. Iversen, Aimee Bence Lin, Richard P. Beckmann,Kateryna Krytska, Kristina A. Cole, John M. Maris,Douglas S. Hawkins, Brian P. Rubin,Raushan T. Kurmasheva, Peter J. Houghton,Richard Gorlick, E. Anders Kolb, Min H. Kang,C. Patrick Reynolds, Stephen W. Erickson,Beverly A. Teicher, Malcolm A. Smith, andLouis F. Stancato

2290 Coordinately Targeting Cell-Cycle CheckpointFunctions in Integrated Models of PancreaticCancerSejin Chung, Paris Vail, Agnieszka K. Witkiewicz, andErik S. Knudsen

2305 Dopamine Receptor D5 is a Modulator of TumorResponse to Dopamine Receptor D2 AntagonismVarun V. Prabhu, Neel S. Madhukar, Coryandar Gilvary,C. Leah B. Kline, Sophie Oster, Wafik S. El-Deiry,Olivier Elemento, Faye Doherty,Alexander VanEngelenburg, Jessica Durrant,Rohinton S. Tarapore, Sean Deacon, Neil Charter,Jinkyu Jung, Deric M. Park, Mark R. Gilbert, Jessica Rusert,Robert Wechsler-Reya, Isabel Arrillaga-Romany,Tracy T. Batchelor, Patrick Y. Wen, Wolfgang Oster, andJoshua E. Allen

Table of Contents

vi

on June 25, 2020. © 2019 American Association for Cancer Research. clincancerres.aacrjournals.org Downloaded from

2314 Dynamic Contrast-enhanced MRI DetectsResponses to Stroma-directed Therapy in MouseModels of Pancreatic Ductal AdenocarcinomaJianbo Cao, Stephen Pickup, Cynthia Clendenin,Barbara Blouw, Hoon Choi, David Kang, Mark Rosen,Peter J. O'Dwyer, and Rong Zhou

2323 Nuclear–Cytoplasmic Transport Is a TherapeuticTarget in MyelofibrosisDongqing Yan, AnthonyD. Pomicter, Srinivas Tantravahi,Clinton C. Mason, Anna V. Senina, Jonathan M. Ahmann,QiangWang, Hein Than, Ami B. Patel, William L. Heaton,Anna M. Eiring, Phillip M. Clair, Kevin C. Gantz,Hannah M. Redwine, Sabina I. Swierczek,Brayden J. Halverson, Erkan Baloglu, Sharon Shacham,Jamshid S. Khorashad, Todd W. Kelley,Mohamed E. Salama, Rodney R. Miles,Kenneth M. Boucher, Josef T. Prchal, Thomas O'Hare, andMichael W. Deininger

2336 Human Breast Cancer Xenograft ModelImplicates Peroxisome Proliferator–activatedReceptor Signaling as Driver of Cancer-inducedMuscle FatigueHannah E. Wilson, Kacey K. Rhodes, Daniel Rodriguez,Ikttesh Chahal, David A. Stanton, Joseph Bohlen,Mary Davis, Aniello M. Infante, Hannah Hazard-Jenkins,David J. Klinke, Elena N. Pugacheva, and Emidio E. Pistilli

2348 An Epithelial-to-Mesenchymal TranscriptionalSwitch Triggers Evolution of PulmonarySarcomatoid Carcinoma (PSC) and IdentifiesDasatinib as New Therapeutic OptionGloria Manzotti, Federica Torricelli, Donati Benedetta,Filippo Lococo, Valentina Sancisi, Giulio Rossi,Simonetta Piana, and Alessia Ciarrocchi

AC icon indicates AuthorChoice

For more information please visit www.aacrjournals.org

ABOUT THE COVER

The cover shows a color-segmented Masson trichrome stained image obtained from a humanBxPC-3 xenograft tumor. Quantitative image analysis shows elevated collagen deposition andreduced drug uptake in the stiffer BxPC-3 xenograft tumors. For details, see the article by Wangand colleagues on page 2136 of this issue.

Table of Contents

vii

on June 25, 2020. © 2019 American Association for Cancer Research. clincancerres.aacrjournals.org Downloaded from

2019;25:2019-2360. Clin Cancer Res     25 (7)

  Updated version

  http://clincancerres.aacrjournals.org/content/25/7

Access the most recent version of this article at:

   

   

   

  E-mail alerts related to this article or journal.Sign up to receive free email-alerts

  Subscriptions

Reprints and

  .pubs@aacr.org

To order reprints of this article or to subscribe to the journal, contact the AACR Publications Department at

  Permissions

  Rightslink site. Click on "Request Permissions" which will take you to the Copyright Clearance Center's (CCC)

.http://clincancerres.aacrjournals.org/content/25/7To request permission to re-use all or part of this article, use this link

on June 25, 2020. © 2019 American Association for Cancer Research. clincancerres.aacrjournals.org Downloaded from