Clinical Challenges in the Transplant-Eligible Patient With

Newly Diagnosed Multiple Myeloma

Multiple MyelomaChoice of Induction Regimen

Multiple MyelomaCompeting Induction Regimens

Choice of Induction Regimen Use the best drugs early to get maximum remission for as long as possible, both for the standard-risk as well as the high-risk

patients.

Multiple MyelomaEarly vs Delayed HDT/ASCT

Timing of HDT/ASCT Patients with no high-risk disease, who are

responsive and tolerate therapy, may do extremely well with delayed HDT/ASCT.

Multiple MyelomaMaintenance Therapy

Consider No Maintenance For patients with standard-risk disease, stringent CR, normal FLC ratio, who are immunofixation negative in urine and

serum, and have completely negative BM.

Consider Triplet Maintenance For patients with a truly high-risk disease

(eg, stage III myeloma with high-risk cytogenetics).

Abbreviations

Abbreviations (cont)

References

References (cont)

References (cont)