Clinical Experience With Antibiotic Protocol & RSD

• N=22

• Duration of treatment: 2-4 months

• Retrospective, open label, clinical trial

• Responses are based on patient perceived outcomes

A.P. Lab Results In RSD Patients*

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All Normal+ CBC, CMP+ Rheum. Profile+ ASO Titer+Mycoplasma Titer+ Candida Titer

*12 patients had more then one abnormality

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Exacerbations of Pain & FatigueAt 1-4 Months Of Treatment

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1 month 2 months 3 months 4 months

Inc. Pain*Inc. Fatigue**Inc. P & FNo Effect

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*Increase in pain by 20-80% **Increase in fatigue by 20-30 %

Decrease In Pain, Fatigue & Dystrophic Findings (At 2-4 Months Of Treatment)

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2 Months 3 Months 4 Months

Dec. Pain*Dec. Fatigue**Dec. Dystropy***No Effect

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*Dec. Pain at 20-100%

**Dec. Fatigue at 25-50% ***Dec. Dystrophy at 25-75%

Note: Only 1 of 2 of the “No effect” patients has completed 4 months of A.P. therapy.All “No Effect” patients continue to report increased pain or fatigue from treatment.

Conclusions

• Antibiotic protocol can offer substantial improvement in at least some patients with RSD.

• It remains speculation as to which RSD cases will respond to A.P.

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