clinical importance of nutritional intravenous...

Clinical Importance of Nutritional Intravenous TherapyClinical Importance of Nutritional Intravenous Therapy

David Brownstein, M.D.Center for Holistic Medicine5821 W. Maple Rd. Ste. 192West Bloomfield, MI 48322248.851.1600www.drbrownstein.com

Center for Holistic MedicineCenter for Holistic Medicine

• Over 100,000 Meyer’s IV cocktails• Over 30,000 H2O2 IV’s• Over 35,000 Long IV Vitamin C

• Ranging from 25-75,000mg Vitamin C

• Over 7,000 Super C IV’s• Vitamin C and hydrochloric acid IV’s

• Over 15,000 Lipid Exchanges• Phosphatidyl choline and glutathione

• Over 15,000 DMPS IV’s


• Adverse effects of nutritional IV’s over 20 years:• No hospitalizations• No cellulitis• No sepsis• No bleeding complications• Rare episodes of dizziness and gastrointestinal upset• No serious phlebitis• Approximately 5 superficial phlebitis

• Due to using the wrong kind of phosphatidyl choline• U.S. v. Switzerland manufacture

• Has not occurred with any other nutritional IV’s

Intravenous IV’s: What To Have On HandIntravenous IV’s: What To Have On Hand

• Have emergency equipment on hand• Oxygen• Epinephrine• Steroids

• Have nurses trained in CPR

In 18 years of using nutritional IV’s as a major part of my practice, I have not had the need to use any of the above drugs or had to

perform CPR on a patient. Clinically, I have found nutritional IV’s one of the safest medical procedures.

Intravenous IV’s and AllergiesIntravenous IV’s and Allergies

• Caution with using any IV substance where patient has an allergy to it• However, most patients allergic to oral versions of

vitamins and minerals seem to tolerate the IV version without incident

• NAET• www.naet.com

Indications for Nutritional IV’sIndications for Nutritional IV’s

• Allergic rhinitis• Asthma• Bacterial illnesses• Cancer• Cardiovascular disease• Chemical toxicity

• Mercury, lead, cadmium, arsenic, nickel

• Chronic Fatigue Syndrome• COPD

• Hypoadrenalism• Immune disorders• Infection• Macular degeneration• Migraine• Multiple sclerosis• Muscle Spasms• Neurologic Disorders

• Parkinson’s, Alzheimer’s disease

• Viral illnesses


• Nutritional IV’s are very safe and effective• Choose the correct IV for the appropriate

patient• Know your biochemistry and physiology as it

relates to vitamins and minerals• Proper technique

• Have all supplies on hand• Syringes

• 60cc, 30cc (lots), 20cc, 10cc, 5cc, 3cc, and 1cc

• Tubing• IV bags

• NS, Ringers lactate, D5W, Sterile water250cc, 500cc, and 1Liter

• IV stands

Technique for Nutritonal IV’s (1)Technique for Nutritonal IV’s (1)

• Decide where patient will be• Seated or supine• Most IV pushes can be accomplished in the seated

position• Use supine if patient is nervous or has history of fainting• Have patient eat before IV

• Ensures less GI upset and less chance of dizziness



• Pick site• Tourniquet• Use appropriate needle or catheter

• Most IV’s do well with 25g butterfly• Some prefer a 21g butterfly

• Arm, forearm, hand, leg, ankle• Difficult-to-draw people may need pic line or

mediport

• After tourniquet applied, betadyne, alcohol site• Once IV accessed, tape butterfly or catheter

down• Have all items in room—patient should not be

left alone until needle is secure• If getting a long IV, we give patients a bell to ring

once everything proceeding appropriately


Fundamental Rules of Nutrient IV’sFundamental Rules of Nutrient IV’s

• Have emergency equipment on hand• Telephone• Oxygen• Ambu bag• Heparin• Epinephrine• Injectable steroids

Train staff in CPR!!

Supplies for Nutrient IV’s (1)Supplies for Nutrient IV’s (1)

• Syringes• 60cc, 30cc, 20cc, 10cc, 5cc, 3cc, 1cc• Different needles

• 18g easiest to draw up with• Butterfly infusion

• 22g and 25g

• IV tubing• Cotton swabs, alcohol, betadyne swabs


• IV solution• Glass bottles (if you choose)• Sterile water

• 250cc, 500cc, 1,000cc bags• 10cc bottles• Vitamin C IV’s and Adrenal IV’s

• D5W• 150cc, 250cc, and 500cc• Hydrogen peroxide IV and Clindamycin IV’s

• Ringers solution• Isotonic• 250cc and 500cc• Hydration and macular degeneration

• IV poles• Hooks• Hangers• Be sure to hang IV at least 6 feet in air


OsmolarityOsmolarity

• Measure of the solute concentration• Number of osmoles of solute per liter

OsmolarityOsmolarity

• DO NOT USE HYPOSMOLAR SOLUTIONS!! EVER!!!• Hemolysis

Osmolarity (2)Osmolarity (2)

• Ideally, every injection should be iso-osmolar• 280-310milliosmoles/L• 0.28-0.31 mOsm/ml• Better to err on the higher side

• Hyperosmolar solutions are generally not a problem


• How to calculate osmolarity• Total mOsm (all nutrients)/cc of additives

CIPHERING!


• Sample calculations• Super C: 10cc of vitamin C and 10cc of dilute

HCL• Osmolarity of vitamin C; 5.8mOsm/ml• Osmolarity of HCL: 0.11mOsm/ml

What is the osmolarity of the solution?

Osmolarity (4a1)Osmolarity (4a1)

• Sample calculations• Super C: 10cc of vitamin C and 10cc of dilute

HCL• Osmolarity of vitamin C; 5.8mOsm/ml• Osmolarity of HCL: 0.11mOsm/ml

10 x 5.8mOsm/ml = 58mOsm Vitamin C10 x 0.11mOsm/cc = 1.1mOsm HCL

59.1mOsm/20cc = 2.96mOsm/cc

How much water do you add to make an iso-osmolar solution?

Osmolarity (4a): How much water to Become Iso-OsmolarOsmolarity (4a): How much water to Become Iso-Osmolar

• 59.1mOsm/20cc + X = .310mOsm/cc• 59.1mOsm = 0.310mOsm/cc x 20cc + X• 59.1mOsm/0.310mOsm/cc = 20cc + X• 191cc = 20cc + X• 171cc= X

Different Way to Calculation Osmolarity: How much Water to Add to Become Iso-osmolar (4)Different Way to Calculation Osmolarity: How much Water to Add to Become Iso-osmolar (4)

• Example: Headache protocol• Calcium gluconate: 100mg/cc: 1cc

• 0.72mOsm/ml x 1ml = 0.72mOsm

• B-6: 300mg (100mg/cc): 6cc• 1.11mOsm/ml x 6cc = 6.66mOsm

• MgSO4: 1.5gm (500mg/cc): 3cc • 2.95mOsm/ml x 3ml = 12.18mOsm

Total quantity of cc’s added: 10. total mOsm: 19.56Divide 19.56mOsm/0.310mOsm/ml = 63ml. Since we added 10cc already, we can subtract 63ml-10ml = 53ml. If we add 53cc sterile

water to the solution, we will have an isotonic solution.

Modified Myers’ IVModified Myers’ IV

• In a 30 cc syringe• 10 cc sterile water• 4 cc vitamin C (500mg/cc in a 50cc vial or 2,0000mg) {5.8mOsm/cc}• 2 cc calcium gluconate (200mg) {0.72mOSm/cc}• 2cc magnesium chloride (1gm) {2.95mOSm/cc}• 1cc each of:

• Hydroxy or methyl B12 (1mg) {0.30mOSm/cc}• Vitamin B5 (1.21mOsm/cc)• Folic Acid (10mg) {0.20mOsm/cc}• B-complex (100mg) {2.14mOsm/cc}• B6 (100mg) {1.11mOsm/cc}• Multi Trace {0.131mOsm/cc}

Osmolarity of solution is high

36mOsm/23cc = 1.6mOsm/cc

Osmolarity: Myers’ IV CalculationOsmolarity: Myers’ IV Calculation

• To make the Meyers’ IV iso-osmolar:• 36mOsm/23cc + X(cc) = 0.310mOsm/cc• 36mOsm/0.310mOsm/cc= 23cc + X• 116cc = 23cc + X• X= 93cc of water

Why Nutritional IV’s?Why Nutritional IV’s?

• Many patients have inadequate nutritional intake due to:• Achlorhydria• Food allergies or

intolerance• Surgery

• Cholycystectomy• Gastric bypass• Lap band

• Inflammation• Gastritis• Crohn’s disease

• Chronic use of NSAID’s

• Intestinal dysbiosis• Poor diet

Why Nutritional IV’s?Why Nutritional IV’s?

• Impossible to obtain IV serum nutrient levels with oral and/or IM administration• Increasing oral vitamin C from 200 to 2,500mg (1.1

to 14.2mmol) increased the plasma steady state concentration from 1.2 to 1.5mg/dL.

Am. J. Clin. Nutr. 1997;66:1165-71

Am. J. Clin. Nutr. 1997;66:1165-71

Vitamin CVitamin C

• RDA is 60mg/day• RDA is only good for preventing scurvy • RDA is inadequate to meet the body’s needs for

ascorbic acid• IV therapy is the best absorbed form of vitamin C

• Plasma concentrations significantly higher after IV dosing as compared to oral dosing

• Negligible increase in plasma concentration of vitamin C when oral doses are >200mg/d

Proc Natl. Acad Sci U S A 1990;87:7245-7249.

Vitamin C Absorption OralVitamin C Absorption Oral

• When oral dose increased from 200mg/day to 2,500mg/day• Plasma concentration increases only 25%

• 1.2 to 1.5mg/dL

Am. J. Clin. Nutr. 1997;66:1165-71

Vitamin C IVVitamin C IV

• Oral dosing of vitamin C has shown to result in a maximal serum concentration of 9.3mg/dl

• Inconsistent research

• Antiviral effects of vitamin C demonstrated at IV dosing of vitamin C• 10-15mg/dl has antiviral effects

• Above oral dosing

• IV administration of 50gm/d vitamin C • Plasma concentration of 80mg/dl

• Has potent antihistamine effects• Immune-modifying effects

Biochim Biophys Acta 1989;991:377-379

Am. J. Clin. Nutr. 1997;66:1165-71Proc Natl. Acad Sci U S A 1990;87:7245-7249

Nutrient DepletionNutrient Depletion

• Micronutrient depletion is common• Poor farming• Soil mineral content declining• Toxic chemicals applied to soil

• Intracellular nutrient depletion is common• RBC mineral testing

My clinical experience has been clear: mineral levels are declining in patients. It is difficult to raise intracellular nutrient levels with oral

dosing of minerals.

MagnesiumMagnesium

• Oral dosing has little effect on rbc magnesium levels

• Myocardial cells have 10x more magnesium intracellular as compared to extracellular

• IV dosing has been shown to increase rbcmagnesium levels 3x

JAMA. 1987;257:1076-78Intensive Care Med 1993;19:467-471.

MagnesiumMagnesium

• Intracellular magnesium deficiency can lead to arrhythmias and heart failure

• Cardiomyopathy• Mean myocardial Mg level was 65% lower in patients with

cardiomyopathy as compared to controls

My clinical experience has shown it very difficult to raise RBC magnesium levels with oral dosing. IV magnesium is a very effective method for quickly raising RBC magnesium levels. More importantly,

IV magnesium is helpful for nearly all cases of heart disease.

Lancet 1987;2:1019

Intravenous NutrientsIntravenous Nutrients

• In the case of aging or ailing cells, intravenous nutrients may achieve a serum concentration which provides a gradient to allow the nutrients to flow or be transported into the cell.

Meyer’s IVMeyer’s IV

• Dr. John Myers• Baltimore, MD• 1970’s developed a nutritional IV protocol—

Meyer’s IV protocol• B-vitamins, vitamin C, calcium pantothenate,

Vitamin B6, thiamine, magnesium chloride, and/or calcium gluconate


• Myer’s IV• Over 100,000 Meyer’s IV’s given over a 16 year

period (40/day)• No phlebitis• No cellulitis• No sepsis• Occasional dizziness or upset stomach--transient• No serious adverse effects observed

Myer’s IV ProtocolMyer’s IV Protocol

• All-around nutritional IV• Combination of vitamins and minerals

• Krebbs cycle• Detoxification pathways• Methylation pathways• Oxidative phosphorylation

Original Myer’s IVOriginal Myer’s IV

• Not clear exactly what was in it• Slow IVP• 10cc syringe

Contents of Dr. Myer’s IVContents of Dr. Myer’s IV

• Magnesium chloride• Calcium gluconate• Thiamine• Vitamin B6• Vitamin B12• Calcium pantothenate• Vitamin B Complex• Vitamin C• Dilute HCL

Modified Myers’ IVModified Myers’ IV

• In a 30 cc syringe• 10 cc sterile water• 4 cc vitamin C (2,0000mg)• 2 cc calcium gluconate (200mg)• 2cc magnesium chloride (1gm)• 1cc each of:

• Hydroxy or methyl B12 (1mg)• Vitamin B5 (1mg)• Folic Acid (10mg)• B-complex (100mg)• B6 (100mg)

Osmolarity of solution is high

AsthmaAsthma

• Numerous literature citations for magnesium helping asthma• Magnesium can counteract the spasm of

bronchioles• Vitamin C has anti-histamine effect

Clinical experience has been clear: Nearly all patients with asthma benefit from Myers’ IV, especially if in acute episode.

Case History: AsthmaCase History: Asthma

• 57 year old female• Long history of asthma exacerbations

• Treated with steroids, inhalers

• After four Myers’ IV’s, asthma symptoms markedly improved• Peak flow meter significantly increased• No longer needed daily steroid meds• Able to taper steroid inhalers• Now, uses rescue inhaler infrequently• Comes into office at first sign of wheezing for Myers’ IV

• Add 1 additional cc of magnesium and/or vitamin C to her IV when having exacerbation of asthma

Case History: Migraine HeadachesCase History: Migraine Headaches

• 38 year old female• 10+year history of migraine headaches• On Imitrex as abortive

• Did not like adverse effects of imitrex

• At onset of headache, was told to come in for Myers’ IV• Myers’ IV was modified with 1cc extra of magnesium chloride (usual

protocol for headaches)

• While Myers’ IV being administered, felt headache releasing• Headache totally resolved by end of IV push• Patient came in for weekly Myers’ IV pushes for six weeks. Migraine

headaches dminished rapidly from 1/week to infrequent• Patient now maintains with monthly IV’s

Adverse Effects from Myers’ IV (1)Adverse Effects from Myers’ IV (1)

• Warm sensation around groin and axilla• Vitamin taste in mouth• Upset stomach or dizziness

• Usually only occurs on empty stomach• Transient

• Pain at site of infusion• Rare• May occur if used in small vessel of hand or foot

• Slow infusion rate• Very rarely, add more sterile water to solution

Adverse Effects from Myers’ IV: Hypokalemia (2)

Adverse Effects from Myers’ IV: Hypokalemia (2)

• Magnesium stimulates membrane pump that moves potassium into cell

• Important to ensure adequate potassium levels before giving Myers’ IV

• If potassium is depleted (e.g., diuretics), shift of potassium from extracellular to intracellular may result in a hypokalemic episode

• We have not observed this to occur in our office

Am Heart J 1979;97:12-18.

How to Modify Myers’ IVHow to Modify Myers’ IV

• Stop and think about what you are trying to accomplish• Vasodilation: Magnesium• Immune support: Vitamin C or glutathione

My clinical experience has been clear: Adding an additional 1cc of magnesium, vitamin C or glutathione may enhance the Myers’ IV.

IV Vitamin CIV Vitamin C

• AIDS• Bronchitis• Chickenpox• Coronary artery disease• Dysentery• Herpes• Influenza• Malaria• Measles• Mumps• Polio

• Pneumonia• Pseudomonas• Rabies• Rocky mountain spotted

fever• Staphylococcal infections• Typhoid fever• URI• Viral Encephalitis• Viral hepatitis• Viral Pneumonia

IV Vitamin C and toxicitiesIV Vitamin C and toxicities

• Aflatoxin• Alcohol• Amphetamine• Arsenic• Barbiturates• Benzene derivatives• Bromine• Cadmium• Carbon monoxide• Chlorinated inesecticides• Endotoxin• Fluoride• Mercury

• Herbicides• Lead• Medications

• Hypnotics, analgesics, muscle relaxants, antirheumatics, etc.

• Methemoglobinemia• Mushroom poisoning• PCB’s• Pesticides• Radiation• Root canal removal• Strychnine• Tetanus toxin• Venoms

I.V. Vitamin C and AlcoholI.V. Vitamin C and Alcohol

• Helpful for toxicities• Alcohol

• Good way to detoxify alcohol and protect organs from alcohol toxicity

• Accelerates ethanol clearance

• Repair past alcohol damage

Biochem. Pharm. 21(10): 1377-92

IV Vitamin C and MercuryIV Vitamin C and Mercury

• One of the most common toxicities seen in practice• Dental amalgams• Pharmaceuticals

• Corticosporin otic

• Seafood• Used in a variety of industrial capacities• Vaccines

• Influenza vaccine

IV Vitamin C and Mercury (2)IV Vitamin C and Mercury (2)

• Research from 60 years ago showed vitamin C lessened the toxicity of mercurial drugs given to dogs

• Damage to various organs—kidneys, liver, brain can be mitagated by vitamin C

• Exposure to mercury increases the body’s need for vitamin C

Arch. Of Int. Med. 1947. 79:449-456

My experience has been clear: Vitamin C IV’s are invaluable in patients suffering from mercury toxicity.


• Acute infections• Adrenal dysfunction• Amalgam removal• Pre-immunization• Pre/post toxicity exposure• Root canal removal


• Infections• Macrophages and leukocytes are the first line of

defense against invaders• Vitamin C helps cells produce hydrogen peroxide

to destroy foreign invaders• Similar mechanism used against virus, bacteria,

yeast/fungus

IV Vitamin C and Amalgam RemovalIV Vitamin C and Amalgam Removal

• Amalgam contain mercury (50% of weight of amalgam)

• Mercury vapor has been demonstrated to release from amalgam with chewing and ingestion of hot substances

• When amalgam removed, mercury levels increase in patient unless precautions taken

Mercury ToxicityMercury Toxicity

• Very common in practice• Low-grade, chronic exposure occurring in a

wide percentage of patients• Insomnia, nervousness, tremor, impaired judgment

and coordination, decreased clarity of thought, emotional instability, headache, fatigue, low libido, and depression.

A thorough evaluation for mercury toxicity should be undertaken in patients suffering from above symptoms.

IV Vitamin C and Amalgam Removal (2)

IV Vitamin C and Amalgam Removal (2)

• Before having amalgam removed, ensure patient has adequate vitamin C levels

• Blood tests• Supplementation of vitamin C a must before,

during, and after amalgam removal

My clinical experience has shown that the best results are achieved with a combination of oral and IV vitamin C.

IV Vitamin C and Amalgam RemovalIV Vitamin C and Amalgam Removal

• Myers’ IV adequate for healthy patients• Supplies 4,000mg/IV

• Patients with chronic/serious illness require higher vitamin C dosing• 25,000-50,000mg IV

Case History: Amalgam RemovalCase History: Amalgam Removal

• 35 year-old female• 8 amalgams• Brain fog, headaches, dizziness • High mercury levels in hair testing• DMPS challenge test

Case History: Mercury ToxicityCase History: Mercury Toxicity

• 22 year old male• Brain fog, depression, nervousness, anxiety,

insomnia• No amalgam• Mercury levels high in hair

• DMPS

IV Vitamin C and Mercury DetoxificationIV Vitamin C and Mercury Detoxification

• Vitally important to ensure adequate vitamin C levels before, during and after mercury detoxification

• More severe cases require higher doses of vitamin C (IV)

• Usual protocol is 4 IV’s starting two weeks before detoxification• If amalgam being removed, have last one IV just

before dental visit


• Sterile Water: 250ml• Ascorbic Acid: 25 gm• Magnesium Sulfate: 2cc• Calcium Gluconate: 2cc• Hydroxy- or Methyl Cobalamine: 1cc• Vitamin B6: 1cc• B-Complex: 1cc• Pantothenic Acid (Vitamin B5): 1cc• Folic Acid: 1cc• Multi Trace Minerals: 1cc

Long IV Vitamin C AdrenalLong IV Vitamin C Adrenal

• Sterile Water: 250ml• Ascorbic Acid: 25 gm• Magnesium Sulfate: 2cc• Calcium Gluconate: 2cc• Hydroxy- or Methyl Cobalamine: 1cc• Vitamin B6: 1cc• B-Complex: 1cc• Pantothenic Acid (Vitamin B5): 1cc• Folic Acid: 1cc• Multi Trace Minerals: 1cc

Add in 9ml of 8.4% Sodium Bicarbonate

Super C IVSuper C IV

• A mixture of vitamin C and dilute hydrochloric acid

• Mixed up in same syringe and injected as an IV push

• Used for acute infections or acute allergy symptoms

Macular Degeneration IVMacular Degeneration IV

• 100cc Lactated Ringers• 8cc Selenium• 2cc Trace Minerals

IV Dilute Hydrochloric AcidIV Dilute Hydrochloric Acid

• In WW I, Burr Ferguson, M.D. from Birmingham Alabama witnessed the problems with bacterial infections in wounds

• In 1927, Dr. Ferguson met Dr. Granville Hains• Dr . Hains was treating infections with IV HCL• IV HCL (1/3000) for treating pruritis ani

• Dr. Ferguson began using dilute HCL to treat a variety of bacterial infections• 10cc of 1/1,000 HCL

Dr. Burr FergusonDr. Burr Ferguson

• Began reporting success with using dilute HCL as IV therapy

• Reported a marked increase in WBC and phagocytosis immediately after IV HCL• RBC increased oxygen content• Claimed increase RBC oxygen content better than

maintaining a patient in an oxygen tent

Dr. Burr Ferguson (2)Dr. Burr Ferguson (2)

• Reported cure of gonorrhea with dilute HCL• From that time on, began using dilute HCL

with success for treating a variety of infectious illnesses

Hydrogen PeroxideHydrogen Peroxide

• Naturally produced in organisms as a byproduct of oxygen metabolism• All aerobes produce copious amounts of hydrogen

peroxide• Peroxidase break down H202

2 H202 2 H20+ 02

Body’s first line of defense is hydrogen peroxide!


• Antibacterial• Antifungal• Antiparasitic• Antiviral

Hydrogen Peroxide (2)Hydrogen Peroxide (2)

• AIDS• Allergies• Arthritis• Atherosclerosis• Cancer• COPD• Dental gum disease

• Depression• Diabetes• Melasma• Parasites• Prostatitis• Temporal arteritis• Ulcers• Viral infections


• Adrenal and gonadal hormone production• Dilates blood vessels in heart and brain• Improves glucose control • Interferon production• Thyroid production

Mol Cell Endocrinol 86;46(2): 149-154) (Steroids 82;40(5):5690579) J. Immunol. 85;134(4):2449-55

Am J Physiol 86;250 (5 pt 2): H815-821 and (2 pt 2):H157-162)


• Can generate heat in cells• Intracellular thermogenesis

• Has been shown to clear atherosclerosis in vessels where H2O2 was given

History of Hydrogen PeroxideHistory of Hydrogen Peroxide

• First used in 1920 by British physician T.H. Oliver• 25 Indian patients critically ill with pneumonia• Oliver’s patients had a 48% mortality compared to

80% for standard mortality for pneumonia• William Koch

• Reported positive results in treating cancer with H2O2

IV Hydrogen PeroxideIV Hydrogen Peroxide

• Not an IVP• Slow Drip

• 1-2 hours• In blood, H202 encounters two enzymes;

• Catalase• Converts H202 to H20 and O2

• Found in nearly all living organisms• Oxygenates tissue

• Cytochrome-C Peroxidase• Water soluble heme-containing enzyme

• Peroxidase family


• Cytochrome-C• Does not break down immediately

• Can transport H202 throughout body• When acted upon by catalase, release O2 into tissue

• Oxygenating effect• Singlet oxygen--?oxidant effect?

Case HistoryCase History

• 62 year old priest• Developed prostatitis three years ago

• Has been treated with numerous antibiotics• Developed sensitivity to antibiotics• Antibiotics help for a short period of time, then

symptoms return• Having trouble doing his job due to discomfort

Case History (2)Case History (2)

• After first H202 IV, he reported, “I haven’t felt this good in years. I have always had a congested feeling I my prostate. It feels normal.”

• Patient received H202 twice per week for 4 weeks, then maintenance (1/month) • Has not been treated with antibiotics in over 2.5

years• Feels like his is health is restored

Hydrogen Peroxide IVHydrogen Peroxide IV

• Best not to take supplements before and after therapy (for 4 hours)

• Can be done on empty stomach• No clinical difference with or without food

• Homeopathic glyoxyllic acid (IM) given after H202 seems to potentiate it

• When using lower-dose H202, no phlebitis or disappearance of veins observed

Potential Adverse Effects of H202 IVPotential Adverse Effects of H202 IV

• Free radicals• Singlet oxygen damage

• Embolism• Phlebitis• Locusts, plague, death of first-born

My clinical experience is clear: H202 is one of the safest IV’s. We have found it very safe and effective for treating a variety of

conditions.

H202H202

• Use food grade hydrogen peroxide for IV’s• Must dilute food grade 35% to 3%• How much water is needed to do that?

How to Mix IV H202How to Mix IV H202

• 150ccD5W• 1.8cc Peroxide (food grade diluted to 3%)• 0.6cc MgSulfate (500mg/cc)• 3cc Manganese (0.1mg/cc)

H202 IV Alternate ProtocolH202 IV Alternate Protocol

• 250cc D5W• 2.3ml 3% Peroxide (food grade diluted to 3%)• 1.0cc MgSulfate (500mg/cc)• 5.0cc Manganese Sulfate (0.1mg/cc)• Given over 45 minutes• Charles Turner, M.D.

Lipid ExchangeLipid Exchange

• Term coined by Patricia Kane• Glutathione and Phosphatidyl choline• Liver disorders

• Hepatitis• Cirrhosis• Fatty liver

• Aids in detoxification• Toxins have affinity for lipids

• Lipid exchange can help replace damaged fatty acids

• Useful for neurologic disorders• Parkinson’s• Alzheimer’s • Brain fog

GlutathioneGlutathione

• Glutathione is a tripeptide• Synthesized from amino acids

• L-cysteine, L-glutamic acid and glycine• Sulfhydryl group of cysteine is a proton donor and is

responsible for biological acitivty of gsh• Osmolarity: 1.97mOsm/cc

• Protects cells from reactive oxygen species• Free radicals and peroxides

Glutathione (2)Glutathione (2)

• Major endogenous antioxidant produced by cells• Maintains reduced state of other antioxidants

• Vitamin C and E

• Detoxifies many xenobiotics• Maintains numerous metablic and biochemical reactions

• DNA synthesis and repair• Protein synthesis• Prostaglandin synthesis• Amino acid transport• Enzyme activation

Phosphatidyl CholinePhosphatidyl Choline

• Primary dietary source of choline• Choline can be manufactured from either

methionine or serine• Little is manufactured in body• Considered an essential nutrient

• Phosphate group, fatty acids and choline• When ingested, it is broken down into choline,

glycerol free fatty acids and phosphate group• Not incorporated into cell membrane


• The most abundant phospholipid of the cell membrane• Protects the cell against toxicity and infection• Protects the liver against damage from:

• Alcohol• Drugs• Pollutants• Xenobiotics• Infections

Alcoholism Clin Exp Res 1997;21:375-379


• Choline is required for proper metabolism of fats

• Acts as a methyl donor• Choline is essential in synthesis of acetylcholine

• Improves memory• Lipotrophic effect on liver

• Help remove fat from the liver• Absence of choline can cause fat to be trapped in

liver


• Phosphatidyl choline increases the solubility of cholesterol

• Aids in lowering cholesterol levels• Removes cholesterol from tissue deposits• Inhibits platelet aggregation

Biochem Med Metabol Biol. 35;31-39, 1986


• Food sources• Whole grains, liver, vegetables (cauliflower and

lettuce), and soy• Lecithin (10-20% phosphatidyl choline) in grains,

meat, and egg yolk

Lipid ExchangeLipid Exchange

• 3cc Glutathione (200mg/cc)• 5cc Phosphatidyl Choline

• European version superior

Put 5cc Phosphatidyl choline in 10cc syringe, access vein and draw back 2 or 3cc blood and mix in syringe. Inject with slow IVP. Change

syringe and inject 3cc Glutathione.

Final ThoughtsFinal Thoughts

• IV nutritional therapy is safe and effective• Follow a good protocol• THINK about what you are doing each time• Can enhance almost any therapeutic plan

Suppliers of IV IngredientsSuppliers of IV Ingredients

• Apothecure Pharmacy 800.969.6601• Methyl B12, pyridoxine, dexpanthenol, HCL

• Merit Pharmacy 800.421.9657• Ascorbic acid, B-complex

• Torrance Pharmacy 800.327.0722• Multi trace, water

• Health Dimensions Pharm. 248.489.1573• University Compounding 248.267.5002

• Hydroxy B12

• Spectrum Chemical (H202): 1.800.813.1514Wellness Pharmacy 800.227.2627

• Leucovorin• J and B Medical Supply 248.896.6201• Paracelsus Apotheke Switzerland 011 41 55 418 4070

• Phosphatidyl choline

clinical importance of nutritional intravenous...

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