clinical pearls: locked great toe

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Vol. 45, No. 4, July 1998 BIOCHEMISTRY and MOLECULAR BIOLOGY INTERNATIONAL Pages783-790 EFFECTS OF D-GLUCOSE AND STARVATION UPON THE CYCLIC ADP-RIBOSE CONTENT OF RAT PANCREATIC ISLETS O. SCRUEL, T. WADA, K. KONTANI, A. SENER, T. KATADA and W.J. MALAISSE Laboratory of Experimental Medicine, Brussels Free University, Brussels, Belgium and Department of Physiological Chemistry, Graduate School of Pharmaceutical Sciences, University to Tokyo, Tokyo, Japan Received April 14, 1998 SUMMARY: Rat pancreatic islets were found to display a much lower content of immunoreactive CD38 and a much lower ADP-ribosyl cyclase activity than rat spleen or brain. Cyclic ADP-ribose was also measured by a radioimmunological procedure in rat pancreatic islets. In fed rats, the cyclic ADP-ribose content appeared higher after isolation of the islets in the presence of 2.8 mM D-glucose rather than in the absence of the hexose, progressively increased during incubation of the islets for 5-60 min at 37~ but failed to be affected by the concentration of D-glucose (zero to 20.0 raM) in the incubation medium. In rats fasted for 24 hours, the cyclic ADP-ribose islet content also increased during incubation, but again failed to be affected by the concentration of D-glucose in the incubation medium. Although these findings indicate that the islet cyclic ADP-ribose content is influenced by nutritional and environmental factors, they do not support the view that the insulinotropic aciton of D-glucose involves major change in the islet cell content of the cyclic nucleotide. Key words : cyclic ADP-ribose, pancreatic islets, insulin release INTRODUCTION Although CD38 (NADase/ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) is expressed in pancreatic islets [1-3], the participation of cyclic ADP-ribose (cADPR) in the process of glucose-induced insulin release remains a matter of debate [4-8]. In a recent study [8], the cADPR content of rat pancreatic islets was found to much higher than that of liver, whole pancreas or tumoral islet cells, but failed to differ in islets incubated for 90 min in either the absence or presence of D-glucose (6.0 to 20.0 raM) and/or D-fructose (80.0 mM). The major aims of the present study were to investigate the time course for changes in the cADPR content of rat islets during incubation at increasing concentrations of D-glucose and to explore the possible influence of starvation upon the islet content of this cyclic nucleotide. 783 1039-9712/98/100783-08505.00/0 Copyright 1998 by Academic Press Australia. All rights of reproduction in any form reserved.

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878 Banerjee et al. d LOCKED GREAT TOE

Clinical Pearls: Locked Great Toe

Rahul Banerjee, MD, Michael P. Bradley, MD, Eric M. Bluman, MD, PhD,Christopher W. DiGiovanni, MD

Chief Complaint. Pain and inability to flex the greattoe.

History of Present Illness. A previously healthy 28-year-old man presented to the emergency departmentafter he tripped and struck his right great toe againsta table. After the injury, he was unable to move the toeand was unable to ambulate secondary to pain.

Physical Examination. On presentation, the patient’sright great toe was mildly swollen with no obviousdeformity compared with the contralateral side. Thegreat toe was warm and well perfused, and therewere no open wounds. Sensation to the distal phalanxwas intact to light touch, and there was no evidence ofa subungual hematoma. The patient’s great toe waslocked in extension. The interphalangeal joint of thegreat toe could not be actively or passively flexed.

Radiographic Examination. Anteroposterior andlateral radiographs of the right great toe showeddistraction of the interphalangeal joint of the patient’sright great toe (Figure 1). An accessory sesamoid bonewas noted to be incarcerated within the interphalan-geal joint. Contralateral radiographs showed normalalignment of the first ray with an accessory sesamoidlocated plantar to the interphalangeal joint.

Diagnosis. Acute great toe interphalangeal jointdislocation with sesamoid interposition.

Treatment. A digital block of the right great toe wasperformed using 2% lidocaine. A reduction maneuverwas performed as follows. Gentle longitudinal tractionwas applied to the great toe. This was followed byexaggeration of the extension deformity at the in-terphalangeal joint to unlock the incarcerated bone

and soft tissue. Subsequent flexion of the interphalan-geal joint facilitated immediate joint reduction. Afterthis maneuver, full active and passive motion of thejoint was restored, and the joint was stable. Post-reduction radiographs were obtained showing normalalignment of the interphalangeal joint (Figure 2). Theaccessory sesamoid was noted to be in a reducedposition compared with the contralateral side.

Discussion

History. Sesamoid bones originally were named afterthe seeds of the plant sesamum indicum by thephysician Galen.1 The term sesamoid refers to anybone that is embedded within a tendon and serves tomodify pressure and alter the direction of muscleforces. Common sesamoid bones include the patella,the sesamoids of the palmar surface of the thumbmetacarpophalangeal joint, and the sesamoids be-neath the head of the first metatarsal.

The sesamoid bone located at the great toe in-terphalangeal joint (subhallucal sesamoid), whenpresent, is rare and found in approximately 13% ofthe population.2 Subhallucal sesamoids are oftenbilateral and are embedded within the tendon of theflexor hallucis longus.3 Several authors have reportedcases of interphalangeal joint dislocation with sub-hallucal sesamoid interposition.4–15 With the excep-tion of two previous reports,9,13 however, all of thesecases required operative reduction with removal ofthe incarcerated intra-articular sesamoid bone.

Clinical Features. Patients with sesamoid interposi-tion of the great toe interphalangeal joint present withpain and inability to flex or extend the great toe. Inmost cases, the toe is fixed in an extended orhyperextended position. The interphalangeal jointmay be grossly dislocated. Although most reportsindicate that the sesamoid interposition occurs at thetime of injury, it is possible that reduction maneuversmay force the subhallucal sesamoid into the in-terphalangeal joint.12

Treatment. Although sesamoid interposition mayresult in an irreducible interphalangeal joint, closedreduction always should be attempted on initial di-agnosis. Anesthesia can be achieved easily usinga digital block. As described earlier, reduction shouldconsist of gentle longitudinal traction along the axis of

From the Department of Orthopaedic Surgery, Rhode IslandHospital, Brown University School of Medicine, Providence, RI.Received March 8, 2003; accepted April 1, 2003.Section editor: Michelle H. Biros, MS, MD, Department ofEmergency Medicine, Hennepin County Medical Center, Minneap-olis, MN.Address for correspondence and reprints: Christopher W.DiGiovanni, MD, Department of Orthopaedic Surgery, Rhode IslandHospital, 2 Dudley Street, COOP 1st Floor, Providence, RI 02905.Fax: 401-444-6243; e-mail: [email protected].

Figure 1. Injury radiographs.

Figure 2. Postreduction radiographs.

ACAD EMERG MED d August 2003, Vol. 10, No. 8 d www.aemj.org 879

the great toe, exaggeration of the extension deformityto unlock it, followed by rapid flexion to enactrelocation. If a successful, stable closed reduction isobtained, splinting can be achieved by buddy-tapingthe great toe to the second toe or using an aluminumsplint over the dorsum of the great toe. Althoughsuccessful closed reductions are typically stable, anygross instability, persistent bony or soft tissue in-carceration, or residual incongruity of the joint afterthis attempt necessitates operative intervention.

Clinical Pearls

1. Interphalangeal joint dislocation with sesamoid in-terposition is a rare condition after blunt trauma to thegreat toe.

2. Patients typically present with a swollen, painful greattoe fixed in an extended or hyperextended position.

3. Closed reduction should be attempted using a digitalblock and gentle longitudinal traction, followed bya maneuver of extension and rapid toe flexion.

4. Inability to reduce the interphalangeal joint, failure toextract the intra-articular sesamoid, and instability ofthe interphalangeal joint after reduction all areindications for surgical treatment of this problem.

References

1. Inge GAL, Ferguson AB. Surgery of the sesamoid bones of thegreat toe. Arch Surg. 1933; 27:466–88.

2. Burman MS, Lapidus PW. The functional disturbances causedby the inconstant bones and sesamoids of the foot. Arch Surg.1931; 22:9–36.

3. Jahss MD. The sesamoids of the hallux. Clin Orthop 1981;157:88–97.

4. Muller GM. Dislocation of sesamoid hallux. Lancet. 1944;1:789 (abstract).

5. Eibel P. Dislocation of the interphalangeal joint of the big toewith interposition of the sesamoid bone. J Bone Joint Surg Am.1954; 36:880–2.

6. Laczay V, Csapo K. Interphalangeal luxation der grobzehe mitinterposition eines sesambeiwes. Fortschr Rontgenstr. 1972;116:571–2.

7. Murakawami Y, Tokuyasu Y. A case of dislocation of the firsttoe with the sesamoid bone interfering with orthopedicmanipulation. Orthop Surg (Tokyo). 1971; 22:751–3.

8. Kursunoglu S, Resnick D, Goergen T. Traumatic dislocationwith sesamoid entrapment in the interphalangeal joint of thegreat toe. J Trauma. 1987; 27:959–61.

9. Szucs R, Hurwitz J. Traumatic subluxation of theinterphalangeal joint of the hallux with interposition ofthe sesamoid bone. AJR Am J Roentgenol. 1989;152:652–3.

10. Wolfe J, Goodhart C. Irreducible dislocation of the great toefollowing a sports injury: a case report. Am J Sports Med.1989; 17:695–6.

11. Yasuda T, Fujio K, Tamura K. Irreducible dorsal dislocation ofthe interphalangeal joint of the great toe: report of two cases.Foot Ankle. 1990; 10:331–6.

12. Weiss AP, Yates AJ. Irreducible dorsal interphalangeal greattoe dislocation. Orthopedics. 1992; 15:480–2.

13. Dave D, Jayaraj VP, James SE. Intra-articular sesamoiddislocation of the interphalangeal joint of the great toe.Injury. 1993; 24:198–9.

14. Ward SJ, Sheridan RP, Kendall IG. Sesamoid bone interpositioncomplicating reduction of a hallux joint dislocation. J AccidEmerg Med. 1996; 13:297–8.

15. Berger JL, LeGeyt MT, Ghobadi R. Incarcerated subhallucalsesamoid of the great toe: irreducible dislocation of theinterphalangeal joint of the great toe by an accessory sesamoidbone. Am J Orthop. 1997; 26:226–8.

880 Banerjee et al. d LOCKED GREAT TOE