code substance@) 2or3 · irdm’ list i list ii +12g4 list i list ii 1,oooppm toc standard yes...

Table G.l(ii) Details of Process related Raw Materials, Intermediates, Products, etc., used or generated on the site

N

.

Ref. TA Luft Odour i EU Lists I and II NE or Material/ Class 1, Code Substance@)

(Tick and specify Group/Family Number) 2or3 Odourous Threshold Dangerous Substances Directive Groundwater Directive

Yes/No Description 76l464iEEC 80/68/EEC k&m3 List I List II +12g4 List I List II

DY07100 PROMAZINE HCL DRY - - PML84000 Pure ISDN Mother Liquor

: - - .,

w793 S-DIMETHOXY (WET) W793 - DY511 SPM 7438 Dry - - w905 SPM 7599 in Solution - - w907 SPM 7604 in Solution - DY906 SPM 7642 Dry - - - - DY691 SPM7535 - R85100 SUGAR SEEDS - R98300 SULPHURIC ACID IO % No -

(IBC) for WWTP WTO8600 TAMOXIFEN CITRATE WET - No - - WO8200 TOLUENE BULK (For use in 2 Yes Aromatic - 4 -

BPC) PS555000 Toluene Bulk (For use in 2 Yes Aromatic - - J

Nitration) WB588 Toluene Extracts Ex 588 2 Yes Aromatic - - RX767001 TOLUENE/BENZYLALCOHO 2 Yes Aromatic s

L90/10 wT08100 TRIMEPRAZINE TARTRATE - -

WET R64400 UREA 46% Yes Ammonia-like W722 VALPROIC ACID CUDE

: No * - - -

PSO73000 VALPROIC ACID FORERUN No - - W822 VALPROIC ACID LIBER.EX No - * *

0751049 RX496001 XYLENE 97% SOLIDS 3% 2 Yes Aromatic 0.27 W49600 XYLENE BULK 2 Yes Aromatic 0.27 ss (cont.): 4. The European Commission priority candidate list

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Table G.l(i) Details of Process related Raw Materials, Intermediates, Products, etc., used or

11 Ref. 1 generr

Material/ ed on the ite

Danger(*) N2 or Code

Substance”)

F78500 BMS-207873.01 N-(Trifluoroacetyl))-L- Homocysteinyl-6,6-dimethoxy-l- norleucine,methvl ester.(l->I’)- disulfide - .’ ’

785’RW BMS-207873-01 Rework 537’REX Rex Harkoseride(R-2-acetamido-N-

benzyl-3-methyoxypropionamide) 577’ML Recovery of Harkoseride Mother

tiquor(R-Z-acetamido-N-benzyl-3- methyoxypropionamide)

DY53700 Low Temperature Rex Harkoseride (R-2-acetamido-N-benzyl-3- methyoxypropionamide)

Filtered Low Temperature Rex F53700 Harkoseride (R-2-acetamido-N- Filtered Rex benzyl-3-methyoxypropionamide) 092734

092’RX

681S3

67OS4

BLD’MIDZ

670’REW

W591’Sl w592s2 7000412

lmipramine HCI

Rex lmipramine HCI

Midazolam Maleate

Midazolam Free Base (S.M.P.U)

Blended Midazolam Base

Reworked Midazolam Base

Benzyl Ester Hydrochloride Crude Moexipril HCI Reworked Moexipril HCI (dry) Slurried Moexipril HCI

CAS Number Category

2 !55387-46-3 Irritant

- 75481-36-4

75481-36-4

Harmful

Harmful

1 7548-I-36-4 Harmful

1 75481-36-4 Harmful

5 o-49-7

51 o-49-7

51 9467-70-8

5! 9467-70-8

5! 3467-70-8

5! 3467-70-8

Harmful, Flammable Irritant

Harmful, Flammable Irritant

8 2586-52-5 8 2586-52-5 8 2586-52-5

Notes: 1. 1x1 cases where a material comprises a number of distinct and availal 2. c.f. Article 2(2) of SI Ng 77/94 3. c.f Schedules 2 d 3 of SI NQ 77194

I de

Amoun Stored

(tonnes)

- Annua Usage (tonnes)

Intermediate Intermediate

Intermediate

20,21:22,36 24,25 OI, 3 7 !i 36 I 37 > 39

20,21,22,36 24,25,3,7,9,36,37,39

Intermediate 20,21,22,36 24,25,3,7,9,36,37,39

Intermediate 20,21,22,36 24,25,3,7,9,36,37,39

Intermediate

Intermediate

- Intermediate

- Intermediate

- Intermediate

-

6.65

Intermediate

Not Not asigned asigned Not Not asigned asigned 20,21,22,26 16,22,26,24,33,36,37

,38,39,46 20,21,22,26 16,22,26,24,33,36,37

,38,39,46 20,21,22,26 16,22,26,24,33,36,37

,38,39,46 20,21,22,26 16,22,26,24,33,36,37

,38,39,46 Intermediate - Intermediate 61,64 16,22,24,25,37,39 Intermediate 61,64 16,22,24,25,37,39 Intermediate 61,64 16,22,24,25,37,39

dangerous substances, please give details for each component substance.

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Ref. TA Luft ; Odour EU Lists I and II Ng or MateriaY Class 1, (Tick and specify Group/Family

Number) Code Substance@) 2or3 Odourous Threshold Dangerous Substances Directive Groundwater

Yes/No Description 761464iEEC Directive 80/68iEEC

ah3 List I List II +12g4 List I List II

F78500 BMS-207873-01 - N-(Trifluoroacetyl))-L-Homocysteinyl-6,6- dimethoxy-L-norleucine,methyl ester,(l->I’)- disulfide

785’RW BMS-207873-01 Rework 537’REX Rex Harkoseride No - * - 577’ML Recovery of Harkoseride Mother liquor - No - - DY53700 Low Temperature Rex Harkoseride -

Ii: - -

F53700 Filtered Low Temperature Rex Harkoseride - - Filtered Rex 09234 lmipramine HCI -

092’Rx Rex lmipramine HCI 681’S3 Midazolam Maleate 670’54 Midazolam Free Base (S.M.P.U) -

BLD’MID Blended Midazolam Base Z 670’REW Reworked Midazolam Base -

W591’Sl Benzyl Ester Hydrochloride -

W592’52 Crude Moexipril HCI 7000412 Reworked Moexipril HCI (dry) -

DY13500 Slurried Moexiprii HCI ‘Slurry Notes (cont.): 4. The European Commission priority candidate list

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Table G.l(i) Details of Process related Raw Materials, Intermediates, Products, etc., used or generated on the site

Ref. Material/ N” or Substance”) Code

DYl3500’ Reprocessed Moexipril HCI reprocess ed DY771’S Crude Benzyl Ester Maleate 5 813’reslur Reslurried Benzyl Ester Maleate ried DY793’S S-Di phenylalanine 3 572’S2 Crude Pindolol Ex. Tartarate salt W621’Sl DMPUXYLENE Solution W554’S2 Crude Promazine Base

581’Sl DMMPC/Xylene Solution R38400 ISDN-LACTOSE 40/60

R38500 ISDN-LACTOSE 40/60 NIT

R38600 ISDN-LACTOSE D 40160

R39200 ISDN-LACTOSE D 40/60 NIT

CAS Number

-

)2586-52-5 ,

53-60-I

87-33-2

87-33-2

87-33-2

87-33-2

Danger” Category

Highly toxic, flammable Harmful

Dangerous for the Environment Highly toxic, flammable

Highly flammable, Harmful Irritant



Highly flammable,Harmful Irritant

comprises a number of distinct and availal In cases where a mate c.f. Article 2(2) of SI Ne 77194 c.f. Schedules 2 and 3 of SI NQ 77194

Notes: 1. 2. 3.

i

Amount Stored (tonnes)

- Intermediate 61,64 16,22,24,25,37,39

- 0.651 Intermediate

Intermediate

4.088 Intermediate

0.1 6.509 2.754

0.1

- Intermediate 47.167 Intermediate 13.07 Intermediate

- - IO, 26, 27,28 36, 37,39

22,43,50 36

Intermediate Intermediate/Raw Material

Intermediate /Raw Material

Intermediate/ Raw Material

Intermediate/Raw Material

10,26,27,28 36, 37, 39 1 I ,20,22 1,2,,7,16,24,45

1 I ,20,22 1,2,,7,16,24,45

1 I ,20,22

11,20,22

1,2,,7,16,24,45

1,2,,7,16,24,45

innu al Usage (tonnes)

Nature of Use Rc3) - Phrase S”’ -

Phrase

: aangerous sutxtances, please give details for each component substance.

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n

Ref. TA Luft Odour EU Lists I and II Ng or Material/ Class 1, (Tick and specify Group/Family Number) Code Substance(‘) 2 or3 Odourous Threshold Dangerous Substances Directive Groundwater Directive

Yes/No Description 761464lEEC 80/68/EEC I.cdm3 List I List II +12g4 List I List II

DY13500’rep Reprocessed Moexipril HCI - - - recessed DY771’55 Crude Benzyl Ester Maleate - - - 813’reslurrie Reslurried Benzyl Ester - - * d Maleate DY793S3 S-Di phenylalanine - - - 572S2 Crude Pindolol Ex. Tartarate - - -

salt W621’Sl DMPUXYLENE Solution 2 Not - d -

detected W554’52 Crude Promazine Base - 581’51 DMMPC/Xylene Solution 2 Not - - ; -

detected R38400 ISDN-LACTOSE 40/60 No - R38500 ISDN-LACTOSE 40/60 NIT - No - - 938600 ISDN-LACTOSE D 40/60 - No - - =!39200 ISDN-LACTOSE D 40/60 NIT - No - - -

. 4. The European Commission priority candidate list

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Table G.l(i) Details of Process related Raw Materials, Intermediates, Products, etc., used or Penerated on the site

Danger” Amixmt Annual Nature of Use Rc3’ - S”’ - Category Stored Usage Phrase Phrase

(tonnes) (tonnes)

Environmental Laboratory - None assigned

Corrosive - Environmental Laborratory 35 26130145 Corrosive 12.00 190 Environmental Laboratory 35 26130145

- - Environmental Laboratory -



Corrosive - Environmental Laboratory 35 2-026-37139 Environmental Laboratory -

-

* c ,. ,. . 1 .1 11 1 , . . ,_..P .

----__---_ _- _-_ _-__

Ref. Material/ CAS Ng or Substance”) Number Code

1,OOOppm TOC Standard

Potassium hydrogen phthalate 7732-q 8-5 Water 7732-l 8-5

10% Sulphuric Acid 7664-93-9 50% Sulphuric Acid 7664-93-9 Antifoam Water 7732-l 8-5 Dimethyl Siloxane 63148-62-Q Methyl Cellulose 9004-67-5 Hydrogenated tallow glyceride 68308-54-3 Buffer 7 solution Water 7732-l 8-5 Potassium phosphate 7778-77-O Sodium phosphate 7558-79-4

Buffer 9 solution Water 7732-l 8-5 Potassium Chloride 7447-40-7 Boric Acid 10043-35-3 Sodium Hydroxide 131 O-73-2 Tetrasodium salt 64-02-a Pearl Caustic 13 1 O-73-2 Sodium peroxidisulphate -

Diltiazem HCI (Crude) 33286-22-5 Diltiazem HCI 33286-22-5 3-(Acetyloxy)-5-(2- dimethylamino)-ethyl)-2,3-dihydro- P-(4-Methoxyphenyl-I ,5- benzothiazepin-4(5H)-one. HCL(+)-cis-)

XT-L--. , T.. ---.- ---4.. .- - ~-L- .-i lYolcs: 1. m cases wnere a marenal comprises a numDer OI msnncr ana avauatxe aangerous suostances, please give aetalls tar eacn component substance.

2. c.f. Article 2(2) of SI Ng 77/94 3. c-f. Schedules 2 and 3 of SI Ng 77f94

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Ref. TA Luft Odour” EU Lists I and II NE or Material/ Class 1, (Tick and specify Group/Family Number) Code Substance(l) 2or3 Odourous Threshold Dangerous Substances Directive Groundwater Directive

Yes/No Description 76l464iEEC 80/68/EEC

Irdm’ List I List II +12g4 List I List II

1,OOOppm TOC Standard Yes Characteristic - - - - -

Potassium hydrogen phthalate Water 10% Sulphuric Acid 50% Sulphuric Acid Antifoam Water Dimethyl Siloxane Methyl Cellulose Hydrogenated tallow glyceride Buffer 7 solution Water Potassium phosphate Sodium phosphate

No No No

No

Light odour

Buffer 9 solution No Water Potassium Chloride Boric Acid Sodium Hydroxide Tetrasodium salt Pearl Caustic No Sodium peroxidisulphate - No - -

Diltiazem HCI (Crude) - No - - -

Diltiazem HCI No - - 3-(Acetyloxy)-5-(2- dimethylamino)-ethyl)-2,3- dihydro-2-(4-Methoxyphenyl- 1 $benzothiazepin-4(5H)-one. HCL(+)-cis-)

4* - . I . . . . . . . . . .I he buropean ~0mRltssion pnonty candIdate list

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Ref. Material/ CAS Danger”) Am6unt Annual Nature of Use Rc3) - Phrase S”’ - N2 or Substance”) Number Category Stored Usage Phrase Code (tonnes) (tonnes)

- Fesoterodine

Propanoic acid P-methyl, 2-[(IR)- 3-[bis(l-methylethyl)amino]-l- phenylpropyll-4- (hydroxymethyl)phenylester(2E)- 286930-03-8 2-butenedioate(l:l)(salt) Methoxy ethanol 109-86-4

Hydroxylammonium chloride 5470-I l-l

Lactam

Harmful

Toxic

Harmful, dangerous for the environment

0.086 -

-

20,21,22, 36 3, 7, 9,24, 25, 36, 37, 39

60,61,10,20/21/2 53,45, 2 PI2

22-36/38-43- 22-24-37-61 48122-50

33286-22-5 Reworked Diltiazem HCI (Crude 1 -Hydroxybenzotriazole 80029-43-2 Highly Flammable - monohydrate

1, II,44 15, 16, 33

4-Benzyloxybenzyl Alcohol 836-43-l 24125 Benzyl chloroformate for 501-53-I Corrosive, dangerous for the - - 34-50153 26-45-60-61 synthesis environment Ephedrine Hydrochloride 24221-86-1 Harmful 22,36,37,38 26,36 4-chloroS-methylphenol for 59-50-7 Harmful, dangerous for the - - 21122-41-43-50 26-36137139-61 synthesis environment Glycerene Monostearate 31566-31-1 - -

Hydrogen Sulphide 7783-06-4 Toxic - - - Flammable

4-Hydroxybenzyl Alcohol - - - 24,25,28A,37,45 N-Ethyldiisopropylamine 7087-68-5 Highly flammable 11,22,34 16,26,33,45

Corrosive Harmful

Notes: 1. In cases where a material comprises a number of distinct and available dangerous substances, please give details for each component substance. 2. c.f. Article 2(2) of SI NG 77/94 3. c.f. Schedules 2 and 3 of SI NQ 77194

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Ref. TA Luft Odour ’ EU Lists I and II Ng or Material/ Class 1, (Tick and specify Group/Family Number) Code Substance(‘) 2or3 Odourous Threshold Dangerous Substances Directive Groundwater Directive

Yes/No Description W4WEEC 80/68/EEC pglm’ List I List II +12g4 List I List II

Fesoterodine - No Odourless to slight solvent odour -

Propanoic acid 2-methyl, 2- [(IR)-3-[bis(l- methylethyl)amino]-l- phenylpropyll-4- (hydroxymethyl)phenylester(2 E)-P-butenedioate(l:l)(salt) Methoxy ethanol Yes Mild - - Hydroxylammonium chloride - Yes Chlorine - -

Lactam Yes ‘unpleasant’ - - Reworked Diltiazem HCI - No - - (Crude I-Hydroxybenzotriazole No - monohydrate 4-Benzyloxybenzyl Alcohol No -

Benzyl chloroformate for Yes Pungent - synthesis Ephedrine Hydrochloride No -

4-chloro9-methylphenol for Yes Phenol-like synthesis

4- : :

Glycerene Monostearate - No - - Hydrogen Sulphide 2 Yes Rotten egg - - 4-Hydroxybenzyl Alcohol No N-Ethyldiisopropylamine No * -

Notes (cont.): 4. The European Commission priority candidate list

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Ref. Material/ CAS Danger(‘) Amount Annual Nature of Use Rc3’ m fp’ - N2 or Substance(l) Number Category Stored Usage Phrase Phrase Code (tonnes) (tonnes)

Nitrate I OOOppm 7732-l 8-5 - -

Tetraoctylammonium bromide 14866-33-2 Irritant 36,37,38 26,36

P0lygylc0l400 25322-68-3 - -

Mobil Special 2OW-50 - - - -

Magnesium chloride anhydrous 7786-30-3 - for synthesis Potassium Tert-Pentylate 41233-93-6 Flammable m * Solution, 5% in Toluene Nitrification Inhibitor Formula 2533 None s -

2-Chloro-6- 1929-82-4 (Trichloromethyl)pyridine 7757-82-6 Sodium Sulfate Valproic Acid Flex (R) Reagent 99-66-l Flammable 2.86 42.04 10,36,37,38, 7,16,22,24,25,26,38 Cartridge Irritant 20,21,22 ,36,37,39 Flunixin Meglumine (Crude) - I -

24’S I Flunixin Ethyl Ester I 98S3 Flunixin Meglumine - - - - 32’Sl Crude Glibenclamide - - 78’52 Glibenclamide - - - 11655’Sl N-Boc-methoxypropionamide o-01-1 Not known s 14.35 None 24125

assigned J42900 Recovered IMS - Highly flammable, Harmful - II ,20,22 1,2,,7,16,24,45

Irritant 5318429 Wet Distilled IMS for STILL2 Highly flammable, Harmful - - II ,20,22 1,2,,7,16,24,45

Irritant S318648 Recovered IMS ex Nitration Plant - Highly flammable,Harmful - - 11,20,22 1,2,,7,16,24,45

Irritant 1705’52 MIBK Solution of Crude 5-ISM 108-I O-l Highly Flammable 442.5 - II 9/I 6123133

- - - 91’52 ASC-C

Notes: 1. In cases where a material comprises a number of distinct and available dangerous substances, please give details for each component substance. 2. c.f. Article 2(2) of SI N9 77/94 3. c.f. Schedules 2 and 3 of SI N’ 77194

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Ref. N2 or Code

324’Sl 198’S3 53231 178’S2 N655’Sl

N42900 ‘S318429 ‘S318648

TA Luft Odoul;’ EU Lists I and II Material/ Class 1, (Tick and specify Group/Family Number)

Substance(‘) 2or3 Odourous Threshold Dangerous Substances Directive Groundwater Directive Yes/No Description 16/464/EEC 80/68/EEC

Lckdm3 List I List II +l 2g4 List I List II

Nitrate 1 OOOppm - YEi Characteristic - -

Tetraoctyiammonium bromide - No -

P0lygylc0l400 Yes Mild Mobil Special 2OW-50 Yes Mild -

Magnesium chloride No - anhydrous for synthesis Potassium Tert-Pentylate 2 None - - 4 Solution, 5% in Toluene detected Nitrification Inhibitor Formula - Yes Sweet - 2533 2-ChloroB- (Trichloromethyl)pyridine Sodium Sulfate Valproic Acid Flex (R) Reagent - No Cartridge Flunixin Meglumine (Crude) Flunixin Ethyl Ester

Flunixin Meglumine -

Crude Glibenclamide Glibenclamide N-Boc-methoxypropionamide _ Not

available Recovered IMS Yes Ethanol-like Wet Distilled IMS for STILL2 Yes Ethanol-like Recovered IMS ex Nitration Yes Ethanol-like Plant

‘V705S2 MIBK Solution of Crude 5-ISM _ Yes

I91 ‘S2 ASC-C Notes (cont.): 4. The European Commission priority candidate list

Camphor

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Ref. Material/ N2 or Substance”) Code

69O’Sl ASC-B 72 lsosorbide Concentrate 705’TRL Hydrolysed Solution of Crude 5-

ISM (ph Trials) 943’SOD’AC Recovered Sodium Acetate ex ET MIBK Solution of Crude 5-ISM 027’B Blended 5-ISM (027) DY02000’R’ Rex Recovered 5-ISM R W80200 5-ISM ex Toluene 02O'S4 5-ISM

II 576’SPU I Crude 5-ISM Distillation Trails

DY844’53 ESC-Ketone

F786’54 Mepinol 786’Reslurry Reslurried Mepinol 223'51 Ametolam Base 224'S2 Dihydrobenzodiazepine (Stage 5) W49600.WD Xylene WDD (Washed, Dryed ant D distilled) TOL’WDD Toluene WDD (VVashed,dryed

and distilled) 932’RNA R-N-

Acetyldimethoxyphenylalanine DY07100’54 Promazine Hydrochloride

1330-20-7

108-88-3

3-60-I

071'Fu Rex Promazine HCI 3-60-I

Notes: 1. In cases where a material

CAS Number

j52-67-5 I6051 -77-i

127-09-3

16051-77-T 16051-77-7

08-88-3 6051-77-7 6051-77-7

bmpnses a c.f. Article 2(2) of SI NC 77194 cf. Schedules 2 and 3 of SI NG 77194

-

Danger(*) Category

Amouni Stored (tonnes)

- -

Harmful

Irritant

Harmful Harmful

Harmful Harmful Harmful

0.012 0.084 - - - -

Harmful

- -

12.5

Harmful -

Harmful I dangerous for the Environment

Harmful I 3angerous for the Environment

number of distinct and available i lgerous su

- 4nnua Usage (tonnes)

- 87.7

tances, I

Nature of Use Rt3) - Phrase

II-20 20,21 20,21

-

10/20/21/38 25

II-20 2-16-25-29-33

22,43,50 36

22,43,50 36

ase give details for each component suostance.

S”’ - Phrase

- 3125125

15,29,33,45

15,29,33,45 15,29,33,45

2-16-25-29-33 15,29,33,45 15,29,33,45

2. 3.

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Ref. TA Luft Odour EU Lists I and II Ne or Material/ Class 1,

Substance(‘) (Tick and specify Group/Family Number)

Code 2 or 3 Odourous Threshold Dangerous Substances Directive Groundwater Directive Yes/No Description 76/464/EEC 80/68/EEC

k&n3 List I List II +l 2g4 List I List II

69031 ASC-B - - 72 lsosorbide Concentrate No - 705’TRL Hydrolysed Solution of Crude No -

5-ISM (ph Trials) 943’SOD’AC Recovered Sodium Acetate ex - Yes Slight acetic acid odour

ET MIBK Solution of Crude 5-ISM 027’B Blended 5-ISM (027) No - - DY02000’R Rex Recovered 5-ISM No -

I030200 5-ISM ex Toluene - Yes Aromatic 02O’S4

4 - 5-ISM No * - - - -

576’SPU Crude 5-ISM Distillation Trails - No - - DY844’S3 - -

ESC-Ketone F786’S4 Mepinol - - 786’Reslurry Reslurried Mepinol - - 223’51 Ametolam Base - 224’S2 Dihydrobenzodiazepine (Stage - - -

5) W49600.WD Xylene WDD (Washed, Dryed 2 Yes Aromatic - - - D and distilled)

-f

TOL’WDD Toluene WDD (Washed,dryed 2 Yes Aromatic and distilled)

d

332’RNA R-N- * Acetyldimethoxyphenylalanine

DY071 OO’S4 Promazine Hydrochloride - - 371’RX Rex Promazine HCI - -

)tes (cont.): . .\ 4. __ _ _ . . . _. _ _

‘l’he European Comnussion pnollty candidate list

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Ref. Material/ CAS Danger”) Amount Annual Nature of Use Rc3) - Phrase $3’ - N2 or Substance”) Number Category Stored Usage Phrase Code (tonnes) (tonnes)

23’S2 Crude Trimipramine Base - 95S4 Trimipramine Maleate 95’RX Rex Trimipramine Maleate - 72’52 Crude Trimeprazine Base - - - 74 Reworked Trimeprazine Base - 81’S4 Trimeprazine Tartrate 4330-99-8 Harmful 0.014 : v722’S2 Valproic Acid (Crude)

20,22 22,24,25 99-66-l Flammable 2.86 42.04 -

Irritant 10,36,37,38,20,2 7,16,22,24,25,26,38,36,3

22DIVA Valproic Acid fm Divalproex I,22 39

99-66-l Flammable 2.86 42.04 Sodium

10,36,37,38,20,2 7,16,22,24,25,26,38,36,3’ Irritant

22SOV Valproic Acid fm Sodium I,22 39

99-66-l Flammable 2.86 42.04 L Valproate

10,36,37,38,20,2 7,16,22,24,25,26,38,36,3’ Irritant

07300 Valproic Acid-Distilled ex STILL 2 I,22 $39

99-66-l Flammable 2.86 42.04 RIAL

10,36,37,38,20,2 7,16,22,24,25,26,38,36,3’ Irritant

07300’S Valproic Acid Distilled/Blended I,22

99-66-l 39

Flammable 2.86 42.04 10,36,37,38,20,2 7,16,22,24,25,26,38,36,3’ Irritant

23’Sl I,22

2,6-Dimethylphenylthiourea 39

- - 16’S2 2,6-Dimethylphenylisothiocyanate - - - 01800 ISDN-GEMSA 50/50 5,20/21 I22 36

lsosorbide Dinitrate Pure 87-33-2 Harmful 0.202 0.282 Product Glycerene Monostearate 31566-31-l

Methyl acetoacetate for synthesis 105-45-3 Irritant - - 36 26

Tetramethylammonium bromide 64-20-o Toxic - - Benzyl bromide for synthesis

25,36,37,38 100-39-O

26,28,36,45 Irritant - 36, 37, 38 39

i’6’back Back Extracted Crude 5-ISM ex 16051-77-7 Harmful - salting process

20,21 15,29, 33,45

j5’S2 Tamoxifen Malonate (Rex) - - jO’SI Tamoxifen Malonate Crude - - 16’RW Reworked Tamoxifen Citrate 54965-24-l Toxic 22,45 45,53

- 1 -Bromo-2-methyl propane 78-77-3 NPD Laboratory Highly flammable, irritant II, 37 16,23

Notes: 1. In cases where a material comprises a number of distinct and available dangerous substances, please give details for each component substance. 2. c.f. Article 2(2) of SI N’? 77/94 3. c.f. Schedules 2 and 3 of SI NQ 77194

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Table G.l(ii) Details of Process related Raw Materials, Intermediates, Products, etc., used or rrnnnratnrl nn thn citn ~~ULaCLCWU “mx cmw uI*b

Ref. TA Luft Odour EU Lists I and II N2 or Material/ Class 1, i (Tick and specify Group/Family Number) Code Substance(‘) 2or3 Odourous Threshold Dangerous Substances Directive Groundwater Directive

Yes/No Description 761464iEEC 80/68/EEC !-elm’ List I List II +12g4 List I List II

723S2 Crude Trimipramine Base * - - 09534 Trimipramine Maleate - - - - 095’Rx Rex Trimipramine Maleate - m - - 772’52 Crude Trimeprazine Base - m - - 774 Reworked Trimeprazine Base I - 081S4 Trimeprazine Tartrate - - W722S2 Valproic Acid (Crude) - No - - 722DIVA Valproic Acid fm Divalproex - No I - - L Sodium 722SOV Valproic Acid fm Sodium No - - - AL Valproate FO7300 Valproic Acid-Distilled ex STILL 2 - No I - - - TRIAL FO73OO’S Valproic Acid Distilled/Blended - No - 3 523’51 2,6-Dimethylphenylthiourea - - - 516S2 2,6-Dimethylphenylisothiocyanate - - - FOl800 ISDN-GEMSA 50/50 - No I -

- lsosorbide Dinitrate Pure - Glycerene Monostearate

Methyl acetoacetate for synthesis - Yes Pleasant - - Tetramethylammonium bromide - - Benzyl bromide for synthesis Yes Pungent - -

576’back Back Extracted Crude 5-ISM ex No salting process

455’52 Tamoxifen Malonate (Rex) - - 450’S 1 Tamoxifen Malonate Crude - 086’RW Reworked Tamoxifen Citrate No - - -

I-Bromo-2-methyl propane Not detected - -

:s (cont.): 4. The European Commission priority candidate list

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Ref. Material/ CAS Danger(*) Amount Annual Nature of Use Rc3) - Phrase S”’ - NE or Substance”) Number Category Stored Usage Phrase Code (tonnes) (tonnes)

Orthophosphoric Acid 7664-38-2 Corrosive - NPD Laboratory 34 26 Sodium Sulphate 7757-82-O - - - NPD Laboratory -

Diisopropylamine 108-18-g Flammable NPD Laboratory 1 I-36137138 9-16 Irritant

Thionyl Chloride 7719-09-7 Corrosive - - NPD Laboratory 14/20/22,29,35 26/37/38/39/45 Lithium Hydroxide Monohydrate 131 O-65-2 Corrosive NPD Laboratory 22135 22l26/36/37/39l45 Toluene sulphonic acid 9000-59-3 Corrosive monohydrate

NPD Laboratory 36137138 26137

(dicyclohexylcarbdimide) Benzylamine 100-46-g Corrosive - NPD Laboratory 21l22l34l36l37l39 7/16/22/24/33/36/3~

I39149 Hexyliithium - - - NPD Laboratory -

Butyllithium 109-72-8 Flammable, Corrosive NPD Laboratory 11,14,15,17,34,48, 16,33,6A,43B 20,62,51,53,65,67

2-methyl-2-propanol 75-65-O Flammable * NPD Laboratory 1 I-20 9-16 Harmful

Tetrabutyl Ammonium Bromide 1643-19-2 - NPD Laboratory -

3-Chloro-I-propanol - NPD Laboratory Succinimide 123-56-8 - NPD Laboratory

I-(2-methoxyphenyl)-piperazine 6968-76-9 Irritant ^ NPD Laboratory 36137138 I-Bromo-3-chloropropane 109-70-6 Harmful NPD Laboratory 20,21,22,36, 37,38 24,25,

26,36,

Glutarimide P,&Piperidinedione 1121-89-7 None - NPD Laboratory None :i, 25, 28A, 37,45 Methyl Chloroformate 79-22-l Flammable, Toxic NPD Laboratory 1 I-23-36137138 9-l 6-33-44 Ammonium Chloride 12125-02-g Harmful NPD Laboratory 22-36 22 Chloroform 67-66-3 Harmful NPD Laboratory 22-38-40-48120122 36137 Citric Acid 77-92-9 Irritant - NPD Laboratory 36,37,38 26,37/39 Methyl Formate 107-31-3 Harmful NPD Laboratory 12,20/22, 36137 16,24,26,33,9

Notes: 1. In cases where a material comprises a number of distinct and available dangerous substances, please give details for each component substance. 2. c.f. Article 2(2) of SI NQ 77194

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3. c.f. Schedules 2 and 3 of SI NQ 77194


Ref. Ne or Code

Material/ Substance(‘)

Orthophosphoric Acid Sodium Sulphate Diisopropylamine Thionyl Chloride Lithium Hydroxide Monohydrate Toluene sulphonic acid monohydrate (dicyclohexylcarbdiimide) Benzylamine

Hexyllithium Butyllithium 2-methyl-2-propanol Tetrabutyl Ammonium. Bromide 3-Chloro-I-propanol Succinimide

l-(Bmethoxyphenyl)- piperazine I-Bromo-3-chloropropane Glutarimide - 2,6-Piperidinedione Methyl Chloroformate Ammonium Chloride

Chloroform Citric Acid Methyl Formate

4. The European Corm

TA Luft Class 1, 2 or3

- 1

Odourous Yes/No

No No No

Yes No

Yes

No Yes Not

available -

None reported

None reported

Yes No

Yes

No Yes No

Yes

lsion priority candidate 1

Odour

Descriptioh

Amine-like pungent

-

Ammonia Like

Camphor odour -

Sweet chloroform-like odour

Pungent-

Ether-like ^

‘agreeable odour’

-

T Threshold

,4b3

EU Lists I and II (Tick a:

Dangerous Sub, 76l46

List I

1 specify G Ices Directive :EC

List II +12g4

up/Family Grounds

801 List I

‘umber) x Directive ‘EEC

List II

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Ref. Material/ CAS Danger”) Amount Annual Nature of Use Rc3) - Phrase S”’ - NC or Substance”) Number Category Stored Usage Phrase Code (tonnes) (tonnes)

Methyl Sulfoxide 67-68-5 Irritant - - NPD Laboratory 36,37,38 26,37,39 Hexane 11 o-54-3 Flammable - - NPD Laboratory 1 I-48120 9-l 6 24125-29-51

Harmful Hydrochloric Acid 7647-01-o Corrosive - NPD Laboratory 34137 2126 Benzyl Chloride 100-44-7 Toxic - NPD Laboratory 22l23l37/38l4Ol4 361371

38145 Sodium Iodide 7681-82-5 Harmful - NPD Laboratory :0/21/22136/65 24125 Sulfuric Acid 7664-93-9 Corrosive - NPD Laboratory -

2-Butanone 78-93-3 Flammable NPD Laboratory 1 I-36137 9-l 6-25-33 Irritant

Trans Cinnamic Acid 140-10-3 Irritant - NPD Laboratory 36137138 26/28Al37/39/45 4-Bromophenol 106-41-21 Irritant NPD Laboratory 22/36l37l38/51l5 60161

Harmful 3 Methyl Alcohol 67-56-l Flammable - NPD Laboratory 1 I-23125 7-l 6-24-25

Toxic Methanesulfonic Acid 75-75-2 Toxic, causes burns NPD Laboratory 34 26, 36,45 Formic Acid 64-18-6 Harmful - NPD Laboratory 12,20/22, 36137 16,24,26,33,9 Dimethyl Sulphate 77-88-l Toxic 0.264 0.679 NPD Laboratory

Corrosive 25,26,34,43,45 25,26,34,43,45

Glacial Acetic Acid 64-l 9-7 Flammable - - NPD Laboratory IO,35 23126145 Sodium Hydroxide 131 O-73-2 Corrosive - NPD Laboratory 35 26,37/39,45 Sodium Chloride 7647-14-5 - - NPD Laboratory Dimethylacetamide 127-19-5 Toxic - NPD Laboratory 20, 21, 61 45,53

Ammonium Formate 540-69-2 Irritant NPD Laboratory 22124125 Ammonium Acetate 631-61-8 - NPD Laboratory -

Sodium Acetate 127-09-3 Irritant - NPD Laboratory Sodium Metal in Kerosene 744-23-5 Highly Flammable - NPD Laboratory 14/15/34 8128145

Corrosive Notes: 1. In cases where a material comprises a number of distinct and available dangerous substances, please give details for each component substance.

2. c.f. Article 2(2) of SI NQ 77194 3. c.f. Schedules 2 and 3 of SI Ng 77194

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Ref. TA Luft Odour ’ EU Lists I and II Ne or Material/ Class 1, (Tick and specify Group/Family Number) Code Substance(‘) 2or3 Odourous Threshold Dangerous Substances Directive Groundwater Directive

Yes/No Description 761464lEEC 80/68iEEC I.rdm’ List I List II +12g4 List I List II

Methyl Sulfoxide - Yes Sulphurous -

Hexane Yes Light Odour - - - - -

Hydrochloric Acid 3 Yes Pungent - -

Benzyl Chloride 1 Yes Pungent - 1, Sodium Iodide - No -

Sulfuric Acid No - - - -

P-Butanone 2 Yes Sharp, minty - - - -

Trans Cinnamic Acid -

4-Bromophenol - Not - - available

Methyl Alcohol Yes Characteristic - - - *

Methanesulfonic Acid Not - - - detected

Formic Acid 1 Yes Pungent - -

Dimethyl Sulphate 2 Yes Faint odour - - -

Glacial Acetic Acid 2 Yes vinegar 0.001 - - -

Sodium Hydroxide No - - - - -

Sodium Chloride - No - - -

Dimethylacetamide Yes Ammonia - -

Ammonium Formate - No Ammonium Acetate Yes Slight acetic acid odour Sodium Acetate Yes Slight acetic acid odour -

Sodium Metal in Kerosene No - -

I^^--& \. 4. TX- l-J __I- -^-- r-l---I--I-- -L-LL. ---J:?l-I- 12-r

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i Ref. Material/ CAS Danger@) Amount Annual Nature of Use Rc3) - Phrase S”’ -

N’ or Substance”) Number Category Stored Usage Phrase Code (tonnes) (tonnes)

Xylene 1330-20-7 Harmful NPD Laboratory 1 ot2ot2 1 I38 25 Toluene 108-88-3 Harmful NPD Laboratory II-20 2-16-25-29-33 Cyclohexane 11 O-82-7 Flammable NPD Laboratory 11 9-l 6-33 Methyl Ethyl Ketone 78-93-3 Flammable - NPD Laboratory 1 I-36137 9-l 6-25-33

Irritant Dimethyl Formaldehyde (DMF) 68-12-2 Toxic NPD Laboratory 2Ol21l36/61 53l45l

Propanol 71-23-8 Irritant p-12

- - NPD Laboratory 1 I ,41,67 16,24,26,39,7 Flammable

Dimethoxynaphthalene (DMN) 3900-49-O Harmful - NPD Laboratory 22 22,24,25 Liquid Ammonia 1336-21-6 Corrosive 0.169 0.177 NPD Laboratory 34-37 7-26-45 Methyl lsobutyl Ketone 108-10-I Highly Flammable NPD Laboratory II 9/I 6123133 Potassium dihydrogen phosphate 778-77-O - NPD Laboratory Ethanol 64-I 7-5

-

Highly Flammable - NPD Laboratory 11 7116 Acetone 67-64-l Flammable, Irritant - NPD Laboratory 1 l/36/66/67 2146151 Methanol 67-56-l Flammable NPD Laboratory 1 I-23125 7-I 6-24-25

Toxic Heptane 142-82-5 Highly Flammable NPD Laboratory 11/51/53/65 9/16/24/29/29/33/61 I62 0.1 N Sodium Hydroxide 131 O-73-2 Corrosive NPD Laboratory 35 26,37/39,45 Lithium Aluminium Hydride (10% - Highly Flammable Solution

NPDLaboratory 11119/14/15/35/3 Corrosive 6137.

Triethylamine 121-44-8 Highly Flammable NPD Laboratory 11 l36l2Ol21 I22 i 6/29/26/36/37/39/45 Benzyl Alcohol 100-51-6 Harmful NPD Laboratory 20122 26 Dichloromethane 75-09-2 Harmful NPD Laboratory 45 23, 24125, 3637 Tetrahydrofuran (THF) 109-99-9 Irritant NPD Laboratory 11,19,36/37

Flammable 16,29,33

Ethyl Acetate 141-78-6 Highly flammable, Irritant 10.135 39.94 NPD Laboratory II 2 Potassium Hydroxide 131 O-38-3 Corrosive NPD Laboratory 35 2126137139

Notes: 1. Iu cases where a material comprises a number of distinct and available dangerous substances, please give details for each component substance. 2. c.f. Article 2(2) of SI NQ 77/94

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3. c.f. Schedules 2 and 3 of SI NG 77194 Table G.l(ii) Details of Process related Raw Materials, Intermediates, Products, etc., used or

generated on the site ;

Ref. TA Luft Odour EU Lists I and II NC or Material/ Class 1,


Code 2or3 Odourous Threshold Dangerous Substances Directive Groundwater Directive Yes/No Description 761464lEEC 80/68/EEC

Mm3 List I List II +I 2g4 List I List II

Xylene 2 Yes Aromatic - 7f Toluene 2 Yes Aromatic - 4 *

Cyclohexane Yes Faint ether-like odour Methyl Ethyl Ketone Yes Sharp, minty Dimethyl Formaldehyde (DMF) _ Yes Fishy, pungent Propanol Yes Alcohol-like - -

Dimethoxynaphthalene (DMN) - Not - - detected

Liquid Ammonia Yes Pungent d - 4

Methyl lsobutyl Ketone 2 Yes camphor - -

Potassium dihydrogen No phosphate Ethanol 2 Yes Pungent Acetone 3 Yes Pungent - -

Methanol 1 Yes Characteristic Heptane - Yes Ether-like - -

0.1 N Sodium Hydroxide - No - - - - Lithium Aluminium Hydride - - (10% Solution Triethylamine 2 Yes fishy - -

Benzyl Alcohol Yes Characteristic - - Dichloromethane 3 Yes Ether-like, chloroform-like 4 Tetrahydrofuran (THF) 2 Yes Ether-like - - Ethyl Acetate 3 Yes Fruity -

Potassium Hydroxide No - I \ 4. -.- - . . _.- -.

‘l’he mropean Conmnsslon priority candidate list

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Ref. Material/ CAS Danger(*) Amount Annual Nature of Use Rc3) - Phrase S”’ - NE or Substance(‘) Number Category Stored Usage Phrase Code (tonnes) (tonnes)

Hydranol Working medium K - QC Laboratory lsobutyl chloroformate 543-27-l Toxic - QC Laboratory 10,23,34

Flammable 26,36,45

Corrosive n-Butyl acetate 123-86-4 Flammable - QC Laboratory IO Nitric Acid 7697-37-2 Corrosive - - QC Laboratory a-35 23-26-36-45

Oxidising Diethylamine 109-89-7 Highly flammable, corrosive - QC Laboratory 11, 20, 21,22,35, 3, 16,26,29, 36, 37, 39,

Diethyl ether 36,37 45

60-29-7 Highly flammable - QC Laboratory 12-19 9-l 6-29-33 MEK 78-93-3 Flammable, Irritant - QC Laboratory 1 I-36137 9-l 6-25-33 Cyclohexane I I O-82-7 Flammable QC Laboratory II 9-I 6-33 36% Hydrochloric Acid 7647-01-o Corrosive 3.27 8.48 QC Laboratory 34137 2126 96% Sulphuric Acid 7664-93-9 Corrosive - QC Laboratory 35 26130145 Orthophosphoric Acid 7664-38-2 Corrosive - QC Laboratory 34 26 0.1 m Perchloric Acid 7601-90-3 Corrosive - QC Laboratory IO,35

- acetic acid 23,26,45

- perchloric acid Acetic Anhydride 65-l 9-7 Flammable - QC Laboratory IO,35 23126145 Acetic Acid 100% 64-l 9-7 Flammable QC Laboratory IO,35 23126145 Hydranol Comp - QC Laboratory -

I,4 Dioxane 123-91-l Flammable - QC Laboratory II-19-36137-40 16-36137 Harmful

Formamide 68-I 2-2 Toxic QC Laboratory 2Ol21/36/61 531451

n Pentane 109-66-o Flammable p-12

- QC Laboratory 11 9-l 6-29-33 Methyl lsobutyl Ketone 108-10-I Highly Flammable QC Laboratory II 9/16/23/33 Ethanol 64-17-5 Highly Flammable - QC Laboratory 11 7116 Propan-P-01 71-23-8 Irritant,Flammable - - QC Laboratory 11,41,67 16,24,26,39,7

Notes: 1. 2.

In cases where a material comprises a number of distinct and available dangerous substances, please give details for each component substance. c.f. Article 2(2) of SI N’! 77/94

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3. cf. Schedules 2 and 3 of SI N’ 77194 Table G.l(ii) Details of Process related Raw Materials, Intermediates, Products, etc., used or

generated on the site i

Ref. TA Luft Odour EU Lists I and II N2 or Material Class 1, (Tick and specify Group/Family Number) Code Substance(‘) 2or3 Odourous Threshold Dangerous Substances Directive Groundwater Directive

Yes/No Description 16i464/EEC 80/68/EEC i4M List I List II +12g4 List I List II

Hydranol Working medium K e

lsobutyl chloroformate Yes Unpleasant pungent odour

n-Butyl acetate 2 Yes Fruity

Nitric Acid Yes Pungent Odour

Diethylamine 1 Yes Amine, fishy - i- I :

Diethyl ether 3 Yes Sweet, ethereal odour I

MEK Yes Sharp, minty -

Cyclohexane Yes Faint ether-like odour I

36% Hydrochloric Acid 3 Yes Pungent odour of hydrogen - chloride

96% Sulphuric Acid - No Orthophosphoric Acid No 0.1 m Perchloric Acid Yes Pungent vingear I

Acetic Anhydride Yes Pungent odour s

Acetic Acid 100% 2 Yes vinegar -

Hydranol Comp * - -

I,4 Dioxane 1 Yes Faint ether like

Formamide Yes Ammonia Like -

n Pentane Yes Mild gasoline like Methyl lsobutyl Ketone 2 Yes camphor

Ethanol 2 Yes Pungent

Propan-Sol Yes Alcohol-like - , .\ -. - - . . .a_ . . . . . z (cont.): 4. l.ne mropean Comnmsion pnorny cancuaate mt

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i Ref. Material/ CAS Danger” Amount Annual Nature of Use Rc3) - Phrase S(3) -

Ne or Substance”) Number Category Stored Usage Phrase Code (tonnes) (tonnes)

Toluene 108-88-3 Harmful QC Laboratory II-20 2-l 6-25-29-33 Isopropyl acetate I OS-21 -4 flammable . QC Laboratory II 16-23-29-33 2,2,4 Trimethylpentane 540-84-I - QC Laboratory Acetone 67-64-l Flammable - QC Laboratory I l/36/66/67

Irritant 2/24t46/51

Buffer pH 13 Irritant Water

- - QC Laboratory 7732-l 8-5

36137138 24125

Potassium Chloride 7447-40-7 Hydrochloric Acid 7647-01-o Formalehyde 50-00-O Methyl Alcohol 67-56-l Buffer pH IO Irritant Water

- QC Laboratory 36137138 7732-l 8-5

24125

Potasium carbonate 584-08-7 Potasium Borate 1222-88-5 Potassium Hydroxide 1310-58-3 Disodium 6381-92-6 ethylenediaminetetraacetate Buffer pH 4 Irritant Water

- QC Laboratory 7732-l 8-5

36137138 24125

Potassium Chloride 7447-40-7 Hydrochloric Acid 7647-01-o Formalehyde 50-00-O Methyl Alcohol 67-56-l Buffer pH 3 Irritant Water

- QC Laboratory 36137138 7732-l 8-5

24125

Potassium Chloride 7447-40-7 Hydrochloric Acid 7647-01-o Formalehyde 50-00-O Methyl Alcohol 67-56-l

Notes: 1. In cases where a material comprises a number of distinct and available dangerous substances, please give details for each component substance. 2. cf. Article 2(2) of SI N”- 77/94 3. c.f. Schedules 2 and 3 of SI Ne 77194

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Ref. TA Luft Odour : EU Lists I and II N” or Material/ Class 1, (Tick and specify Group/Family Number) Code Substance(‘) 2or3 Odourous Threshold Dangerous Substances Directive Groundwater Directive

Yes/No Description Xil464iEEC 80/68/EEC Irglm3 List I List II +12g4 List I List II

Toluene 2 Yes Aromatic - d Isopropyl acetate Yes Characteristic -

2,2,4 Trimethylpentane Yes Gasoline-like odour -

Acetone 3 Yes Pungent -

Buffer pH 13 - No m - Water Potassium Chloride Hydrochloric Acid Formalehyde Methyl Alcohol Buffer pH 10 - No - Water Potasium carbonate Potasium Borate Potassium Hydroxide Disodium ethylenediaminetetraacetate Buffer pH 4 No - * - Water Potassium Chloride Hydrochloric Acid Formalehyde Methyl Alcohol Buffer pH 3 No * Water Potassium Chloride Hydrochloric Acid Formalehyde Methyl Alcohol

4. ~- Notes (cont.): The European Commission priority candidate list

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Ref. Material/ CAS Danger”) Ambunt Annual Nature of Use Rc3) - Phrase S(3) - N2 or Substance”) Number Category Stored Usage Phrase Code (tonnes) (tonnes)

Buffer pH 1 Irritant - - QC Laboratory 36137138 24125 Water 7732-l 8-5 Potassium Chloride 7447-40-7 Hydrochloric Acid 7647-01-o Formalehyde 50-00-O Methyl Alcohol 67-56-l Acetonitrile 75-05-B Flammable, Toxic QC Laboratory 23124125 16127144 n-Hexane 11 o-54-3 Flammable, Harmful QC Laboratory II-48120 9-16 24125-29-U Dichloromethane 75-09-2 Harmful - QC Laboratory 45 23,24/25,3637 I, 2 Dichloroethane 107-06-2 Flammable, Toxic * QC Laboratory 45-11-22 53-45

36137130 Dimethylformamide 68-12-2 Toxic QC Laboratory 20/21/36/61 531451

Chloroform 67-66-3 p-12

Harmful - QC Laboratory 22-38-40-48120122 36137 Methanol Specially Dried 67-56-l Flammable, Toxic - - QC Laboratory II-23125 7-16-24-25 Methanol AR 67-56-l Flammable, Toxic - - QC Laboratory II-23/25 7-16-24-25 Methanol HPLC 67-56-l Flammable, Toxic - QC Laboratory II-23125 7-16-24-25 Tetrahydrofuran 109-99-9 Irritant, Flammable QC Laboratory 11,19,36/37 16,29,33 0.1 N Hydrochloric Acid 7647-01-o Corrosive - QC Laboratory 34137 2126 1 N Hydrochloric Acid 7647-01-o Corrosive - QC Laboratory 34137 2126 Sodium Hydroxide 1310-73-2 Corrosive - QC Laboratory 35 26,37/39,45 lsopropanol 67-63-O Highly Flammable, Irritant - - QC 11/36/67 2/7/16/24/25/26

Laboratory Ammonia 32% 1336-21-6 Corrosive - - QC 34-37 7-26-45

n-Heptane Laboratory

142-82-5 Highly Flammable QC 11/51/53/65 9/l6/24/29/29/33/61/6:

Ethyl Acetate AR Laboratory

141-78-6 Highly flammable 10.135 39.94 QC 11 2 Irritant Laboratory

2,2 dimethoxypropane 77-76-9 Irritant QC 10,36/37l38 16,26,33,37/39.9 Flammable Laboratory

Notes: 1. In cases where a material comprises a number of distinct and available dangerous substances, please give details for each component substance. 2. c.f. Article 2(2) of SI NQ 77194 3. c.f. Schedules 2 and 3 of SI NE 77194

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Table G.l(ii) Details of Process related Raw Materials, Intermediates, Products, etc., used or venerated nn the site

- I - - - - - - - - - - - - - I -

Ref. TA Luft Odour EU Lists I and II Ne or Material Class 1, i


Code 2or3 Odourous Threshold Dangerous Substances Directive Groundwater Directive Yes/No Description 76l464nEC 80/68/EEC

.bcg/m’ List I List II +12g4 List I List II

Buffer pH I No - - Water Potassium Chloride Hydrochloric Acid Formalehyde Methyl Alcohol Acetonitrile Yes Ether-like -

n-Hexane Yes Light Odour - -

Dichloromethane 3 Yes Ether-like, chloroform-like 4 I,2 Dichloroethane 1 Yes Chloroform-like - ;

Dimethylformamide Yes Fishy, pungent - -

Chloroform 1 Yes Ether-like - 4 -

Methanol Specially Dried 1 Yes Characteristic - -

Methanol AR 1 Yes Characteristic * -

Methanol HPLC 1 Yes Characteristic - -

Tetrahydrofuran 2 Yes Ether-like - -

0.1 N Hydrochloric Acid 3 Yes Pungent - -

1 N Hydrochloric Acid 3 Yes Pungent Sodium Hydroxide No -

lsopropanol Yes Alcohol-like -

Ammonia 32% Yes Pungent 4 4 n-Heptane - Yes Mild, gasoline-like - -

Ethyl Acetate AR 3 Yes Fruity - -

2,2 dimethoxypropane None reported .

. \ -* - - . ltes (cont.): 4. ‘l’he European Commission priority candidate list

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Table G.l(i) Details of Process related Raw Materials, Intermediates, Products, etc., used or generated on the site i

Ref. Material/ CAS Danger(‘) Amount Annual Nature of Use Rc3) - Phrase fp’ - Ne or Substance(‘) Number Category Stored Usage Phrase Code (tonnes) (tonnes)

OVEN-BEARINGS (045) - Maintenance EFFLUENT NEW AERATOR, - Maintenance &

GEAR BOX ,TANKFARM PUMP - - Maintenance BEARINGS, NITRATION PLANT(319) BR 56 7, VELCOITE IO: AIR HOISTS - - Maintenance - -

‘02187 MOBIL 1 IO. - - . Maintenance - - CUTTING OIL

102189 MOBILTHERM 605. 64742-48-9 Flammable Maintenance - HEAT TRANSFER OIL: CHURCHILL Irritant HEATERS.

02191. MOBIL ATF 220. - Maintenance CENTRIFUGES : 2,3,4,6.

02193. DELVAC - - Maintenance - * - ,AUTOMOTIVE ENGINE OIL. BUSH PUMPS

02195 MOBIL ARTIC - Maintenance - - - bARGOYLE SCH 226: CHILLERS

02196. MOBIL ARTIC - Maintenance GARGOYLE 155: CHILLERS

02197 SSR COOLANT: Maintenance SCREW COMPRESSOR (066)

02207 MAINLUBE 150/ OMEGA 69O.VACUUM - - Maintenance BOOSTERS

02217 MOBIL DTE FM 46. - Maintenance - - - PHARMA GENERAL PURPOSE MILL

02219 MOBILE DTE AA. - Maintenance -

BLOWERS ,WASTE WATER TREATMENT PLANT

^_. . _ ..mv. . . . . ..I.. * . ,-A- Notes: 1.

2. 3.

Incases where amaterialcomprises anumber ot dlstmctandavallable dangerous substances,please give aeraus Ioreacncomponenrsuvsrance. c.f. Article 2(2) of SI Ne 77/94 c.f. Schedules 2 and 3 of SI N’ 77194

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Ref. TA Luft N2 or Material/ Class 1, Code Substance(‘) 2or3 Odourous

Yes/No

OVEN-BEARINGS (045) EFFLUENT NEW AERATOR, GEAR BOX ,TANKFARM PUMP BEARINGS, NITRATION PLANT(319) BR 56 7, VELCOITE IO: AIR HOISTS

902187 MOBIL I IO. - CUTTING OIL

302189 MOBILTHERM 605. - Yes HEAT TRANSFER OIL: CHURCHILL HEATERS.

302191. MOBIL ATF 220. Yes CENTRIFUGES : 2,3,4,6.

302193. DELVAC ,AUTOMOTIVE ENGINE OIL. BUSH PUMPS

302195 MOBIL ARTIC GARGOYLE SCH 226: CHILLERS

-

302196. MOBIL ARTIC Yes GARGOYLE 155: CHILLERS

302197 SSR COOLANT: - SCREW COMPRESSOR (066)

102207 MAINLUBE 15O/OMEGA GQO.VACUUM - BOOSTERS

902217 MOBIL DTE FM 46. - PHARMA GENERAL PURPOSE MILL

302219 MOBILE DTE AA. - BLOWERS ,WASTE WATER TREATMENT PLANT

Notes (cont.): 4. The European Commission priority candidate list

Odour

Description

Mild

Mild

-

Mild

-

-

EU Lists I and II (Tick and specify Group/Family Number)

Threshold Dangerous Substances Directive Groundwater Directive 761464EF.C 80/68/EEC

cl& List I List II +12g4 List I List II - -

- - -

- - - -

-

- -

-

- -

-

- -

-

-

-

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a 0


Ref. /I I Ng or Material/

Substance(‘)

Code 902964 MOBIL GLYCOYLE 22

902171

902172

902174

902176

902177

90217%

902179

902180

902184

902185

902186

SYNTHEIC GEAR OIL. AGITATOR GEAR BOX WHITREX 408. ALL REACTORS, MECHANICAL SEALS RARAUS 427.

COMPRESSOR OlL,(O66) (341) MOBIL DTE 24 .HYDRAULIC OIL MOBIL DTE 26. HYDRAULIC OIL LIFT (074) MOBIL DTE 27. HYDRAULIC OIL .MOBIL DTE HEAVY MEDIUM. LABOUR PUMPS, I. D. U. GEAR BOX MOBIL GEAR 627. GEAR BOX 0IL:REACTORS 9,10. MOBIL GEAR 629. OVEN-BEARINGS(311) ALPINE MILL- BEARINGS(337) MOBIL GEAR 636. GEAR BOX OIL: REACTOR 103, BDI-GEAR BOX, BD2

MOBIL GEAR 626/634 ‘GEAR BOX OIL. REACTORS :2,7,8 MOBIL DTE EXTRA HEAVY. GEAR BOX REACTORS 1,4,5,12,19,27,28 NITRATION PLANT, DRIVE FLUID LEWA

CAS Num ber

IPUMPS. Notes: 1. In cases where a material comm-ises a number

Danger@ ’ 4mount 4nnual Category Stored Usage

.

2. c.f Article 2(2) of SI Ne 77194 3. c.f. Schedules 2 and 3 of SI NC 77194

(tonnes) (tonnes)

Nature of Use

Maintenance

Maintenance

Maintenance

Maintenance

Maintenance

Maintenance

Maintenance

Maintenance -

Maintenance

Maintenance

Maintenance

of distinct and available dangerous substances, please gwe details for

R’J’ - $3’ -

Phrase Phrase

component substance.

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Ref. TA Luft Odour EU Lists I and II Ne or Material/ Class 1, (Tick and specify Group/Family Number) Code Substance(‘) 2or3 Odourous Threshold Dangerous Substances Directive Groundwater Directive

Yes/No Description 76l464lEEC W68lEEC h4h’ List I List II +12g4 List I List II

902964 MOBIL GLYCOYLE 22 - - SYNTHEIC GEAR OIL. AGITATOR

GEAR BOX 902171 WHITREX 408. Yes Mild

ALL REACTORS, MECHANICAL SEALS

902172 RARAUS 427. COMPRESSOR OIL,(O66) (341)

902174 MOBIL DTE 24 - - - .HYDRAULIC OIL

902176 MOBIL DTE 26. - - - - HYDRAULIC OIL LIFT (074)

902177 MOBIL DTE 27. HYDRAULIC OIL

902178 .MOBIL DTE HEAVY - - - - - MEDIUM. LABOUR PUMPS, I. D. U. GEAR BOX

902179 MOBIL GEAR 627. - GEAR BOX 0IL:REACTORS 9,lO.

902180 MOBIL GEAR 629. -

Yes Mild - OVEN-BEARINGS(31 I) ALPINE MILL- BEARINGS(337)

9021 a4 MOBIL GEAR 636. GEAR BOX OIL: REACTOR 103, BDI- GEAR BOX, BD2

902185 MOBIL GEAR 6261634 - - - - - - - ‘GEAR BOX OIL. REACTORS :2,7,8

902186 MOBIL DTE EXTRA - * - - - - - HEAVY. GEAR BOX REACTORS I ,4,5,12,19,27,28 NITRATION PLANT, DRIVE FLUID - LEWA PUMPS.


Note :s (cont.): 4. The European Commission priority candidate list

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Ref. Material/ N2 or Substance”) Code

NITRATION PLANT.( SHELL TIVELA SA SYNTHEIC LUB CAN BE USED ALSO) NITRATION PRECIPITATION VESSEL BRI ,2. DRESSER HOLMES BLOWERS W’WTP) SIHI VAC SET (117) ,CRYSTALLISER

Notes: 1. In cases where a mate

CAS Number

Danger” Category

Amdrunt Stored (tonnes)

Qnnual Usage (tonnes)

-

Nature of Use

Maintenance

- Maintenance

Maintenance

,.,,,,,,

al comprises a number of distinct and available dangerous substances, please give details for each component suostance. 2. c.f. Article 2(2) of SI NQ 77/94 3. c.f. Schedules 2 and 3 of SI NG 77194


Ref. NE or Code

Material/ Substance(‘)

NITRATION PLANT.( SHELL TIVELA SA SYNTHEIC LUB CAN BE USED ALSO) NITRATION PRECIPITATION VESSEL BRI ,2. DRESSER HOLMES BLOWERS (WWTP) SIHI VAC SET (117)

1 ,CRYSTALLISER ?Totes (cont.): 4. The European Corn

! - m

TA Luft Class 1, 2 or 3

Odour

Odourous Yes/No Description

Threshold

I.cdm3

EU Lists I and II (Tick and specify Group/Family Number)

Dangerous Substances Directive 1 Groundwater Directive 761464lEEC

List I 1 List II +12g4 80/68/EEC

List I List II I

ission priorit candidate list

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Table G.l(i) Details of Process related Raw Materials, Intermediates, Products, etc., used or

- Ref.

Ne or Code 901014

901015

901016 , \

__

generated on the site

Material/ CAS Substance(l) Number

Danger”) Category

32 second light fuel oil (diesel) . Benzene . Hydrocarbons

sulphur 32 slcond light fuel oil (diesel)

. Benzene

. Hydrocarbons sulphur

32 sicond light fuel oil (diesel) . Benzene . Hydrocarbons . sulphur

60334-30-5 71-4-2

7704-39-g 60334-30-5

71-4-2

7704-39-g 60334-30-5

71-4-2

7704-39-g

Extremely Flammable Toxic

(known carcinogen)


(known carcinogen)


(known carcinogen)

Am&ml Annual Stored Usage (tonnes) (tonnes)

25 51

117

2.55

820

7.37

= Nature of Use R(‘) - Phrase $3’ -

Phrase

Heating-Bay 130 40,65,6652,53 2,24,36,37,43,61,62

Heating-Main Plant 40,65,6652,53 2,24,36,37,43,61,62

Heating-Administration Building

40,65,6652,53 2,24,36,37,43,61,62

Notes: 1. In cases where a material comprises a number of distinct and available dangerous substances, please give details for each component substance. 2. c.f. Article 2(2) of SI NC 77194 3. c.f. Schedules 2 and 3 of SI NC 77194


Notes (cont.): I

4. The European Commission priority candidate list I ,

Ref. 1 1 TALuft 1 Odour I EU Lists I and II Ng or Material/ Class 1, (Tick and specify Group/Family Number) Code Substance@) 2or3 Odourous Threshold Dangerous Substances Directive Groundwater Directive

Yes/No Description 76l464iEEC 80/68/EEC !4h3 List I List II +12g4 List I List II

32 second light fuel oil Yes Oil Type Benzene Class 3

-\, - 4

Hydrocarbons sulphur

I I I I I

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code substance@) 2or3 · irdm’ list i list ii +12g4 list i list ii 1,oooppm toc standard yes...

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