coe ontology research group (org) barry smith center of excellence in bioinformatics and life...
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CoE Ontology Research Group (ORG)
Barry SmithCenter of Excellence in Bioinformatics and Life Sciences
Ontology Research GroupDepartment of Philosophy
www.org.buffalo.edu
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Faculty and Staff
Directors– Werner Ceusters Medical School – Louis Goldberg Dental School– Barry Smith Philosophy Dept.
Other researchers: – 3 philosophers, 1 computer scientist, 1 business
process analyst
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Projects, funding & collaborationNational Center for Biomedical Ontology
(http://NCBO.us)
Collaborating Center for Terminology under the auspices of the World Health Organisation (WHO)
Advisory for the German national Electronic Health Record initiative
Cleveland Clinic, Duke University
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we need to know where in the body,
where in the cell
we need to know what kind of
disease process
= we need ontologies
we need semantic annotation of data
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Ontologies are systems of annotations
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• cellular locations
• molecular functions
• biological processes
used to annotate the entities represented in the major biochemical databases
thereby creating integration across these databases
A set of standardized textual descriptions of
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what cellular component?
what molecular function?
what biological process?
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This processyields a slowly growing computer-interpretable map of biological reality within which major databases are automatically integrated in semantically searchable form
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But alsoneed to extend the methodology to other domains, including clinical medicine
need disease, symptom (phenotype) ontologies
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the problem
need for prospective standards to ensure mutual consistency and high quality of clinical counterparts of GO
need to ensure consistency of the new clinical ontologies with the basic biomedical sciences
if we do not start now, the problem will only get worse
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the solution
establish common rules governing best practices for creating ontologies and for using these in annotations
apply these rules to create a complete suite of orthogonal interoperable biomedical reference ontologies
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a shared portal for (so far) 58 ontologies (low regimentation)
http://obo.sourceforge.net NCBO BioPortal
First step (2003)
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Second step (2004):reform efforts initiated, e.g. linking GO to other
OBO ontologies to ensure interoperability
id: CL:0000062name: osteoblastdef: "A bone-forming cell which secretes an extracellular matrix. Hydroxyapatite crystals are then deposited into the matrix to form bone." is_a: CL:0000055relationship: develops_from CL:0000008relationship: develops_from CL:0000375
GO
Cell type
New Definition
+
=Osteoblast differentiation: Processes whereby an osteoprogenitor cell or a cranial neural crest cell acquires the specialized features of an osteoblast, a bone-forming cell which secretes extracellular matrix.
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The OBO FoundryThe OBO Foundryhttp://obofoundry.org/http://obofoundry.org/
Third step (2006)Third step (2006)
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a family of interoperable gold standard biomedical reference ontologies to serve the annotation of
scientific literature model organism databases clinical data experimental results
The OBO FoundryThe OBO Foundry
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A prospective standarddesigned to guarantee interoperability of ontologies from the very start (contrast to: post hoc mapping)
established March 2006
12 initial candidate OBO ontologies – focused primarily on basic science domains
several being constructed ab initio
now 16 ontologies
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Ontology Scope URL Custodians
Cell Ontology (CL)
cell types from prokaryotes to mammals
obo.sourceforge.net/cgi-
bin/detail.cgi?cell
Jonathan Bard, Michael Ashburner, Oliver Hofman
Chemical Entities of Bio-
logical Interest (ChEBI)
molecular entities ebi.ac.uk/chebiPaula Dematos,Rafael Alcantara
Common Anatomy Refer-
ence Ontology (CARO)
anatomical structures in human and model
organisms(under development)
Melissa Haendel, Terry Hayamizu, Cornelius
Rosse, David Sutherland,
Foundational Model of Anatomy (FMA)
structure of the human body
fma.biostr.washington.
edu
JLV Mejino Jr.,Cornelius Rosse
Functional Genomics Investigation
Ontology (FuGO)
design, protocol, data instrumentation, and
analysisfugo.sf.net FuGO Working Group
Gene Ontology (GO)
cellular components, molecular functions, biological processes
www.geneontology.org
Gene Ontology Consortium
Phenotypic Quality Ontology
(PaTO)
qualities of anatomical structures
obo.sourceforge.net/cgi
-bin/ detail.cgi?attribute_and_value
Michael Ashburner, Suzanna
Lewis, Georgios Gkoutos
Protein Ontology (PrO)
protein types and modifications
(under development)Protein Ontology
Consortium
Relation Ontology (RO)
relationsobo.sf.net/
relationshipBarry Smith, Chris
Mungall
RNA Ontology(RnaO)
three-dimensional RNA structures
(under development) RNA Ontology Consortium
Sequence Ontology(SO)
properties and features of nucleic sequences
song.sf.net Karen Eilbeck
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RELATION TO TIME
GRANULARITY
CONTINUANT OCCURRENT
INDEPENDENT DEPENDENT
ORGAN ANDORGANISM
Organism(NCBI
Taxonomy)
Anatomical Entity(FMA, CARO)
OrganFunction
(FMP, CPRO) Phenotypic
Quality(PaTO)
Biological Process
(GO)CELL AND CELLULAR
COMPONENT
Cell(CL)
Cellular Compone
nt(FMA, GO)
Cellular Function
(GO)
MOLECULEMolecule
(ChEBI, SO,RnaO, PrO)
Molecular Function(GO)
Molecular Process
(GO)
Building out from the original GO
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Disease Ontology (DO) [SNOMED CT]
Biomedical Image Ontology (BIO)
Environment Ontology (EnvO)
Biobank Ontology (BrO)
Clinical Trial Ontology (CTO) [with WHO Global Trial Bank, Immune Tolerance Network, ACGT Advancing Genomics Clinical Trials in Cancer EU IP]
Under construction
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OBO low-regimentation ontology portal
OBO Foundry high-regimentation collaborative initiative to create a gold standard suite of interoperable ontologies
The vision
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MICheck: ‘a common resource for minimum information checklists’ analogous to OBO / NCBO BioPortal
MICheck Foundry: will create ‘a suite of self-consistent, clearly bounded, orthogonal, integrable checklist modules’ *
* Taylor CF, et al. Nature Biotech, in press
The vision is spreading
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Transcriptomics (MIAME Working Group)
Proteomics (Proteomics Standards Initiative)
Metabolomics (Metabolomics Standards Initiative)
Genomics and Metagenomics (Genomic Standards Consortium)
In Situ Hybridization and Immunohistochemistry (MISFISHIE) Phylogenetics (Phylogenetics Community)
RNA Interference (RNAi Community)
Toxicogenomics (Toxicogenomics WG)
Environmental Genomics (Environmental Genomics WG)
Nutrigenomics (Nutrigenomics WG)
Flow Cytometry (Flow Cytometry Community)
MICheck/Foundry communities
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Current service offeringsAnalysis of data dictionairies, database
schema’s and database models for ontological adequacy
Curation of biomedical terminologies, ontologies and controlled vocabularies;
Ontology creation, support in database merging and mapping
Ontology support for clinical trialsOntology support for cross-disciplinary
research collaborations