coeliac disease corrected

8/8/2019 Coeliac Disease Corrected

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Coeliac Disease 1

Journey down the bowel: a look at the Coeliac (Celiac) Disease

Noel Sales Barcelona

© 2010 – 2050



Coeliac Disease 2

TABLE OF CONTENTS:

Introduction………………………………………………………………………………… 1

Coeliac disease, a definition……………………………………………………………… 1

CD: a short history ………………………………………………………………………… 2

An autoimmune, genetic disease………………………………………………………… 5

Gluten triggers CD attack…………………………………………………………………. 6

At risk population, prevalence and the need for early detection……………………… 7

Diagnosis and prognosis of CD: a discussion………………………………………….. 10

Ending the journey down there: the conclusion………………………………………… 15

Bibliography………………………………………………………………………………….16



Coeliac Disease 3

Introduction:

IT IS A SILENT PLAGUE. Some of those who have the disease suffer from no

symptoms at all—meaning the disease for most of the time is asymptomatic; while there

are some clinicians say that there are about 200 known signs and symptoms of this

disease (University of Chicago Celiac Disease Center, n. d., p. 1). If you will look at the

profile of those who have already contracted it, you will find that the ‘victims’ vary on

age, civil status, and race (Rodrigo, 2006, p. 6586).

In the past decades, it is estimated that around two to three million Americans

and about three million people in Europe. All over the world, there are about 20 million

people who are suffering with the disease that affects not only their well-being but also

their health. And according to a medical expert from Spain the disease is rapidly

spreading in almost all continents in the world (Rodrigo, 2006, p. 6585). You might have

been asking, what is this disease that we are talking about? It’s the Coeliac Disease

(CD).

Coeliac disease: a definition

NATIONAL DIGESTIVE Diseases Information Clearinghouse (NDDIC) of the

U.S. Department of Health and Human Services defines CD as a “digestive disease that

damages the small intestine and interferes with the absorption of nutrients from food”

(2008, p. 1).

Loftus and Murray, both gastroenterologists and hepatologists from the Mayo

Clinic in Rochester, Minnesota said that CD is a chronic illness, characterized by

irritation or swelling of the fingerlike lining of small intestines called the villi (2010., p. 1).



Coeliac Disease 4

These fingerlike lining in the small bowel (another term for the small intestine) function

helps us in absorbing nutrients in the food we eat (Encyclopædia Britannica Online,

2010).

Photo of healthy (normal) villi of the small bowel (NDDIC 2008)

CD: a short history

In a lecture delivered by Samuel Gee in 1887, it was the first time that the

disease has been mentioned (Dewar & Ciclitira, 2004 p. 23). Gee, cites Dewar &

Ciclitira (2004) said that the disease is being characterized by lassitude, failure to thrive

and diarrhea (p. 23).

It was Paulley who has provided the medical community the accurate picture or

description of a coeliac lesion in 1954, for it was he who has carefully examined the

biopsies taken at lapatory. (Dewar & Ciclitira, 2004 p. 23). On the other hand, it was

Marsh who had proposed to classify different types of celiac lesions as he is the one

who has dug into the subject more deeply, as he examined, in 1992, relatively a huge

number of samples of tissues taken from the patients (Dewar & Ciclitra, 2004, p. 23).



Coeliac Disease 5

An autoimmune, genetic disease

Prof. Luis Rodrigo of the Gastroenterology Service of Hospital Universitario

Central de Asturias, in Asturias, Spain had said that CD is autoimmune disease (2006 p.

8565). When the disease is called autoimmune, it means that the person’s own immune

system attacks some healthy tissues thus causing the disorder (MedicineNet.com,

2010). Those people who suffer from autoimmune diseases usually have “unusual”

antibodies circulating in their blood that target their own body tissues (MedicineNet.com,

2010).

Most of the detected cases of CD involve patients who have family members who

are also suffering with the disease (Loftus and Murray, 2010., p. 1), thus making the

disease genetic (Mäki et al., 2003 p. 2517; University of Chicago Celiac Disease

Center, n. d., p. 2).

Kaskoff (2004) had identified the gene HLA class II DQ subregion on

chromosome 6, is necessary—but insufficient—for a person to develop CD; the person

must also have DQ2 heterodimer comprised of DQB1*02 and DQA1*05 (as found in 95

per cent of the patients diagnosed with CD). Nevertheless, five per cent of the people

diagnosed with CD having DQ8 heterodimer that is comprised of DQB1*0302 and

DQA1*03. He also explained that a small percentage or a few number of people who

lacks the aforementioned heterodimers—had either DQA1*05 or DQB1*02 (p.19).

Likewise, gene dosage also affects CD susceptibility, says Kaskoff (2004, p. 20).

“The DR17 homozygous individuals who carry DQB1*02 and DQA1*05 in cis on both

chromosomes have a greater risk of [having the] disease,” Kaskoff (2004) said.



Coeliac Disease 6

Gluten triggers CD attack

Moreover, contrary to the popular belief that CD is just a pure digestive alteration,

says Rodrigo, CD is a protean systemic disease (2006 p. 8565). Gluten, a certain type

of protein found in wheat, barley and rye was said to be “triggering device” for the

disease to “launch an offence” against the sensitive lining of the small bowel (Mäki et

al., 2003, p. 2518). Lemkin writes in December 2003,

“Celiac disease (also known as gluten intolerance, celiac sprue, non-tropical

sprue, or gluten-sensitive enteropathy) is a lifelong autoimmune genetic digestive

disorder in which there is an abnormal response to gliadin, a protein fraction of

gluten naturally found in some grains.” (p.1)

Lemkin further explained that eating food containing gliadin pulls the trigger for

the T-cells to attack the lining of the small bowel, thus damaging that sensitive lining of

the intestine (p. 1). Some gastroenterologists said that oats can be “fatal” to those who

are suffering from the disease. Meanwhile the NDDIC (2008) said that:

“When people with celiac disease eat foods or use products containing gluten,

their immune system responds by damaging or destroying villi… Villi normally

allow nutrients from food to be absorbed through the walls of the small intestine

into the bloodstream. Without healthy villi, a person becomes malnourished, no

matter how much food one eats.” (p. 1)

This is why health experts say that CD is a multi-symptom, multi-system disease.

(Case, 2006 as cited in Ward, 2006 p. 1; NDDIC 2008, p. 1).



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The photo shows the features of healthy villi (left), against the damaged by the CD (right)

(Loftus and Murray, 2010.)

At risk population, prevalence and the need for early detection

THE NDDIC (2008) stated that celiac disease is also more common among

people with other genetic disorders including Down syndrome and Turner syndrome, a

condition that affects girls’ development (p. 3). In addition to this, people with the

disease are also detected to have other autoimmune disorders such as rheumatoid

arthritis and type-1 diabetes (Ward, 2006 p. 1). Moreover, the NDDIC also stated that

CD is also common to persons with Addison’s disease (a condition in which the glands

that produce critical hormones are damaged); Sjögren’s syndrome, a condition in which

the glands that produce tears and saliva are destroyed; and those who have

autoimmune thyroid and liver diseases (p. 2).

Calling it a chameleon disease (Fasano, 2003 p. 2568), medical scientists from

Finland admitted that there is a serious concern over the under-diagnosis of the disease



Coeliac Disease 8

for it is detrimental to the health of the patient, especially for growing children, despite

the fact that the disease is well-known in the country (Mäki et al., 2003 p. 2518).

What is more alarming is that, if the disease remains undetected, it will cause

more harm to the patient (Case, as cited in Ward, 2006, p. 1) as CD is usually linked to

anemia, osteoporosis, depression, behavioral problems, and stunted growth in children,

among other problems (p. 1).

Mäki et al’s view about the disease is being supported by the study made by

Rodrigo (2006) that states in the past decade, CD is treated as a rare disease being

clearly under-diagnosed and underestimated by experts worldwide, but now considered

[as] one of the of the most commonly known genetic diseases, with a mean prevalence

of one to two per cent (1% - 2%) in the general (pp. 6585 – 6586).

Based on the latest statistics, as mentioned earlier in the prefatory part of this

essay, it is estimated that 20 million people, globally are infected with the disease. In the

U.S., about 1:133 Americans are affected by the disease and prevalence of the disease

between two people with first degree of consanguinity is 1:22 (Lemkin, 2003 p. 1). This

means that in the U.S. alone, there are about three million people who suffer from this

chronic illness (Rodrigo, 2003 p. 8586).

If experts are to include all the diseases that have something to do with gluten,

the prevalence would shoot up, between five per cent of the entire American population

to as high as 30 per cent (Lemkin, 2003 p. 1).

Moreover, in European countries, there are about three (3) million people, who

are affected by the disease. In Asia, it is suspected that there about 10 million Chinese

are suspected of having this lifelong disease, which is equivalent to 10 per cent of the



Coeliac Disease 9

entire population of the People’s Republic of China. (Rodrigo, 2003 p. 8586).

Furthermore, in South Asia, especially in India, the prevalence of the disease is

relatively high. It is said that 26 to 49 per cent of children who are suffering from chronic

diarrhea are diagnosed of having CD (p.8686).

Detection is hard, says Pietzak (as cited in Ward, 2006 p. 1) says that the it

would take, 12 years—more or less—to have a definitive diagnosis of CD in some adult

patients (p. 1).

The NDDIC revealed that symptoms of the disease vary from person to person

(2008 p. 2). However, in children the common symptoms are these: abdominal bloating

and pain; chronic diarrhea; vomiting; constipation; pale, foul-smelling, or fatty stool; and

weight loss (NDDIC, 2008 p. 2). Due to malabsorption of nutrients from food, irritability

is also common with children affected by CD (NDDIC, 2008 p. 2)

The NDDIC, meanwhile said, that some adults may not have a digestive

manifestation or symptoms of the disease, the State agency enumerated some signs

that may signal the patient to undergone testing in order to find if he or she is suffering

from celiac disease:

• unexplained iron-deficiency anemia

• fatigue

• bone or joint pain

• arthritis

• bone loss or osteoporosis

• depression or anxiety



Coeliac Disease 10

• tingling numbness in the hands and feet

•

seizures

• missed menstrual periods

• infertility or recurrent miscarriage

• canker sores inside the mouth

• an itchy skin rash called dermatitis herpetiformis

Although some people might not suffer from any of these symptoms, there are still

dangers they might catch the complications associated with CD. That is why, experts

highly recommends that they may also undergo CD testing.

Diagnosis and prognosis of CD: a discussion

Even the U.S. Health Department admits that detecting the disease is difficult as

symptoms of some digestive diseases are similar with the known symptoms of CD

(NDDIC 2008, p. 4).

“Celiac disease can be confused with irritable bowel syndrome, iron-deficiency

anemia caused by menstrual blood loss, inflammatory bowel disease, diverticulitis,

intestinal infections, and chronic fatigue syndrome. As a result, celiac disease has long

been underdiagnosed or misdiagnosed,” read the primer of NDDIC (2008, p. 4).

There are two methods to diagnose if the patient has CD: one is through serum

test (blood test) and intestinal biopsy (NDDIC 2008, p. 4).



Coeliac Disease 11

A. The map of the blood: the serological testing in determining CD on suspect

patients

In the former, the doctors will test the blood of the patient if there are indications

of high levels of anti-tissue transglutaminase antibodies (tTGA) or the anti-endomysium

antibodies (EMA), the antibodies that attacks healthy tissues inside the body.

Hill (2004) said that serological tests are very important for the identification of

patients who need intestinal biopsy in order to diagnose correctly if the patient has CD.

Hill said that the most common types of test being administered commercial laboratories

in order to diagnose a patient who is suspected of having CD are IgG- and IgA-based

antigliadin antibodies (AGA-IgG and AGA-IgA), IgA endomysium antibody (EMA-IgA),

IgA tissue transglutaminase antibody (TTG-IgA), and IgA antireticulin antibody (ARA-

IgA) (p. 27).

However, there are some questions on the sensitivity and specificity of these

tests as some scientists had tested this only in research, and not, in the clinical setting

and the accuracy of such tests might not that accurate as some may presumed (Hill

2004, p. 27).

Hill (2004) had identified three (3) reasons of why some of the tests might not be

accurate: (1) there is inadequacy of standardization of tests between laboratories; (2)

study populations in the research settings usually differ from those in clinical practice;

and (3) the definition of “gold standard” for diagnosing CD is quite problematic (p. 26).

In order to support this claim, Hill (2004) had presented a table that presents the

high variability of the sensitivity and specificity of different tests administered in adults

and in children:



Coeliac Disease 12

From the aforementioned, comparative results, Hill (2004) had drawn the

following conclusion(s):

1. TTG-IgA (human recombinant) and EMA-IgA are the most sensitive and

specific serological tests available for identifying individuals who require an

intestinal biopsy for CD diagnosis. Their accuracy in clinical practice may not

be as good as that reported from the research setting. Therefore, a positive

diagnosis of CD should not be made on the basis of a serological test alone

without intestinal biopsy confirmation.

2. Serological tests may be less reliable in very young children. AGA tests are

no longer recommended as a screening test because of the variable

sensitivity and specificity associated with this test. There is no advantage to

using a panel of tests incorporating AGA, EMA, and TTG antibodies over a

single test using EMA or TTG. (p. 28).



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Rostom, on the other hand, in his study about the sensitivity and specificity of different

serological testing needed in determining the presence of certain antibodies in some

patients that poses the possibility of the subject of having CD, presented at the NIH

Consensus Development Conference on Celiac Disease in 2004, had concluded that,

overall, the results suggest that EMA and tTG antibodies demonstrate extremely high

specificities in both adults and children (p. 42)

Based on his review, Rostom (2004) had found out that in the studied

populations, testing for the IgA-EMA and IgA-tTG have sensitivities and specificities

each in excess of 90 percent in both children and adults; that the pooled specificity of

EMA was 100 percent in adults using either EMA-ME or EMA-HU; that in studies of

children, the specificity of EMA using these two substrates was 97 percent and 95

percent, respectively, with overlapping 95 percent CIs, suggesting that there is no

statistical difference between these values; that in adults, the pooled specificity of tTG-

GP and tTGHR were 95 percent and 98 percent, respectively, with overlapping CIs; that

in children, similarly, the specificities were 96 percent and 99 percent, again with

overlapping CIs; and that among the three studies in adults, and four studies in children

that assessed both EMA and tTG, the specificities were nearly identical (p. 42).

On the other hand, Eisentbarth (2004) since most of the cases of CD are genetic,

it is good for the babies to be subjected in the newborn screening process in order to

detect if the child is susceptible to the autoimmune disease (p. 39).

He also said that newborn screening can also prevent the repeated testing to

certain population, in order to discover or diagnose individuals or groups susceptible in



Coeliac Disease 14

developing transglutaminase autoantibodies (TGAs), which cause autoimmune

diseases, such as CD and type-1 diabetes (p. 39).

He also said that testing from a public health perspective is likely to be useful,

given the prevalence of celiac disease and the potential for altering relatively simple

factors such as the timing of introduction of gliadin (p. 39).

B. Scrutinizing the tissues: Intestinal Biopsy

If the blood tests had already shown the indicators that someone might have CD,

the doctor might recommend that the patient must undergo intestinal biopsy or small

bowel biopsy (SBB). This method is done by getting some tissues from the small bowel

to check the extent of the damage that CD had done (NDDIC, 2008 p. 4).

However, there are some deficiencies in this method as the manifestations of

CD, in some cases, are very subtle and can only affect older children and some adults

(Rewers, 2004 p. 45). On the other hand, some of the patients poorly accept the

method, especially to those who suffer from very mild, to no symptoms at all (Rewers,

2004 p. 45).

Rewers also furthered that SBB “also hardly a “gold standard”—occasionally

false-negative due to patchy mucosal changes, often most severe in proximal jejunum,

and typically not reached by endoscopic biopsy.”

As the diagnosis shows that the patient is positive with CD, the recommendation

is the shift from a gluten-full to gluten-free diet (GFD) in order for the small bowel to heal

(NDDIC 2008 p. 5).



Coeliac Disease 16

CD is considered as a rare disease but the rapid spread of this autoimmune, lifelong

disease had caused alarm to the scientific and medical communities, that they have

arrived in the conclusion that the disease is often misdiagnosed or under-diagnosed.

On the other hand, the two known methodologies in detecting the presence of

the disease are the serological testing and intestinal (small bowel) biopsy. The former

tests the patients in the presence of the gene HLA class II DQ subregion on

chromosome 6, is necessary, though this is insufficient for a person to develop CD and

the DQ2 heterodimer comprised of DQB1*02 and DQA1*05 (as found in 95 per cent of

the patients diagnosed with CD). The latter is invasive, for it needed to obtain portions

of the small intestine’s tissue in order to assess the damage.

Furthermore, research on the disease is being advanced in order to arrest future

problems associated with the CD. (30)

Bibliography:

Dewar D. and Ciclitira, P. J. (2004). The Pathology of Celiac Disease . In: U.S. Institutes

on Health Consensus Development Conference on Celiac Disease, Bethesda,

Maryland, (MD) USA. Maryland: .U.S. Institutes on Health.

Eisenbarth, G. S. In: U.S. Institutes on Health Consensus Development Conference on

Celiac Disease, Bethesda, Maryland, (MD) USA. Maryland: .U.S. Institutes on

Health.

Encyclopædia Britannica (2010). Viilus. Available at: Encyclopædia Britannica Online:

<http://www.britannica.com/EBchecked/topic/629261/villus> [Accessed 24

September 2010]



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Fasano, A. (2003) Celiac Disease — How to Handle a Clinical Chameleon. New

England Journal of Medicine, 348 (25), p. 2568

Hill, I. (2004) What Are the Sensitivity and Specificity of Serological Tests for Celiac

Disease? Do Sensitivity and Specificity Vary in Different Populations? In: U.S.

Institutes on Health Consensus Development Conference on Celiac Disease,

Bethesda, Maryland, (MD) USA. Maryland: .U.S. Institutes on Health.

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Maryland, (MD) USA. Maryland: .U.S. Institutes on Health

Lemkin, J. (2003). The Emerging Role of Nutritional Supplementation in Celiac Disease .

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<http://www.pioneernutritional.com/literature/health_ed_library.html> [Accessed

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Loftus, C. G. and Murray, J. A. (2010.) Celiac Disease . Bethesda, MD: The American

College of Gastroenterology. [PDF] Available at

<http://www.acg.gi.org/patients/gihealth/pdf/celiac.pdf> [Accessed 24 September

2010]

Mäki, M. et al., Prevalence of Celiac Disease among Children in Finland. The New

England Journal of Medicine 348 (25) pp. 2517 – 2518

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Bethesda, MD: U.S. National Institute of Diabetes and Digestive and Kidney

Diseases, National Institutes of Health, U. S. Department of Health and Human

Services. [PDF]. Available at



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<http://digestive.niddk.nih.gov/ddiseases/pubs/celiac/index.htm> [Accessed 23

September 2010]

Rewers, M. J. (2004) Epidemiology of Celiac Disease: What Are the Prevalence,

Incidence, and Progression of Celiac Disease? . In: U.S. Institutes on Health Consensus

Development Conference on Celiac Disease, Bethesda, Maryland, (MD) USA.

Maryland: .U.S. Institutes on Health.

Rodrigo L. (2006) Celiac disease. World Journal of Gastroenterology , 12(41) pp. 6585-

6586

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(MD) USA. Maryland: .U.S. Institutes on Health.

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<http://www.celiacdisease.net/> [Accessed 22 September 2010]

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