cognivue - critical path institute...2017/07/10 · cognitive disorders –dementias, deliriums,...
TRANSCRIPT
Cognivue®
Charles J. Duffy, MD, PhD
Founder and CEO
May 10, 2017
Cognivue is an artificial intelligence neurological tool,
not a computerized psychological questionnaire
COGNIVUE ENABLES CARE
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Cognivue promotes cost-effective dementia care
in primary care office practices
Cognivue aligns patients, families, and practitioners by
moving beyond dementia as an accusation
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LocalMotion
GlobalPattern
LocalMotion
GlobalPattern
LocalMotion
GlobalPattern
Psychophysics Distinguishes Aging and AD
Mo
tio
n C
oh
eren
ce T
hre
sho
ld
ORIGINS OF COGNIVUE
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UTILITY OF COGNIVUE
Year in Study (off treatment)
0
10
20
30
40
50
60
70
1 2
ON Radial IO
ON Radial Out
ON Planar
AD Radial IO
AD Radial Out
AD Planar
NAD = 12
NON = 31
One Year Longitudinal Study in Aging and AD M
oti
on
Co
heren
ce T
hresh
old
One Year Longitudinal Study in Aging and AD
Stability in normal aging
Decline in early Alzheimer’s
Detect and monitor disease neurological deficits
Monitor
Detect
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NEURAL MECHANISMS OF COGNIVUE
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LINKS TO AGING AND ALZHEIMER’S
Hyperactivity of soluble AβLoss od activity with Aβ plaques
Loss of signal coherencein aging and early AD
SIX KEY POINTS
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1. Detect functional impairment
2. Monitor disease progression
3. Assess therapeutic efficacy
4. Access neural mechanisms
5. Foundation of complex behaviors
6. Domain-specific impairment measures
Shape Processing
Occipital
Language
Parietal
Temporal
Language Processing
cat
dal
daf
cbt
gca
erfltv
kif
ris
pfg
Visuo-Motor Function
Motion Processing
Dynamic Adaptation
Spatial Attention
Temporal Integration
Learning & Memory
Bottom-Up Processing
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COGNIVUE COMMERCIALIZATION
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COGNIVUE PSYCHOPHYSICAL TESTING
Motor
Control Report Generation
Visual
Salience
Sensory-Motor Testing
Calibrate
to Patient
Perceptual Testing Shapes
Motion
Letters
Words
Calibrate
to Patient
Memory Testing Shapes
Motion
Letters
Words
Calibrate
to Patient
Cloud Archives
Post-hocAnalyses
Contextualized
F/U Testing
Practitioners& Researchers
Doe, John02-01-1956
Secure access on Cognivue, desktops, and portable devices
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THE COGNIVUE SYSTEM
N = 356 subjects tested twice
Cognivue re-test correlation = .90
PPA = .89, NPA = .93, ICC = .94
SLUMs re-test correlation = .82
PPA = .87, NPA = .87, ICC = .87
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COGNIVUE’S FDA VALIDATION
N = 401 subjects 55- 95 yo
impaired vs. unimpaired
Cognivue vs. SLUMS
PPA & NPA
.82 & .98
1) Objective psychophysics
2) Neurological assessment
3) Linked to brain electrical activity
4) 10 minute testing in doctor’s office
5) Simple test interpretation algorithm
6) Easily explained to patients and families
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COGNIVUE’S ADVANTAGES
Cognitive Disorders – Dementias, Deliriums, Syndromes
Movement Disorders – Parkinsonism and overlap syndromes
Affective Disorders – Depressions, Manias, Psychoses
Acquired Disorders – Head injury and medicinal SEs
Developmental Disorders – Conditions and Pathopotential
PLATFORM TECHNOLOGY TARGETS
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COGNIVUE CONTINUING EXPANSION
Domain-specific cortical function
Bringing cognitive care to primary care
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