collaboratory research projects: macewan physical sciences dr. samuel mugo 1
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COLLABORATORY RESEARCH PROJECTS: MACEWAN PHYSICAL SCIENCES
Dr. Samuel Mugo
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Listen to Nature, Learn from Nature
The world will not evolve past its current state of crisis by using the same thinking that created the situation. -Albert Einstein
“Being ‘less bad’ is no good.”
Collaboratory Research Project Themes
FATS and OILs Natural ProductsNovel Analytical Platforms for Environmental and Food monitoring
Hormones and Antibiotics-NSERC project
Value added Green Products
Profiling Bioactive, sensory, antioxidants, allelopathic compounds
On-site integrated sampling techniques
Destroy antibiotics in cattle manure: use it as fertilizer U of A: Dr
CurtisDr. Njenga, Dr Mellisa Hills
ARDN Dr. Withey, Highmark
FATS and OILs
Transformations (natural catalysts) Wax esters,
Structured lipids, Biodiesel,
Green ProductsOils and fats: Most important renewable materials. Exploit carboxylate chemistry
Natural Products
Profiling Bioactive, sensory, antioxidants, allelopathic compounds
Natural Products: Antioxidants
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Synthetic antioxidants:Natural antioxidants:
Safety (Carcinogenic) Concerns?
No harmful physiological effects
Not Fat-soluble (mainly hydrophilic)
Economical
Quercetin-3-glucoside
- If you keep food for a long time on shelf they go bad: Preserve
TIME
Antioxidants (polyphenolics) From Herbal Plants
Rosemary (Rosmarinus Officinalis L.): Common spice widely used in food processing
Yanishlineva et al. Eur. J. Lipid. Technol. 108(2006): 776
Obtained by extraction with ethanol/methanol fraction
More effective than BHT and BHA
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Antioxidants (polyphenolics) From Herbal Plants
Oregano (Oreganum Vulgare L.) antimicrobial and antioxidant properties
Yanishlineva et al. Eur. J. Lipid. Technol. 108(2006): 7768
Herbal Plants and Spices of Interest
Strychnos heningsii (muteta)
Cure and Prophylaxis of arthritis
Clausena anisata(Give herbal preparations sweet smell)
Tamarindus indica.
Compounds to look for with antioxidant activity: flavonols, flavonoids, isoflavones, diterpenes and phenolic acids
Botany Depart: JKUAT (KENYA)Plants from:
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Ixora scheffleri K.Schum
Concomitant study of the secondary Metabolites
Characterization of active compounds makes their use safer!
Piper capense
Used in the management of flu and cold; antimicrobial
Seeds used to treat boils, bark decoction for lowering sugar level
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Our research
Figure 1. Myrianthus Hostii, an East African Herbal Plant
Often taken as a concoction for myriad remedies
Natural Products
Bioactive and sensory compoundsallelopathic compounds
Aloe Vera
Novel Analytical Platforms for Environmental and Food monitoring
MUGO-Rural Alberta Water Quality Monitoring: concept map
Different types of polymer in different morphologies entrained in the microbore to extract the contaminant
In House Developed microbore microextractors
Online couple to GC-MS (trihalomethanes, volatile compounds)
Elute to LC-MS (polyromatichydrocarbons, EDCs)
Online couple to ICP or AAS (heavy metal analysis)
Onsite microboremicroextractor
Drinking water from tap
CHEMOMETRICs (DR. KAREN BURO
Using statistical tools to quickly interpret complex data quickly acquired by Fourier Transform Spectroscopic Methods: FTIR and RAMAN
Adulteration in Foods
Case of Melamine tainted Milk, cat food etc.
Nitrate tainted milk
Trans Fats in Cookies
Olive oil spiked with Canola oil
NSERC-funded research on hormones and antibiotics
Project: Development of a novel, practical approach for the detection, tracing anddestruction of antibiotics and hormones in animal biowaste
Collaborative project with Highmark Renewables Research, and part of the larger bioWaste to Energy for Canada Integration Initiative (BECii)
Currently funded by a two-year $200,000 NSERC CCI grant
Method development taking place entirely at the MacEwan campus, utilizingstart-of-art instrumentation and dedicated research space acquired as part of thenew baccalaureate degree programs Project involves two MacEwan faculty members, one post-doctoral researchassociate, and employs four undergraduate students as research assistants eachyear.
Equipment Infrastructure
LCQ Fleet ion trap MSn
GC-MS
LC
Dual-laser Raman spectrometer (3 cm-1)with optical microscope
We service clients off-campus for a reasonable fee
400 MHz NMRspectrometer
FT-IR
iCAP (inductively coupled plasma spectroscopy)
Atomic absorption spectrometry
We service clients off-campus for a reasonable fee
Challenges/opportunities
Students Training Opportunity: Karl ayton, Alex Cerezo, Samuel Langman, Linh Tran, Jennifer, Lauren, Patrick, Merrill Singleton etc.
We are collaboration crazy! It is the way to go
Money- Getting access to money from other funding agencies (NSERC, ARDN, Canola growers Association, CIDA, CHIR, AACTI, AIF etc.