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Combined Objective and Subjective Optometer James Copland Daniel Neal, Phd Wavefront Sciences NIH Grant 1R43EY14295-1

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Page 1: Combined Objective and Subjective Optometervoi.opt.uh.edu/VOI/WavefrontCongress/2006/presentations/...Combined Objective and Subjective Optometer James Copland Daniel Neal, Phd Wavefront

Combined Objective andSubjective Optometer

James CoplandDaniel Neal, Phd

Wavefront Sciences

NIH Grant 1R43EY14295-1

Page 2: Combined Objective and Subjective Optometervoi.opt.uh.edu/VOI/WavefrontCongress/2006/presentations/...Combined Objective and Subjective Optometer James Copland Daniel Neal, Phd Wavefront

Aberrometers and Autorefractorsuse Infrared Light

• Probe beam hits retina

• 0.03% of light scattersout of retina forwavefrontmeasurement

• Conversion is neededfrom infraredmeasurement to visiblerefraction

Page 3: Combined Objective and Subjective Optometervoi.opt.uh.edu/VOI/WavefrontCongress/2006/presentations/...Combined Objective and Subjective Optometer James Copland Daniel Neal, Phd Wavefront

Two reasons visible refractionsdiffers from infrared reading

1) Chromatic aberration

2) Infrared scatter layer isat a different plane thanthe photoreceptors

Scatter Layer might be RPE (retinal pigment epithelium),sclera, cone entrances, choroid, inner limiting membrane,outer limiting membrane.

Page 4: Combined Objective and Subjective Optometervoi.opt.uh.edu/VOI/WavefrontCongress/2006/presentations/...Combined Objective and Subjective Optometer James Copland Daniel Neal, Phd Wavefront

Combined Instrument was built tostudy location of scatter layer

COAS

Lens

Lens

Eye

Beam Splitter Subjective Optometer

Step 1. Cycloplege subject’s eye to freeze accommodation

Step 2. COAS measures eye

Step 3. Subject adjusts stage in subjective optometer for “in focus” condition

Page 5: Combined Objective and Subjective Optometervoi.opt.uh.edu/VOI/WavefrontCongress/2006/presentations/...Combined Objective and Subjective Optometer James Copland Daniel Neal, Phd Wavefront

Subjective optometer uses 840 nmto avoid chromatic aberration

• Chromatic aberration wouldobscure effect we want to study

• 50 microwatts of 840 nm are clearlyvisible (lab experiment)

• Safety limit at 840 nm is 770microwatts for 8 hours a day so itpossible to build a safe infraredoptometer (ANSI Z136.1-2000)

• Plots from Modern Optical Engineering (Warren JSmith) show eye is sensitive to 840 nm light. (Butdoes decline by factor or ten every 50 nm.)

Eye Sensitivity versus wavelength(Linear y axis)

00.20.40.60.81

1.2

0.4 0.5 0.6 0.7 0.8 0.9 1 1.1

Wavelength (microns)

Rel

ativ

e Se

nsiti

vity

Eye Sensitivity versus Wavelength(Logarithmic y axis)

1E-121E-101E-081E-06

0.00010.0110.4 0.5 0.6 0.7 0.8 0.9 1 1.1

Wavelength (microns)

Rel

ativ

e Se

nsiti

vity

Page 6: Combined Objective and Subjective Optometervoi.opt.uh.edu/VOI/WavefrontCongress/2006/presentations/...Combined Objective and Subjective Optometer James Copland Daniel Neal, Phd Wavefront

Options for Subjective Optometer• Young’s Optometer: Subject

adjusts stage until targetappears to be in best focus– Not suitable because 840

nm appears dim. Subjectswould be frustrated.

• Scheiner Disk: Subjectadjusts stage until dotsoverlap– 840 nm bright enough– Astigmatism affects power

that is measured,complicating data reduction

Eye Lens Target on Stage

Eye Lens &Mask

Target on Stage

Page 7: Combined Objective and Subjective Optometervoi.opt.uh.edu/VOI/WavefrontCongress/2006/presentations/...Combined Objective and Subjective Optometer James Copland Daniel Neal, Phd Wavefront

Laser Speckle Optometer• Laser Speckle Optometer:

Subject adjusts stage untilspeckle pattern does notmove– 840 nm bright enough– Astigmatism does not affect

stage location for stationarity(instead affects apparentdirection of speckle motionchanges angle)

Eye SpinningDiffuser

Lens Coherent PointSource

Page 8: Combined Objective and Subjective Optometervoi.opt.uh.edu/VOI/WavefrontCongress/2006/presentations/...Combined Objective and Subjective Optometer James Copland Daniel Neal, Phd Wavefront

Laser Speckle is built intoBadal Optometer

When stage is set “in focus”, dots appear to “boil.”When stage is too myopic, dots appear to move to left.When stage is too hyperopic, dots appear to move to right.

Laser

10o Holographic Diffuser works best for hightransmission and large speckles

Coherent Point Source

Diffuser Wheel on 26 RPM motor

Page 9: Combined Objective and Subjective Optometervoi.opt.uh.edu/VOI/WavefrontCongress/2006/presentations/...Combined Objective and Subjective Optometer James Copland Daniel Neal, Phd Wavefront

Combined Instrument

Page 10: Combined Objective and Subjective Optometervoi.opt.uh.edu/VOI/WavefrontCongress/2006/presentations/...Combined Objective and Subjective Optometer James Copland Daniel Neal, Phd Wavefront

Calibrate Instrument with Model Eye

• CCD simulates retina and it is on amicrometer stage

• Lens simulates cornea and lens

• Step 1: Set CCD to some distance• Step 2: COAS measure eyes sphere S• Step 3: Researcher adjust stage to D in

optometer for stationary speckle• Step 4: Plot S versus D for many points.

Calculate slope (mm per diopter)

Subjective Optometer

Lens

CCD

Page 11: Combined Objective and Subjective Optometervoi.opt.uh.edu/VOI/WavefrontCongress/2006/presentations/...Combined Objective and Subjective Optometer James Copland Daniel Neal, Phd Wavefront

Preliminary Results

• Speckle optometer is creates clearly visible speckles• Alignment to speckle optometer is sensitive• Objective and subjective readings are about 0.5 to

1.0 diopter different• Corresponds to differences of about 0.10 mm to 0.15

mm• Limited data taken up to now. Better results expected

in future

Page 12: Combined Objective and Subjective Optometervoi.opt.uh.edu/VOI/WavefrontCongress/2006/presentations/...Combined Objective and Subjective Optometer James Copland Daniel Neal, Phd Wavefront

Combining Chromatic and ScatterLayer in Optical Model

• Chromatic Aberrationbased on IndianaChromatic Eye– single ellipsoidal

refracting surface– homogenous media

• Add Infrared ScatterLayer located distance Xfrom photoreceptors

X

Page 13: Combined Objective and Subjective Optometervoi.opt.uh.edu/VOI/WavefrontCongress/2006/presentations/...Combined Objective and Subjective Optometer James Copland Daniel Neal, Phd Wavefront

Refractive Adjustment Equation• S(vis) = 1/L - ( V(ir) + 1/(L+X) ) * (n(vis)-1)/(n(ir)-1)

– S(vis) = Spectacle Refraction– L = assumed length on an emmetropic eye (16.666 for 60 D eye_– V(ir) = vergence of infrared light actually measured by

aberrometer– X = distance between infrared scatter layer and photoreceptors– n(vis) = index of refraction of eye at 555 nm = 1.328020– n(ir) = index of refraction of the eye 840 nm = 1.334278

– Values of index of refraction from Larry Thibos, Ming Ye, X Zhangand Arthur Bradley “The chromatic eye, a new model of ocularchromatic aberration, Applied Optics, Volume 31, 1992, page3594-3600)

Page 14: Combined Objective and Subjective Optometervoi.opt.uh.edu/VOI/WavefrontCongress/2006/presentations/...Combined Objective and Subjective Optometer James Copland Daniel Neal, Phd Wavefront

Effect of Chromatic Aberration Only

• Set X=0 inrefractiveadjustmentequation.

• Adjustment hasnegative value

• Adjustment isstronger for moremyopic eyes

Refractive Adjustment due to Chromatic Aberration Only (x=0)

-2.00-1.50-1.00-0.50

0.000.501.00

-20.00 -15.00 -10.00 -5.00 0.00 5.00 10.00

Visible Spherical Equivalent (Diopters)

Ad

justm

en

t (D

iop

ters

)

Page 15: Combined Objective and Subjective Optometervoi.opt.uh.edu/VOI/WavefrontCongress/2006/presentations/...Combined Objective and Subjective Optometer James Copland Daniel Neal, Phd Wavefront

Effect of Scatter Layer only

• Use samewavelength offor both n(ir)and n(vis)

• Effect is aconstant valuein positivedirection

Refractive Adjustment due to Infrared Scatter Layer Offset only (x=0.125 mm)

-2.00-1.50-1.00-0.50

0.000.501.00

-20.00 -15.00 -10.00 -5.00 0.00 5.00 10.00

Visible Spherical Equivalent (Diopters)

Ad

justm

en

t (D

iop

ters

)

Page 16: Combined Objective and Subjective Optometervoi.opt.uh.edu/VOI/WavefrontCongress/2006/presentations/...Combined Objective and Subjective Optometer James Copland Daniel Neal, Phd Wavefront

Combine both effects

• Scatter layer andchromatic aberrationadjustments offseteach other for atotal effect of about0.7 diopters

• Combined modelgives better fit toclinical data thanapplying 0.7 diopterto all patients

Combined Refractive Adjustment due to Chromatic and Infrared Scatter Layer Offset

-2.00-1.50-1.00-0.50

0.000.501.00

-20.00 -15.00 -10.00 -5.00 0.00 5.00 10.00

Visible Spherical Equivalent (Diopters)

Ad

justm

en

t (D

iop

ters

)