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What is it?
28 year old femaleveteran complainsof burning,blistering lesionsaround her lipsafter a day at thebeach.
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Herpes Simplex
Common triggers: fever, stress, and sun
Most common on the lips and genitalia
Tzanck smear: multinucleated giant cells
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What is it?
46 year old man
complains of painful,
burning rash on hisleft chest.
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Herpes Zoster
Recurrence of VZV in a specific nerve
Individual lesions are preceded by intense
local pain on then arise as grouped blisters
on an erythematous base, which may
become hemorrhagic and crusted
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What is it?
46 year old healthy man with intenseitching of his groin and burning of his feet.
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Tinea Cruris- jock itch
Chronic fungal infection of groin area,
usually associated with tinea pedis
Involves the groin, but NOT scrotum
Candida more likely to involve scrotum
Differential: erythrasma, candida
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What is it?
Patient complains of enlarging rash in
groin without any itching.
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Erythrasma
Caused by Corynebacterium minutissimum
Usually asymptomatic but can itch
Occur in flexural areas, especially in the groin and in
between toes; macules with fine scales and sharplydefined borders
Woods lamp: lesions are coral red because bacteriaproduce fluorescent porphyrins
Differential:
Tinea cruris: raised scaly border
Candidiasis: often has peripheral pustules
Therapy: erythromycin (topical or oral)
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Woods Lamp with Erythrasma
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What is it?
64 year old obese
female with history
of diabetescomplains of rash
under her breast.
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Candidal Infection
Occur in most intertriginous or moist areas
Obesity, diabetes, immunosuppression, and
antibiotics are important risk factors
Therapy: topical with nystatin or
imidazoles, but may require oral keto or
fluconazole
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What is it?
52 year old woman
notices darkening
of the skin aroundher neck.
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Acanthosis Nigricans
Hyperkeratosis and hyperpigmentationwith velvety folds seen in the genital
region, axillary region, or nape of theneck
Associated with insulin resistance,obesity, or malignancy (especiallyadenocarcinoma of the GI tract)
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What is it?
32 year oldkindergarten teachergrade teacher
complains of a diffuserash across his chestand back. He statesthat it started severaldays after a severe
sore throat.
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Psoriasis
Typical lesion is a round sharply borderederythematous patch with silvery scale
Lesions shown is second most common form,guttate type, which usually occurs afterstreptocoocal infection
Elbows, knees, scalp, lumbosacral region
Differential: pityriasis rosea, dermatitis,secondary syphillis, drug eruption
Auspitz sign: when a patch is scraped away,tiny blood vessels are seen
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What is it?
42 year old man
complains of this
diffuse rash acrosshis back and chest.
One week ago it
started with thelarge lesion in his
upper left chest.
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Pityriasis Rosea
Initial lesion: herald patch (several cm wide erythematouspatch)
Secondary lesion several weeks later: Christmas tree
pattern on the back (several finely scaled papules arrangedalong the skin line)
Differential: fungal infection, secondary syphillis, guttatepsoriasis, drug eruptions
Patients usually asymptomatic and lesions resolve in 2-3
weeks without treatment. In African Americans, tends tobe more pruritic and may require systemic steroids.
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Hypopigmented rash?
Patient complains of a rash onhis chest and back whichstarted 3 weeks ago. He did
not have time to visit his PCPprior his vacation, so he took apicture of the rash to show hisdoctor when he got back. Hewas surprised that the area of
the rash did not get tan overthe week. He presents to hisPCP with his picture.
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Tinea Versicolor
Caused by Pityrosporum orbiculare, previously
called Malassezia furfur
Sharply defined, yellowish-brown macules withtiny scales on chest and back; these become
very visible by stroking with tongue depressor
KOH prep: spaghetti and meatball-like hyphae
and spores
Treatment: selenium sulfide lotion
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What is it?
37 year old father
of toddler twins
presents with thisrash.
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Ringworm
Caused by parasitic fungi
(Dermatophytosis)
May be spread by skin-to-skin contact, aswell as via contact with contaminated
items
Rx: Topical antifungals or pyrithionezinc (Head & Shoulders) shampoo
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What is it?
37 year old manreturns from a
camping trip inConnecticut withcomplaints of fatigue,chills, headache,
muscle and joint aches,and rash as seen on hisflank.
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Lyme Disease Borrelia burgdorferi is the predominant cause
Bacteria are transmitted to humans by the biteof infected hard ticks belonging to the genus
Ixodes Early manifestations include fever, headache,
fatigue, and a characteristic skin rash callederythema migrans
Late manifestations involve the joints, heart,and nervous system
Rx: doxycyline (adults), amoxicillin (children),and ceftriaxone
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What is it?
36 year old woman
with history of
recurrent HSV of thelips presents with
these lesions.
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Erythema Multiforme
Sharply defined, flat papules with sunkencenters; lesions have an iris or targetappearance
Caused by herpes, mycoplasama, or viralinfections; may also be caused by drugs
May progress to Stevens-Johnson syndrome ifmucosal involvement or toxic epidermal
necrolysis Treatment: symptomatic treatment only;
systemic steroids may even be harmful insevere cases
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What is it?
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Seberrhoic Keratosis
Exophytic waxy brownish papules and plaques;appear that they can be easily scraped orflicked off
Unknown etiology
Usually benign, however, when erupt suddenly,they may represent a paraneoplastic syndromecaused by tumor production of epidermalgrowth factors
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What is it?
82 year old man concerned about somelesions on his forehead.
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Actinic Keratosis
Sharply bordered, erythematous lesions
with slight scale that eventually can
become thick and crusted Early lesions are often easier to find by
palpaion than by visual examination
Pre-cancer lesions of SCC (small % willturn to cancer over 10-15 years)
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Acne in an adult?
62 year old man
presents to your
office complainingthat friends have
noted worsening rash
on face and slightenlargement of my
nose.
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Rosacea
Central facial erythema with some
telangectasias initially, progressing to
papules and pustules Etiology unknown but many patients
have an abnormal flushing response to
various substances Therapy: topical metronidazole; severe
forms oral tetracycline or metronidazole
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What is it?
Pt complains of sudden-onset of diffuse, itchyrash across his chest, back, abdomen, arms, andupper thighs. He states that he was started on a
new blood pressure medicine two days prior torash.
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Drug-induced exanthem
Well recognized with many drugs including
Anticonvulsants
Aspirin and NSAIDs
Antibiotics: penicillins
Sulfonamides
Usually no specific investigation is undertaken
CBC may show leukopenia, thrombocytopenia, andeosinophilia in patients with serious drug eruptions.
Rx: remove suspected drug(s); antihistamines+/- steroids