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    What is it?

    28 year old femaleveteran complainsof burning,blistering lesionsaround her lipsafter a day at thebeach.

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    Herpes Simplex

    Common triggers: fever, stress, and sun

    Most common on the lips and genitalia

    Tzanck smear: multinucleated giant cells

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    What is it?

    46 year old man

    complains of painful,

    burning rash on hisleft chest.

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    Herpes Zoster

    Recurrence of VZV in a specific nerve

    Individual lesions are preceded by intense

    local pain on then arise as grouped blisters

    on an erythematous base, which may

    become hemorrhagic and crusted

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    What is it?

    46 year old healthy man with intenseitching of his groin and burning of his feet.

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    Tinea Cruris- jock itch

    Chronic fungal infection of groin area,

    usually associated with tinea pedis

    Involves the groin, but NOT scrotum

    Candida more likely to involve scrotum

    Differential: erythrasma, candida

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    What is it?

    Patient complains of enlarging rash in

    groin without any itching.

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    Erythrasma

    Caused by Corynebacterium minutissimum

    Usually asymptomatic but can itch

    Occur in flexural areas, especially in the groin and in

    between toes; macules with fine scales and sharplydefined borders

    Woods lamp: lesions are coral red because bacteriaproduce fluorescent porphyrins

    Differential:

    Tinea cruris: raised scaly border

    Candidiasis: often has peripheral pustules

    Therapy: erythromycin (topical or oral)

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    Woods Lamp with Erythrasma

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    What is it?

    64 year old obese

    female with history

    of diabetescomplains of rash

    under her breast.

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    Candidal Infection

    Occur in most intertriginous or moist areas

    Obesity, diabetes, immunosuppression, and

    antibiotics are important risk factors

    Therapy: topical with nystatin or

    imidazoles, but may require oral keto or

    fluconazole

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    What is it?

    52 year old woman

    notices darkening

    of the skin aroundher neck.

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    Acanthosis Nigricans

    Hyperkeratosis and hyperpigmentationwith velvety folds seen in the genital

    region, axillary region, or nape of theneck

    Associated with insulin resistance,obesity, or malignancy (especiallyadenocarcinoma of the GI tract)

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    What is it?

    32 year oldkindergarten teachergrade teacher

    complains of a diffuserash across his chestand back. He statesthat it started severaldays after a severe

    sore throat.

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    Psoriasis

    Typical lesion is a round sharply borderederythematous patch with silvery scale

    Lesions shown is second most common form,guttate type, which usually occurs afterstreptocoocal infection

    Elbows, knees, scalp, lumbosacral region

    Differential: pityriasis rosea, dermatitis,secondary syphillis, drug eruption

    Auspitz sign: when a patch is scraped away,tiny blood vessels are seen

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    What is it?

    42 year old man

    complains of this

    diffuse rash acrosshis back and chest.

    One week ago it

    started with thelarge lesion in his

    upper left chest.

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    Pityriasis Rosea

    Initial lesion: herald patch (several cm wide erythematouspatch)

    Secondary lesion several weeks later: Christmas tree

    pattern on the back (several finely scaled papules arrangedalong the skin line)

    Differential: fungal infection, secondary syphillis, guttatepsoriasis, drug eruptions

    Patients usually asymptomatic and lesions resolve in 2-3

    weeks without treatment. In African Americans, tends tobe more pruritic and may require systemic steroids.

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    Hypopigmented rash?

    Patient complains of a rash onhis chest and back whichstarted 3 weeks ago. He did

    not have time to visit his PCPprior his vacation, so he took apicture of the rash to show hisdoctor when he got back. Hewas surprised that the area of

    the rash did not get tan overthe week. He presents to hisPCP with his picture.

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    Tinea Versicolor

    Caused by Pityrosporum orbiculare, previously

    called Malassezia furfur

    Sharply defined, yellowish-brown macules withtiny scales on chest and back; these become

    very visible by stroking with tongue depressor

    KOH prep: spaghetti and meatball-like hyphae

    and spores

    Treatment: selenium sulfide lotion

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    What is it?

    37 year old father

    of toddler twins

    presents with thisrash.

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    Ringworm

    Caused by parasitic fungi

    (Dermatophytosis)

    May be spread by skin-to-skin contact, aswell as via contact with contaminated

    items

    Rx: Topical antifungals or pyrithionezinc (Head & Shoulders) shampoo

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    What is it?

    37 year old manreturns from a

    camping trip inConnecticut withcomplaints of fatigue,chills, headache,

    muscle and joint aches,and rash as seen on hisflank.

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    Lyme Disease Borrelia burgdorferi is the predominant cause

    Bacteria are transmitted to humans by the biteof infected hard ticks belonging to the genus

    Ixodes Early manifestations include fever, headache,

    fatigue, and a characteristic skin rash callederythema migrans

    Late manifestations involve the joints, heart,and nervous system

    Rx: doxycyline (adults), amoxicillin (children),and ceftriaxone

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    What is it?

    36 year old woman

    with history of

    recurrent HSV of thelips presents with

    these lesions.

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    Erythema Multiforme

    Sharply defined, flat papules with sunkencenters; lesions have an iris or targetappearance

    Caused by herpes, mycoplasama, or viralinfections; may also be caused by drugs

    May progress to Stevens-Johnson syndrome ifmucosal involvement or toxic epidermal

    necrolysis Treatment: symptomatic treatment only;

    systemic steroids may even be harmful insevere cases

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    What is it?

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    Seberrhoic Keratosis

    Exophytic waxy brownish papules and plaques;appear that they can be easily scraped orflicked off

    Unknown etiology

    Usually benign, however, when erupt suddenly,they may represent a paraneoplastic syndromecaused by tumor production of epidermalgrowth factors

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    What is it?

    82 year old man concerned about somelesions on his forehead.

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    Actinic Keratosis

    Sharply bordered, erythematous lesions

    with slight scale that eventually can

    become thick and crusted Early lesions are often easier to find by

    palpaion than by visual examination

    Pre-cancer lesions of SCC (small % willturn to cancer over 10-15 years)

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    Acne in an adult?

    62 year old man

    presents to your

    office complainingthat friends have

    noted worsening rash

    on face and slightenlargement of my

    nose.

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    Rosacea

    Central facial erythema with some

    telangectasias initially, progressing to

    papules and pustules Etiology unknown but many patients

    have an abnormal flushing response to

    various substances Therapy: topical metronidazole; severe

    forms oral tetracycline or metronidazole

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    What is it?

    Pt complains of sudden-onset of diffuse, itchyrash across his chest, back, abdomen, arms, andupper thighs. He states that he was started on a

    new blood pressure medicine two days prior torash.

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    Drug-induced exanthem

    Well recognized with many drugs including

    Anticonvulsants

    Aspirin and NSAIDs

    Antibiotics: penicillins

    Sulfonamides

    Usually no specific investigation is undertaken

    CBC may show leukopenia, thrombocytopenia, andeosinophilia in patients with serious drug eruptions.

    Rx: remove suspected drug(s); antihistamines+/- steroids