comobio research in france comobio project communications mobiles et biologie réseau national de...
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COMOBIO
Research in FranceResearch in FranceCOMOBIOCOMOBIO ProjectProject
COmmunications MObiles et BIOlogie• Réseau National de Recherches en
Télécommunications (RNRT, Ministries of Research and Industry)
• Objectives – Promote a significant contribution of French
research teams to the research effort on mobile telephone and health
– Participation in the research programmes coordinated by WHO (along with the EMF programme agenda)
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• Participants – Manufacturers :
• Alcatel, Sagem
– Network providers : • Bouygues Telecom, Cégétel, France Télécom
– Engineering schools and research centres: • ENST de Paris et de Brest, IRCOM Limoges, Supélec,
– Universities : • Bordeaux, Marseille, Nîmes, Orsay, Rennes.
• Duration: 33 months, from January 99• Budget: 2 M€ excluding salaries
http://tsi.enst.fr/comobio/http://tsi.enst.fr/comobio/
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Project organisation Project organisation
Scientific committee B. Veyret, J. Wiart
C. Grangeat P. AubineauG. Faucon
1-2-
3-4- 5-6- 7-8-
dosimetry human animal
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1: Dosimetry Certification of mobile telephones Certification of mobile telephones [email protected]@alcatel.fr
• Objectives 1. Analysis of homogeneous phantoms
2. Improvement of electrical-field probes
3. Assessment of SAR test protocols and evaluation of uncertainty
4. Transfer to industry
• Results : Major contribution to standardisation by international
committees Successful transfer to companies
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•
•Miniature isotropic probe
Calibration set-up
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2: Dosimetry of exposure systemsDosimetry of exposure systems [email protected]
• Objective– improve exposure systems for animals and in particular
the local « loop » antenna
• Results Good agreement between numerical calculations (FDTD)
and measurements (E field and T) Efficiency: 6 W/kg/W (BASAR)
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QuickTime™ and aPhoto - JPEG decompressor
are needed to see this picture.
Manuscript in preparation
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3: Human study Evoked auditory potential Evoked auditory potential
and dosimetry of the innerand dosimetry of the inner [email protected]@univ-rennes1.fr
• Objective– Study on healthy and epileptic subjects
• Results– No detectable effects so far
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0,004 0,07 0,136 0,203 0,269 0,336 0,402 0,469 0,535 0,601 0,668 0,734 0,801 0,867 0,934 1
(a) placebo (b) non placebo (c) non placebo2
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0,004 0,07 0,136 0,203 0,269 0,336 0,402 0,469 0,535 0,601 0,668 0,734 0,801 0,867 0,934 1
(a) placebo (b) non placebo (c) non placebo2
Correlation histogrammeCorrelation histogramme
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4: animal study Rat brain metabolismRat brain metabolism
• Objective – Map gene expression (c-fos) and functionnal
activity of the brain (14C-2-deoxyglucose) in rats exposed head-only to GSM-900 at 0.7, 1.5, 3, and 6 W/kg
• Results– C-fos decreased in rats that underwent memory
tests but increased in resting rats!
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C-fos
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Manuscripts in preparation
2-DG
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5: Animal study
Rat learning and memory Rat learning and memory [email protected]@ibaic.u-psud.fr
• Objective – Confirmation study of the Lai experiments
(Lai et al., 1994; Wang et Lai, 2000)Head-only exposure at 1.5 and 5 W/kg BASAR for 45 min
– 8-arm maze and dry Morris water maze• Results
No effects on working and reference memory
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• Dubreuil et al. (2002) Behavioural Brain Research, 129, 203-210
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6: Animal study Rat blood-brain-barrier and dura materRat blood-brain-barrier and dura mater
• Objective Assess the permeability of the blood-brain-barrier (BBB)
and dura mater in rats under head-only exposure to GSM 900 signals (2-h exposure at 3, 3/4 and 3/16 W/kg BASAR)
• Results Increases in BBB permeability and dura mater
inflammation were observed above around 0.3 W/kg (in particular in sympathectomised animals).
Manuscript in preparation
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normal
sham
Sympathectomised
sham
Exposed
Dura mater
Brain
3 W/kg BASAR
Exposed
3 W/kg BASAR
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7: Animal study Guinea-pig auditory system Guinea-pig auditory system [email protected]@bordeaux.inserm.fr
• Objective
– Auditory evoked potentials are measured in guinea pigs
exposed locally (one ear) to GSM 900 (1 h/d, 5 d/w for
2 months at 1, 2 et 4 W/kg).
– Cells of the organ of Corti are exposed in vitro
• Results
– No effects on guinea pigs nor on the organ of Corti
Manuscript submitted
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4 WattsO R E I L L E G A U C H E
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8: Animal study Rat neurotransmitters and their receptors
• 1st Objective : Measurement of NT levels by immuno-histochemistry following local exposure of rats
• Result: decrease of GABA at high SAR • 2nd Objective : Measurement of NT receptor by
auto-radiography following 15-min local exposure• Result: decrease of the binding of several radio-
ligands on their specific receptors
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Glial reaction
• At 6 W/kg BASAR, reactive astrocytes area
increased by about 20-25% in the cortex and
the hippocampus and up to 140 % in the
striatum revealing astrocyte hypertrophy
and/or hyperplasy
[GFAP (Glial Fibrillary Acidic Protein)]
• Manuscript submitted to Nature
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Other research projectsOther research projects
• European programmes– Interphone, Reflex, Ramp, Guard
• MMF and GSM Association– Perform B : replication studies
• Service providers (AFOM)– Ethnology, Sociology, Dosimetry, Biology
(neurodegenerative, skin, HSP, etc.)
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Recent French reports on Recent French reports on mobile telephony and healthmobile telephony and health
• « Zmirou » report, Jan 2001www.sante.gouv.fr/
• OPECST, Nov 2002www.senat.fr/opecst/
• update of the Zmirou report, Feb 2003