comparison of direct and indirect bypass for moyamoya disease jared pisapia mgh neurosurgery grand...
TRANSCRIPT
![Page 1: Comparison of Direct and Indirect Bypass for Moyamoya Disease Jared Pisapia MGH Neurosurgery Grand Rounds September 23, 2010](https://reader030.vdocument.in/reader030/viewer/2022032517/56649c955503460f94951d39/html5/thumbnails/1.jpg)
Comparison of Direct and Indirect Bypass for Moyamoya
Disease
Jared PisapiaMGH Neurosurgery Grand Rounds
September 23, 2010
![Page 2: Comparison of Direct and Indirect Bypass for Moyamoya Disease Jared Pisapia MGH Neurosurgery Grand Rounds September 23, 2010](https://reader030.vdocument.in/reader030/viewer/2022032517/56649c955503460f94951d39/html5/thumbnails/2.jpg)
Overview• Moyamoya disease (MMD)
• Case presentation– Clinical course– Surgical approach (EDAS)
• Revascularization options– Indirect– Direct
• Evidence supporting revascularization techniques
![Page 3: Comparison of Direct and Indirect Bypass for Moyamoya Disease Jared Pisapia MGH Neurosurgery Grand Rounds September 23, 2010](https://reader030.vdocument.in/reader030/viewer/2022032517/56649c955503460f94951d39/html5/thumbnails/3.jpg)
www.brain-aneurysm.com
![Page 4: Comparison of Direct and Indirect Bypass for Moyamoya Disease Jared Pisapia MGH Neurosurgery Grand Rounds September 23, 2010](https://reader030.vdocument.in/reader030/viewer/2022032517/56649c955503460f94951d39/html5/thumbnails/4.jpg)
Moyamoya Disease (MMD)
• More common in Asian populations– Incidence: < 1/100,000
• Bimodal age of presentation– Pediatric (Ischemia)– Adults (Hemorrhage)
• Treatment – Revascularization
![Page 5: Comparison of Direct and Indirect Bypass for Moyamoya Disease Jared Pisapia MGH Neurosurgery Grand Rounds September 23, 2010](https://reader030.vdocument.in/reader030/viewer/2022032517/56649c955503460f94951d39/html5/thumbnails/5.jpg)
Case Report
• JB is a 32 year old RH woman with PMH of congenital rubella syndrome referred by PCP to MGH ED for evaluation of R MCA stenosis
• Intermittent numbness: L facial (V2 and V3), R finger/toe x 1 month
• Episodes increased in frequency over prior year; lasting less than 20 min and resolving spontaneously
![Page 6: Comparison of Direct and Indirect Bypass for Moyamoya Disease Jared Pisapia MGH Neurosurgery Grand Rounds September 23, 2010](https://reader030.vdocument.in/reader030/viewer/2022032517/56649c955503460f94951d39/html5/thumbnails/6.jpg)
Case Report
• Outpatient MRI – multifocal stenoses in anterior and
posterior circulation• PMH/PSH: as above• Meds: OCP• FH: Ischemic stroke, 72 year old father• SH: clerk, non-smoker
![Page 7: Comparison of Direct and Indirect Bypass for Moyamoya Disease Jared Pisapia MGH Neurosurgery Grand Rounds September 23, 2010](https://reader030.vdocument.in/reader030/viewer/2022032517/56649c955503460f94951d39/html5/thumbnails/7.jpg)
CTA
• Multiple intracranial stenoses
• Bilateral involvement of the supraclinoid ICAs and ICA terminus
• Near-occlusion of right M1 segment with intact flow distally
![Page 8: Comparison of Direct and Indirect Bypass for Moyamoya Disease Jared Pisapia MGH Neurosurgery Grand Rounds September 23, 2010](https://reader030.vdocument.in/reader030/viewer/2022032517/56649c955503460f94951d39/html5/thumbnails/8.jpg)
Brain MRI
• > 3 small DWI and T2- hyperintense lesions
• Recent infarcts
• Embolic or low-flow infarcts
• No evidence of ICH
![Page 9: Comparison of Direct and Indirect Bypass for Moyamoya Disease Jared Pisapia MGH Neurosurgery Grand Rounds September 23, 2010](https://reader030.vdocument.in/reader030/viewer/2022032517/56649c955503460f94951d39/html5/thumbnails/9.jpg)
Hospital course
• She was placed on ASA 81 mg daily and her OCP was discontinued
• She was discharged without further symptoms
• Follow-up in Neurosurgery Clinic; scheduled for EDAS for revascularization
![Page 10: Comparison of Direct and Indirect Bypass for Moyamoya Disease Jared Pisapia MGH Neurosurgery Grand Rounds September 23, 2010](https://reader030.vdocument.in/reader030/viewer/2022032517/56649c955503460f94951d39/html5/thumbnails/10.jpg)
Encephaloduroarteriosynangiosis (EDAS)
• Transposition of a segment of superficial temporal artery (STA) to surface of brain
• Formation of spontaneous anastomoses between the arteries of the cerebral cortex, dura mater, and the scalp
![Page 11: Comparison of Direct and Indirect Bypass for Moyamoya Disease Jared Pisapia MGH Neurosurgery Grand Rounds September 23, 2010](https://reader030.vdocument.in/reader030/viewer/2022032517/56649c955503460f94951d39/html5/thumbnails/11.jpg)
![Page 12: Comparison of Direct and Indirect Bypass for Moyamoya Disease Jared Pisapia MGH Neurosurgery Grand Rounds September 23, 2010](https://reader030.vdocument.in/reader030/viewer/2022032517/56649c955503460f94951d39/html5/thumbnails/12.jpg)
EDAS
HEAD
![Page 13: Comparison of Direct and Indirect Bypass for Moyamoya Disease Jared Pisapia MGH Neurosurgery Grand Rounds September 23, 2010](https://reader030.vdocument.in/reader030/viewer/2022032517/56649c955503460f94951d39/html5/thumbnails/13.jpg)
![Page 14: Comparison of Direct and Indirect Bypass for Moyamoya Disease Jared Pisapia MGH Neurosurgery Grand Rounds September 23, 2010](https://reader030.vdocument.in/reader030/viewer/2022032517/56649c955503460f94951d39/html5/thumbnails/14.jpg)
![Page 15: Comparison of Direct and Indirect Bypass for Moyamoya Disease Jared Pisapia MGH Neurosurgery Grand Rounds September 23, 2010](https://reader030.vdocument.in/reader030/viewer/2022032517/56649c955503460f94951d39/html5/thumbnails/15.jpg)
![Page 16: Comparison of Direct and Indirect Bypass for Moyamoya Disease Jared Pisapia MGH Neurosurgery Grand Rounds September 23, 2010](https://reader030.vdocument.in/reader030/viewer/2022032517/56649c955503460f94951d39/html5/thumbnails/16.jpg)
![Page 17: Comparison of Direct and Indirect Bypass for Moyamoya Disease Jared Pisapia MGH Neurosurgery Grand Rounds September 23, 2010](https://reader030.vdocument.in/reader030/viewer/2022032517/56649c955503460f94951d39/html5/thumbnails/17.jpg)
![Page 18: Comparison of Direct and Indirect Bypass for Moyamoya Disease Jared Pisapia MGH Neurosurgery Grand Rounds September 23, 2010](https://reader030.vdocument.in/reader030/viewer/2022032517/56649c955503460f94951d39/html5/thumbnails/18.jpg)
![Page 19: Comparison of Direct and Indirect Bypass for Moyamoya Disease Jared Pisapia MGH Neurosurgery Grand Rounds September 23, 2010](https://reader030.vdocument.in/reader030/viewer/2022032517/56649c955503460f94951d39/html5/thumbnails/19.jpg)
![Page 20: Comparison of Direct and Indirect Bypass for Moyamoya Disease Jared Pisapia MGH Neurosurgery Grand Rounds September 23, 2010](https://reader030.vdocument.in/reader030/viewer/2022032517/56649c955503460f94951d39/html5/thumbnails/20.jpg)
Multiple Burr Holes
Baaj et al., 2009
![Page 21: Comparison of Direct and Indirect Bypass for Moyamoya Disease Jared Pisapia MGH Neurosurgery Grand Rounds September 23, 2010](https://reader030.vdocument.in/reader030/viewer/2022032517/56649c955503460f94951d39/html5/thumbnails/21.jpg)
Indirect Bypass: EDAS
a. main trunk of the STA
b. posterior branch of the STA
c. anterior branch of the STA
d. galeal flape. dura mater
![Page 22: Comparison of Direct and Indirect Bypass for Moyamoya Disease Jared Pisapia MGH Neurosurgery Grand Rounds September 23, 2010](https://reader030.vdocument.in/reader030/viewer/2022032517/56649c955503460f94951d39/html5/thumbnails/22.jpg)
Direct Bypass: STA-MCA bypass
Baaj et al., 2009)
![Page 23: Comparison of Direct and Indirect Bypass for Moyamoya Disease Jared Pisapia MGH Neurosurgery Grand Rounds September 23, 2010](https://reader030.vdocument.in/reader030/viewer/2022032517/56649c955503460f94951d39/html5/thumbnails/23.jpg)
Matsushima et al., 1998
Combination:
b. posterior branch of the STA;
c. anterior branch of the STA;
f. temporal muscle; g. branch of the MCA; h. anastomosis
Direct and Indirect Bypass: STA-MCA Anastomosis + EMS.
![Page 24: Comparison of Direct and Indirect Bypass for Moyamoya Disease Jared Pisapia MGH Neurosurgery Grand Rounds September 23, 2010](https://reader030.vdocument.in/reader030/viewer/2022032517/56649c955503460f94951d39/html5/thumbnails/24.jpg)
Additional Indirect Options
• EMAS = EDAS + EMS
• EDAMS = EMAS + dura (includes middle meningeal artery)
• Multiple burr holes
Baaj et al., 2009; Chang SD, Steinber GK, 2010
![Page 25: Comparison of Direct and Indirect Bypass for Moyamoya Disease Jared Pisapia MGH Neurosurgery Grand Rounds September 23, 2010](https://reader030.vdocument.in/reader030/viewer/2022032517/56649c955503460f94951d39/html5/thumbnails/25.jpg)
Multiple Combined Indirect Bypass
a. main trunk of the STA; b. posterior branch of the STA; c. anterior branch of the STA; d. galeal flap; e. dura mater; f. temporal muscle;
Matsushima et al., 1998
![Page 26: Comparison of Direct and Indirect Bypass for Moyamoya Disease Jared Pisapia MGH Neurosurgery Grand Rounds September 23, 2010](https://reader030.vdocument.in/reader030/viewer/2022032517/56649c955503460f94951d39/html5/thumbnails/26.jpg)
Indirect vs. Combined vs. Direct Bypass
EDAS MCI STA-MCAN 12 22 16
Collateral vessel formation
44% 52% 74%
Clinical improvement
56% 63% 74%
Complications 1 minor stroke 2 epidural hematomas
1 major & 1 minor stroke
• 50 patients with pediatric MMD, 76 hemispheres,
Direct STA-MCA is associated with the greatest postoperative collateral formation and clinical improvement
EDAS and MCI were safer, and MCI caused formation of collaterals in the ACA distribution and is best procedure in children
Matsushima et al., 1998
![Page 27: Comparison of Direct and Indirect Bypass for Moyamoya Disease Jared Pisapia MGH Neurosurgery Grand Rounds September 23, 2010](https://reader030.vdocument.in/reader030/viewer/2022032517/56649c955503460f94951d39/html5/thumbnails/27.jpg)
Rebleeding in Hemorrhagic MMD• STA-MCA bypass in prevention of future stroke, including
rebleeding or ischemia
Conservative EDAS STA-MCAN 11 5 6Ischemic or rebleeding event
6 3 0
Stroke-free time (years)
8.1 +/- 1.5 4.0 +/- 1.5 8.5 +/- 1.3
Recurrent ICH occurred less frequently in patients undergoing STA-MCA bypass than those who underwent EDAS
Authors recommend STA-MCA bypass over indirect bypass for patients presenting with intracranial hemorrhage
Kawaguchi et al., 2000)
![Page 28: Comparison of Direct and Indirect Bypass for Moyamoya Disease Jared Pisapia MGH Neurosurgery Grand Rounds September 23, 2010](https://reader030.vdocument.in/reader030/viewer/2022032517/56649c955503460f94951d39/html5/thumbnails/28.jpg)
Adults vs. Pediatric; Ischemia
• 23 patients underwent indirect bypass– 16 adults (mean 35, 20-59 years old)– 7 children (mean 10, 3-16 years old)
• Good collaterals on postoperative angiography– 7/7 pediatrics, 7/16 adults
Advancing age decreases development of collaterals through indirect bypass
Direct bypass is main treatment option for patients > 40 years
![Page 29: Comparison of Direct and Indirect Bypass for Moyamoya Disease Jared Pisapia MGH Neurosurgery Grand Rounds September 23, 2010](https://reader030.vdocument.in/reader030/viewer/2022032517/56649c955503460f94951d39/html5/thumbnails/29.jpg)
Comparison of Direct versus Indirect
Indirect (EDAS)• Useful if inadequate donor
artery grafts
• At least several weeks required to form collaterals
• Easier and safer in patients with serious medical comorbities
Direct (STA-MCA bypass)• Technically difficult; size and
progressive MCA occlusion
• Immediate revascularization
• Symptomatic cerebral hyperperfusion, although transient
![Page 30: Comparison of Direct and Indirect Bypass for Moyamoya Disease Jared Pisapia MGH Neurosurgery Grand Rounds September 23, 2010](https://reader030.vdocument.in/reader030/viewer/2022032517/56649c955503460f94951d39/html5/thumbnails/30.jpg)
Conclusions
• The most appropriate revascularization procedure for patients with MMD is not fully defined.
• Case series are limited by inadequate power, selection bias, and inherent differences in patient characteristics.
• Choice of procedure may depend on surgeon’s experience, nature of symptoms, and patient age.
![Page 31: Comparison of Direct and Indirect Bypass for Moyamoya Disease Jared Pisapia MGH Neurosurgery Grand Rounds September 23, 2010](https://reader030.vdocument.in/reader030/viewer/2022032517/56649c955503460f94951d39/html5/thumbnails/31.jpg)
References• Baaj AA, Agazzi S, Sayed ZA, Toledo M, Spetzler RF, van Loveren H: Surgical
management of Moyamoya disease: a review. Neurosurg Focus 26(4):E7, 2009
• Kawaguchi S, Okuno S, Sakaki T: Effect of direct arterial bypass on the prevention of future stroke in patients with the hemorrhagic variety of moyamoya disease. J Neurosurg 93:397-410, 2000.
• Matsushima T, Inoue T, Ikezaki K, Matsukado K, Natori Y, Inamura T, et al: Multiple combined indirect procedure for the surgical treatment of children with moyamoya disease. A comparison with single indirect anastomosis with direct anastomosis. Neurosurg Focus 5(5):4, 1998
• Mizoi K, Kayama T, Yoshimoto T, Nagamine Y.:Indirect revascularization for moyamoya disease: is there a beneficial effect for adult patients? Surg Neurol 45:541-9, 1996.
• Starke RM, Komotar RJ, Connolly ES: Optimal surgical treatment for moyamoya disease in adults: direct versus indirect bypass. Neurosurg Focus 26(4):E8, 2009.
![Page 32: Comparison of Direct and Indirect Bypass for Moyamoya Disease Jared Pisapia MGH Neurosurgery Grand Rounds September 23, 2010](https://reader030.vdocument.in/reader030/viewer/2022032517/56649c955503460f94951d39/html5/thumbnails/32.jpg)
Acknowledgements
• Christopher S. Ogilvy, M.D.• Brian V. Nahed, M.D.• Brian P. Walcott, M.D.• Robert L. Martuza, M.D.• Neurosurgery Department