www.medicoapps.org

Adverse Drug Reactions are important not only for various entrance exams like NEET PG ,

PLAB and FMGE but also very relevant in day to day clinical practice. Here is a compilation of

Adverse Drug Reactions (Which are relevant clinically as well often asked as MCQs in exams like

NEET PG , USMLE, PLAB and FMGE.

If you Like the compilation please don’t forget to download the PDF version and share this

compilation with your friends via facebook/twitter or any other means.

Antibiotics • Chloramphenicol

• Cotrimoxazole

• Nitroforantoin

Antiinflammatory • Phenylbutazone

• Indomethacin

• Diclofenac

Others • Zidovudin

• Felbamate

• Colchicine

• Trimethadione

• Methotrexate

• Phenytoin

• Cytosine arabinoside

• Phenobarbitone

www.medicoapps.org

Adverse Drug Reactions are important not only for various entrance exams like NEET PG ,

PLAB and FMGE but also very relevant in day to day clinical practice. Here is a compilation of

Adverse Drug Reactions (Which are relevant clinically as well often asked as MCQs in exams like

on please don’t forget to download the PDF version and share this

compilation with your friends via facebook/twitter or any other means.

Aplastic Anemia

Antirheumatic • Gold salts

• D penicillamine

Antithyroid • Carbimazole

• Methimazole

• Methylthiouracil

Cytotoxic drugs • Vincristine

• Adriamycin

• Methotrexate

• Chlorambucil

Psychotropic • Phenothiazine

Anticonvulsant

• Phenytoin (alpha methyl

hydantoin)

MegaloblasticAnemia

• Pentamidine

• Pyrimethamine

• Zidovudine

• Sulfasalazine

• 5-Fluorouracil

• Triamterene

• Primidone

• Azathioprine

• Trimethoprim

Adverse Drug Reactions are important not only for various entrance exams like NEET PG , USMLE,

PLAB and FMGE but also very relevant in day to day clinical practice. Here is a compilation of

Adverse Drug Reactions (Which are relevant clinically as well often asked as MCQs in exams like

on please don’t forget to download the PDF version and share this

Carbimazole

Methimazole

Methylthiouracil

Phenothiazine

Phenytoin (alpha methyl

hydantoin)

Triamterene

Primidone

Azathioprine

Trimethoprim

www.medicoapps.org

• Daunorubicin

• Emetine

• Lithium

• Amiodarone

• Oral contraceptives

• Cyclophosphamide

• Vitamin A

• Amiodarone

• Oral contraceptives

• Cyclophosphamide

• Busulfan

• Calcium channel

antagonist

• Digitalis

• Phenytoin

• Griseofulvin

• Isoniazide

• Methyldopa

www.medicoapps.org

Cardiomyopathy

• Phenothiazines

• Trastuzumab

• Sympathomimetics

• Doxorubicin

(Adriamycin

Hyperpigmentation

• Busulfan

• Minocyclines

• Corticotropin

• Bleomycin

• Phenothiazines

• Gold salts

• Chloroquine

• Clofazimine

Hyperpigmentation

• Vitamin A

• Minocyclines

• Corticotropin

• Bleomycin

• Phenothiazines

• Gold salts

• Chloroquine

• Clofazimine

Gynaecomastia

• Spironolactone

• Reserpine

• Estrogens

• Ethionamide

• Cyprotenrone acetate

• Clomiphene

• Testosterone

• Griseofulvin

• Ketoconazole

• Flutamide

• Goserelin

• Cimetidine

Sympathomimetics

Doxorubicin

(Adriamycin)

Phenothiazines

Gold salts

Chloroquine

Clofazimine

Phenothiazines

Gold salts

Chloroquine

Clofazimine

Testosterone

Griseofulvin

Ketoconazole

Flutamide

Goserelin

Cimetidine

www.medicoapps.org

Hyperprolactinemia and galactorrhea

• Estrogens

• Phenothiazines

(chlorpromazine)

• Butyrophenones(haloperidol)

• Opiates

• Fluoxetine

• NSAIDs

• Beta blockers

• Heparin

• Broad spectrum

antibiotics

• Clindamycin

• Cocaine

• Colchicine

• Digitalis

• Aluminium Hydroxide

• Barium sulphate

• Phenothiazines

• Ion exchange resins

www.medicoapps.org

Hyperprolactinemia and galactorrhea

Butyrophenones(haloperidol)

• Alpha

methylodopa

• Reserpine

• Verapamil

• Amitriptyline,

amoxapine

• Thioxanthenes

• Antiestrogen

• Metoclopramide

• Cimetidine

• Ranitidine

Precipitation of Asthma

• Opioids

• Heparin

• Disulfiram

• Nitrofurantoin

• Organophosphates

Diarrhea

• Magnesium antacids

• Donepezil

• Guanethidine

• Lactose

• Lincomycine

• Mesoprostol

• OCP

• Purgative

• Reserpine

• Ticlopidine

• Methyl dopa

Constipation

• Opiates

• Tricyclic

antidepresants

• Verapamil

• Ferrous sulphate

• Calcium carbonate

• Ganglionic

Thioxanthenes

Antiestrogen

Metoclopramide

Cimetidine

Ranitidine

Nitrofurantoin

Organophosphates

Purgative

Reserpine

Ticlopidine

Methyl dopa

Ferrous sulphate

Calcium carbonate

Ganglionic blockers

www.medicoapps.org

• Cocaine

• Tricyclic

antidepressants

• Erythropoietin

• MAO inhibitors

• Theophylline

• Bretylium

• Quinidine

• Chlorpromazine

• Calcium channel

• Adenosine

First dose hypotension (First dose phenomenon)

• Prazosin

• Murumonab CD3

• Minoxidil

• Phenylbutazone

• Estrogens

• Indomethacin

www.medicoapps.org

Hypertension

• Cyclosporine

• Valdecoxib (NSAID)

• Oral contraceptives

• Glucocorticoids

• Sympathomimetics

• Clonidine withdrawl

• Rofecoxib (NSAID)

Hypotension

• Morphine

• Glyceryl trinitrate

• Amiodarone

• Clonidine

• Guanethidine

• Alpha blockers

• Fosphenytoin (I.V.)

• Diuretics

• Levo-dopa

• Blockers

• IL-2

• β-blockers (I.V.)

First dose hypotension (First dose phenomenon)

• Sargramostim

• ACE inhibitors

Captopril)

C H F

• β - blockers

• Verapamil

• Mannitol

• Carbenoxolone sodium

• Diazoxide

• CCBs

• Corticosteroids

Sympathomimetics

Clonidine withdrawl

Rofecoxib (NSAID)

Fosphenytoin (I.V.)

dopa

blockers (I.V.)

ACE inhibitors

Diazoxide

Corticosteroids

www.medicoapps.org

Precepitation of MI or

• Amphetamines

• Dipyridamol

• Excessive thyroxine

• Nifedipine

• Theophylline

• Minoxidil

• Anticonvulsants

• Bromocriptine

• Fluoroquinolones

• Levodopa

• Opioides

• β Lactam antibiotics

• Quinolones

• Acyclovir & Ganciclovir

• Isoniazid

• Meperidine

• Tramadol

• Pethidine

• Flumazanil

• Cocaine

www.medicoapps.org

Precepitation of MI or exacerbation of angina

• Alpha blocker

• Vasopressin

• Hydralazine

• Nicotine and cocaine

• Beta agonists

• Sumatriptan

• Ergotamine

• Methysergide

• Oxytocin

• Beta blockers

withdrawal

• Decongestants

Depression

• β – blockers

• Disulfiram

• Statins

• Estrogen (OCPs)

• Benzodiazepines

• Interferon

• Barbiturates

• Calcium channel

blockers

Seizures

• Local anaesthetics

• Cyclosporine

• OKT3

• Tacrolimus

• Interferons

• Antidepressants

• Nalidixic acid

• Amphetamine

• Phencyclidine

• Antipsychotics

• Lithium

• Theophylline

• Alcohol withdrawl

• Barbiturate withdrawl

• Benzodiazepine

withdrawl

• Physostigmine (iv)

• Methyphenidate

• Vincristine

Ergotamine

Methysergide

Beta blockers

withdrawal

Decongestants

Benzodiazepines

Interferon- α

Barbiturates

Calcium channel

Antipsychotics

Theophylline

Alcohol withdrawl

Barbiturate withdrawl

Benzodiazepine

withdrawl

Physostigmine (iv)

Methyphenidate

Vincristine

www.medicoapps.org

• Butyrophenones

(Haloperidol)

• Levodopa

• Reserpine

• Clonidine

• Methyldopa

• TCAs

• TCAs

• Theophylline

• β agonist

• Steroids

• Vitamin B12

• Amphotericin B

• Gentamicin

• ACE inhibitors

• Heparin

• ARBs (angiotensin

antagonists)

www.medicoapps.org

Extrapyramidal symptoms

• Methyldopa

• Metoclopromide

• Tricyclic

Antidepressants

• OCP 'S

• Phenothiazines

Sedation

• Anthistaminics

• Barbiturates

• Benzodiazepines

• Reserpine

Tremers

• Lithium

• Sympathomimetics (

agonists)

Hypokalemia

• Licorice

• α Blockers

• Diuretics

• Lithium(AI13)

• Theophylline

• Penicillin derivatives

• Toluene abuse

• Carbenoxalone

• Insulin

• CA inhibitors

Hyperkalemia

• Trimethoprim

• NSAIDS

• Succinylcholine

• Pentamidine

• Digoxin toxicity

• K+ sparing diuretic

• Cyclosporine

• β -blockers (initially)

Phenothiazines

Benzodiazepines

Reserpine

Sympathomimetics (β2 -

Penicillin derivatives

Toluene abuse

Carbenoxalone

CA inhibitors

Digoxin toxicity

K+ sparing diuretic

Cyclosporine

blockers (initially)

www.medicoapps.org

• Pyrazinamide

• Ethambutol

• Diuretics

• Cyclosporine

• Insulin

• Sulfonylureas

• ACE inhibitors

• Asparaginase

• Chlorthalidone

• Diazoxide

• Encainide

• Thyroid hormones

• Glucagon

• L-Asparaginase

• β -adrenergic agonists

• β -blockers

(propranolol)

• Calcitonin

• Plicamycin

www.medicoapps.org

Hyperuricemia (gout)

• Alcohol

• Levodopa

• Nicotinic acid

• Chlorthalidone

• Cytotoxic drugs

• Aspirin (Low dose)

Hypoglycemia

• Ethanol

• Pentamidine

• Octreotide

• Quinine

• Sulfonamide

• Salicylates

Hyperglycemia

• Ethacrinic acid

• Frusemide

• Glucocorticoids

• Growth-hormone

• Vacor

• Cyclosporine

• HIV protease inhibitors

• α -IFN

• Niacin

• OCP

• Phenytoin

• Clozapine

• Tacrolimus

• Pentamidine

• Thiazides

• Protease inhibitors

Hypocalcemia

• Gallium nitrate

• Bisphosphonates

• Phenytoin

Chlorthalidone

Cytotoxic drugs

Aspirin (Low dose)

Sulfonamide

Salicylates

Phenytoin

Clozapine

Tacrolimus

Pentamidine

Thiazides

Protease inhibitors

Phenytoin

www.medicoapps.org

• Cholecalciferol

• Estrogen

• Glucocorticoids

• Furosemide

• OCPs

• Thiazide

• Aminosalicylicacid

• Sulfonamides (Sulfamethoxazole)

• Nitrofurantoin

• Analgesics - Aspirin, Acetanilid

• Vitamin K (water soluble form)

• Probenecid

• Cotrimoxazole

• Niridazole – Phenazopyridine

• Quinidine

Hemolyticanemia (even without deficiency of G

• Isoniazid

• Rifampicin

• Sulfonamide

www.medicoapps.org

Hypercalcemia

• Calcium(IV)

• Thiazides

Hypertriglyceridemia

• Retinoic acid

• Bile acid - binding

resin

• Thiazides

• HIV protease

inhibitors

• Ethanol

• β - blockers

Hypercholesterolemia

• Tegretol

• Cyclosporine

Hemolysis in G-6-PD deficiency

Sulfonamides (Sulfamethoxazole)

Aspirin, Acetanilid

Vitamin K (water soluble form)

Phenazopyridine

• Nalidixic acid

• Antimalarials — Primaquine, Quinine,

Chloroquine (sometimes)

• Vitamin C

• Phenacetin

• Chloramphenicol

• Methylene blue

• Procainamide

• Dapsone

• Doxorubicin

Hemolyticanemia (even without deficiency of G-6-PD)

• Quinidine

• Procainamide

• Penicillin

• Phenacetin

• Dapsone

• Melphalan

Thiazides

HIV protease

inhibitors

blockers

Cyclosporine

Primaquine, Quinine,

Phenacetin

Dapsone

Melphalan

www.medicoapps.org

Dysguesia (Altered taste sensations)

• Acetazolamide

• Biguanide

• Captopril

• Antibiotics –

Metronidazole

• Anticancer - cisplatin,

dacarbazine

• Anti-arrhythmatics-

amiodarone,

adenosine

• Phenytoin

• Calcium antagonists

• Aniline and its derivatives

• Aminophenols

• Aminophenones

• Chlorates

• Dapsone

• Local anaesthetics - Prilocaine,

Benzocaine

• Nitrites

www.medicoapps.org

Dysguesia (Altered taste sensations)

• Griseofulvin

• Lithium

• Metronidazole

• Penicillamine

• Rifampin

Metallic taste

• Disulfiram

• Antidiabetics-

phenformin

• TCA-Nortryptiline

• Anticonvulsants

• Acetazolamide

• Antithyroid drugs

• Gold

• Vincristine

Gingival hyperplasia

• Sirolimus

• Lamotrigine

• Cyclosporine

Methemoglobinemia

Prilocaine,

• Naphthalene

• Nitrates (Nitroglycerine is included in

nitrates)

• Nitrobenzenes and related compounds

• Oxides of Nitrogen

• Phenazopyridine

• Primaquine and related antimalarials

• Sulfonamides

Penicillamine

Rifampin

Acetazolamide

Antithyroid drugs

Vincristine

Cyclosporine

(Nitroglycerine is included in

Nitrobenzenes and related compounds

Primaquine and related antimalarials

www.medicoapps.org

Pseudotumorcerebri (Increased ICT)

• Amiodarone

• Glucocorticoids

(withdrawl)

• Quinolones

• Amiodarone

• Chloramphenicol

• Chloroquine

• Cisplatin

• Clioguinol

• Clofibrate

• Zalcitabine

• Procarbazine

• Polymyxin, colistin

Predominant sensory neuropathy

• Cisplatin

• Hydralazine

• Metronidazole

Predominant motor neuropathv

• Dapsone

www.medicoapps.org

Pseudotumorcerebri (Increased ICT)

• Mineralocorticoids

(withdrawl)

• Hypervitaminosis A

• Nalidixic acid

• Oral contraceptives

• Tetracyclines

• Sympathomimetics

Peripheral neuropathy

• Demeclocycline

• Disopyramide

• Ethambutol

• Ethionamide

• Glutethemide

• Hydralazine

• Isoniazid

• Didanosine

• Paclitaxol

• Mustine

• Nalidixic acid

• Nitrofurantoin

• Perhexiline

• Phenelzine

• Phenytoin

• Streptomycin

• Stavudine

Predominant sensory neuropathy

• Misonidazole

• Pyridoxine

• Taxol

• Vincristine

• Nucleoside analogues

(Dinanosine,

Stavudine)

Predominant motor neuropathv

• Suramine • Lead

Oral contraceptives

Tetracyclines

Sympathomimetics

Nalidixic acid

Nitrofurantoin

Perhexiline

Phenelzine

Phenytoin

Streptomycin

Vincristine

Nucleoside analogues

(Dinanosine,

Stavudine)

www.medicoapps.org

Pulmonary fibrosis

• Acyclovir

• Amiodarone

• Bleomycin

• Methotrexate

• Busulphan

• Carmustine

• Clofibrate

• Zidovudine

• Amphotericin-B

• Gemfibrozil

• Statin

• Cimetidine

• Phenformin

• Metformin

• Zidovudine

• Lithium

• Amiodarone

• Iodides

• Ethionamide

• Carbamazepine

www.medicoapps.org

Pulmonary fibrosis (pulmonary infiltrate or interstitial lung disease)

• Chlorambucil

• Vinblastin

• Cyclophosphamide

• Nitrofurantoin

• Procarbazine

• Gold

• Melphalan

• Methysergide

• Mitomycin

• Sulfonamides

• Penicillamine

Myopathy

• Glucocorticoids

• Cyclosporine

• Chloroquine

• OCPs

• Spironolactone

• Acetazolamide

• Danazol

• D penicillamine

• Daptomycine

• Gold

Lactic acidosis

• Zalcitabine

• Spironolactone

• Acetazolamide

• Salicylates

Hypothyroidism

• Sulfonamide

• Paraminosalycylic acid

(PAS)

• Carbimazole

• Phenylbutazone

• Phenobarbitone

• Rifampicin

• Acetazolamide

• Phenytoin

Melphalan

Methysergide

MitomycinC

Sulfonamides

Penicillamine

Acetazolamide

D penicillamine

Daptomycine

Acetazolamide

Salicylates

Phenobarbitone

Rifampicin

Acetazolamide

Phenytoin

www.medicoapps.org

• Amiodarone

A) Vestibular (primarily

• Aminoglycosides

• Mustine

• Quinidine

• Quinine

• Chloroquine

• Vancomycin

• Furosemide

• Ethacrynic acid

• Salicylates (high dose)

• Aminoglycosides

• Aspirin

• Bleomycin

• Chloroquine

• Cidofovir

• Aminosalicylic acid

• Amiodarone

• Isoniazid

• Phenylbutazone

www.medicoapps.org

Hyperthyroidism

• Iodides

Ototoxicity

B) Auditory (primarily)

• NSAIDs

• Ethacrynic acid

• Vancomycin

• Aminoglycosides

• Cisplatin

Deafness

• Cisplatin

• Quinine

• Erythromycin

• Ethacrynic acid

• Furosemide

• Interferon

• Mustine

hydrochloride

• Deferoxamine

Optic neuritis

• Streptomycin

• Quinine

• Penicillamine

• Chloramphenicol

• Ethambutol

• Phenothiazines

Furosemide

Interferon

Mustine

hydrochloride

Deferoxamine

Chloramphenicol

Ethambutol

Phenothiazines

www.medicoapps.org

• Sulfonamides

• Thiazides

• Barbiturates

• Mydriatics

• Synpathomimetics

Addison's disease (Medical adrenalectomy

• Metyrapone

• Aninoglutethimide

• Glucocorticoids

• Cyclosporine

• Cytotoxic drugs

• Anticonvulsants

• Antiarrhythmics : Procainamide,

disopyramide, propafenome, quinidine

• Anti-hypertensives : hydralazine,

methyldopa

• ACE inhibitors

• Beta-blockers

• Antithyroid-propylthiouracil, iodides

• Antipsychotics - Chlorpromazine,

lithium

www.medicoapps.org

Disturbed color vision

• Digitalis

• Ethambutol

• Quinine

• Streptomycin

Precipitation of glaucoma

• TCAs

• Corticosteroids

Addison's disease (Medical adrenalectomy)

• Cytotoxic drugs

(mitotane)

• Ketoconazole

Osteoporosis

• Excessive alcohol

intake

• Aluminum

• Excessive thyroxine

• GnRH agonist

• Heparin

• Lithium

SLE (antinuclear antibodies)

Antiarrhythmics : Procainamide,

disopyramide, propafenome, quinidine

hypertensives : hydralazine,

propylthiouracil, iodides

Chlorpromazine,

• Anti-convulsauts : Carbamazepine,

phenytoin

• Antibiotic : Isoniazid, minocycline,

macrodantin, sulphonamide

• Antirheumatic : Sulfasalazine

• Diuretics : Hydroclorothiazide

• Statins : Lovastatin, simvastatin

• Biologics : IFN, TNF-a inhibitors

• Anticancer : Bleomycin, asparginase

Streptomycin

Corticosteroids

Ketoconazole

GnRH agonist

: Carbamazepine,

Antibiotic : Isoniazid, minocycline,

macrodantin, sulphonamide

Antirheumatic : Sulfasalazine

Diuretics : Hydroclorothiazide

Statins : Lovastatin, simvastatin

a inhibitors

Anticancer : Bleomycin, asparginase

www.medicoapps.org

Androgenic drugs

• Acetazolami

de

• Anabolic

steroids

• Androgenic

progestins(N

orethisteron

e)

• Dihydroepia

ndrosterone

• Testosterone

• Danazole

• Corticotropin

• Metyrapone

• Phenytoin

• Streptomycin

• Acetazolamide

• Interferon

• β – blockers

• Antipsychotics

• Lithium

• Procainamide

• Isoniazid

• Phenytoin

www.medicoapps.org

Hirsutism

Non - androgenic drugs

Testosterone

Danazole

Corticotropin

Metyrapone

• Phenytoin

• Penicillamine

• Triamterene –

hydrochlorthiaz

ide

• Cyclosporine

• Minoxidil

• Penicillamine

• Phenothiazines

Hypertrichosis

• Diazoxide

• Corticosteroids

• Cyclosporine

• Psorelin

• Latanoprost

• Minoxidil

Decreased libibo(impotence)

• Clonidine

• Diuretics

• Methyldopa

• Oral contraceptives

• Sedatives

• TCAs

Pericarditis

• Anticoagulants

• Methysergide

• Minoxidil

• Hydralazine

Minoxidil

Penicillamine

Phenothiazines

Latanoprost

Minoxidil

Oral contraceptives

Sedatives

Minoxidil

Hydralazine

www.medicoapps.org

• Methyl testosterone

• Sulindac

• Methimazole

• Chlorpropamide

• Nitrofurantoin

• Nifedipine, verapamil

• Asparaginase

• Corticosteroids

• Didanosine

• Opioids

• Stavudine

• Oral contraceptives

• Amiodarone

• Carbamazepine

• Gold salts

• Nilutamide

• Captopril

• Phenytoin

• Aminoglycosides

• Amphotericin B

• Cephaloridine

• Cisplatin

• Colistin

www.medicoapps.org

Cholestatic jaundice

• Erythromycin,

Nitrofurantoin,

Rifampin

• Amoxicillin -clavulanic

acid, oxacillin

• Norethynodrel with

mestranol

• Chlorpromazine

• Methimazole

• Anabolic steroids,

busulfan, tamoxifen

• Cyclosporine

• Gold salts

Pancreatitis

• Thiazides

• Zalcitabine

• Estrogens

• Azathioprine

• Mercaptopurine

• Ethacrynic acid

• Pentamidine

• Sulfonamides

• Valproic acid

• Furosemide

Pulmonary eosinophilia

• Sulfasalazine

• Nitrofurantoin

• Penicillamine

• GM-CSF

• Propylthiouracil

• Bleomycin

• L-tryptophan

• Minocycline

• Contrast media

• Methotrexate

• Iodine

• Aspirin

Acute tubular necrosis

• Cyclosporine

• Intravenous immune

globulin

• Methoxyfluranes

• Polymyxin

• Radioiodinatedcontrast

medium

• Sulfonamides

• Tetracyclines

• Acetaminophen

Chlorpromazine

Methimazole

Anabolic steroids,

busulfan, tamoxifen

Cyclosporine

Gold salts

Ethacrynic acid

Pentamidine

Sulfonamides

Valproic acid

Furosemide

tryptophan

Minocycline

Contrast media

Methotrexate

Radioiodinatedcontrast

Sulfonamides

Acetaminophen

www.medicoapps.org

• Cephalosporine

• Rifampcin

• NSAIDS

• Allopurinol

• Chloroquine

• Iron salts

• Levodopa

• Methyldopa

• Metronidazole

• Naphthalene

• Nitrofurantoin

• Phenacetin

• Aminopyrine

• Phenolphthalein

• Thiazides

• Cytarabine

• Carbamazepine

• Aspirin

• Quinine

• Methotrexate

www.medicoapps.org

Interstitial nephritis

• Penicillins (esp.

methicillin)

• Furosemide

• Phenindione

• Ciprofloxacin

• Thiazides

• Sulphonamides

Urine disolouration

• Quinine

• Sulfonamides

• Anthraquinone

• Methylene blue

• Triamterene

• Amitriptyline

• Primaquine

• Rifampin

• Daunorubicin

• Doxorubicin

• Aminosalicylic acid

• Indomethacin

• Chlorzoxazone

• Heparin

• Phenazopyridine

• Phenindione

• Sulfasalazine

• Warfarin

• Riboflavin

Thrombocytopenia

• Chloroquine

• Busulfan

• Gold salts

• Daunorubicin

• PAS

• Sulfonamides

• Ethanol

• 6-mercaptopurine

• Chlorpropamide

• Cycophosphamide

• Methyldopa

• Quinidine

Ciprofloxacin

Sulphonamides

Aminosalicylic acid

Indomethacin

Chlorzoxazone

Phenazopyridine

Phenindione

Sulfasalazine

Riboflavin

mercaptopurine

Chlorpropamide

Cycophosphamide

Methyldopa

www.medicoapps.org

Interference with folic

acidabsorption

• Phenytoin

• Phenobarbitone

• Primidone

• Sulfasalazine

• Cotrimoxazole

Precipitating

• Barbiturates

• Oral contraceptives

• Griseofulvin

• Narcotic analgesics

• Aspirin

• Acetaminophen

• Atropine

• Bupivacaine

• NSAIDs (most

common)

• Bisphosphonates

• Chemotherapy

www.medicoapps.org

Folate deficiency

Inhibition of dihydrofolate

reductase

Impair folate metabolism

• Methotrexate

• Pyrimethamine

• Triameterene

• Pentamidine

• Trimethoprim

• Alcohol

Precipitating acute intermittent porphyria

• Estrogen

• Chlorpropramide

• Phenytoin

• Rifampicin

• Sulfonamides

SAFE drugs in Porphyria

• Penicillin and

derivatives

• Streptomycin

• Benzodiazepines

• Glucocorticoids

• Insulin

• Muscle relaxants

• Bromides

Peptic ulcer

• Clopidogrel

• Crack cocaine

• Glucocorticoids

• Mycophenolatemofetil

• Potassium chloride

Impair folate metabolism

Alcohol

Rifampicin

Sulfonamides

Glucocorticoids

Muscle relaxants

Bromides

Mycophenolatemofetil

Potassium chloride

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Syndrome of

• Vasopressin or

desmopressin

• Vincristine or

vinblastine

• Phenothiazines

• Monoamine oxidase

inhibitors

Aggravation of my

• Aminoglycosides:- Streptomycin,

kanamycin, tobramycin

• Tetracyclines

• Nondepolarizing muscle relaxants :

Pancuronium, atracurium

• Local anaesthetics : Procaine,

xylocaine

• Quinine derivatives : Quinine,

quinidine, chloroquine

Drugs precipitating in urine and causing obstruction

• Antiviral: Acyclovir, atazanavir, indinavir,

• Sulfa drugs: Sulfasalazine, sulfadiazine, acetylsulfamethoxazole, acetylsulfasoxazole,

acetylsulfaguanidine

• Other: Triametrine, silicate,

• Metronidazole

• Cefamandole

• Procarbazine

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Syndrome of inappropriate AIH (SIADH)

• Chlorpropamide

• Carbamazepine

• Cyclophosphamide

• Serotonin reuptake

inhibitors

• Oxytocin, high dose

• Nicotine

• Tricyclic

antidepressants

Aggravation of mysthenia gravis

Streptomycin,

Nondepolarizing muscle relaxants :

Local anaesthetics : Procaine,

Quinine derivatives : Quinine,

• Quinolones Ciprofloxacin, levofloxacin,

ofloxacin

• Macrolides : Erythromycin, azithromycin

• β-blockers : Propranolol, atenolol

• Antiarrhythmics : Procainamide,

phenytoin

• Miscellaneous : Penicillamine,

botulinum toxin

Drugs precipitating in urine and causing obstruction

atazanavir, indinavir,

Sulfasalazine, sulfadiazine, acetylsulfamethoxazole, acetylsulfasoxazole,

, silicate, guatfensin, magnesium trisilicate, ciprofloxacin.

Disulfiram like reaction

• Cefotetan

• Cefoperazone

• Moxalactam

• Chlorpropamide

Oxytocin, high dose

Nicotine

Tricyclic

antidepressants

Quinolones Ciprofloxacin, levofloxacin,

Macrolides : Erythromycin, azithromycin

blockers : Propranolol, atenolol

Antiarrhythmics : Procainamide,

Miscellaneous : Penicillamine, magnesium,

Sulfasalazine, sulfadiazine, acetylsulfamethoxazole, acetylsulfasoxazole,

Moxalactam

Chlorpropamide

www.medicoapps.org

Aggravation of mvsthenia gravis

• Antiarrhythmics

• Antimicrobials

• Antihistaminics

• Antidepressants

• Antipsychotics

• Prokinetic

• Sulphones

• Quinolones

• Ethosuximide

• Salicylates

• Tocainide

• Phynylbutazone

• Penicillins (ampicillin)

• Sulfonamides

• Diuretics

• INH

Serum sickness like drug

• Cefclor

• Sulfonamides

• Thiouracil

• Ciprofloxacin

www.medicoapps.org

Aggravation of mvsthenia gravis

: Quinidine, procainamide, disopyramide, propafenone,

amiodarone

Quinine, mefloquine, artemisinin, halofantrine, sparfloxacin,

gatifloxacin

: Terfenadine, astemizole, ebastine

: Amitryptyline and other tricyclics

: Thioridazine, risperidone

: Cisapride

Erythema muliforme (SJS/TEN)

• Cephalosporins

• Valproic acid

• Nalidixic acid

• Codeine

• Chlorpropamide

• Tetracyclines

• Piroxicam

• Lamotrigine

• Allopurinol

• Penicillins

Exanthematous reaction

• Phenytoin

• Carbamezapine

• Barbiturates

• Phenylbutazone

• Lamotrigine

(Nevirapine)

• Allopurinol

• Rifampicin

Serum sickness like drug reaction (SSLDR)

• Penicillins

• Barbiturates

• Allopurinol

• Propranolol

• Tetracyclines

• Carbamazepine

• NSAIDs

ide, disopyramide, propafenone,

Quinine, mefloquine, artemisinin, halofantrine, sparfloxacin,

Tetracyclines

Piroxicam

Lamotrigine

Allopurinol

Penicillins

Lamotrigine

Nevirapine)

Allopurinol

Rifampicin

Tetracyclines

Carbamazepine

www.medicoapps.org

• Phenylbutazone

• Sulfonamides

Cytotoxic drugs causing mucositis

• Bleomycin

• Methotrexate

• Amasacrine

• Actinomycin-D

a) Phototoxic

• Tetracyclines

• Nalidixic acid

• Phenothiazines

• Sulfonamides

• Thiazides

• Fluroquinolones

• Amiodaroneom

www.medicoapps.org

Granuloma in liver

• Allopurinol

• Quinidine

• Diltiazem

• Carbamazepine

Cytotoxic drugs causing mucositis

• Paclitaxel

• Hydroxyurea

• Daunorubicin

• Mithramycin

• Cytosine arabinoside

• Fluorouracil

• Etoposide

• Topotecan

Photosensitivity

b) Photoallergy

• Sulfonamide

• Chloroquine

• Sulfonylureas

• Chlorpromazine

• Griseofulvin

Diltiazem

Carbamazepine

Cytosine arabinoside

Fluorouracil

Etoposide

Topotecan