2019 sales data obtained from LePro PharmaCompass OPC Private Limited

Humira Eliquis Keytruda Revlimid Imbruvica Opdivo Eylea Avastin Enbrel Xarelto Rituxan Stelara Herceptin Prevnar 13 Remicade Ibrance Biktarvy Tecfidera Trulicity Xtandi 1 k2 K3 K4 5 6 K7 K8 K9 10 11 12 13 14 15 16 17 18 19 20(Adalimumab) (Apixaban) (Pembrolizumab) (Lenalidomide) (Ibrutinib) (Nivolumab) (Aflibercept) (Bevacizumab) (Etanercept) (Rivaroxaban) (Rituximab) (Ustekinumab) (Trastuzumab) (Pneumococcal

7-Valent Conjugate)(Infliximab) (Palbociclib) (Bictegravir, Emtricitabine,

Tenofovir Alafenamide)(Dimethyl Fumarate) (Dulaglutide) (Enzalutamide)

$19.723 Billion $12.149 Billion $11.084 Billion $9.378 Billion $8.085 Billion $8.015 Billion $7.363 Billion $7.285 Billion $7.216 Billion $6.81 Billion $6.671 Billion $6.594 Billion $6.22 Billion $5.847 Billion $5.304 Billion $4.961 Billion $4.738 Billion $4.433 Billion $4.394 Billion $4.35 BillionImmunology Cardiovascular Diseases Oncology Oncology Oncology Oncology Ophthalmology Oncology Immunology Cardiovascular Diseases Oncology Immunology Oncology Vaccine Immunology Oncology Infectious Diseases CNS & Anesthesia Diabetes Oncology

21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40Lucentis Soliris Genvoya Ocrevus Botox Gardasil Perjeta Lyrica Cosentyx Januvia Invega Sustenna Victoza Jardiance Lantus Gilenya Neulasta Xolair Tagrisso Triumeq Entyvio(Ranibizumab) (Eculizumab) (Elvitegravir, Cobicistat, Emtricitabine,

Tenofovir Alafenamide)(Ocrelizumab) (Onabotulinumtoxin A) (HPV Quadrivalent Vaccine) (Pertuzumab) (Pregabalin) (Secukinumab) (Sitagliptin) (Paliperidone Palmitate) (Liraglutide) (Empagliflozin) (Insulin Glargine) (Fingolimod) (Pegfilgrastim) (Omalizumab) (Osimertinib) (Abacavir, Dolutegravir, Lamivudine) (Vedolizumab)

$3.967 Billion $3.946 Billion $3.931 Billion $3.819 Billion $3.791 Billion $3.737 Billion $3.628 Billion $3.589 Billion $3.551 Billion $3.482 Billion $3.33 Billion $3.29 Billion $3.29 Billion $3.283 Billion $3.223 Billion $3.221 Billion $3.201 Billion $3.189 Billion $3.161 Billion $3.085 BillionOphthalmology Hematology Infectious Diseases CNS & Anesthesia Nephrology Vaccine Oncology CNS & Anesthesia Immunology Diabetes CNS & Anesthesia Diabetes Diabetes Diabetes CNS & Anesthesia Hematology Immunology Oncology Infectious Diseases Gastrointestinal Disorders

41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60Darzalex Orencia Mavyret Humalog Truvada Zytiga Symbicort NovoRapid Prolia Sprycel Vyvanse Actemra ProQuad Dupixent Shingrix Spiriva Xeljanz Nexium Simponi Pomalyst(Daratumumab) (Abatacept) (Glecaprevir/Pibrentasvir) (Insulin Lispro) (Emtricitabine, Tenofovir

Disoproxil Fumarate)(Abiraterone Acetate) (Budesonide, Formoterol) (Insulin Aspart) (Denosumab) (Dasatinib) (Lisdexamfetamine) (Tocilizumab) (Measles, Mumps, Rubella,

Varicella Virus Vaccine Live)(Dupilumab) (Zoster Vaccine Recombinant,

Adjuvanted)(Tiotropium bromide) (Tofacitinib Citrate) (Esomeprazole) (Golimumab) (Pomalidomide)

$2.998 Billion $2.977 Billion $2.893 Billion $2.821 Billion $2.813 Billion $2.795 Billion $2.711 Billion $2.709 Billion $2.672 Billion $2.398 Billion $2.383 Billion $2.38 Billion $2.275 Billion $2.261 Billion $2.244 Billion $2.243 Billion $2.242 Billion $2.223 Billion $2.188 Billion $2.162 BillionOncology Immunology Infectious Diseases Diabetes Infectious Diseases Oncology Respiratory Disorders Diabetes Musculoskeletal Oncology CNS & Anesthesia Immunology Vaccine Immunology Vaccine Respiratory Disorders Immunology Gastrointestinal Disorders Immunology Oncology

61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80Advair Pentacel Alimta Prezista Spinraza Lipitor Influenza Vaccines Tivicay Aubagio Janumet Epclusa Cimzia Xgeva Tecentriq Tysabri Tasigna Velcade Prograf Latuda Aranesp(Salmeterol) (Vaccine) (Pemetrexed) (Darunavir, Cobicistat) (Nusinersen) (Atorvastatin Calcium) (Vaccine) (Dolutegravir) (Teriflunomide) (Metformin, Sitagliptin) (Sofosbuvir, Velpatasvir) (Certolizumab pegol) (Denosumab) (Atezolizumab) (Natalizumab) (Nilotinib) (Bortezomib) (Tacrolimus) (Lurasidone) (Darbepoetin Alfa)

$2.145 Billion $2.121 Billion $2.116 Billion $2.11 Billion $2.097 Billion $2.096 Billion $2.061 Billion $2.061 Billion $2.048 Billion $2.041 Billion $1.965 Billion $1.953 Billion $1.935 Billion $1.931 Billion $1.892 Billion $1.88 Billion $1.851 Billion $1.785 Billion $1.739 Billion $1.729 BillionRespiratory Disorders Vaccine Oncology Infectious Diseases Genetic Disorders Cardiovascular Diseases Vaccine Infectious Diseases CNS & Anesthesia Diabetes Infectious Diseases Infectious Diseases Oncology Oncology CNS & Anesthesia Oncology Oncology Immunology CNS & Anesthesia Hematology

81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100Entresto Jentadueto Ozempic Pradaxa Avonex Odefsey Xyrem Lynparza Otezla Sandostatin Brilinta Crestor Farxiga Afinitor Vimpat Copaxone Descovy Yervoy Lovenox Myrbetriq(Sacubitril, Valsartan) (Linagliptin, Metformin

Hydrochloride)(Semaglutide) (Dabigatran Etexilate) (Interferon Beta-1a) (Emtricitabine, Rilpivirine,

Tenofovir Alafenamide)(Sodium Oxybate) (Olaparib) (Apremilast) (Octreotide) (Ticagrelor) (Rosuvastatin Calcium) (Dapagliflozin) (Everolimus) (Lacosamide) (Glatiramer acetate) (Emtricitabine, Tenofovir

Alafenamide)(Ipilimumab) (Enoxaparin Sodium) (Mirabegron)

$1.726 Billion $1.699 Billion $1.686 Billion $1.667 Billion $1.666 Billion $1.655 Billion $1.643 Billion $1.642 Billion $1.607 Billion $1.585 Billion $1.581 Billion $1.565 Billion $1.543 Billion $1.539 Billion $1.537 Billion $1.512 Billion $1.5 Billion $1.489 Billion $1.481 Billion $1.472 BillionCardiovascular Diseases Diabetes Diabetes Hematology CNS & Anesthesia Infectious Diseases CNS & Anesthesia Oncology Dermatology Oncology Cardiovascular Diseases Cardiovascular Diseases Diabetes Oncology CNS & Anesthesia CNS & Anesthesia Infectious Diseases Oncology Hematology Nephrology

101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120Imfinzi Pulmicort Plavix Xifaxan Advate NovoMix Kadcyla Hemlibra Symdeko Promacta Forteo Levemir Tresiba TNKase Taltz Edoxaban Abraxane Human Insulins Tafinlar/Mekinist Synagis(Durvalumab) (Budesonide) (Clopidogrel Bisulfate) (Rifaximin) (Antihemophilic Factor ) (Biphasic Insulin Aspart) (Trastuzumab Emtansine) (Emicizumab) (Tezacaftor, Ivacaftor) (Eltrombopag Olamine/

Eltrombopag)(Teriparatide) (Insulin Detemir) (Insulin Degludec) (Alteplase/Tenecteplase) (Ixekizumab) (Edoxaban) (Paclitaxel Protein Bound) (Human Insulin) (Dabrafenib/Trametinib) (Palivizumab)

$1.469 Billion $1.466 Billion $1.454 Billion $1.452 Billion $1.443 Billion $1.438 Billion $1.435 Billion $1.421 Billion $1.418 Billion $1.416 Billion $1.405 Billion $1.396 Billion $1.389 Billion $1.372 Billion $1.366 Billion $1.364 Billion $1.356 Billion $1.355 Billion $1.338 Billion $1.335 BillionOncology Respiratory Disorders Cardiovascular Diseases Infectious Diseases Hematology Diabetes Oncology Hematology Genetic Disorders Oncology Musculoskeletal Diabetes Diabetes Cardiovascular Diseases Immunology Hematology Oncology Diabetes Oncology Respiratory Disorders

121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140Mirena Lenvima Opsumit Galvus Humulin Gleevec Juvederm Abilify Maintena Simponi NovoSeven Breo Ellipta Restasis Rexulti Orkambi Ventolin Esbriet Bridion Somatuline Jakavi Basaglar(Levonorgestrel) (Lenvatinib) (Macitentan) (Vildagliptin) (Insulin Isophane) (Imatinib) (Hyaluronic Acid) (Aripiprazole) (Golimumab) (Coagulation Factor VIIa

[Recombinant])(Fluticasone Furoate ) (Cyclosporine) (Brexpiprazole) (Lumacaftor, Ivacaftor) (Albuterol) (Pirfenidone) (Sugammadex) (Lanreotide) (Ruxolitinib) (Insulin Glargine )

$1.333 Billion $1.332 Billion $1.327 Billion $1.297 Billion $1.29 Billion $1.263 Billion $1.244 Billion $1.241 Billion $1.224 Billion $1.218 Billion $1.204 Billion $1.189 Billion $1.177 Billion $1.176 Billion $1.163 Billion $1.163 Billion $1.131 Billion $1.124 Billion $1.114 Billion $1.113 BillionUrology Oncology Cardiovascular Diseases Diabetes Diabetes Oncology Dermatology CNS & Anesthesia Immunology Hematology Respiratory Disorders Immunology CNS & Anesthesia Respiratory Disorders Respiratory Disorders Immunology CNS & Anesthesia Oncology Oncology Diabetes

141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160Chantix Kyprolis Hepatitis Diovan Group Olmesartan Creon Exforge Tremfya Leuprorelin Lumizyme Kalydeco Jadenu Isentress Cymbalta Toujeo Kovaltry Acthar Nucala Norvasc Vectibix(Varenicline) (Carfilzomib) (Vaccine) (Hydrochlorothiazide, Valsartan) (Olmesartan) (Pancrelipase) (Amlodipine, Valsartan) (Guselkumab) (Leuprorelin) (Alglucosidase Alfa) (Ivacaftor) (Deferasirox) (Raltegravir) (Duloxetine) (Insulin Glargine) (Antihemophilic Factor ) (Corticotropin) (Mepolizumab) (Amlodipine) (Panitumumab)

$1.107 Billion $1.096 Billion $1.084 Billion $1.064 Billion $1.062 Billion $1.041 Billion $1.025 Billion $1.012 Billion $1.005 Billion $1.001 Billion $991 Million $975 Million $975 Million $964 Million $962 Million $961 Million $953 Million $952 Million $950 Million $948 MillionCNS & Anesthesia Oncology Vaccine Cardiovascular Diseases Cardiovascular Diseases Rare Disorders Cardiovascular Diseases Immunology Oncology Rare Disorders Respiratory Disorders Oncology Infectious Diseases CNS & Anesthesia Diabetes Rare Disorders Immunology Respiratory Disorders Cardiovascular Diseases Oncology

161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180Sutent Pneumovax 23 Cyramza Pediarix Alecensa Faslodex Cialis Lupron Fabrazyme NuvaRing Adempas Epogen Edurant Vraylar Samsca Saxenda Bexsero Keppra Linzess Uptravi(Sunitinib Malate) (Pneumococcal Vaccine

Polyvalent)(Ramucirumab) (Diphtheria, Pertussis,

Tetanus Acellular)(Alectinib) (Fulvestrant) (Tadalafil) (Leuprolide Acetate) (Agalsidase Beta) (Ethinyl Estradiol, Etonogestrel) (Riociguat) (Epoetin Alfa) (Rilpivirine) (Cariprazine) (Tolvaptan) (Liraglutide) (Meningococcal Vaccine) (Levetiracetam) (Linaclotide) (Selexipag)

$936 Million $926 Million $925 Million $909 Million $902 Million $892 Million $891 Million $887 Million $886 Million $879 Million $875 Million $867 Million $861 Million $858 Million $853 Million $852 Million $842 Million $839 Million $827 Million $819 MillionOncology Vaccine Oncology Vaccine Oncology Oncology Urology Oncology Rare Disorders Women's Healthcare Cardiovascular Diseases Hematology Infectious Diseases CNS & Anesthesia Cardiovascular Diseases Nutritional Deficiency Vaccine CNS & Anesthesia Gastrointestinal Disorders Cardiovascular Diseases

181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200Zoladex Nexgard Nplate Venclexta Lixiana RotaTeq Eprex Nexplanon Synthroid Flovent Pulmozyme Cerezyme Nexavar Benlysta Toprol-XL Votrient Augmentin Eloctate YAZ Invokana(Goserelin Acetate) (Afoxolaner) (Romiplostim) (Venetoclax) (Edoxaban) (Rotavirus Vaccine) (Epoetin Alfa) (Etonogestrel) (Levothyroxine Sodium) (Fluticasone Propionate) (Dornase Alfa) (Imiglucerase) (Sorafenib) (Belimumab) (Metoprolol Hydrochloride) (Pazopanib) (Amoxicillin, Clavulanate Potassium) (Antihemophilic Factor,

Fc Fusion Protein)(Drospirenone, Ethinyl Estradiol) (Canagliflozin, Metformin)

$813 Million $807 Million $795 Million $792 Million $791 Million $791 Million $790 Million $787 Million $786 Million $780 Million $774 Million $772 Million $770 Million $760 Million $760 Million $755 Million $746 Million $746 Million $742 Million $735 MillionOncology Infectious Diseases Immunology Oncology Hematology Vaccine Hematology Women's Healthcare Hormonal Disorders Respiratory Disorders Immunology Rare Disorders Oncology Rare Disorders Cardiovascular Diseases Oncology Infectious Diseases Hematology Urology Diabetes

Key Immunology Cardiovascular Diseases Oncology Ophthalmology Vaccine Infectious Diseases CNS & Anesthesia Diabetes Hematology Nephrology Gastrointestinal Disorders Respiratory Disorders Genetic Disorders Dermatology Rare Disorders Miscellaneous

Top 200 Pharmaceuticals by Retail Sales in 2019Compiled and Produced by the Njarðarson Group (The University of Arizona)