1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20Humira Harvoni Enbrel Lantus Avastin Herceptin Remicade Prevnar family Revlimid MabThera/Rituxan Sovaldi Seretide/Advair Crestor Total Lyrica Neulasta Gleevec/Glivec Copaxone Januvia Tecfidera Truvada( Adalimumab ) ( Ledipasvir and Sofosbuvir ) ( Etanercept ) ( Insulin Glargine ) ( Bevacizumab ) ( Trastuzumab ) ( Infliximab ) ( Pneumococcal 7-Valent Conjugate ) ( Lenalidomide ) ( Rituximab ) ( Sofosbuvir ) ( Salmeterol ) ( Rosuvastatin Calcium ) ( Pregabalin ) ( Pegfilgrastim ) ( Imatinib ) ( Glatiramer ) ( Sitagliptin ) ( Dimethyl Fumarate ) ( Emtricitabine, and Tenofovir Disoproxil Fumarate )

$14,012 Million $13,864 Million $8,697 Million $7,029 Million $6,751 Million $6,603 Million $6,561 Million $6,245 Million $5,801 Million $5,696 Million $5,276 Million $5,227 Million $5,017 Million $4,839 Million $4,715 Million $4,658 Million $4,023 Million $3,863 Million $3,638 Million $3,459 MillionIMMUNOLOGY INFECTIOUS DISEASES IMMUNOLOGY DIABETES ONCOLOGY ONCOLOGY IMMUNOLOGY ANTI-BACTERIAL BLOOD RELATED DISORDERS ONCOLOGY INFECTIOUS DISEASES RESPIRATORY DISORDERS CARDIOVASCULAR NEUROSCIENCE AND MENTAL HEALTH BLOOD RELATED DISORDERS ONCOLOGY NEUROSCIENCE AND MENTAL HEALTH DIABETES NEUROSCIENCE AND MENTAL HEALTH INFECTIOUS DISEASES

21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40Symbicort Atripla NovoRapid/NovoLog Abilify Humalog Gilenya Levemir Victoza Avonex Soliris Zetia Nexium Alimta Xarelto Stelara Cialis Zytiga Janumet Plavix Lucentis( Budesonide and Formoterol ) (Efavirenz, Emtricitabine, and Tenofovir Disoproxil Fumarate) ( Insulin ) ( Aripiprazole ) ( Insulin lispro ) ( Fingolimod ) ( Insulin ) ( Liraglutide ) ( Interferon beta-1a ) ( Eculizumab ) ( Ezetimibe ) ( Esomeprazole Magnesium ) ( Pemetrexed ) ( Rivaroxaban ) ( Ustekinumab ) ( Tadalafil ) ( Abiraterone Acetate ) ( Metformin and Sitagliptin ) ( Clopidogrel Bisulfate ) ( Ranibizumab )

$3,394 Million $3,134 Million $3,108 Million $3,058 Million $2,842 Million $2,776 Million $2,745 Million $2,704 Million $2,630 Million $2,590 Million $2526 Million $2,496 Million $2,493 Million $2,477 Million $2,474 Million $2,311 Million $2,231 Million $2151 Million $2122 Million $2,060 MillionRESPIRATORY DISORDERS INFECTIOUS DISEASES DIABETES NEUROSCIENCE AND MENTAL HEALTH DIABETES NEUROSCIENCE AND MENTAL HEALTH DIABETES DIABETES NEUROSCIENCE AND MENTAL HEALTH BLOOD RELATED DISORDERS CARDIOVASCULAR GASTROINTESTINAL DISORDERS ONCOLOGY ANTICOAGULANTS IMMUNOLOGY SEXUAL HEALTH ONCOLOGY DIABETES CARDIOVASCULAR OPTHAMOLOGY

41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60Aranesp Gardasil/Gardasil 9 Lovenox Tysabri Orencia Xarelto Eliquis Lipitor Epogen Invega Sustenna/Xeplion Stribild Prezista Remicade Prograf Total Viagra Human Insulins NovoMix/NovoLog Mix Viekira Pak Tasigna Sandostatin( Darbepoetin Alfa ) ( Vaccine ) ( Enoxaparin Sodium ) ( Natalizumab ) ( Abatacept ) ( Rivaroxaban ) ( Apixaban ) ( Atorvastatin Calcium ) ( Epoetin Alfa ) ( Paliperidone Palmitate ) (Cobicistat, Elvitegravir, Emtricitabine & Tenofovir Disoproxil Fumarate) ( Darunavir ) ( Infliximab ) ( Tacrolimus ) ( Sildenafil Citrate ) ( Insulin ) ( Insulin ) ( Ombitasvir/Paritaprevir/Ritonavir ) ( Nilotinib ) ( Octreotide )

$1951 Million $1,908 Million $1,891 Million $1,886 Million $1,885 Million $1,868 Million $1,860 Million $1,860 Million $1,856 Million $1,830 Million $1,825 Million $1,810 Million $1,794 Million $1,713 Million $1,708 Million $1,685 Million $1,672 Million $1,639 Million $1,632 Million $1,630 MillionBLOOD RELATED DISORDERS ONCOLOGY ANTICOAGULANTS NEUROSCIENCE AND MENTAL HEALTH IMMUNOLOGY ANTICOAGULANTS ANTICOAGULANTS CARDIOVASCULAR BLOOD RELATED DISORDERS NEUROSCIENCE AND MENTAL HEALTH INFECTIOUS DISEASES INFECTIOUS DISEASES IMMUNOLOGY IMMUNOLOGY SEXUAL HEALTH DIABETES DIABETES INFECTIOUS DISEASES ONCOLOGY ONCOLOGY

61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80Sprycel Afinitor/Votubia NovoSeven RT Lucentis Isentress ProQuad/MMR II/Varivax Polio/Pertussis/Hib Perjeta Actemra/RoActemra Complera/Eviplera MabThera/Rituxan Sensipar/Mimpara Xgeva Eylea Forteo Velcade Simponi/Simponi Aria Prolia Baraclude Invokana/Invokamet( Dasatinib ) ( Everolimus ) ( Recombinant Human Coagulation Factor VIIa ) ( Ranibizumab ) ( Raltegravir ) ( Vaccine ) ( Vaccine ) ( Pertuzumab ) ( Tocilizumab ) ( Rilpivirine, Emtricitabine, and Tenofovir Disoproxil Fumarate ) ( Rituximab ) ( Cinacalcet ) ( Denosumab ) ( Aflibercept ) ( Teriparatide ) ( Bortezomib ) ( Golimumab ) ( Denosumab ) ( Entecavir ) ( Canagliflozin )

$1,620 Million $1,607 Million $1,597 Million $1,535 Million $1,511 Million $1,505 Million $1,483 Million $1,459 Million $1,446 Million $1,427 Million $1,419 Million $1,415 Million $1,405 Million $1,351 Million $1,348 Million $1,333 Million $1,328 Million $1,312 Million $1,312 Million $1,308 MillionONCOLOGY ONCOLOGY BLOOD RELATED DISORDERS OPTHAMOLOGY INFECTIOUS DISEASES VACCINE VACCINE ONCOLOGY IMMUNOLOGY INFECTIOUS DISEASES ONCOLOGY HORMONAL DISORDERS ONCOLOGY DIABETES BONE HEALTH ONCOLOGY IMMUNOLOGY BONE HEALTH INFECTIOUS DISEASES TYPE 2 DIABETES

81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100Humulin Xolair Diovan Kogenate Sustiva Vytorin Xtandi Tarceva Vesicare Norditropin Galvus Reyataz Cubicin Yervoy Sutent Viread Procrit/Eprex Mirena Product Family Neupogen Exforge( Insulin Isophane ) ( Omalizumab ) ( Hydrochlorothiazide and Valsartan ) ( Antihemophilic Factor (Recombinant) ) ( Efavirenz ) ( Ezetimibe and Simvastatin ) ( Enzalutamide ) ( Erlotinib ) ( Solifenacin Succinate ) ( Somatropin ) ( Vildagliptin ) ( Atazanavir Sulphate ) ( Daptomycin ) ( Ipilimumab ) ( Sunitinib Malate ) ( Tenofovir Disoproxil Fumarate ) ( Epoetin Alfa ) ( Levonorgestrel ) ( Filgrastim ) ( Amlodipine and Valsartan. )

$1,307 Million $1,290 Million $1,284 Million $1,271 Million $1,252 Million $1,251 Million $1,207 Million $1,193 Million $1,190 Million $1,173 Million $1,140 Million $1,139 Million $1,127 Million $1,126 Million $1,120 Million $1,108 Million $1,068 Million $1,065 Million $1,049 Million $1,047 MillionDIABETES RESPIRATORY DISORDERS ANTIHYPERTENSIVES RARE DISEASE INFECTIOUS DISEASES CARDIOVASCULAR ONCOLOGY ONCOLOGY OVERACTIVE BLADDER HORMONAL DISORDERS DIABETES INFECTIOUS DISEASES ANTI-BACTERIAL ONCOLOGY ONCOLOGY INFECTIOUS DISEASES BLOOD RELATED DISORDERS SEXUAL HEALTH BLOOD RELATED DISORDERS ANTIHYPERTENSIVES

101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120Infanrix, Pediarix Triumeq Renagel/Renvela Cymbalta Seroquel XR Pulmicort Epzicom/Kivexa Norvasc Pomalyst/Imnovid Nexavar Risperdal Consta Abraxane Aubagio Activase/TNKase Opdivo Zyprexa Avodart Singulair Exjade Betaferon/Betaseron( Vaccine ) ( Abacavir, Dolutegravir and Lamivudine ) ( Sevelamer Hydrochloride and Sevelamer Carbonate ) ( Duloxetine ) ( Quetiapine Fumarate ) ( Budesonide ) ( Abacavir and Lamivudine ) ( Amlodipine ) ( Pomalidomide ) ( Sorafenib ) ( Risperidone ) ( Paclitaxel protein-bound ) ( Teriflunomide ) ( Tenecteplase ) ( Nivolumab ) ( Olanzapine ) ( Dutasteride ) ( Montelukast Sodium ) ( Deferasirox ) ( Interferon Beta-1b )

$1,041 Million $1,037 Million $1,029 Million $1,028 Million $1,025 Million $1,014 Million $991 Million $991 Million $983 Million $981 Million $970 Million $968 Million $958 Million $944 Million $942 Million $940 Million $933 Million $931 Million $917 Million $906 MillionVACCINE INFECTIOUS DISEASES UROLOGY NEUROSCIENCE AND MENTAL HEALTH NEUROSCIENCE AND MENTAL HEALTH RESPIRATORY DISORDERS INFECTIOUS DISEASES ANTIHYPERTENSIVES ONCOLOGY ONCOLOGY NEUROSCIENCE AND MENTAL HEALTH ONCOLOGY NEUROSCIENCE AND MENTAL HEALTH CARDIOVASCULAR ONCOLOGY NEUROSCIENCE AND MENTAL HEALTH UROLOGY RESPIRATORY DISORDERS ONCOLOGY NEUROSCIENCE AND MENTAL HEALTH

121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140Flixotide/Flovent Zyvox Ventolin Nasonex Aprovel/CoAprovel Tivicay Cerezyme Celebrex Lupron Concerta Zoladex CellCept Onglyza/Kombiglyze XR Strattera YAZ/Yasim Kadcyla Synthroid Xolair Imbruvica Lamictal( Fluticasone Propionate ) ( Linezolid ) ( Albuterol ) ( Mometasone Furoate ) ( Irbesartan / Irbesartan+Hydrochlorothiazide ) ( Dolutegravir ) ( Imiglucerase ) ( Celecoxib ) ( Leuprolide acetate ) ( Methylphenidate ) ( Goserelin Acetate ) ( Mycophenolate Mofetil ) ( Saxagliptin/Saxagliptin+Metoprolol Hydrochloride ) ( Atomoxetine ) ( Drospirenone and Ethinyl Estradiol ) ( Trastuzumab Emtansine ) ( Levothyroxine Sodium ) ( Omalizumab ) ( Ibrutinib ) ( Lamotrigine )

$885 Million $883 Million $880 Million $858 Million $838 Million $835 Million $833 Million $830 Million $826 Million $821 Million $816 Million $793 Million $786 Million $784 Million $777 Million $777 Million $755 Million $755 Million $754 Million $754 MillionRESPIRATORY DISORDERS ANTI-BACTERIAL RESPIRATORY DISORDERS RESPIRATORY DISORDERS ANTIHYPERTENSIVES INFECTIOUS DISEASES RARE DISEASE BONE HEALTH ONCOLOGY NEUROSCIENCE AND MENTAL HEALTH ONCOLOGY IMMUNOLOGY DIABETES NEUROSCIENCE AND MENTAL HEALTH SEXUAL HEALTH ONCOLOGY HORMONAL DISORDERS RESPIRATORY DISORDERS CHRONIC LYMPHOCYTIC LEUKEMIA NEUROSCIENCE AND MENTAL HEALTH

141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160BeneFIX Augmentin Zostavax Abilify Treanda Synagis NuvaRing Exelon/Exelon Patch Ibrance Pristiq Myozyme/Lumizyme Tamiflu Seloken /Toprol-XL Faslodex Kaletra Letairis Adalat Androgel Simponi Imbruvica ( Coagulation Factor IX ) (Amoxicillin and Clavulanate Potassium) ( Vaccine ) ( Aripiprazole ) ( Bendamustine ) ( Palivizumab ) ( Ethinyl Estradiol And Etonogestrel ) ( Rivastigmine ) ( Palbociclib ) ( Desvenlafaxine ) ( Alglucosidase alfa ) ( Oseltamivir Phosphate ) ( Metoprolol Hydrochloride ) ( Fulvestrant ) ( Lopinavir/Ritonavir ) ( Ambrisentan ) ( Nifedipine ) ( Testosterone ) ( Golimumab ) ( Ibrutinib )

$752 Million $750 Million $749 Million $746 Million $741 Million $740 Million $732 Million $728 Million $723 Million $715 Million $715 Million $712 Million $710 Million $704 Million $700 Million $700 Million $696 Million $694 Million $690 Million $689 MillionRARE DISEASE ANTI-BACTERIAL INFECTIOUS DISEASES NEUROSCIENCE AND MENTAL HEALTH ONCOLOGY RESPIRATORY DISORDERS SEXUAL HEALTH NEUROSCIENCE AND MENTAL HEALTH ONCOLOGY NEUROSCIENCE AND MENTAL HEALTH RARE DISEASE INFECTIOUS DISEASES ANTIHYPERTENSIVES ONCOLOGY INFECTIOUS DISEASES ANTIHYPERTENSIVES ANTIHYPERTENSIVES HORMONAL DISORDERS IMMUNOLOGY ONCOLOGY

161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180Vfend Meningitis/Pneumonia Chantix/Champix Cozaar/Hyzaar Synagis Pulmozyme Fabrazyme Creon Kalydeco Olysio/Sovriad Brilinta/Brilique Genotropin RotaTeq Rotarix Vidaza Ranexa Implanin/Nexplanon Bydureon Aspirin Cardio Glucobay( Voriconazole ) ( Vaccine ) ( Varenicline ) ( Losartan and Hydrochlorothiazide ) ( Palivizumab ) ( Dornase Alfa ) ( Agalsidase beta ) ( Pancrelipase ) ( Ivacaftor ) ( Simeprevir ) ( Ticagrelor ) ( Somatropin ) ( Vaccine ) ( Vaccine ) ( Azacitidine ) ( Ranolazine ) ( Etonogestrel ) ( Exenatide ) ( Acetylsalicylic Acid ) ( Acarbose )

$682 Million $675 Million $671 Million $667 Million $662 Million $659 Million $651 Million $632 Million $632 Million $621 Million $619 Million $617 Million $610 Million $592 Million $591 Million $588 Million $588 Million $580 Million $576 Million $575 MillionANTI-FUNGAL VACCINE NEUROSCIENCE AND MENTAL HEALTH ANTIHYPERTENSIVES RESPIRATORY DISORDERS RARE DISEASE RARE DISEASE RARE DISEASE RESPIRATORY DISORDERS INFECTIOUS DISEASES CARDIOVASCULAR RARE DISEASE VACCINE VACCINE ONCOLOGY CARDIOVASCULAR SEXUAL HEALTH DIABETES CARDIOVASCULAR DIABETES

181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200Invega Cancidas Neoral/Sandimmun Invanz Esbriet Keytruda Votrient Voltaren Vectibix ProAir Iressa Pegasys Pneumovax 23 Synflorix Dulera Emend Refacto AF/Xyntha Nplate Effient Xeljanz( Paliperidone ) ( Caspofungin ) ( Cyclosporine ) ( Ertapenem ) ( Pirfenidone ) ( Pembrolizumab ) ( Pazopanib ) ( Diclofenac ) ( Panitumumab ) ( Albuterol Sulfate ) ( Gefitinib ) ( Peginterferon Alfa-2a ) ( Vaccine ) ( Vaccine ) ( Formoterol and Mometasone ) ( Aprepitant ) ( Antihemophilic Factor (Recombinant) ) ( Romiplostim ) ( Prasugrel ) ( Tofacitinib citrate )

$573 Million $573 Million $570 Million $569 Million $569 Million $566 Million $565 Million $558 Million $549 Million $549 Million $543 Million $543 Million $542 Million $541 Million $536 Million $535 Million $533 Million $525 Million $523 Million $523 MillionNEUROSCIENCE AND MENTAL HEALTH ANTI-FUNGAL IMMUNOLOGY ANTI-BACTERIAL IDIOPATHIC PULMONARY FIBROSIS ONCOLOGY ONCOLOGY OTHERS ONCOLOGY RESPIRATORY DISORDERS ONCOLOGY INFECTIOUS DISEASES VACCINE VACCINE RESPIRATORY DISORDERS OTHERS RARE DISEASE IMMUNOLOGY CARDIOVASCULAR IMMUNOLOGY

Top 200 Pharmaceutical Products by Retail Sales in 2015Compiled and Produced by the Njardarson Group (The University of Arizona): David T. Smith, Brandon R. Smith, Haziq Qureshi, Jón T. Njarðarson