compiledandproducedbythenjardarsongroup(cornelluniversity ...€¦ · o n oh h n hn s cl so2nh2 o o...

O

N

OH

HN

HNS

Cl

SO2NH2OO

71 Hyzaar

Company: 2008 Sales:$0.53 Billion

2007 Rank:82

Profile:An angiotensin II receptor blocker and adiuretic used to treat hypertension.

N

N

Cl

OHN

N N

NH

72 ProAir HFA


2007 Rank:91

Profile:Inhaler used to treat obstructive airwaydisease and prevent bronchiospasms .

HO

HN

OH OH

73 Reyataz


2007 Rank:87

Profile:A protease inhibitor used to treat HIV.

O NH

HN N

NH

O

O

OH OHN O

O

N

HN

HNS

Cl

SO2NH2OO

74 Benicar HCT


2007 Rank:93


N

N

N

NN

HN

HO

O

O

OO

O

CO2H

75 Synthroid


2007 Rank:69

Profile:A thyroid hormone used to treat hypo-thyroidism and to suppress goiters.

H2N

O

OH

I

I

I

I

76 Avandia


2007 Rank:29

Profile:A thiazolidinedione used to treat type 2diabetes.

N NO

SNH

O

O

77 Boniva


2007 Rank:96

Profile:A bisphosphonate used to treat andprevent osteoporosis.

NP

OH

P

OHO

HOO

OH

OH

78 Strattera


2007 Rank:73

Profile:A selective norepinephrine reuptakeinhibitor used to treat ADHD.

NH

O

79 Polymagma Plain


2007 Rank:N/A

Profile:A fluid absorbent used to controldiarrhea.

80 Skelaxin


2007 Rank:78

Profile:A muscle relaxant used to treatmusculoskeletal discomfort.

O

O

NH

O

HO

81 Evista


2007 Rank:81

Profile:A selective estrogen receptor modulatorused to prevent and treat osteoporosis.

S

O

ON

OH

82 Asacol


2007 Rank:92

Profile:An anti-inflammatory agent used totreat inflammation of the colon.

CO2H

OH

H2N

83 Depakote


2007 Rank:67

Profile:An anticonvulsant used to controlseizures in patients with epilepsy.

OHO

O O

84 Xalatan


2007 Rank:88

Profile:A prostaglandin analogue used totreat ocular hypertension or glaucoma.

HO

HO

O

O

HO

Ph

85 Humira


2007 Rank:85

Profile:A tumor necrosis factor-blocker used totreat rheumatoid arthritis.

86 Benicar


2007 Rank:102

Profile:An angiotensin II receptor blocker usedto treat hypertension.

N

N

N

NN

HN

HO

O

O

OO

O

87 Gleevec


2007 Rank:99

Profile:A protein-tyrosine kinase inhibitor usedto treat chronic myeloid leukemia.

N

N

NHN

HN

O

N

N

88 AndroGel


2007 Rank:103

Profile:A testosterone gel used to treat menwith testosterone deficiencies.

O

OH

H

H

H

O

O

O

OHN

OH

HN

c

93 RenaGel


2007 Rank:113

Profile:A prosphate binder used for patientswith chronic kidney disease on dialysis.

H2N

H2N

a

bm

94 Avapro


2007 Rank:98


N

HN N

NN

N

O

95 Humira Pen


2007 Rank:162

Profile:A tumor necrosis factor-blocker used totreat rheumatoid arthritis.

96 Vyvanse


2007 Rank:N/A

Profile:A central nervous system stimulant fortreatment of ADHD.

NH

O

NH2

H2N

97 Kaletra


2007 Rank:100

Profile:Two protease inhibitors used to treatHIV.

HN

O

NHN

O

NH

OH

O

O

HN

O

NH

NH

OH

O

O

SN

N

O

SN

98 Xopenex


2007 Rank:104

Profile:A bronchodilator used to treat andprevent asthma attacks.

OH

HO

OHHN

CO2H

99 Copaxone


2007 Rank:112

Profile:A polypeptide mixture used to treatrelapsing-remitting multiple sclerosis.

H2N O

HN

NH2

O

NH O

HN

OH

O

OH

5n

3n

1.5n

nNH

O

H

H

H

H

O HN

CF3

F3C

100 Avodart


2007 Rank:121

Profile:A 5-alpha-reductase inhibitor used totreat enlarged prostates.

101 Femara


2007 Rank:114

Profile:An aromatase inhibitor used to treatbreast cancer.

N

N

N

CNNC

102 Avalide


2007 Rank:107


N

NO

NHN

N N

HN

NHS

O O

Cl

H2NO2S

103 Ortho TriCyclen Lo


2007 Rank:101

Profile:An estrogen and progestin combinationused as birth control.

NHO

H H

O

O

H H

HO

H H

H

OH

104 Sensipar


2007 Rank:127

Profile:A calcimimetic agent used to treathyperparathyroidism in dialysis patients.

HN

CF3

105 Aldara


2007 Rank:118

Profile:An immune response modifier used totreat skin cancer and genital warts.

N

N

NH2

106 NovoLog Mix70/30


2007 Rank:116

Profile:A mixture of insulin analogs used totreat diabetes.

107 Restasis


2007 Rank:125

Profile:An immunomodulator used to treatchronic dry eyes.

MeLeu-MeVal

Me-Leu-D-Ala-Ala-MeLeu-Val-MeGlu

Abu-MeGly

NO

OH

N

SNH2

HN

108 Mirapex


2007 Rank:132

Profile:A dopamine agonist used to treatParkinson's disease.

O

O

O

H

HHOH

H

HHHO

109 Yasmin 28


2007 Rank:76


110 Solodyn


2007 Rank:143

Profile:A semi synthetic tracycline derivativeused to treat severe acne vulagirs.

H

OH

HN(CH3)2

CONH2

OH

OHOH

N(CH3)2

O O

111Lantus SoloSTAR


2007 Rank:N/A

Profile:A long-acting insulin analog used totreat diabetes.

112 Norvir


2007 Rank:123

Profile:A protease inhibitor used to treat HIV.

S

NN

O

HN

ONH

HO HN

O

O

S N

113 Focalin XR


2007 Rank:133

Profile:A central nervous system stimulantused to treat ADHD.

HN O

O

114 Actoplus Met


2007 Rank:140

Profile:Combination of two antihyperglycemicsused to treat type II diabetes.

NH3C O

NH

S

O

O

NHN NH2

NH NH

115 Vesicare


2007 Rank:152

Profile:A muscarinic receptor antagonist usedto treat overactive bladder.

N O

NO

OHHO

O

O

116 Forteo


2007 Rank:119

Profile:A synthetic parathyroid hormone usedto treat osteoporosis.

OH

NH

117 Allegra-D12 Hour


2007 Rank:110

Profile:An antihistamine and a decongestantused to treat seasonal allergies.

NHO

HO

CO2H

118 Procrit


2007 Rank:105

Profile:A glycoprotein used to treat anemia inpatients with kidney failure or cancer.

119 Nasacort AQ


2007 Rank:108

Profile:An adrenocortical steroid used totreat nasal allergy symptoms.

O

HO O

O

O OH

F

H

H

120 Tarceva


2007 Rank:128

Profile:A tyrosine kinase inhibitor used to treatlung cancer.

N

N

HN

O

O

O

O

121 Combivir


2007 Rank:109

Profile:Two reverse transcriptase inhibitorsused to treat HIV.

N

NH2

O N

S

O

OH

O

N3

HON

NH

O

O

122 Tamiflu


2007 Rank:N/A

Profile:A viral neuraminidase inhibitor used totreat influenza types A and B.

O

O

O

NH

NH2

O

123 Avonex


2007 Rank:126

Profile:An interferon used to treat relapsingforms of multiple sclerosis.

O

OH

HO

OH

H

H H

H H

H H

124 NuvaRing


2007 Rank:137


125 Coreg CR


2007 Rank:199

Profile:A ß-adrenergic blocking agent used totreat mild to severe heart failure.

NH

O

NH

O

OH

H3CO

HO

NN

N N

NH

NH2

126 Epzicom


2007 Rank:136


127 Levemir


2007 Rank:N/A


128 Duragesic


2007 Rank:111

Profile:An opioid analgesic used to managechronic pain.

N

O N

129 RisperdalConsta


2007 Rank:160

Profile:An antipsychotic used to treatschizophrenia and bipolar mania.

NO

NF

N

N

O

130 Zyvox


2007 Rank:135

Profile:An oxizolidinone antibiotic used to treatserious bacterial infections.

N

F

NO

HN

O

O

O

NN

Cl

131 Tussionex


2007 Rank:167

Profile:A cough-suppressant and antihistamineused to treat colds and allergies.

O

N

OO

132 Invega


2007 Rank:N/A

Profile:An antipsychotic used to treatschizophrenia

N

N

ON

ON

F

133 Fosamax


2007 Rank:24

Profile:A bisphosphonate used to treat Paget'sdisease and osteoporosis.

HO P

O

OH

P

O

OH

H2N

HO OH

134 Kadian


2007 Rank:163

Profile:An opiate analgesic used to treatmoderate to severe pain.

O

HO

HO

H

N

O

O

N N

HN

N

O

135 Levitra


2007 Rank:158

Profile:A phosphodiesterase inhibitor usedto treat erectile dysfunction.

N

NS

O

136 Differin


2007 Rank:164

Profile:A retinoid used to treat acne.

O

CO2H

N

N

O

N

Cl

137 Astelin


2007 Rank:146

Profile:An antihistamine used to treat nasalallergy symptoms.

138 Lumigan


2007 Rank:141

Profile:A prostaglandin analog used to treatglaucoma and ocular hypertension.

OH

HO

HO

O

NH

139 Symbicort


2007 Rank:N/A

Profile:Combination of bronchodialator andanti-inflammatory used for asthma.

HOO

O

H

HH H

O

OH

O

O

HN

OH

OH

NHO

140 Janumet


2007 Rank:N/A

Profile:A combination of two complementaryantihyperglycemic agents for diabetes.

89 Enbrel Sureclick


2007 Rank:115

Profile:A tumor necrosis factor inhibitor used totreat arthritis and psoriasis.

CO2H

N

O

O

N

F

HN

H

H

90 Avelox


2007 Rank:90

Profile:A fluoroquinolone antibiotic used to treatbacterial infections.

91 Fantanyl Oral Citra


2007 Rank:94

Profile:An opioid analgesic used to managebreakthrough cancer pain.

N

NO

92 Lovaza


2007 Rank:131

Profile:Ethyl esters from omega-3 fatty acidsused to lower high triglyceride levels.

F

FF

H2N

O N

NN

N

CF3

HNN

NH

NH2

NH

NHN

141 Xeloda


2007 Rank:156

Profile:An antimetabolite used to treat breastand colon cancers.

N

O

F

O

HO OH

OO

142 Clarinex


2007 Rank:117

Profile:An antihistamine used to treat thesymptoms of allergies.

N

Cl

HN

143 Proventil HFA


2007 Rank:N/A

Profile:A bronchodilator used to treat asthmaand obstructive pulmonary disease

HO

HO

OHHN

144 Humalog Mix75/25 Pn


2007 Rank:153

Profile:A mixture of insulin analogs used totreat diabetes.

O

O O

O

145 BenzaClin


2007 Rank:147

Profile:An antibiotic and a drying agent usedto treat acne.

N

O

NH

Cl

O

OH

OH

S

O

P OH

OH

O

N

O

O

F

NHNH

H

HO2C

146 Vigamox


2007 Rank:151

Profile:A fluoroquinolone antibiotic used to treateye infections.

147 Foxamax Plus D


2007 Rank:139

Profile:A bisphosphonate and vitamin D usedto treat and prevent osteoporosis.

OHP

OH

O

OH

P

O

OH

HO

NH2H

H

OH

148 Maxalt


2007 Rank:169

Profile:A serotonin receptor agonist used totreat migranes.

NH

N

NN

N

149 Cosopt


2007 Rank:134

Profile:A carbonic anhydrase inhibitor and abeta blocker used to treat glaucoma.

S S

NH

OO

S NH2

O

O

NNS

ON

O

HNHO

150 Requip


2007 Rank:95

Profile:A dopamine agonist used to treatParkinson’s disease and RLS.

NH

N

O

151 Relpax


2007 Rank:148


S

O

O

HN

N

152 Patanol


2007 Rank:129

Profile:An antihistamine used to relieve watery,red, or itchy eyes caused by allergies.

O HO

O

N

F3C

NH

O

HO S

O

O

F

NC

153 Casodex


2007 Rank:150

Profile:A nonsteroidal antiandrogen used totreat prostate cancer.

154 Welchol


2007 Rank:176

Profile:A non-absorbed polymeric LDL-C andglucose-lowering agent.

**

NH2

**

NH2

NH2

**

NH2

**

NH2

N

OH

ClCl

Cl

Cl Cl

Cl

...... ...... ...... ............a b c d

m

155 Ciprodex Otic


2007 Rank:172

Profile:An antibiotic and a corticosteroid usedto treat ear infections.

N

HO2C

N

NH

O

F

O

O OH

OHHO

F

H

H

156 Viread


2007 Rank:149

Profile:A reverse transcriptase inhibitor used totreat HIV.

N

NN

N

NH2

O P O

O

O

O O

O

O O

O

157 Catapres-TTS


2007 Rank:165

Profile:An alpha agonist used to treathypertension.

Cl

Cl

HN

HN

N

158 Loestrin 24 Fe


2007 Rank:N/A

Profile:An estrogen and progestin combinationused as an oral contraceptive.

H

H H

HO

H H

H H

O

O

O

OH

159 Thalomid


2007 Rank:144

Profile:An immunomodulator used to treat skininflammation and multiple myeloma.

N

O

O

NH

O

O

160 Alphagan P


2007 Rank:166

Profile:An adrenergic agonist used to treatglaucoma and ocular hypertension.

N

NN

BrHN

NH

O

NH

HO

161 Endocet


2007 Rank:159

Profile:A narcotic and an analgesic/antipyreticused to treat moderate pain.

O

OH

N

OO

162 Revlimid


2007 Rank:N/A

Profile:An immomodulatory compound to treatmultiple myeloma.

N

NH

NH2

O

O

O

163 Avandamet


2007 Rank:124

Profile:An insulin resistance reducer and abiguanide used to treat type 2 diabetes.

N NO

SNH

O

O

NHN NH2

NH NH

164 Maxalt MLT


2007 Rank:177


NH

N

NN

N

165 Altace


2007 Rank:56

Profile:An ACE inhibitor used to treathypertension and heart disease.

N

HO2C

O

HN

OO

166 Budeprion SR


2007 Rank:155

Profile:A norepinephrine and dopamine reuptakeinhibitor used to treat depression.

Cl

O

NH

167 Pegasys


2007 Rank:183

Profile:An interferon used to treat chronichepatitis C infection.

169 Fentora


2007 Rank:194

Profile:An opeoid analgesic intended for opeoidtolerant cancer patients..

N N

O

170 Asmanex


2007 Rank:178

Profile:A corticosteroid inhaler used to treatasthma.

OHO

Cl

O

O

OClH2C

H

171 Rhinocort Aqua


2007 Rank:142

Profile:A corticosteroid used to treat nasalallergy symptoms.

O

HO

H

O

O

O OH

H

N

NN

N

O

NNH2

O

172 Temodar


2007 Rank:173

Profile:An antineoplastic agent used to treatrecurrent malignant brain tumors.

173 Micardis HCT


2007 Rank:191

Profile:An orally active angiotensin II antagonistused to treat hypertension.

NN

N

N

OOH

NH

NHS

O OH2NO2S

Cl

174 Sotret


2007 Rank:N/A

Profile:A retinoid that inhibits sebaceous glandfunction used to treat nodular acne

O OH

N3

175 Trizivir


2007 Rank:154

Profile:Three reverse transcriptase inhibitorsused to treat HIV.

N

N N

N

H2N

HN

OH

S

OOH

N

N

NH2

O ONHO

NH

O

O

176 Enablex


2007 Rank:195

Profile:A muscarinic receptor antagonist usedto treat overactive bladder.

O

N

O NH2

177 Isentress


2007 Rank:N/A

Profile:An antiviral that inhibits HIV-1 integraseused to treat HIV.

N

N

O

HN

O

NN

O

OH

O

NH

F

180 Sustiva


2007 Rank:157

Profile:A non-nucleoside reverse transcriptaseinhibitor used to treat HIV.

NH

OCl

O

F3C

179 Trileptal


2007 Rank:75

Profile:An anticonvulsant used to treat seizuresin patients with epilepsy.

N

O NH2

O

O

OHO

HO

F

H

H

OH

178 TobraDex


2007 Rank:174

Profile:An antibiotic and a glucocorticoid usedto treat eye infections.

O

O

OOH

H2N

O

HO

H2N OH

NH2

OHNH2

NH2

OH

168 Ultram ER


2007 Rank:184

Profile:An analgesic used to treat severe tomoderate chronic pain.

HO

NCH3

CH3

H3CO

181 Amitiza


2007 Rank:N/A

Profile:A chloride channel activator that is usedto for chronic constipation.

O

O

F F

OH

O

OH

H

H

182 Micardis


2007 Rank:N/A

Profile:An orally active angiotensin II antagonistused to treat hypertension.

NN

N

N

OOH

183 Zovirax Topical


2007 Rank:186

Profile:An antiviral used to treat the symptomsof herpes simplex virus infections.

HN

N N

N

OOH

H2N

O

184 Ocella


2007 Rank:N/A

Profile:An ethinyl estradiol and drospirenonemix used as an oral contraceptive.

H

H

H

O

O

O

H

H H

HO

OH

185 Propecia


2007 Rank:N/A

Profile:An azasteroid used for the treatment ofmale pattern hair loss.

NH

H

H

H H

O

OHN

186 Taclonex


2007 Rank:N/A

Profile:Combination of a corticosteroid and avitamin D analogue used for psoriasis.

H

F H

O

O

OH

HH

O

HOO

O

O

187 Actiq


2007 Rank:138

Profile:An opioid analgesic used to managecontinual breakthrough cancer pain.

N

O N

188 Valcyte


2007 Rank:N/A

Profile:An inhibitor viral DNA synthesis used totreat cytomegalovirus retinitis.

N

NH

N

N

O

H2N

O

HO

O

O

NH2

189 Klor-Con


2007 Rank:182

Profile:Potassium chloride used as potassiumsupplementation.

190 Atacand


2007 Rank:179

Profile:An angiotensin II receptor blocker usedto treat hypertension and heart failure.

N

HN

N

N

NN

HO2C

O

191 Doryx


2007 Rank:N/A

Profile:A tetracycline broad-spectrum antibioticused to treat a variety of infections.

OH O HOHO

O O

NH2

OH

NH

OHH

192 Veramyst


2007 Rank:N/A

Profile:An anti-inflammitory corticosteroid usedto treat nasal symptoms and allergies.

H

F H

O

O

F

O

O

S

O

F

193 Avinza


2007 Rank:197

Profile:An opioid analgesic used to treatmoderate to severe pain.

O

HO

HO

H

N

194 Allegra-D 24 Hour


2007 Rank:N/A

Profile:An antihistamine and a decongestantused to treat seasonal allergies.

OH

NH

NHO

HO

CO2H

195 Opana ER


2007 Rank:N/A

Profile:An opiate analgesic used to treatmoderate to severe pain.

O

HO

O

OH

N

196 Zomig


2007 Rank:N/A


HN

N

NHO

O

197 Humulin 70/30


2007 Rank:N/A

Profile:An insulin analog used to treat diabetes.

198 Prempro


2007 Rank:198

Profile:A combination of hormones used to treatmenopausal symptoms.

O3SO

H H

H

O

O3SO

H H

O

O

H

H

H

OO

O

199 Humulin N


2007 Rank:190

Profile:An insulin analog used to treat diabetes.

200 Xopenex HFA


2007 Rank:N/A

Profile:A bronchodilator used to treat andprevent asthma attacks.

HO

HO

OHHN

Profile:An HMG-CoA reductase inhibitor usedto lower LDL cholesterol levels.

1 Lipitor


2007 Rank:1

HN

O

NHO

HO

HO2C

F

7 Singulair


2007 Rank:6

Profile:A leukotriene receptor antagonist usedto treat asthma and allergies.

NCl

OH

S

CO2H

8 Effexor XR


2007 Rank:8

Profile:A serotonin and norepinephrine reuptakeinhibitor used to treat depression.

O

N

OH

Profile:A proton pump inhibitor used to treatheartburn and esophagitis.

2 Nexium


2007 Rank:2

N

O

S

O

HN

N

O

3 Plavix


2007 Rank:5

Profile:A platelet aggregation inhibitor used toreduce stroke and heart attack risk.

S

N

OOCl

4 Advair Diskus


2007 Rank:3

Profile:A corticosteroid and a bronchodilatorused to treat and prevent asthma.

O

HO

F

H

H

SO

F

O

F

O

HO

HO

OH HN

OPh

Profile:A proton pump inhibitor used to treatgastric reflux disease.

5 Prevacid


2007 Rank:4

N

HN

SO

N

OCF3

6 Seroquel


2007 Rank:7


S

NN

N OOH

9 OxyContin


2007 Rank:33

Profile:An opioid analgesic used to treatmoderate to severe pain.

10 Actos


2007 Rank:10

Profile:A thiazolidinedione used to treat type 2diabetes.

N

O

S

NH

O

O

11 Lexapro


2007 Rank:9

Profile:A selective serotonin reuptake inhibitorused to treat depression and anxiety.

O

NF

NC

12 Abilify


2007 Rank:15


HN

O

O

N N

Cl Cl

13 Topamax


2007 Rank:13

Profile:A carbonic anhydrase inhibitor used totreat seizures and prevent migranes.

O

OO

O O

S OO

O

NH2

14 Cymbalta


2007 Rank:16

Profile:A serotonin and norepinephrine reuptakeinhibitor used to treat depression.

O

NH

S

15 Zyprexa


2007 Rank:18

Profile:A thienobenzodiazepine used to treatschizophrenia and bipolar mania.

NH

N

S

N

N

16 Valtrex


2007 Rank:22

Profile:An antiviral agent for treating shingles,cold sores, and genital herpes.

HN

N N

N

O

H2N

O

OO

H2N

17 Crestor


2007 Rank:23

Profile:An HMG-CoA reductase inhibitor usedto lower LDL cholesterol levels.

N

N

CO2H

NSO

O

F

OH OH

18 Vytorin


2007 Rank:12

Profile:A statin and a cholesterol absorptionblocker used to treat high cholesterol.

FN

O

OH

F

OH

H

O

O

O

HO O

19 Lamictal


2007 Rank:17

Profile:An anticonvulsant used to treatseizures and bipolar disorder.

N

N N

H2N

NH2

Cl Cl

20 Celebrex


2007 Rank:20

Profile:A COX-2 inhibitor NSAID used to treatarthritis pain.

S

O

H2NO

NN

CF3

21 Lantus


2007 Rank:26


22 Levaquin


2007 Rank:19

Profile:A fluoroquinolone antibiotic used to treatbacterial infections.

F

N

N

N

O

O

CO2H

23 Adderall XR


2007 Rank:27

Profile:An amphetamine used to treat ADHDand narcolepsy.

NH2

24 Lyrica


2007 Rank:37

Profile:An anticonvulsant used to treat nervepain and seizures.

CO2H

H2N

25 Diovan


2007 Rank:28

Profile:An angiotensin II receptor blocker usedto treat hypertension and heart failure.

N

HNNN

N

CO2HO

26 Tricor


2007 Rank:30

Profile:A lipid-lowering agent used to treat highcholesterol and triglyceride levels.

Cl

O

O

OO

O O

NH2

27 Flomax


2007 Rank:36

Profile:An alpha blocker used to treat enlargedprostates.

S

O

NH

O

O

28 Risperdal


2007 Rank:14


N

N

ON

ON

F

HN

HNS

Cl

SO2NH2OO

29 Diovan HCT


2007 Rank:32


N

HNNN

NCO2HO

30 Zetia


2007 Rank:21

Profile:An antihyperlipidemic agent used tolower cholesterol levels.

NO

OH

F

FOH

31 Aricept


2007 Rank:39

Profile:A cholinesterase inhibitor used to treatAlzheimer's disease.

N

O

OO

32 Spiriva

Company: 2008 Sales:$1.14Billion

2007 Rank:47

Profile:An anticholineric agent used to treatchronic obstructive pulmonary disease.

N

O

O

O

OH

S

S

33 Concerta


2007 Rank:34

Profile:A central nervous system stimulantused to treat ADHD.

O

O

HN

34 Aciphex


2007 Rank:31

Profile:A proton pump inhibitor used to treatduodenal ulcers and acid reflux.

HN

NSO

N

O O

35 Imitrex Oral


2007 Rank:40


NH

N

S OO

NH

36 Lidoderm


2007 Rank:49

Profile:A local anesthetic used to relieve painassociated with shingles.

NH N

O

37 Keppra


2007 Rank:57

Profile:An anticonvulsant used to treat seizuresin patients with epilepsy.

N O

NH2

O

38 Viagra

Company: 2008 Sales:$0.92Billion

2007 Rank:48

Profile:A phosphodiesterase inhibitor used totreat erectile dysfunction.

NH

NS

N

N

O

O

NN O

O

39 Atripla


2007 Rank:61

Profile:Efavirenz, Emtricitabine, and TenofovirDF combination used to treat HIV.

N

NN

N

PO

OO

O

O

OO

O

O

NH2

NH

O

F3CCl

O

S

O

OH

N

NH2N

F

O

O

O

O

O

OH

HO3SO

OH

OSO3H

OOSO3H

O

HO3SHN

O OSO3H

O

HN

HOO

HO

OH

O

HO

O

40 Lovenox


2007 Rank:53

Profile:An antithrombotic used to prevent bloodclots.

41 Januvia


2007 Rank:84

Profile:A DPP-4 enzyme inhibitor used to treattype II diabetes.

N

NN

N

O

F

F

F

CF3

NH2

42 Nasonex


2007 Rank:43

Profile:A corticosteroid used to treat allergicand nonallergic nasal symptoms.

O

O

OCl

H

HO

Cl

HO

O

43 Ambien CR


2007 Rank:45

Profile:A sedative-hypnotic used to treatinsomnia.

N

N

N

O

44 Provigil


2007 Rank:54

Profile:A wakefullness-promoting agent used totreat narcolepsy.

S

O

NH2

O

45 Geodon Oral


2007 Rank:58

Profile:An antipsychotic used to treat acuteagitation in patients with schizophrenia.

N

N

NS

Cl NH

O

46 Truvada


2007 Rank:62


NN

N

NH2N

O PHO

OH

O

S

OHON

NO

NH2

F

47 Lunesta


2007 Rank:55

Profile:A hypnotic agent used to treat insomnia.

N

N

N

N

O

N

O

N

O

Cl

48 Enbrel


2007 Rank:46

Profile:A tumor necrosis factor inhibitor used totreat arthritis and psoriasis.

49 Actonel


2007 Rank:50

Profile:A bisphosphonate used to treat andprevent osteoporosis.

N

OH

P P

OH

O

OH

O

HO

HO

50 CellCept


2007 Rank:63

Profile:An immunosuppressant used to preventorgan transplant rejection.

O

O

CO2H

OH

OCH3

51 Humalog


2007 Rank:65

Profile:A rapid acing insulin analog used totreat diabetes.

52 Detrol LA


2007 Rank:60

Profile:An antimuscarinic agent used to treatoveractive bladders.

OH

N

53 Depakote ER


2007 Rank:66

Profile:An anticonvulsant used to controlseizures in patients with epilepsy.

OHO

O O

54 Cozaar


2007 Rank:59


N

N

N

NHN

N

Cl

OH

55 PulmicortRespules


2007 Rank:64

Profile:An inhaled corticosteroid used to treatand prevent asthma.

O

O

O

OHO

H

HO

H

H

56 Niaspan


2007 Rank:70

Profile:A vitamin used to lower LDL and raiseHDL cholesterol levels.

N

CO2H

57 Wellbutrin XL


2007 Rank:38

Profile:A norepinephrine and dopaminereuptake inhibitor that treats depression.

O

NH

Cl

58 Chantix


2007 Rank:51

Profile:An oral tablet taken to aid in smokingcessation.

N

N

NH

59 Budeprion XL


2007 Rank:72

Profile:A norepinephrine and dopamine reuptakeinhibitor used to treat depression.

Cl

O

NH

60 Byetta


2007 Rank:71

Profile:An incretin mimetic used to treat type 2diabetes.

61 Yaz


2007 Rank:130

Profile:An Ethinyl Estradiol and Drospirenonemix used as an oral contraceptive.

O

H

HH

H

HH

H

O

O

OH

H

H

HO

H

OHO

O

HOO

NO

O

O

OH

OO

H

O

62 Prograf


2007 Rank:79

Profile:An immunosuppressant used to preventliver or kidney transplant rejection.

63 Namenda


2007 Rank:83

Profile:An NMDA-receptor antagonist used totreat Alzheimer-type dementia.

NH2

64 Arimidex


2007 Rank:80

Profile:An aromatase inhibitor used to treatbreast cancer.

CNNN

N

NC

65 Combivent


2007 Rank:74

Profile:A bronchodilator and beta-receptorstimulant used to treat COPD.

N

O

OHOOH

NH

HO

OH

66 Cialis


2007 Rank:86

Profile:A phosphodiesterase inhibitor used totreat erectile dysfunction.

OO

N

N

NH

O

OH

67 Flovent HFA


2007 Rank:77

Profile:A corticosteroid used to prevent and toreduce the frequency of asthma attacks.

O

F

F

O

S O

F

O

HO

H

68 Protonix


2007 Rank:11

Profile:A proton pump inhibitor used to treatesophagus inflammation and erosion.

N

O

O

S

O

NH

N

O

F

FO

HH

O3S

69 Premarin Tabs


2007 Rank:68

Profile:Estrogen mixture used to treat breastcancer and menopausal symptoms.

O

H

HH

O3S

70 Suboxone


2007 Rank:120

Profile:An opioid agonist/antagonist and an ant-agonist used to treat opioid dependence.

O

HO

O

HO

N

O

HO

OH

OH

HO

Compiled and Produced by the Njardarson Group (Cornell University): Matthew Brichacek, Nicholas McGrath, Dan Mack, Jón T. Njarðarson

http://drugtopics.modernmedicine.com/drugtopics/data/articlestandard//drugtopics/192009/597083/article.pdf

S

OOH

N

N

NH2

O

O

O

O

OH

N

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