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Autoantibodies in the diagnosis and monitoring of

auto immunedisease

Eye

Inner ear

Nervous system

Anti cochlea Abs

Anti collagen type II Abs

Cogan syndrome

Meniere disease

Anti retina, cornea, crystallin Abs

Retinitis, keratitis,Uvetitis

Anti acetylcholine receptor AbsAnti MuSK AbsAnti striated muscle AbsAnti titin Abs

Anti calcium channel Abs (VGCC)

Anti potassium channel Abs (VGKC)

Anti glutamate decarboxylase Abs 67 = GAD IAnti amphiphysin Abs

Anti myelin AbsAnti MAG AbsAnti sulfatide AbsAnti gangliosides Abs IgG/IgM (GM1, GM2, GD1a, GD1b, GD3, GT1b, GQ1b…)

Anti neuromyelitis optica Abs (NMO)

Anti neuronal Abs: Hu, Ri, Yo, amphiphysin, CV2, Ma1, Ma2

Myasthenia

Lambert Eaton syndrome

Isaac syndrome

Stiffman syndrome

Peripheral neuropathies

Devic disease

Paraneoplasic syndromes

ParathyroidHypoparathyroid Anti parathyroid Abs

Anti calcium sensing receptor Abs (CaSR) Biomnis Ireland

Three Rock RoadSandyford Industrial EstateSandyfordDublin 18Tel.: (01) 295 8545Fax: (01) 295 5399E-mail: sales@biomnis.ieWeb: www.biomnis.ie

Intestine

Description

Auto-antibodies that are underlined are of significant diagnostic valueAuto antibodies written in italics are of low diagnostic valueAll of these tests are performed routinelyAbs = Antibodies

Liver

Stomach

Pancreas

Thyroid

Kidney, lung

Adrenal, OvariesAddison disease

Premature Meno-pause Hypofertility

Goodpasture syndrome

Wegener disease

Microscopic Polyan-giitis extra capillaryglomerulonephritis

Polychondritis

Pemphigus

Bullous pemphigoid

Herpes gestationis

Herpetiform dermatitis

Sub acute cutaneouslupus

Anti cortico-adrenal AbsAnti 21 hydroxylase Abs

Anti testicular AbsAnti ovary Abs

Anti glomerular basement membrane Abs

Anti neutrophil cytoplas-mic Abs – ANCA proteinase 3 - anti-Abs= PR3

Anti neutrophil cytoplasmic Abs – ANCA anti-myeloperoxidase Abs= MPO

Anti collagen type II Abs

Anti intracellular substance Abs = desmosomes Anti desmoglein 1+3 Abs

Anti epidermal basal membrane AbsAnti BP180 Abs

Anti IgG/IgA transglutami-nase AbsAnti endomysium Abs IgA/IgG

Anti SSA Abs

Anti TSH receptor Abs = TSI = LATS = TRAK

Anti thyroperoxydase Abs = TPOAnti thyroglobulin Abs = Tg

Grave’s Disease

HashimotoThyroiditis PrimaryMyxoedema

Anti transglutaminase Abs IgA/IgG Anti endomysium Abs IgA/IgGAnti gliadin Abs IgA/IgG Anti reticulin Abs IgA

Anti saccharomyces cerevisiae Abs IgA/IgG = ASCA

Anti polynuclear neutrophil cytoplasm Abs, type X or pANCA

Coeliac disease = gluten intolerance

Crohn disease

Haemorrhagic rectocolitis

Anti Langerhans cell AbsAnti glutamatedecarboxylase Abs 65 = GAD IIAnti tyrosinephosphatase Abs = IA2

Anti insulin AbsAnti lactoferrine Abs

Insulin dependentdiabetes

Autoimmune Pancreatitis

Anti intrinsic factor AbsAnti parietal cell AbsAnti H+K+ ATPase Abs

Type A Gastritis,Biermer Anemia

Anti mitochondrial type 2 Abs anti-pyruvate dehydrogenase = PDHAnti gp 210 Abs (Nuclear pores)Anti SP100 (nuclear dots)

Anti smooth muscle AbsAnti actin AbsAnti soluble liver Abs antigen = SLA/LP

Anti endoplasmic reticulum Abs = anti liver/kidney microsome Abs = anti LKM type 1 anti-cytochromeP450 II D6Anti cytosol Abs = anti-LC1 Abs

Anti polynuclear neutrophil cytoplasm Abs, type X or pANCA

Primary biliary cirrhosis

Type 1 AutoimmuneHepatitis

Type 2 AutoimmuneHepatitis

Primary sclerosingcholangitis

Cartilage

Systemic disorders

Skin

Disseminated LupusErythematosis (DLE)

Drug induced Lupus

Sjögrensyndrome

Mixed connectivetissue disease

Myositis,anti-synthetase Syndrome

SystemicScleroderma

CREST Syndrome

Antiphospholipidsyndrome

RhumatoidPolyarthritis

Anti nuclear AbsAnti ds DNA AbsAnti nucleosome AbsAnti ENA Abs (Sm, RNP, SSA)Anti ribosomal AbsAnti C1q Abs Circulating immune complexes

Anti nuclear AbsAnti histone AbsAnti ss DNA Abs

Anti nuclear Abs Anti SSA – SSB Abs

Anti nuclear Abs Anti RNP Abs

Anti nuclear AbsAnti Jo1 AbsAnti PL7,PL 12,Ku,Mi2 AbsAnti SRP AbsAnti Pm/Scl Abs

Anti nucleoli AbsAnti Scl70 Abs= topoisomeraseAnti Pm/Scl Abs

Anti centromere Abs

Anti cardiolipin Abs IgG/IgMLupus anticoagulantAnti B2 glycoprotein 1 Abs IgG/IgM Anti phosphatidylethanolamine AbsIgG/IgM Anti phosphatidylserine Abs IgGAnti prothrombine Abs IgGAnti annexin V Abs IgG

Anti rheumatoid factors Abs IgM Anti rheumatoid factor Abs IgA Anti citrullinated peptides AbsAnti keratin Abs

NB : Anti salivary gland Abs are not of diagnostic use

NB : anti microsomes thyroid Abs have been replaced by anti TPO Abs

NB: Anti elastase Abs, cathepsin, lactoferrin, BPI have no diagnostic use