Cover: Blood vessels. Coloured scanningelectron micrograph (SEM) of a resin cast ofblood vessels supplying the small intestine.Susuma Nishinaga/Science Photo Library.

Journal of the British Society ofGastroenterology

Impact Factor: 9.02

EditorProfessor Robin C Spiller (UK)

Deputy EditorMagnus Simren (Sweden)

Associate EditorsRamon Bataller (Spain)Jean-Frederic Colombel (France)Alexander Gerbes (Germany)Subrata Ghosh (UK)William Grady (USA)Ernst Kuipers (The Netherlands)Markus M Lerch (Germany)David Mutimer (UK)Severine Vermeire (Belgium)

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ISSN: 0017-5749 (print)ISSN: 1468-3288 (online)

Disclaimer: Gut is owned and published by BMJPublishing Group Ltd, a wholly owned subsidiary ofthe British Medical Association and the BritishSociety of Gastroenterology. The owners granteditorial freedom to the Editor of Gut. Gut followsguidelines on editorial independence produced bythe World Association of Medical Editors and thecode on good publication practice of the Committeeon Publication Ethics.

Gut is intended for medical professionals and isprovided without warranty, express or implied.Statements in the Journal are the responsibility oftheir authors and advertisers and not authors’institutions, the BMJ Publishing Group, the BritishSociety of Gastroenterology or the BMA unlessotherwise specified or determined by law.Acceptance of advertising does not implyendorsement.

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Leading article873 Chronic viral hepatitis in children: any role for

the pathologist?M Guido, F Bortolotti

Commentaries879 The cytokine interleukin 21: a new player in

coeliac disease?B Meresse, J Verdier, N Cerf-Bensussan

882 TRPV1: a new target for treatment of visceralpain in IBS?P Holzer

884 Vagal mediation of systemic cardiovascularresponse to portal hypertension: fromexperimental studies in animals to treatment ofhumansS Møller

Coeliac disease887 Interleukin 21 contributes to the mucosal T

helper cell type 1 response in coeliac diseaseD Fina, M Sarra, R Caruso, G Del Vecchio Blanco,

F Pallone, T T MacDonald, G Monteleone

Inflammatory bowel disease893 Randomised trial of once- or twice-daily MMX

mesalazine for maintenance of remission inulcerative colitisM A Kamm, G R Lichtenstein, W J Sandborn,

S Schreiber, K Lees, K Barrett, R Joseph

903 Reduced a-defensin expression is associatedwith inflammation and not NOD2 mutationstatus in ileal Crohn’s diseaseL A Simms, J D Doecke, M D Walsh, N Huang,

E V Fowler, G L Radford-Smith

911 Anti-inflammatory role of sympathetic nerves inchronic intestinal inflammationR H Straub, F Grum, U Strauch, S Capellino,

F Bataille, A Bleich, W Falk, J Scholmerich,

F Obermeier

Neurogastroenterology923 Increased capsaicin receptor TRPV1-expressing

sensory fibres in irritable bowel syndrome andtheir correlation with abdominal painA Akbar, Y Yiangou, P Facer, J R F Walters,

P Anand, S Ghosh

Colorectal cancer931 Integrin-linked kinase regulates cell proliferation

and tumour growth in murine colitis-associatedcarcinogenesisK Assi, J Mills, D Owen, C Ong, R St Arnaud,

S Dedhar, B Salh

941 Association between chromosomal instability andprognosis in colorectal cancer: a meta-analysisA Walther, R Houlston, I Tomlinson

Hepatology951 A prospective national study of acute fatty liver

of pregnancy in the UKM Knight, C Nelson-Piercy, J J Kurinczuk,P Spark, P Brocklehurst, on behalf of UK ObstetricSurveillance System (UKOSS)

957 Uncoupling protein-2 (UCP2) inducesmitochondrial proton leak and increasessusceptibility of non-alcoholic steatohepatitis(NASH) liver to ischaemia–reperfusion injuryG Serviddio, F Bellanti, R Tamborra, T Rollo,N Capitanio, A D Romano, J Sastre,G Vendemiale, E Altomare

966 Central neural activation of hyperdynamiccirculation in portal hypertensive rats dependson vagal afferent nervesH Liu, N Schuelert, J J McDougall, S S Lee

JournalScan975 Edited by P Moayyedi

Recent advances in clinical practice976 High-resolution narrow band imaging

endoscopyA Larghi, P G Lecca, G Costamagna

987 A problem-oriented approach to liver disease inoncology patientsG B McDonald, D Frieze

Guidelines1004 Guidelines on the management of common bile

duct stones (CBDS)E J Williams, J Green, I Beckingham, R Parks,D Martin, M Lombard

PostScript1023 Letters

Editor’s quiz877 A not so uncommon cause of abdominal pain

H Fellows, H Dalton, I Murray, G Maskell

878 A rare cause of obscure gastrointestinalbleedingW-L Wang, J-Y Lee, J-T Lin, K-L Liu, H-P Wang

This article has been chosen by the Editor to be of specialistinterest or importance and is freely available online.

Articles carrying the Unlocked Logo are freely available onlineunder the BMJ Journals unlocked scheme.See http://gut.bmj.com/info/unlocked.dtl

This journal is a member of and subscribes to the principles of theCommittee on Publication Ethicswww.publicationethics.org.uk

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902 An unexpected cause of chronic diarrhoeaC-M Tai, C-H Tu, H-B Wu, D-S Perng, T-C Lee,C-T Shun, H-P Wang

922 Hypoalbuminaemia and coeliac diseaseV Tan, D Stella, H Frydenberg, C Mow,S Nandurkar, P R Gibson

973 A rare complication of a metal stentZ Liao, Z-S Li

974 Unusual angiographic findings of lowergastrointestinal bleedingB-B Chen, C-W Lee, Y-M Tsang, K-L Liu,H-P Wang

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