CONTRIBUTORS

Masao Akimoto Nippon Medical School Tokyo 113-8602, Japan

Waddah Alrefai Dept. of Medicine Rush Medical College Chicago,IL 60612

Ken M. Anderson Dept. of Medicine and Biochemistry Rush Medical College Chicago,IL 60612

Colin Anderson Dept. of Philosophy Loyola University Chicago, IL. 60626

Julie Angerman-Stewart National Institute of Environmental Health Sciences Eicosanoid Biochemistry Section Laboratory of Molecular Carcinogenesis Research Triangle Park, NC 27709

Monica Anton Institute of Biochemistry University Clinics Charite, Humboldt­University Hessiche Str. 3-4, D-I0115 Berlin, F.R. Germany

Kelley M. Argraves Dept. of Biochemistry and Molecular Biology Medical University of South Carolina Div. of General Internal Medicine Ralph H. Johnson Veterans Administration Hospital Charleston, SC 29425

Jonathan P. Arm Dept. of Medicine, Harvard Medical School Div. of Rheumatology, Immunology and Allergy and Partners' Asthma Center Brigham and Women's Hospital Boston, MA 02115

Sandra C. Austin The Center for Experimental Therapeutics University of Pennsylvania Philadelphia, PA 19104

Magnus Back Experimental Asthma and Allergy Research The National Institute of Environmental Medicine Karolinska Institutet SE-171 77 Stockholm, Sweden

Kamal F. Badr Center for Glomerulonephritis Emory University School of Medicine Atlanta, GA

Mostafa Badr Div. of Pharmacology University of Missouri-Kansas City Kansas City, MO 64108, USA

John A. Badwey Center for Experimental Therapeutics and Reperfusion Injury Dept. of Anesthesia Brigham and Women's Hospital and The Harvard Medical School Boston, MA 02115

Leslie R. Ballou Dept. of Veteran Affairs Medical Center Depts. of Medicine and Biochemistry The University of Tennessee Memphis, TN 38104

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Christianne Bandeira-Melo Dept. of Physiology and Pharmacodynarrrics Oswaldo Cruz Institute FIOCRUZ, Rio de Janeiro, Brazil 21045-900

Pierre Beaulieu Pain Research Group Dept. of Anesthetics Imperial College School of Medicine St. Mary's Hospital campus Praed Street, London W21NY, United Kingdom

Timothy D. Bigby Dept. of Veteran Affairs Medical Center,San Diego Dept. of Medicine, University of California San Diego, CA 92161

MacKenzie Hilfers Bilunas Dept. of Pathology The University of Iowa 1046 Medical Laboratories Iowa City, IA 52242

Tiziana Bisogno Endocannabinoid Research Group Istituto per la Chimica di Molecole di Interesse Biologico Via Toiano 6, 80072 Arco Felice, NA, Italy

Elizabeth D. Blume Dept. of Cardiology, Children's Hospital and Harvard Medical School Boston, MA 02115

William E. Boeglin Department of Pharmacology Vanderbilt University School of Medicine Nashville, TN 37232

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Judy Bondar Dept. of Neurosurgery Cleveland Clinic Foundation 9500 Euclid AvenueINB2-120A Cleveland, OH 44195

Patty L. Bonney Dept. of Veterinary Clinical Sciences School of Veterinary Medicine Purdue University West Lafayette,lN 47907

Philip Bonomi Depts. of Medicine Rush Medical College Chicago, IL 60612

Joseph V. Bonventre Dept. of Medicine Harvard Med. School, Boston, MA 02115 Dept. of Medical Services Mass General Hospital, Boston, MA 02114 Harvard-Massachusetts Institute of Technology Div. of Health Services Boston, MA 02115

Christine L. Borscheid Dept. of Chemistry Concordia University St. Paul, MN 55104

Patricia T. Bozza Dept. of Physiology and Pharmacodynarrrics Oswaldo Cruz Institute FIOCRUZ, Rio de Janeiro, Brazil 21045-900

Hugh R. Brady Center for Molecular Inflammation and Vascular Research Dept. of Medicine and Therapeutics Mater Misericordiae Hospital The Conway Institute of Biomolecular and Biomedical Research University College of Dublin, Ireland

Alan R. Brash Department of Pharmacology Vanderbilt University School of Medicine Nashville, TN 37232

Richard M. Breyer Depts. of Medicine (Div. of Nephrology), and Pharmacology Vanderbilt University S 3223 MCN 1161 21st. Avenue South Nashville, TN. 37232-2372, USA

Matthew D. Breyer Depts. of Medicine (Div. of Nephrology), Molecular Physiology and Biophysics Veterans Administration Medical Center Vanderbilt University S 3223 MCN 1161 21st. Avenue South Nashville, TN. 37232-2372, USA

Charles Brink CNRS ESA 8078 Centre Chirurgical Marie Lannelongue 133 av de la Resistance 92350 Le Plessis Robinson, France

Thomas G. Brock Div. of Pulmonary and Critical Care Medicine Dep. of Internal Medicine University of Michigan Ann Arbor, MI 48109-0642, USA

Joanne R. Brown Dept. of Experimental Pathology Div. of Pharmacology St. Bartholomew's and the Royal London School of Medicine Charterhouse Square London, ECIM 6BQ

Robert M. Burk Depart. of Chemistry Allergan Inc. 2525 Dupont Drive Irvine, CA 92623-9543

Denis M. Callewaert Oxford Biomedical Research P.O.Box 522, Oxford MI. USA 48371 and Dept. of Chemistry, Oakland University, Rochester, MI, USA 48309

William B. Cambell Dept. of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, USA 75235

German Camejo Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital S-413 45 Goteborg, Sweden AstraZeneca R&D Molndal S-413 83 Molndal, Sweden

William B. Campbell Dept. of Pharmacology and Toxicology Medical College of Wisconsin Milwaukee, WI 53226

Jeff Carter Monsanto/Searle Discovery Research Chesterfield, Missouri 63198

Ming F. Chan Depart. of Chemistry Allergan Inc. 2525 Dupont Drive Irvine, CA 92623-9543

Lan-Ying Chen Dept. of Biochemistry Cardiovascular Institute Beijing 100037, China

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June Chen Depart. of Biology Allergan Inc. 2525 Dupont Drive Irvine, CA 92623-9543

Min Chen Dept. of Surgery University of Michigan F3970 Mott Hospital Ann Arbor, MI 48109-0245

Nan Chiang Center for Experimental Therapeutics and Reperfusion Injury Dept. of Anesthesia, Brigham and Women's Hospital Harvard Medical School Boston, MA, USA 02115

Quamrul G. Choudhury Dept. of Biochemical Pharmacology The William Harvery Research Institute St. Bartholomew's and the Royal London School of Medicine and Dentistry (Queen Mary and Westfield College) Charterhouse Square London, ECIM 6BQ

Joan Cia ria Hospital Linic-Institut d'lnvestigacions Biomediques August Pi I Sunyer Barcelona 08036, Spain

Cynthia Cohen Dept. of Pathology Emory University Atlanta, GA

Sean P. Colgan Center for Experimental Therapeutics and Reperfusion Injury Brigham and Women's Hospital Boston, MA 02115

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Renato S.B. Cordeiro Dept. of Physiology and Pharmacodynamics Oswaldo Cruz Institute FIOCRUZ, Rio de Janeiro, Brazil 21045-900

Cyndy Corp ron Dept. of Surgery University of Michigan F3970 Mott Hospital Ann Arbor, MI 48109-0245

Bruce N. Cronstein Division of Rheumatology Dept. of Medicine NYU School of Medicine New York, NY 10016

Lisa Crossley Center for Experimental Therapeutics and Reperfusion Injury Dept. of Anesthesia Brigham and Women's Hospital and The Harvard Medical School Boston, MA 02115

Jamie D. Croxtall Dept. of Biochemical Pharmacology The William Harvery Research Institute St. Bartholomew's and the Royal London School of Medicine and Dentistry (Queen Mary and Westfield College) Charterhouse Square London, ECIM 6BQ

Maria Dadaian Dept. of Woman and Child Health Div. of Reproductive Endocrinology Karolinska Hospital, Bldg. L5,S-171 76 Stockholm, Sweden

Kamal Dadr Renal Division, Emory University and Center of Glomerulonephritis Veterans Affairs Medical Center Atlanta, GA 30322

Sven-Erik Dahlen Experimental Asthma and Allergy Research The National Institute of Environmental Medicine Karolinska Institutet SE-171 77 Stockholm, Sweden

Alan Davis Dept. of Surgery Michigan State University Grand Rapids, MI 49503, USA

Biswanath De Procter and Gamble Pharmaceuticals 8700 Mason-Montgomery Rd. Mason, Ohio 45040-9317

Luciano De Petrocellis Endocannabinoid Research Group Istituto per la Chimica di Molecole di Interesse Biologico Via Toiano 6, 80072 Arco Felice, NA, Italy

Amalia E. DeGortari Dept. of Veterinary Clinical Sciences School of Veterinary Medicine Purdue University West Lafayette, IN 47907

Mitchell Anthony de Long Procter and Gamble Pharmaceuticals 8700 Mason-Montgomery Rd. Mason, Ohio 45040-9317

Dennis B. DeNicola Dept. of Veterinary Pathobiology School of Veterinary Medicine Purdue University West Lafayette, IN 47907

Vincenzo Di Marzo Endocannabinoid Research Group Istituto per la Chimica di Molecole di Interesse Biologico Via Toiano 6, 80072 Arco Felice, NA, Italy

Bruno L. Diaz Dept. of Physiology and Pharmacodynamics Oswaldo Cruz Institute FIOCRUZ, Rio de Janeiro, Brazil 21045-900

Bruno L. Diaz Dept. of Medicine, Harvard Medical School Boston, MA 02115 Div. of Rheumatology, Immunology and Allergy Brigham and Women's Hospital Boston, MA 02115

Peter Dieter Institute of Physiological Chemistry Technical University of Dresden Karl-Marx-Strasse 3 D-OII09 Dresden, Germany

Michelle Jeanine Dirr Procter and Gamble Pharmaceuticals 8700 Mason-Montgomery Rd. Mason, Ohio 45040-9317

Jeffrey M. Drazen Combined program in Pulmonary and Critical care Medicine Dept. of Medicine Brigham and Women's Hospital and Harvard Medical School 75 Francis Street Boston, MA 02115

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Thomas E. Eling Laboratory of Molecular Carconogenesis National Institute of Environmental Health Sciences (NIH) Research Triangle Park, North Carolina 27709

Charles Mark Ensor Division of Pharmaceutical Sciences College of Pharmacy, University of Kentucky Lexington, KY 40536-0082

Pablo V. Escriba Dept. of Biology University of the Balearic Islands Cra. Valldemossa km 7,5 E-07071 Palma de Mallorca, Spain

John R. Falck Dept. of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, USA 75235

Janos G. Filep Research Center, Maisonneuve-Rosemont Hospital Dept. of Medicine, University of Montreal Montreal, Quebec, Canada HI T 2M4

Garret A. FitzGerald The Center for Experimental Therapeutics University of Pennsylvania Philadelphia, P A 19104

Roderick J. Flower Dept. of Biochemical Pharmacology The William Harvery Research Institute St. Bartholomew's and the Royal London School of Medicine and Dentistry (Queen Mary and Westfield College) Charterhouse Square London, ECIM 6BQ

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Yutaka Fujii Fukui Medical School 23-3 Shimoaizuki, Matsuoka, Yoshida Fukui 910-1103, Japan

Hiroshi Fujishima Dept. of Medicine, Harvard Medical School Div. of Rheumatology, Immunology and Allergy Brigham and Women's Hospital Boston, MA 02115

Colin D. Funk Center for Experimental Therapeutics Rm 820 BRB IIIIII University of Pennsylvania Philadelphia, P A 19104

Jean-Pierre Gascard CNRS ESA 8078 Centre Chirurgical Marie Lannelongue 133 av de la Resistance 92350 Le Plessis Robinson, France

Joan Gaya Hospital Linic-Institut d'lnvestigacions Biomediques August Pi I Sunyer Barcelona 08036, Spain

Andrew T. Gewirtz Epithelial Pathobiology Research Unit Dept. of Pathology and Laboratory Medicine Emory University School of Medicine Atlanta, GA 30322

Jagadananda Ghosh University of Virginia Cancer Center Charlottesville, Virginia 22908

James Gierse Monsanto/Searle Discovery Research Chesterfield, Missouri 63198

Katherine Gikas Oxford Biomedical Research P.O.Box 522, Oxford, MI USA 48371

Wayne C. Glasgow Div. of Basic Medical Sciences Mercer University School of Medicine Macon, GA 31207

Christopher K. Glass Div. of Cellular and Molecular Medicine University of California at San Diego La Jolla, CA 92093-0651

Honor L. Glenn Department of Biochemistry and Molecular Biology University of Massachusetts Amherst, MA 01003

Nita W. Glickman Office of Research Programs School of Veterinary Medicine Purdue University West Lafayette, IN 47907

Catherine Godson Center for Molecular Inflammation and Vascular Research Dept. of Medicine and Therapeutics Mater Misericordiae Hospital The Conway Institute of Biomolecular and Biomedical Research University College of Dublin, Ireland

Mladen Golubic Dept. of Neurosurgery Cleveland Clinic Foundation 9500 Euclid AvenuelNB2-120A Cleveland, OH 44195

Sravan Kumar Goparaju Dept. of Biochemistry Tokushima University School of Medicine Tokushima 770-8503, Japan

Sylvie Gravel Meakins-Christie Laboratories Dept. of Medicine, McGill University 3626 St. Urbain Street Montreal, Quebec, Canada, H2X 2P2

Youfei Guan Depts. of Medicine (Div. of Nephrology) Vanderbilt University S 3223 MCN 1161 21st. Avenue South Nashville, TN. 37232-2372, USA

Mohamed Hachicha Center for Experimental Therapeutics and Reperfusion Injury Brigham and Women's Hospital and Harvard Medical School Boston, MA 02115

Tove Hammarberg Dept. of Medical Biochemistry and Biophysics Karolinska Insitutet S-171 77 Stockholm, Sweden

Sven Hammarstrom Div. of Cell Biology Linkoping University S-581 85 Linkoping, Sweden

Yusuf A. Hannun Dept. of Biochemistry and Molecular Biology Medical University of South Carolina 173 Ashley Ave., P.O.Box 250509 Charleston, SC 29425

Shuntaro Hara Kitasato University School of Pharmaceutical Sciences Tokyo 108-8641, Japan

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Shuntaro Hara Dept. of Pharmacology National Cardiovascular Center Research Institute Suita, Osaka 565-8565, Japan

Carroll M. Harmon Dept. of Surgery U ni versity of Michigan F3970 Mott Hospital Ann Arbor, MI 48109-0245

Jules Harris Depts. of Medicine Rush Medical College Chicago, IL 60612

Sarah G. Harris Cancer Center Dept. of Microbiology and Immunology University of Rochester School of Medicine and Dentistry 601 Elmwood Avenue Rochester, NY 14642

Jyoti A. Harwalkar Dept. of Neurosurgery Cleveland Clinic Foundation 9500 Euclid AvenueINB2-120A Cleveland, OH 44195

Y oshitaka Hashimoto Nippon Medical School Tokyo 113-8602, Japan

Toshihisa Hatae Dept. of Pharmacology National Cardiovascular Center Research Institute Suita, Osaka 565-8565, Japan

Craig R. Hodulik Dept. of Veteran Affairs Medical Center,San Diego Dept. of Medicine, University of California San Diego, CA 92161

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Bill Hood Monsanto/Searle Discovery Research Chesterfield, Missouri 63198

Linda H. Hsi National Institute of Environmental Health Sciences Eicosanoid Biochemistry Section Laboratory of Molecular Carcinogenesis Research Triangle Park, NC 27709

RiYun Huang Arthritis Unit Massachusetts General Hospital Boston, MA 02114

Rutai Hui Laboratory of Molecular Carconogenesis National Institute of Environmental Health Sciences (NIH) Research Triangle Park, North Carolina 27709

Eva Hurt-Camejo Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital S-413 45 Goteborg, Sweden

Daniel Hwang Pennington Biomedical Research Center Louisiana State University Baton Rouge, LA 70808

Nobumasa Imura Kitasato University School of Pharmaceutical Sciences Tokyo 108-8641, Japan

Hiroyasu Inoue Dept. of Pharmacology National Cardiovascular Center Research Institute Suita, Osaka 565-0873, Japan

Peter Isakson Monsanto/Searle Discovery Research Chesterfield, Missouri 63198

Kazunori Ishimura Dept. of Anatomy and Cell Biology School of Medicine, The University of Tokushima 3-18-15 Kuramoto Tokushima 770-8503, Japan

Bruce S. Jacobson Department of Biochemistry and Molecular Biology University of Massachusetts Amherst, MA 01003

Per-Johan Jakobsson Dept. of Medical Biochemistry and Biophysics Karolinska Institutet S-171 77 Stockholm, Sweden

Peter J. Jose Leukocyte Biology, BMS Division Imperial College School of Medicine Lonodon, UK

Andre Kajdacsy-Balla Dept. of Pathology Medical College of Wisconsin Milwaukee, WI 53226

Terumi Kambe-Ohkura Dept. of Health Chemistry School of Pharmaceutical Sciences Showa University 1-5-8 Hatanodai, Shinagawa-ku Tokyo 142-8555, Japan

Hideto Kameda Laboratory of Molecular Carconogenesis National Institute of Environmental Health Sciences (NIH) Research Triangle Park, North Carolina 27709

Sabine Kamionka Institute of Physiological Chemistry Technical University of Dresden Karl-Marx-Strasse 3 D-OII09 Dresden, Germany

Kazuo Kanai Dept. of Chemistry and Biochemistry, University of Delaware, Newark, DE, USA 19716

Mustapha Kandouz Department of Radiation Oncology Wayne State University Detroit, MI 48202

Kazuhisa Katayama Dept. of Cardiovascular Surgery Tokushima University School of Medicine Tokushima 770-8503, Japan

Sushma Kaul Dept. of Pathology Medical College of Wisconsin Milwaukee, WI 53226

Toshihiko Kawamori Cancer Prevention Division National Cancer Center Research Institute 1-1 Tsukiji 5-chrome, Chuo-ku Tokyo 104-0045, Japan

Uddhav Kelavkar Renal Division, Emory University and Center of Glomerulonephritis Veterans Affairs Medical Center Atlanta, GA 30322

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Cristopher R. J. Kennedy Depts. of Medicine (Div. of Nephrology) Vanderbilt University S 3223 MCN 1161 21st. Avenue South Nashville, TN. 37232-2372, USA

Jim Kiefer Monsanto/Searle Discovery Research Chesterfield, Missouri 63198

Cheryl K. Kim University of Detroit Mercy Detroit, MI 48219

Hyesook Kim Wayne State University Detroit, MI 48201

Go Kimura Nippon Medical School Tokyo 113-8602, Japan

Takahiro Kinoshita Dept. of Surgery Kanazawa University School of Medicine Kanazawa 920-8640, Japan

Klara Kitajka Dept. of Biology University of the Balearic Islands Cra. Valldemossa km 7,5 E-07071 Palma de Mallorca, Spain

Deborah W. Knapp Dept. of Veterinary Clinical Sciences School of Veterinary Medicine Purdue University West Lafayette, IN 47907

Takuya Kobayashi Dept. of Pharmacology Kyoto University Faculty of Medicine Kyoto, Japan

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Carol Koboldt Monsanto/Searle Discovery Research Chesterfield, Missouri 63198

Angelika Kolada Institute of Physiological Chemistry Technical University of Dresden Karl-Marx-Strasse 3 D-OII09 Dresden, Germany

Yukihiro Kondo Nippon Medical School Tokyo 113-8602, Japan

Achim H.P. Krauss Depart. of Biology Allergan Inc. 2525 Dupont Drive Irvine, CA 92623-9543

Ichiro Kudo Dept. of Health Chemistry School of Pharmaceutical Sciences Showa University 1-5-8 Hatanodai, Shinagawa-ku Tokyo 142-8555, Japan

Hartmut Kuhn Institute of Biochemistry University Clinics Charite, Humboldt­University Hessiche Str. 3-4, D-10115 Berlin, F.R. Germany

Yuko Kurahashi Dept. of Biochemistry Tokushima University School of Medicine Tokushima 770-8503, Japan

Kayoko Kurihara Dept. of Neurovirology, Research Institute for Microbial Diseases Osaka University, Yamadaoka Suita 565-0871,Japan

Ravi Kurumbail Monsanto/Searle Discovery Research Chesterfield, Missouri 63198

Hiroshi Kuwata Dept. of Health Chemistry School of Pharmaceutical Sciences Showa University 1-5-8 Hatanodai, Shinagawa-ku Tokyo 142-8555, Japan

Step~anos Kyrkanides Dept. of Neurobiology and Anatomy Eastman Dept. of Dentistry University of Rochester School of Medicine and Dentistry Rochester, NY 14642

Edward F. LaBelle Dept. of Pharmacology and Physiology MCP Hahnemann University 2900 Queen lane Philadelphia, P A 19129

Karen M. Lakkides Dept. of Biochemistry Michigan State University East Lansing, MI 48824

David Lappin Center for Molecular Inflammation and Vascular Research Dept. of Medicine and Therapeutics Mater Misericordiae Hospital The Conway Institute of Biomolecular and Biomedical Research University College of Dublin, Ireland

John A. Lawson Center for Experimental Therapeutics University of Pennsylvania Philadelphia, PA 19104

Joo Y. Lee Pennington Biomedical Research Center Louisiana State University Baton Rouge, LA 70808

Joung H. Lee Dept. of Neurosurgery Cleveland Clinic Foundation 9500 Euclid AvenuelNB2-120A Cleveland, OH 44195

Hongwei Li Center for Experimental Therapeutics Rm 820 BRB IIIIIT University of Pennsylvania Philadelphia, PA 19104

Jian P. Lina Center for Experimental Therapeutics and Reperfusion Injury Dept. of Anesthesia Brigham and Women's Hospital and The Harvard Medical School Boston, MA 02115

Paul F. Lindholm Dept. of Pathology Medical College of Wisconsin Milwaukee, WI 53226

Mark Walden Lundy Procter and Gamble Pharmaceuticals 8700 Mason-Montgomery Rd. Mason, Ohio 45040-9317

James L. Madara Epithelial Pathobiology Research Unit Dept. of Pathology and Laboratory Medicine Emory University School of Medicine Atlanta, GA 30322

Larry Marnett Vanderbilt University School of Medicine Dept. of Biochemistry Nashville, TN 37232

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Esther Martinez Dept. of Biology University of the Balearic Islands Cra. Valldemossa km 7,5 E-07071 Palma de Mallorca, Spain

Marco A. Martins Dept. of Physiology and Pharmacodynamics Oswaldo Cruz Institute FIOCRUZ, Rio de Janeiro, Brazil 21045-900

Ichiro Matsuzawa Nippon Medical School Tokyo 113-8602, Japan

Maeve McDonnell Center for Experimental Therapeutics Rm 820 BRB II/III University of Pennsylvania Philadelphia, PA 19104

Michael F. McEntee Dept. of Pathology, College of Veterinary Medicine University of Tennessee Knoxville, TN 37996-1900

Diane T. Mckay Dept. of Biochemical Pharmacology The William Harvery Research Institute St. Bartholomew's and the Royal London School of Medicine and Dentistry (Queen Mary and Westfield College) Charterhouse Square London, ECIM 6BQ

Peter McNamara Center for Experimental Therapeutics University of Pennsylvania Philadelphia, PA 19104

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Dominique Melck Endocannabinoid Research Group Istituto per la Chimica di Molecole di Interesse Biologico Via Toiano 6, 80072 Arco Felice, NA, Italy

Glen Edward Mieling Procter and Gamble Pharmaceuticals 8700 Mason-Montgomery Rd. Mason, Ohio 45040-9317

Antonio Miralles Dept. of Biology University of the Balearic Islands Cra. Valldemossa km 7,5 E-07071 Palma de Mallorca, Spain

Siobhan Mitchell Center for Molecular Inflammation and Vascular Research Dept. of Medicine and Therapeutics Mater Misericordiae Hospital The Conway Institute of Biomolecular and Biomedical Research University College of Dublin, Ireland

Masashi Miyano Central Pharmaceutical Research Institute Japan Tobacco Inc. 1-1 Murasaki, Takatsuki Osaka 569-1125, Japan

Sulma I. Mohammed Dept. of Veterinary Clinical Sciences School of Veterinary Medicine Purdue University West Lafayette, IN 47907

Joe Monahan Monsanto/Searle Discovery Research Chesterfield, Missouri 63198

Angel Montero Center for Glomerulonephritis Emory University School of Medicine Atlanta, GA

M. Carmen Montesinos Division of Rheumatology Dept. of Medicine NYU School of Medicine New York, NY 10016

Thomas J. Montine Department of Pathology Vanderbilt University School of Medicine Nashville, Tennessee 37232-6602

Steven A. Moore Dept. of Pathology The University of Iowa 1046 Medical Laboratories Iowa City, IA 52242

Kirby Moreland Monsanto/Searle Discovery Research Chesterfield, Missouri 63198

Ralf Morgenstern Dept. of Medical Biochemistry and Biophysics Karolinska Institutet S-171 77 Stockholm, Sweden

Jason D. Morrow Department of Medicine Vanderbilt University School of Medicine Nashville, Tennessee 37232-6602

Karen A. Munger Center for Glomerulonephritis Emory University School of Medicine Atlanta, GA

Makoto Murakami Dept. of Health Chemistry School of Pharmaceutical Sciences Showa University 1-5-8 Hatanodai, Shinagawa-ku Tokyo 142-8555, Japan

Charles E. Myers University of Virginia Cancer Center Charlottesville, Virginia 22908

Yoshihito Nakatani Dept. of Health Chemistry School of Pharmaceutical Sciences Showa University 1-5-8 Hatanodai, Shinagawa-ku Tokyo 142-8555, Japan

Seiichi Nakatsugi Cancer Prevention Division National Cancer Center Research Institute 1-1 Tsukiji 5-chrome, Chuo-ku Tokyo 104-0045, Japan

Sailaja Narravula Center for Experimental Therapeutics and Reperfusion Injury Brigham and Women's Hospital Boston, MA 02115

Shuh Narumiya Dept. of Pharmacology Kyoto University Faculty of Medicine Kyoto, Japan

Andrew S. Neish Epithelial Pathobiology Research Unit Dept. of Pathology and Laboratory Medicine Emory University School of Medicine Atlanta, GA 30322

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Takehiko Nishisho Clinical Research Institute National Zentsuji Hospital Zentsuji, Kagawa 765-0001

Kasem Nithipatikom Dept. of Pharmacology and Toxicology Medical College of Wisconsin Milwaukee, WI, USA 53226

Xavier Norel CNRS ESA 8078 Centre Chirurgical Marie Lannelongue 133 av de la Resistance 92350 Le Plessis Robinson, France

M. Kerry O'Banion Dept. of Neurology, Neurobiology and Anatomy University of Rochester School of Medicine and Dentistry Rochester, NY 14642

Lina M. Obeid Dept. of Medicine Medical University of South Carolina Div. of General Internal Medicine Ralph H. Johnson Veterans Administration Hospital Charleston, SC 29425

T.M. Oberyszyn The Ohio State University Dept. of Molecular Virology, Immunology and Medical Genetics 2058 Graves Hall, 333 W. 10th Ave. ColumbUS, OH 43210

Mark G. Obukowicz Discovery Pharmacology G.D.Searle, c/o Monsanto Company St. Louis, MO 63167

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John F. Ohd Dept. of Laboratory Medicine, Div. of Experimental Pathology Lund University, Malmo General Hospital Entrance 78, Malmo SE-205 02, Sweden

Susumu Ohkawara Dept. of Pharmacology National Cardiovascular Center Research Institute Suita, Osaka 565-8565, Japan

Yasukazu Ohmoto Cellular Technology Institute Otsuka Pharmaceutical Co., Ltd. Tokushima 771-0192, Japan

Toshihisa Ohta Cancer Prevention Division National Cancer Center Research Institute 1-1 Tsukiji 5-chrome, Chuo-ku Tokyo 104-0045, Japan

John A. Olschowka Dept. of Neurobiology and Anatomy University of Rochester School of Medicine and Dentistry Rochester, NY 14642

Jihye Paik Pennington Biomedical Research Center Louisiana State University Baton Rouge, LA 70808

Y ong Seok· Park Dept. of Neurosurgery Cleveland Clinic Foundation 9500 Euclid AvenueINB2-120A Cleveland, OH 44195

M.L. Parrett The Ohio State University Dept. of Molecular Virology, Immunology and Medical Genetics 2058 Graves Hall, 333 W. 10th Ave. Columbus, OH 43210

Jennifer Pawlitz Monsanto/Searle Discovery Research Chesterfield, Missouri 63198

Bengt Persson Dept. of Medical Biochemistry and Biophysics Karolinska Insitutet S-171 77 Stockholm, Sweden

Nicos A. Petasis Dept. of Chemistry University of Southern California Los Angeles, CA 90089

Melissa B. Hansen Petrik Dept. of Nutrition 229 Jessie Harris Building Knoxville, TN 37996-1900

Richard P. Phipps Cancer Center Dept. of Microbiology and Immunology University of Rochester School of Medicine and Dentistry 601 Elmwood Avenue Rochester, NY 14642

Jennifer Pierce Monsanto/Searle Discovery Research Chesterfield, Missouri 63198

Cyril Pilane Dept. of Pharmacology and Physiology MCP Hahnemann University 2900 Queen lane Philadelphia, PA 19129

Michael Pillinger Division of Rheumatology Dept. of Medicine NYU School of Medicine New York, NY 10016

William S. Powell Meakins-Christie Laboratories Dept. of Medicine, McGill University 3626 St. Urbain Street Montreal, Quebec, Canada, H2X 2P2

Charles E. Protz mann Depart. of Biology Allergan Inc. 2525 Dupont Drive Irvine, CA 92623-9543

Gloria Pueyo Quimica Farmaceutica Bayer S.A. Barcelona 08036, Spain

Erica Pych Dept. of Surgery University of Michigan F3970 Mott Hospital Ann Arbor, MI 48109-0245

Kristin B. Pytynia Dept. of Otolaryngology and Communication Sciences Medical College of Wisconsin Milwaukee, WI 53226

Olof Radmark Dept. of Medical Biochemistry and Biophysics Karolinska Insitutet S-171 77 Stockholm, Sweden

Malia Reddy Dept. of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX, USA 75235

Konda Veera Reddy Dept. of Medical Biochemistry and Biophysics Karolinska Insitutet S-171 77 Stockholm, Sweden

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Erin E. Reich Department of Pharmacology Vanderbilt University School of Medicine Nashville, Tennessee 37232-6602

Andrew S.C. Rice Pain Research Group Dept. of Anesthetics Imperial College School of Medicine St. Mary's Hospital campus Praed Street, London W21NY, United Kingdom

Louis A. Roberts Department of Biochemistry and Molecular Biology University of Massachusetts Amherst, MA 01003

L. Jackson Roberts II Department of Medicine and Pharmacology Vanderbilt University School of Medicine Nashville, Tennessee 37232-6602

Elizabeth S. Roberts-Kirchhoff Detroit R&D Inc. Detroit, MI 48201

F.M. Robertson The Ohio State University Dept. of Molecular Virology, Immunology and Medical Genetics 2058 Graves Hall, 333 W. 10th Ave. Columbus, OH 43210

Dwight Robinson Arthritis Unit Massachusetts General Hospital Boston, MA 02114

Joshua Rokach Claude Pepper Institute and Dept. of Chemistry Florida Institute of Technology Melbourne, FL 32901

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Mario Romano Insituto di Patologia Medica e Medicina Mediterranea Universita di Messina, Italia

M.S. Ross The Ohio State University Dept. of Molecular Virology, Immunology and Medical Genetics 2058 Graves Hall, 333 W. 10th Ave. Columbus, OH 43210

Scott Rowlinson Vanderbilt University School of Medicine Dept. of Biochemistry Nashville, TN 37232

Hasan Safayhi Institute of Pharmaceutical Sciences Dept. of Pharmacology D-72076 Tuebingen, Germany

Toshiki Sakashita Dept. of Medicine Kanazawa University School of Medicine Kanazawa 920-8640, Japan

Bengt Samuels son Dept. of Medical Biochemistry and Biophysics Karolinska Institutet S-171 77 Stockholm, Sweden

Adam Sapirstein Dept. of Anesthesia and Critical Care Harvard Medcial School, Boston, MA 02115 Dept. of Anesthesia Services Massachusetts General Hospital, Boston, MA 02114

Sailesh Sarapureddi Div. of Cell Biology Linkoping University S-581 85 Linkoping, Sweden

Diane M. Sasaki Oxford Biomedical Research P.O.Box 522, Oxford, MI USA 48371

Peter Satirpy Wallenberg Laboratory for Cardiovascular Research, Sahlgrenska University Hospital S-413 45 Goteborg, Sweden

Roland Scheibe Institute of Physiological Chemistry Technical University of Dresden Karl-Marx-Strasse 3 D-OII09 Dresden, Germany

Claus Schneider Department of Pharmacology Vanderbilt University School of Medicine Nashville, TN 37232

Kristin Schwarz Institute of Biochemistry University Clinics Charite, Humboldt­University Hessiche Str. 3-4, D-I0115 Berlin, F.R. Germany

Mike P. Seed Dept. of Experimental Pathology Div. of Pharmacology St. Bartholomew's and the Royal London School of Medicine Charterhouse Square London, ECIM 6BQ

Karen Seibert Monsanto/Searle Discovery Research Chesterfield, Missouri 63198

Charles N. Serhan Center for Experimental Therapeutics and Reperfusion Injury Dept. of Anesthesia, Brigham and Women's Hospital Harvard Medical School Boston, MA, USA 02115

Kenneth J. Serio Dept. of Veteran Affairs Medical Center,San Diego Dept. of Medicine, University of California San Diego, CA 92161

Manabu Shimonishi Dept. of Pharmacology National Cardiovascular Center Research Institute Suita, Osaka 565-8565, Japan

Anita Sjolander Dept. of Laboratory Medicine, Div. of Experimental Pathology Lund University, University Hospital Malmo Malmo-S 205 02, Sweden

William L. Smith Dept. of Biochemistry Michigan State University East Lansing, MI 48824

Emer M. Smyth The Center for Experimental Therapeutics University of Pennsylvania Philadelphia, PA 19104

Mats Soderstrom Div. of Cell Biology Linkoping University S-581 85 Linkoping, Sweden

Michelle Elaine Soehner Procter and Gamble Pharmaceuticals 8700 Mason-Montgomery Rd. Mason, Ohio 45040-9317

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David Lindsey Soper Procter and Gamble Pharmaceuticals 8700 Mason-Montgomery Rd. Mason, Ohio 45040-9317

Rick Stegeman Monsanto/Searle Discovery Research Chesterfield, Missouri 63198

Catherine Stenson Center for Molecular Inflammation and Vascular Research Dept. of Medicine and Therapeutics Mater Misericordiae Hospital The Conway Institute of Biomolecular and Biomedical Research University College of Dublin, Ireland

Anna Stevens Monsanto/Searle Discovery Research Chesterfield, Missouri 63198

Takashi Sugimura Cancer Prevention Division National Cancer Center Research Institute 1-1 Tsukiji 5-chrome, Chuo-ku Tokyo 104-0045, Japan

Sachiyo Sunaga Dept. of Health Chemistry School of Pharmaceutical Sciences Showa University 1-5-8 Hatanodai, Shinagawa-ku Tokyo 142-8555, Japan

Hiroshi Suzuki Dept. of Biochemistry Tokushima University School of Medicine Tokushima 770-8503, Japan

616

Toshiko Suzuki Dept. of Anatomy and Cell Biology, School of Medicine The University of Tokushima, Kuramoto­cho Tokushima 770-8503, Japan

Lennart Svensson AstraZeneca R&D Molndal S-413 83 Molndal, Sweden

Larry L. Swift Dept. of Medicine, Pharmacology and Pathology Vanderbilt University Nashville, TN 37232, USA

Kristin Synnestvedt Center for Experimental Therapeutics and Reperfusion Injury Brigham and Women's Hospital Boston, MA 02115

Douglas Taber Dept. of Chemistry and Biochemistry, University of Delaware, Newark, DE, USA 19716

Hsin-Hsiung Tai Division of Pharmaceutical Sciences College of Pharmacy, University of Kentucky Lexington, KY 40536-0082

Tomohiro Takahashi Bioscience Research Laboratory Mochida Pharmaceutical Co. 1-1-1 Kamiya, Kita Tokyo 115-0043, Japan

Y oshitaka Takahashi Dept. of Pharmacology Kanazawa University School of Medicine Kanazawa 920-8640, Japan

Yutaka Taketani Dept. of Biochemistry Tokushima University School of Medicine Kuramoto-cho Tokushima 770-8503

John Talley Monsanto/Searle Discovery Research Chesterfield, Missouri 63198

Tadashi Tanabe Dept. of Pharmacology National Cardiovascular Center Research Institute Suita, Osaka 565-8565, Japan Osaka University Graduate School of Medicine Suita, Osaka 565-0871, Japan

Cormac T. Taylor Center for Experimental Therapeutics and Reperfusion Injury Brigham and Women's Hospital Boston, MA 02115

Charles Kumar Thodeti Dept. of Laboratory Medicine, Div. of Experimental Pathology Lund University, University Hospital Malmo Malmo-S 205 02, Sweden

Staffan Thoren Dept. of Medical Biochemistry and Biophysics Karolinska Institutet S-171 77 Stockholm, Sweden

Elizabeth D. Thuresson Dept. of Biochemistry Michigan State University East Lansing, MI 48824

Esther Titos Hospital Linic-Institut d'lnvestigacions Biomediques August Pi I Sunyer Barcelona 08036, Spain

Hiroyasu Tobe Kochi National College of Technology Nankoku, Kochi 783-8508, Japan

K.L. Tober The Ohio State University Dept. of Molecular Virology, Immunology and Medical Genetics 2058 Graves Hall, 333 W. 10th Ave. Columbus, OH 43210

Tatemi Todaka Dept. of Cerebrovascular Surgery National Cardiovascular Center Research Institute Suita, Osaka 565-8565, Japan

Takeharu Tonai Clinical Research Institute National Zentsuji Hospital Zentsuji, Kagawa 765-0001

Cecilia Trinks Div. of Cell Biology Linkoping University S-581 85 Linkoping, Sweden

Y oshihiro Tsuruo Dept. of Anatomy and Cell Biology School of Medicine, The University of Tokushima 3-18-15 Kuramoto Tokushima 770-8503, Japan

Natsuo Veda Dept. of Biochemistry Tokushima University School of Medicine Tokushima 770-8503, Japan

617

Jose M. Valdivielso Center for Glomerulonephritis Emory University School of Medicine Atlanta, GA

Masayuki Wada Dept. of Pharmacology National Cardiovascular Center Research Institute Suita, Osaka 565-8565, Japan Osaka University Graduate School of Medicine Suita, Osaka 565-0871, Japan

Keiji Wakabayashi Cancer Prevention Division National Cancer Center Research Institute 1-1 Tsukiji 5-chrome, Chuo-ku Tokyo 104-0045, Japan

Laurence Walch CNRS ESA 8078 Centre Chirurgical Marie Lannelongue 133 av de la Resistance 92350 Le Plessis Robinson, France

Mark Walker Monsanto/Searle Discovery Research Chesterfield, Missouri 63198

Yili Wang Procter and Gamble Pharmaceuticals 8700 Mason-Montgomery Rd. Mason, Ohio 45040-9317

Jining Wang Dept. of Biochemistry Tokushima University School of Medicine Tokushima 770-8503, Japan

Susheng Wang Renal Division, Emory University and Center of Glomerulonephritis Veterans Affairs Medical Center Atlanta, GA 30322

618

Kikuko Watanabe Division of Applied Life Sciences Graduate School of Int. Sciences and Arts University of East Asia 2-1 Ichinomiyagakuencho Shimonoseki 751-0807, Japan

Gerald Weissmann Division of Rheumatology Dept. of Medicine NYU School of Medicine New York, NY 10016

Par Westlund Dept. of Woman and Child Health Div. of Reproductive Endocrinology Karolinska Hospital, Bldg. L5,S-171 76 Stockholm, Sweden

Jay Whelan Dept. of Nutrition 229 Jessie Harris Building Knoxville, TN 37996-1900

Rebecca A. Whitfield Department of Biochemistry and Molecular Biology University of Massachusetts Amherst, MA 01003

William R. Widmer Dept. of Veterinary Clinical Sciences School of Veterinary Medicine Purdue University West Lafayette, IN 47907

Jane Wigren Div. of Cell Biology Linkoping University S-581 85 Linkoping, Sweden

Katarina Wikstrom Dept. of Laboratory Medicine, Div. of Experimental Pathology Lund University, Malmo General Hospital Entrance 78, Malmo SE-205 02, Sweden

T.A. Wilgus The Ohio State University Dept. of Molecular Virology, Immunology and Medical Genetics 2058 Graves Hall, 333 W. 10th Ave. Columbus, OH 43210

Linda S. Williams Depart. of Biology Allergan Inc. 2525 Dupont Drive Irvine, CA 92623-9543

Derek A. Willoughby Dept. of Experimental Pathology Div. of Pharmacology St. Bartholomew's and the Royal London School of Medicine Charterhouse Square London, ECIM 6BQ

Ken Wilson Dept. of Pharmacology and Physiology MCP Hahnemann University 2900 Queen lane Philadelphia, PA 19129

David F. Woodward Depart. of Biology Allergan Inc. 2525 Dupont Drive Irvine, CA 92623-9543

John August Wos Procter and Gamble Pharmaceuticals 8700 Mason-Montgomery Rd. Mason, Ohio 45040-9317

Shozo Yamamoto Dept. of Biochemistry Tokushima University School of Medicine Tokushima 770-8503, Japan

Kei Yamamoto Dept. of Biochemistry Tokushima University School of Medicine Tokushima 770-8503, Japan

Shinji Yamamoto Dept. of Health Chemistry School of Pharmaceutical Sciences Showa University 1-5-8 Hatanodai, Shinagawa-ku Tokyo 142-8555, Japan

Kenji Yamanaka Dept. of Biochemistry Tokushima University School of Medicine Tokushima 770-8503, Japan

Fengxiang Yan Division of Pharmaceutical Sciences College of Pharmacy, University of Kentucky Lexington, KY 40536-0082

Hiroji Yanamoto Dept. of Cerebrovascular Surgery National Cardiovascular Center Research Institute Suita, Osaka 565-8565, Japan

Hiromichi Y okoi Dept. of Anatomy and Cell Biology School of Medicine, The University of Tokushima 3-18-15 Kuramoto Tokushima 770-8503, Japan

Chieko Yokoyama Dept. of Pharmacology National Cardiovascular Center Research Institute Suita, Osaka 565-8565, Japan

Tanihiro Yoshimoto Dept. of Pharmacology Kanazawa University School of Medicine Kanazawa 920-8640, Japan

619

Jihan Youssef Div. of Pharmacology University of Missouri-Kansas City Kansas City, MO 64108, USA

Ying Yuan Oxford Biomedical Research P.O.Box 522, Oxford, MI USA 48371

Qian Zhan Center for Experimental Therapeutics and Reperfusion Injury Dept. of Anesthesia Brigham and Women's Hospital and The Harvard Medical School Boston, MA 02115

Yahua Zhang Depts. of Medicine (Div. of Nephrology) Vanderbilt University S 3223 MCN 1161 21st. Avenue South Nashville, TN. 37232-2372, USA

Huiping Zhou Division of Pharmaceutical Sciences College of Pharmacy, University of Kentucky Lexington, KY 40536-0082

Christine Zouki Research Center, Maisonneuve-Rosemont Hospital Dept. of Medicine, University of Montreal Montreal, Quebec, Canada HI T 2M4

620

Index

Acetyl-11-keto-~-boswellic acid (AKBA), meningioma cells, cytotoxic effect and inhibition of phosphorylation of the extracellular-signal regulated kinase 1 and 2, 387-393

Adenylyl cyclase, prostacyclin receptor, activation­dependent internalization of, in human, 295

Adhesion molecule expression, lipoxin (LZ) A4, aspirin-triggered 15-epilipoxin A4 and, 223-228

Allergen-induced eosinophil migration, inhibition by lipoxin (LZ)A4 and aspirin-triggered 15 EPI­LXA4, 211-216

Allergy, prostanoid receptors, lessons from knockout mice, 596

Alzheimer's disease, cyclooxygenase-2 expression and activity, are induced by amyloid-beta 1-42 in brain-derived cells, 93-99

Amyloid-beta 1-42, in brain-derived cells, cyclooxygenase-2 expression and activity are induced by, 93-99

Anandamide amidohydrolase, purified recombinant, catalytic properties of, 251-256

Angiogenesis, apoptosis, colon-26 tumor growth and, after treatment with NSAIDs, 409-414

Antiinflammatories anti-Ieukotrienes, as novel treatment in asthma,

217-221 aspirin III and salicylate, non-prostaglandin

effects of, inhibition of integrin-dependent human neutrophil aggregation and inflammation in COX 2- and NFKB (PI05)­knockout mice, 571-577

Anti-Ieukotrienes, as novel anti-inflammatory treatment in asthma, 217-221

ApCMinl+ knockout mice, eicosapentaenoic acid reduces tumor load in, by altering arachidonic acid metabolism, but conjugated linoleic acid, gamma- and alpha-linolenic acids have no effect, 579-584

ApoB-l00 lipoproteins, coronary artery disease, 3 Apoptosis

angiogenesis, colon-26 tumor growth and, after treatment with NSAIDs, 409-414

cytochrome C, nitration of, by peroxynitrite, putative anti-apoptic pathway mediated by prostaglandin H2 synthase and nitric oxide synthase, 427-431

MK 866 functions as a radiomimetic agent, genomic responses related to oxidative stress, cell cycle, proliferation and programmed cell death in panc-l cells, 451-453

peroxisome proliferator-activated receptor (PPARy) binding induces, in mouse T lymphocytes, 421-425

in vascular smooth muscle accompanied by increases in arachidonic acid, 433-437

Arachidonate 5-lipoxygenase, prostate cancer cell death triggered by inhibition of, molecular mechanisms, involvement of FAS death receptor-mediated signals, 415-419

Arachidonate release, phospholipase A2 (PLA2) and cyclooxygenases functional coupling in, 16

Arachidonic acid ApCMinl+ knockout mice, eicosapentaenoic acid

reduces tumor load in, by altering arachidonic acid metabolism, but conjugated linoleic acid, gamma- and alpha-linolenic acids have no effect, 579-584

621

622

Apoptosis (cont.) apoptosis in vascular smooth muscle accompanied

by increases in, 433-437 cell-substrate adhesion regulation by lipoxygenase

and cyclooxygenase branches of, 525-529 cyclooxygenase-2 gene transcription, suppression

of, by humulon, 73-76 cytosolic phospholipase Az (cPLAz), group IV,

local inflammation, knockout mouse results, 27-29

determination of metabolites, and cyclooxygenase in invasive human prostate cancer cells, 269-274

leukotrienes, pulmonary vascular bed and, 310 lipopolysaccharide, down-regulation of

5-lipoxygenase activity and leukotriene production by prolonged exposure to, 101-105

PGGz, 11R-HPETE and 15R/S-HPETE are formed from different conformers of, in prostaglandin endoperoxide H synthase cyclooxygenase site, 67-72

phospholipase Az (PLAz), MAP kinases and, in modulation of AA release and cell growth in A549 cells, 34

stereospecifically-labeled, cyclooxygenase­substrate interaction analysis, 49-53

Aspirin allergen-induced eosinophil migration, inhibition

by lipoxin (LZ)A4 and aspirin-triggered 15 EPI-LXA4, 211-216

15-epi-lipoxin A4 biosynthesis triggered by, in rat liver cells, 199-209

lipoxin (LZ) A4, aspirin-triggered 15-epilipoxin A4 and, modulate adhesion molecule expression on human leukocytes in whole blood and inhibit neutrophil-endothelial cell adhesion, 223-228

Aspirin ill, salicylate and, non-prostaglandin effects of, inhibition of integrin-dependent human neutrophil aggregation and inflammation in COX 2- and NFKB (P105)-knockout mice, 571-577

Asthma anti-Ieukotrienes as novel anti-inflammatory

treatment in, 217-221 prostaglandins, 33 pulmonary artery, leukotrienes, contraction of

human pulmonary artery by, is resistant to CysLT\ antagonists and counteracted by prostacyclin release, 315-319

Atherogenic lipoprotein profile (ALP), 4-5 Atherosclerosis

pathogenesis of, 3-4 prostaglandins, 33

Index

Biphasic regulation, of leukocyte trafficking by lipoxins, 543-549

Bladder cancer, cyclooxygenase-2 expression, and renal cell carcinoma, 123-126

Blood leukocyte trafficking, by lipoxins, biphasic

regulation of, 543-549 lipoxin (LZ) A4, aspirin-triggered 15-epilipoxin A4

and, 223-228 prostacyclin receptor, activation-dependent

internalization of, in human, 295-301 prostacyclin synthase

activation of transcriptional regulation of, in mouse, 281-286

effects of overexpression of, in vascular smooth muscle cells, 275-280

sphingosine-I-phosphate (S-I-P), 440-442 Bone, osteoporosis, prostaglandin analogs, design

and synthesis of, as bone anabolic agents for potential treatment of, 303-307

Bone-marrow-derived mast cells (mouse), cytosolic phospholipase Az (cPLAz), eicosanoid generation by, 41-46

Brain cyclooxygenase-2 expression and activity, are

induced by amyloid-beta 1-42 in brain­derived cells, 93-99

pantothenic acid, organ-specific pro-oxidant vitamin, neuroprostandevels in rat, 551-555

Brain injury, cytosolic phospholipase Az (cPLAz), group IV, knockout mouse results, 29-30; see also Central nervous system injury

Breast cancer, nimesulide, chemopreventive effects of, against PhIP-induced mammary carcinogenesis, cyclooxygenase-2 (COX-2) inhibitor, 371-376

Calcium binding, to 5-lipoxygenase, 117-121 Calcium signaling, leukotriene D4-induced, in

human intestinal epithelial cells, 187-191 Cancer

cannabimimetic eicosanoids, 381-386 colon-26 tumor, apoptosis, angiogenesis and, after

treatment with NSAIDs, 409-414 colorectal carcinoma cells, modulation of

cyclooxygenase-2 expression by APC in, 127-131

cyclooxygenase, colon carcinoma cells, growth stimulation and epidermal growth factor receptor induction in, 403-407

cyclooxygenase-2, human pathological disease and, 177-184

cyclooxygenase-2 expression, in human bladder and renal cell carcinoma, 123-126

Index

Cancer (cant.) epithelial tumors, of skin and colon,

cyclooxygenase-2, molecular target for chemoprevention of, 445-448

human intestinal epithelial cells, cell viability in, leukotrienes and, 193-198

12(S)-hydroxyeicostatetraenoic acid (12(S)-HETE), pleiotropic functions and multiple signaling pathways, 509-515

melanoma cells, regulation of CD36 expression of, in humans, 337-342

meningioma cells, AKBA is cytotoxic for, and inhibits phosphorylation of the extracellular­signal regulated kinase 1 and 2, 387 - 393

nimesulide, chemopreventive effects of, against PhIP-induced mammary carcinogenesis, cyclooxygenase-2 (COX-2) inhibitor, 371-376

pancreatic, MK 866 functions as a radiomimetic agent, genomic responses related to oxidative stress, cell cycle, proliferation and programmed cell death in panc-l cells, 451-453

piroxicam, antitumor effect of, in spontaneous canine invasive urinary bladder cancer,

. relevant model for human, 377-380 prostaglandins, 33 prostate

adenocarcinoma, 15-lipoxygenase-1 overexpression in, 133-145

cell death triggered by inhibition of arachidonate 5-lipoxygenase, molecular mechanisms, involvement of FAS death receptor-mediated signals, 415-419

cyclooxygenase, determination of, and arachidonic acid metabolites in invasive, 269-274

eicosanoids regulation of transcription factors in PC-3, 563-567

Cannabimimetic eicosanoids, cancer and inflammation, 381-386

Carboxy lic acid, prostaglandin F z'" analogs, ocular hypotensive activity of, with neutral substituents at position 1 is predicted by isolated cat iris sphincter smooth muscle preparation but not Ca+ signaling in Swiss 3T3 cells, 327-330

Cardiovascular disease, epidemiology, 3 CD36 expression, regulation of, in human melanoma

cells, 337-342 Cell-substrate adhesion regulation, by lipoxygenase

and cyclooxygenase branches of arachidonic acid, 525-529

Cell viability, in human intestinal epithelial cells, leukotrienes and, 193-198

623

Central nervous system injury, cyclooxygenase-2, selective inhibition of, attenuates expression of inflammation-related genes in, 155-160; see also Brain injury; Spinal cord injury

Ceramide, biosynthesis of, sphingolipids, 439-440 Chemokines, 5-oxo-ETE interactions and,

eosinophils stimulation by, 237-242 Chemotaxis, in vivo, using CHO cells expressing

human leukotriene B4 receptor, 357-361 CHO cells, in vivo chemotaxis using, expressing

human leukotriene B4 receptor, 357-361 Colon cancer

apoptosis, angiogenesis and, after treatment with NSAIDs, 409-414

cyclooxygenase, growth stimulation and epidermal growth factor receptor induction in, 403-407

epithelial tumors, cyclooxygenase-2, molecular target for chemoprevention of, 445-448

signaling pathways for TNFu-induced COX-2 expression, mediation through MAP kinases and NFKB, and inhibition by nonsteroidal anti-inflammatory drugs, 503-508

Colorectal carcinoma cells, modulation of cyclooxy­genase-2 expression by APC in, 127-131

Coronary artery disease risk factors for, 3-4 secretory phospholipase A2 (SPLA2) modification

of lipoproteins, 4-6 Cutaneous inflammation, inhibition of ultraviolet

light B-induced, by specific cyclooxygenase-2 inhibitor, 85-92

Cyclooxygenase(s) (COX) colon carcinoma cells, growth stimulation and

epidermal growth factor receptor induction in, 403-407

determination of, and arachidonic acid metabolites in invasive human prostate cancer cells, 269-274

15-epi-lipoxin A4 biosynthesis, aspirin-triggered, in rat liver cells, 199-209

liver macrophages, LPS-induced synthesis and release of PGE2 in, regulation by cPLA2, PGE2 synthase and, 403-407

phospholipase Az (PLAz) and, functional coupling between, 15-19

regulation of, in knockout mice, 585-591 sell-substrate adhesion regulation by lipoxygenase

and cyclooxygenase branches of arachidonic acid, 525-529

Cyclooxygenase-2 (COX-2) apoptosis, angiogenesis, colon-26 tumor growth

and, after treatment with NSAIDs, 409-414 aspirin III and salicylate, non-prostaglandin

effects of, inhibition of integrin-dependent human neutrophil aggregation and inflammation in knockout mice, 571-577

624

endothelial, hypoxia induced, liberates 6-KETO­PGFla, a potent epithelial secretagogue, 107-m

epithelial tumors of skin and colon, molecular target for chemoprevention of, 445-448

expression and activity of, are induced by amyloid-beta 1-42 in brain-derived cells, 93-99

expression of in human bladder and renal cell carcinoma,

123-126 modulated by APC in HT-29 human colorectal

carcinoma cells, 127-131 human pathological disease and, 177-184 induction in rat spinal cord injury mediated by

proinflammatory tumor necrosis factor-a and interleukin-I, 397-401

selective inhibition of, attenuates expression of inflammation-related genes in CNS injury, 155-160

signaling pathways for TNFa-induced expression of, mediation through MAP kinases and NFKB, and inhibition by nonsteroidal anti­inflammatory drugs, 503-508

Cyclooxygenase-2 (COX-2) gene transcription, suppression of, by humulon, 73-76

Cyclooxygenase-2 (COX-2) inhibitor inhibition of ultraviolet light B-induced cutaneous

inflammation, by, 85-92 mechanism of inhibition of, 365-369 nimesulide, chemopreventive effects of, against

PhIP-induced mammary carcinogenesis, 371-376

Cyclooxygenase-substrate interaction, analysis of, using stereospecifically-labeled arachidonic acids, 49-53

Cystolic phospholipase ~ (cPLA2), liver macrophages, LPS-induced synthesis and release of PGE2 in, regulation by COX-I, COX-2, PGE2 synthase and, 457-462

Cytochrome C, nitration of, by peroxynitrite, putative anti-apoptic pathway mediated by prostaglandin H2 synthase and nitric oxide synthase, 427-431

Cytosolic phospholipase ~ (cPL~) eicosanoid generation by mouse bone marrow-

derived mast cells and, 41-46 group IV, knockout mouse results, 25-31 microtubule interaction with, 21-24 phospholipase A2 (PLA2) regulated by, 9-13

Delayed-phase PGD2 generation, eicosanoid generation, by mouse bone marrow-derived mast cells, cytosolic phospholipase A2 (cPLA2) participation in, 42-45

Index

Dihydroxyeicosatrienoic acids (DHETs), enzyme immunoassays for, 531-536

Dioxygenation, fatty acid heme dioxygenase, linoleate diol synthase and prostaglandin H synthase, 557-561

Docosahexaenoic acid ApcMinI+ knockout mice, eicosapentaenoic acid

reduces tumor load in, by altering arachidonic acid metabolism, but conjugated linoleic acid, gamma- and alpha-linolenic acids have no effect, 579-584

formation of novel D-ring and E-ring isoprostane­like compounds in vivo from, 519-524

Drosophila SL2 transfection studies, leukotriene C4

synthase gene expression, regulation of, by SPI and SP3 in mononuclear phagocytes, 65

Ducts arteriosus, prostanoid receptors, lessons from knockout mice, 596

EGF receptor, 13(S)-HpODE, mitogenic signal transduction modulated by, through enhancement of phosphorylation and association of EGF receptor with tyrosine phosphatase SHP-2, 463-467

Eicosanoid generation, by mouse bone marrow­derived mast cells, cytosolic phospholipase ~ (cPLA2) participation in, 41-46

Eicosanoid protein conjugates, synthesis of, 532 Eicosanoids

cannabimimetic, cancer and inflammation, 381-386

lipopolysaccharide, down-regulation of 5-lipoxygenase activity and leukotriene production by prolonged exposure to, 101-105

Eicosanoids regulation, of transcription factors in PC-3 prostate cancer, 563-567

Eicosapentaenoic acid, dietary, reduces tumor load in apcMinl+ knockout mice by altering arachidonic acid metabolism, but conjugated linoleic acid, gamma- and alpha-linolenic acids have no effect, 579-584

Endothelial COX-2, hypoxia induced, liberates 6-KETO-PGFla, a potent epithelial secretagogue, 107-112

Enzyme immunoassays for EETs and corresponding DHETS, 531-536 for 15-F2T isoprostane-M, 537-541

Eosinophil migration, allergen-induced, inhibition by lipoxin (LZ)A4 and aspirin-triggered 15 EPI­LXA4, 211-216

Eosinophils, 5-oxo-ETE and chemokines interactions, stimulation of, 237-242

Epidermallipoxygenases, 12 (S) and 12(R),

characterization of, 147-153

Index

Epidermis-type lipoxygenases, 165-170 15-Epi-lipoxin A4 biosynthesis, aspirin-triggered, in

rat liver cells, 199-209 Epithelial cells (human intestinal)

cell viability in, leukotrienes and, 193-198 leukotriene D4-induced calcium signaling in, 187-

191 Epithelial regulation, intestinal inflammation,

lipoxins, mechanisms of active inflammation and potential down-regulation via, 230-231

Epithelial secretagogue, endothelial COX-2, hypoxia induced, liberates 6-KETO-PGF ja, 107-112

Epithelial tumors, of skin and colon, cyclooxygenase-2, molecular target for chemoprevention of, 445-448

Epoxyeicosatrienoic acids (EETs), enzyme immunoassays for, 531-536

Eye FP receptor, prostanoid mediated, endothelium

dependent vasodilation and ocular surface hyperemic response to prostaglandin F Za and related compounds, 331-336

prostaglandin FZa analogs, ocular hypotensive activity of, with neutral substituents at position 1 is predicted by isolated cat iris sphincter smooth muscle preparation but not Ca+ signaling in Swiss 3T3 cells, 327-330

FAS death receptor-mediated signals, prostate cancer cell death triggered by inhibition of arachidonate 5-lipoxygenase, molecular mechanisms, involvement of, 415-419

Fatty acid heme dioxygenase, linoleate diol synthase and prostaglandin H synthase, 557-561

Five-lipoxygenase activating protein (FLAP) activity, inhibition of, decreases proteinuria in streptozotocin (STZ)-induced diabetic rat, 79-83

FP receptor prostaglandin FZa analogs, ocular hypotensive

activity of, with neutral substituents at position 1 is predicted by isolated cat iris sphincter smooth muscle preparation but not Ca+ signaling in Swiss 3T3 cells, 327-330

prostanoid mediated, endothelium dependent vasodilation and ocular surface hyperemic response to prostaglandin F Za and related compounds, 331-336

15-F2T Isoprostane-M, enzyme immunoassays for, 537-541

Glaucoma, FP receptor, prostanoid mediated, endo­thelium dependent vasodilation and ocular surface hyperemic response to prostaglandin F2a and related compounds, 331-336

625

Glutathione, prostaglandin E synthase, microsomal, glutathione dependent, characterization of, 287-291

G protein-coupled receptor(s) P21-activated protein kinases (PAKS) receive and

integrate messages from variety of signaling pathways, 497-502

phosphatidylethanolamine, role in signal transduction associated with, 491-496

prostacyclin receptor, activation-dependent internalization of, in human, 295

Haemostasis, prostanoid receptors, lessons from knockout mice, 594-595

Heart, prostaglandin E synthase, purification and characterization of membrane-bound, in bovine hearts, 257-262

Heparin sulfate proteoglycan (HSPG), phospholipase Az (PLA2) and cyclooxygenases functional coupling, 16, 17

Human intestinal epithelial cells cell viability in, leukotrienes and, 193-198 leukotriene D4-induced calcium signaling in, 187-191

Human leukocytes, lipoxin (LZ) A4, aspirin­triggered 15-epilipoxin A4 and, 223-228

Human NAD+ -linked 15-hydroxyprostaglandin dehydrogenase, structure and function of, 245-250

Human platelets, substrate down regulation of 12-lipoxygenase in, 113-116

Humulon, cyclooxygenase-2 gene transcription suppressed by, 73-76

Hydrolysis, of low density lipoproteins (LDL), 5 13(S)-Hydroperoxyoctadecadienoic acid (HpODE),

mitogenic signal transduction modulated by, through enhancement of phosphorylation and association of EGF receptor with tyrosine phosphatase SHP-2, 463-467

Hydrophobicity, 5-lipoxygenase, calcium binding to, 120

Hydroxyeicostatetraenoic acid(s) (HETEs), enzyme immunoassays for, 531-536

12(S)-Hydroxyeicostatetraenoic acid (12(S)-HETE), pleiotropic functions and multiple signaling pathways, 509-515

15-Hydroxyprostaglandin dehydrogenase, NAD+­linked, structure and function of, 245-250

Hypoxia, endothelial COX-2 induced by, liberates 6-KETO-PGF ja, a potent epithelial secretagogue, 107-112

Immediate-phase mediator generation, eicosanoid generation, by mouse bone marrow-derived mast cells, cytosolic phospholipase A2 (cPLAz) participation in, 42

626

Inflammation asthma, anti-Ieukotrienes as novel anti­

inflammatory treatment in, 217-221 cannabimimetic eicosanoids, 381-386 central nervous system injury, cyclooxygenase-2,

selective inhibition of, attenuates expression of inflammation-related genes in, 155-160

cutaneous, inhibition of ultraviolet light B-induced, by specific cyclooxygenase-2 inhibitor, 85-92

cyclooxygenase-2 human pathological disease and, 177-184 induction in rat spinal cord injury mediated by

proinflammatory tumor necrosis factor-a and interleukin-l, 397-401

eicosanoid generation, by mouse bone marrow­derived mast cells, cytosolic phospholipase A2 (cPLA2) participation in, 41-46

eosinophils, 5-oxo-ETE and chemokines interactions, stimulation of, 237-242

intestinal, lipoxins, mechanisms of active inflammation and potential down-regulation via, 229-236

leukotriene C 4 synthase gene expression, regulation of, by SPI and SP3 in mononuclear phagocytes, 61-66

leukotrienes, pulmonary vascular bed and, 309 lipoxin (LZ) A4, aspirin-triggered 15-epilipoxin A4

and,223-228 local, cytosolic phospholipase A2 (cPLA2), group

IV, knockout mouse results, 27-29 prostaglandins, 33 prostanoid receptors, lessons from knockout mice,

595 Interleukin-l, cyclooxygenase-2 induction in rat

spinal cord injury mediated by proinflammatory tumor necrosis factor-a and, 397-401

Interleukin-ll3, prostaglandin E synthase, microsomal, glutathione dependent, characterization of, 289

Interleukins-4 and -13 divergence in intracellular signaling between, in

human cells localizes to monomericldimeric expression of transcription factor, lupus autoantigen 70/80, induced by both cytokines, 483-489

KU 70/80 lupus autoantigen is transcription factor induced by, leading to induction of 15-lipoxygenase (l5-LO) in human cells, 469-481

Intestinal epithelial cells (human) cell viability in, leukotrienes and, 193-198 leukotriene D 4-induced calcium signaling in, 187-

191

Index

Intestinal inflammation, lipoxins, mechanisms of active inflammation and potential down­regulation via, 229-236

Isoprostane activation, of nuclear hormone receptor PPAR, 351-355

Isoprostane-like compounds, formation of novel D-ring and E-ring forms in vivo from docosabexaenoic acid, 519-524

Knockout mice aspirin III and salicylate, non-prostaglandin

effects of, inhibition of integrin-dependent human neutrophil aggregation and inflammation in, 571-577

cyclooxygenase-l and -2 regulation in, 585 eicosapentaenoic acid reduces tumor load in, by

altering arachidonic acid metabolism, but conjugated linoleic acid, gamma- and alpha­linolenic acids have no effect, 579-584

prostanoids in health and disease, lessons from, 593-597

Leukocytes, lipoxin (LZ) A4, aspirin-triggered 15-epilipoxin A4 and, 223-228

Leukocyte trafficking, by lipoxins, biphasic regulation of, 543-549

Leukotriene(s) asthma, anti-Ieukotrienes as novel anti­

inflammatory treatment in, 217-221 eicosanoid generation, by mouse bone marrow­

derived mast cells, cytosolic phospholipase A2 (cPLA2) participation in, 41

lipopolysaccharide, down-regulation of 5-lipoxygenase activity and leukotriene production by prolonged exposure to, 101-105

pulmonary artery, contraction of human pulmonary artery by, is resistant to CysLT] antagonists and counteracted by prostacyclin release, 315-319

pulmonary vascular bed and, 309-313 Leukotriene B 4 receptor, in vivo chemotaxis using

CHO cells expressing, in human, 357-361 Leukotriene C4 synthase gene expression, regulation

of, by SPI and SP3 in mononuclear phagocytes, 61-66

Leukotriene D 4' calcium signaling induced by, in human intestinal epithelial cells, 187-191

Linoleate diol synthase, prostaglandin H synthase and, new family of fatty acid heme dioxygenase, 557-561

Linolenic acids, ApcMinl+ knockout mice, eicosapentaenoic acid reduces tumor load in, by altering arachidonic acid metabolism, but conjugated linoleic acid, gamma- and alpha­linolenic acids have no effect, 579-584

Index

Lipopolysaccharide down-regulation of 5-lipoxygenase activity and

leukotriene production by prolonged exposure to, 101-105

synthesis and release of PGE2 in liver macrophages induced by, regulation by cPL~, COX-I, COX-2, and PGE2 synthase, 457-462

Lipoproteins coronary artery disease, 3-4 modification of, by secretory phospholipase ~

(SPLA2), 4-6 Lipoxin(s)

leukocyte trafficking by, biphasic regulation of, 543-549

mechanisms of active intestinal inflammation and potential down-regulation via, 229-236

Lipoxin (LZ) A4 allergen-induced eosinophil migration, inhibition

by aspirin-triggered 15 EPI-LXA4 arid, 211-216

aspirin-triggered 15-epilipoxin A4 and, modulate adhesion molecule expression on human leukocytes in whole blood and inhibit neutrophil-endothelial cell adhesion, 223-228

Lipoxygenase(s) epidermal 12(S) and 12(R), characterization of,

147-153 epidermis-type, 165-170 manganese, mononuclear redox center of, 171-

176 positional specificity of, sequence determinants

for, 55-60 sell-substrate adhesion regulation by lipoxygenase

and cyclooxygenase branches of arachidonic acid, 525-529

5-Lipoxygenase, calcium binding to, 117-121 12-Lipoxygenase

intracellular activation and induction of, in mouse peritoneal macrophages, 161-164

substrate down regulation of, in human platelets, 113-116

15-Lipoxygenase, KU 70/80 lupus autoantigen is transcription factor induced by Interleukins-13 and -4 leading to induction of in human cells, 469-481

15-Lipoxygenase-l, overexpression of, in prostate adenocarcinoma, 133-145

5-Lipoxygenase inhibitor, MK 866 functions as a radiomimetic agent, genomic responses related to oxidative stress, cell cycle, proliferation and programmed cell death in panc-l cells, 451-453

Lipoxygenase products, phospholipase A2 (PLA2), cytosolic PLA2 regulation, 10-11

627

Liver, pantothenic acid, organ-specific pro-oxidant vitamin, neuroprostane levels in rat, 551-555

Liver cells 15-epi-lipoxin A4 biosynthesis, aspirin-triggered,

in rat, 199-209 prostaglandin F synthase, cDNA cloning and

mutagenesis study of liver-type, identification of cells producing, 263-268

Liver macrophages, LPS-induced synthesis and release of PGE2 in, regulation by cPL~, COX-I, COX-2, and PGE2 synthase, 457-462

Local inflammation, cytosolic phospholipase ~ (cPLA2), group IV, knockout mouse results, 27-29

Low density lipoproteins (LDL) coronary artery disease, 3, 4 Lung cancer, prostaglandins, 33

Lupus autoantigen 70/80 interleukins-4 and -13, divergence in intracellular

signaling between, in human cells localizes to monomericldimeric expression of transcription factor, induced by both cytokines, 483-489

transcription factor induced by interleukins-13 and -4 leading to induction of 15-lipoxygenase (I5-LO) in human cells, 469-481

Macrophages liver, LPS-induced synthesis and release of PGE2

in, regulation by cPL~, COX-I, COX-2, and PGE2 synthase, 457-462

peritoneal, intracellular activation and induction of 12-lipoxygenase in mouse, 161-164

Manganese lipoxygenase, mononuclear redox center of, 171-176

MAP kinases phospholipase A2 (PL~) and, in modulation of

AA release and cell growth in A549 cells, 33-40

signaling pathways for TNFa-induced COX-2 expression, mediation through NFKB and, inhibition by, nonsteroidal anti-inflammatory drugs, 503-508

Mast cells, bone-marrow-derived (mouse), cytosolic phospholipase A2 (cPL~), eicosanoid generation by, 41-46

Megakaryoblastic cells, purified recombinant anandarnide amidohydrolase, catalytic properties of, 254-255

Melanoma cells, regulation of CD36 expression of, in humans, 337-342

Meningioma cells, AKBA is cytotoxic for, and inhibits phosphorylation of the extracellular­signal regulated kinase 1 and 2, 387-393

628

Microtubules, cytosolic phospholipase A2 (cPLA2) a interaction with, 21-24

MK 866, as a radiomimetic agent, genomic responses related to oxidative stress, cell cycle, proliferation and programmed cell death in panc-l cells, 451-453

Mononuclear redox center, of manganese lipoxygenase, 171-176

Mucosal epithelial cells, endothelial COX-2, hypoxia induced, liberates 6-KETO-PGF1a, lO7-112

Murine mesangial cells, cytosolic phospholipase A2 (cPLA2), group IV, knockout mouse results, 27

NAD+ -linked 15-hydroxyprostaglandin dehydrogenase, human, structure and function of, 245-250

Neutrophil-endothelial cell adhesion, lipoxin (LZ) A4, aspirin-triggered 15-epilipoxin A4 and, 223-228

NFKB, signaling pathways for TNFa-induced COX-2 expression, mediation through MAP kinases and, inhibition by nonsteroidal anti­inflammatory drugs, 503-508

NFKB (PlO5)-knockout mice, aspirin III and salicylate, non-prostaglandin effects of, inhibition of integrin-dependent human neutrophil aggregation and inflammation in, 571-577

Nimesulide, chemopreventive effects of, against PhIP-induced mammary carcinogenesis, cyclooxygenase-2 (COX-2) inhibitor, 371-376

Nitric oxide synthase, cytochrome C, nitration of, by peroxynitrite, putative anti-apoptic pathway mediated by prostaglandin H2 synthase and, 427-431

Non-esterified fatty acids (NEFA) coronary artery disease, 4 secretory phospholipase A2 (SPLA2), 4, 5

Nonsteroidal anti-inflammatory drugs apoptosis, angiogenesis and colon-26 tumor

growth after treatment with, 409-414 cyclooxygenase-2 (COX-2) inhibitors, mechanism

of inhibition of, 365-369 nimesulide, chemopreventive effects of, against

PhIP-induced mammary carcinogenesis, cyclooxygenase-2 (COX-2) inhibitor, 371-376

piroxicam, antitumor effect of, in spontaneous canine invasive urinary bladder cancer, relevant model for human, 377-380

signaling pathways for TNFa-induced COX-2 expression, mediation through MAP kinases and NFKB, and inhibition by, 503-508

Index

Ocular hypotensive activity, of prostaglandin F2a analogs with neutral substituents at position 1 is predicted by isolated cat iris sphincter smooth muscle preparation but not Ca +

signaling in Swiss 3T3 cells, 327-330 Ocular surface hyperemia, FP receptor, prostanoid

mediated, endothelium dependent vasodilation and ocular surface hyperemic response to prostaglandin F 2a and related compounds, 331-336

Osteoporosis, prostaglandin analogs, design and synthesis of, as bone anabolic agents for potential treatment of, 303-307

5-0xo-ETE, chemokines interactions and, eosinophils stimulation by, 237-242

P21-activated protein kinases (PAKS), reception and integration of messages from variety of signaling pathways, 497-502

Pancreatic cancer, MK 866 functions as a radio­mimetic agent, genomic responses related to oxidative stress, cell cycle, proliferation and programmed cell death in panc-l cells, 451-453

Pantothenic acid, organ-specific pro-oxidant vitamin, brain and liver neuroprostane levels in rat, 551-555

Peritoneal macrophages, intracellular activation and induction of 12-lipoxygenase in mouse, 161-164

Peroxisome proliferator-activated receptor (PPAR) apoptosis induced by, in mouse T lymphocytes,

421-425 isoprostane activation of nuclear hormone

receptor, 351-355 novel eicosanoid activators of, formed by RAW

264.7 macrophage cultures, 343-349 Peroxynitrite, nitration of, by cytochrome C,

putative anti-apoptic pathway mediated by prostaglandin H2 synthase and nitric oxide synthase, 427-431

Phosphatidylethanolamine, role of, in G protein­coupled receptor-associated signal transduction, 491-496

Phospholipase A2 (PLA2): see also Cytosolic phospholipase A2 (cPLA2)

cyclooxygenases and, functional coupling between, 15-19

cytosolic PLA2 regulation, 9-13 MAP kinases and, in modulation of AA release

and cell growth in A549 cells, 33-40 Piroxicam, antitumor effect of, in spontaneous

canine invasive urinary bladder cancer, relevant model for human, 377-380

Pleiotropic functions, 12(S)-hydroxyeicostatetraenoic acid (l2(S)-HETE), and multiple signaling pathways, 509-515

Index

Polymorphonuclear neutrophil (PMN), leukocyte trafficking, by lipoxins, biphasic regulation of, 543-549

Polyunsaturated fatty acids, ApcMinl+ knockout mice, eicosapentaenoic acid reduces tumor load in, by altering arachidonic acid metabolism, but conjugated linoleic acid, gamma- and alpha­linolenic acids have no effect, 579-584

Positional specificity, of lipoxygenases, sequence determinants for, 55-60

Prostacyclin receptor, activation-dependent internalization of, in human, 295-301

Prostacyclin release, leukotrienes, contraction of human pulmonary artery by, is resistant to CysLT I antagonists and counteracted by, 315-319

Prostacyclin synthase activation of transcriptional regulation of, in

mouse, 281-286 effects of overexpression of, in vascular smooth

muscle cells, 275-280 Prostaglandin(s)

analogs of, design and synthesis of, as bone anabolic agents for potential treatment of osteoporosis, 303-307

ApCMinl+ knockout mice, eicosapentaenoic acid reduces tumor load in, by altering arachidonic acid metabolism, but conjugated linoleic acid, gamma- and alpha-linolenic acids have no effect, 581

eicosanoid generation, by mouse bone marrow­derived mast cells, cytosolic phospholipase A2 (cPLA2) participation in, 41

human NAD+ -linked l5-hydroxyprostaglandin dehydrogenase, structure and function of, 245-250

lipopolysaccharide, down-regulation of 5-lipoxygenase activity and leukotriene production by prolonged exposure to, 101-105

phospholipase A2 (PLA2) cytosolic PLA2 regulation, 9-13 MAP kinases and, in modulation of AA release

and cell growth in A549 cells, 33-40 Prostaglandin D2, PPAR-y, novel eicosanoid

activators of, formed by RAW 264.7 macrophage cultures, 343-349

Prostaglandin E2, liver macrophages, LPS-induced synthesis and release of PGE2 in, regulation by cPLA2, COX-I, COX-2, and PGE2 synthase, 457-462

Prostaglandin E2EP 2 receptor, targeted gene disruption of, 321-326

Prostaglandin endoperoxide H synthase, PGG2, llR­HPETE and 15R1S-HPETE are formed from different conformers of arachidonic acid in cyclooxygenase site of, 67-72

Prostaglandin E synthase microsomal, glutathione dependent,

characterization of, 287-291

629

purification and characterization of membrane­bound, in bovine hearts, 257-262

Prostaglandin F2o< analogs, ocular hypotensive activity of, with neutral substituents at position 1 is predicted by isolated cat iris sphincter smooth muscle preparation but not Ca+ signaling in Swiss 3T3 cells, 327-330

Prostaglandin F synthase, cDNA cloning and mutagenesis study of liver-type, identification of cells producing in liver, 263-268

Prostaglandin H synthase, linoleate diol synthase and, new family of fatty acid heme dioxygenase, 557-561

Prostaglandin H2 synthase, cytochrome C, nitration of, by peroxynitrite, putative anti-apoptic pathway mediated by nitric oxide synthase and, 427-431

Prostanoid biosynthetic pathways, phospholipase A2 (PLA2) and cyclooxygenases functional coupling in, 15-19

Prostanoid FP receptor, endothelium dependent vasodilation and ocular surface hyperemic response to prostaglandin F 20< and related compounds, 331-336

Prostanoid receptors, health and disease, lessons from knockout mice, 593-597

Prostate cancer adenocarcinoma, 15-lipoxygenase-1 overexpression

in, 133-145 cell death triggered by inhibition of arachidonate

5-lipoxygenase, molecular mechanisms, involvement of FAS death receptor-mediated signals, 415-419

cyclooxygenase, determination of, and arachidonic acid metabolites in invasive, 269-274

eicosanoids regulation of transcription factors in PC-3, 563-567

Proteinuria, in streptozotocin (STZ)-induced diabetic rat, inhibition of five-lipoxygenase activating protein (FLAP) activity decreases, 79-83

Pulmonary artery, leukotrienes, contraction of human pulmonary artery by, is resistant to CysLT I antagonists and counteracted by prostacyclin release, 315-319

Pulmonary vascular bed, leukotrienes and, 309-313 Purified recombinant anandamide amidohydrolase,

catalytic properties of, 251-256

Radiomimetic agents, MK 866 functions as, genomic responses related to oxidative stress, cell cycle, proliferation and programmed cell death in panc-I cells, 451-453

630

Recombinant anandamide amidohydrolase, purified, catalytic properties of, 251-256

Renal cell carcinoma, cyclooxygenase-2 expression, and bladder cancer, 123-126

Reproductive defect, cytosolic phospholipase A2 (cPLA2), group IV, knockout mouse results, 29

Salicylate, aspirin III and, non-prostaglandin effects of, inhibition of integrin-dependent human neutrophil aggregation and inflammation in COX 2- and NFKB (PI05)-knockout mice, 571-577

Salmonella typhimurium, 230 Secretory phospholipase A2 (SPLA2), lipoproteins

modified by, 4-6 Skin cancer, epithelial tumors, cyclooxygenase-2,

molecular target for chemoprevention of, 445-448

Sphingolipids, vascular biology, 439-444 Sphingosine-I-phosphate (S-I-P), 440-442 Spinal cord injury, cyclooxygenase-2 induction in

rat mediated by proinflammatory tumor necrosis factor-a and interleukin-I, 397-401

Stereospecifically-labeled arachidonic acids, cyclooxygenase-substrate interaction analysis, 49-53

Streptozotocin (STZ)-induced diabetic rat, proteinuria in, inhibition of fi ve-lipoxygenase activating protein (FLAP) activity decreases, 79-83

Thrombosis, prostanoid receptors, lessons from knockout mice, 594-595

T lymphocytes, peroxisome proliferator-activated receptor (PPARI') binding, induces apoptosis of, in mouse, 421-425

Index

Transcription factors, eicosanoids regulation of, in PC-3 prostate cancer, 563-567

Tumor necrosis factor-a proinflammatory, interleukin-I and,

cyclooxygenase-2 induction in rat spinal cord injury mediated by, 397-401

signaling pathways for COX-2 expression induced by, mediation through MAP kinases and NFKB, and inhibition by nonsteroidal anti­inflammatory drugs, 503-508

Tyrosine phosphatase SHP-2, 13(S)-HpODE, mitogenic signal transduction modulated by, through enhancement of phosphorylation and association of EGF receptor with, 463-467

Ultraviolet light B, cutaneous inflammation induced by, inhibition by specific cyclooxygenase-2 inhibitor, 85-92

Urinary biomarker, 15-F2T Isoprostane-M, enzyme immunoassays for, 537-541

Urinary bladder cancer, piroxicam, antitumor effect of, in spontaneous canine invasive urinary bladder cancer, relevant model for human, 377-380

Vascular smooth muscle apoptosis in, accompanied by increases in

arachidonic acid, 433-437 prostacyclin synthase, effects of overexpression

of,275-280 Very low density lipoproteins (VLDL)

coronary artery disease, 3 secretory phospholipase A2 (SPLA2) modified by,

5 Vitamins, pantothenic acid, organ-specific pro­

oxidant vitamin, neuroprostane levels in rat, 551-555