convergence research paradigm: a powerful approach to enable … · 2019-08-07 ·...
TRANSCRIPT
![Page 1: Convergence Research Paradigm: A Powerful Approach to Enable … · 2019-08-07 · Multidisciplinarity: juxtaposition of two or more disciplines on a ... Computer Science Engineering](https://reader033.vdocument.in/reader033/viewer/2022050403/5f808daae95a3372a7394c88/html5/thumbnails/1.jpg)
Convergence Research Paradigm: A Powerful Approach to Enable Major Advances
Pramod P. KhargonekarVice-Chancellor for Research
Distinguished Professor of EECSUniversity of California, Irvine
SUNY Research FoundationAugust 6, 2019
![Page 2: Convergence Research Paradigm: A Powerful Approach to Enable … · 2019-08-07 · Multidisciplinarity: juxtaposition of two or more disciplines on a ... Computer Science Engineering](https://reader033.vdocument.in/reader033/viewer/2022050403/5f808daae95a3372a7394c88/html5/thumbnails/2.jpg)
Outline
Convergence Paradigm
Convergence for Biomedical Research
Convergence and Team Science at UCI
Inclusion and Diversity
Conclusions
![Page 3: Convergence Research Paradigm: A Powerful Approach to Enable … · 2019-08-07 · Multidisciplinarity: juxtaposition of two or more disciplines on a ... Computer Science Engineering](https://reader033.vdocument.in/reader033/viewer/2022050403/5f808daae95a3372a7394c88/html5/thumbnails/3.jpg)
Definitions and Terminology
![Page 4: Convergence Research Paradigm: A Powerful Approach to Enable … · 2019-08-07 · Multidisciplinarity: juxtaposition of two or more disciplines on a ... Computer Science Engineering](https://reader033.vdocument.in/reader033/viewer/2022050403/5f808daae95a3372a7394c88/html5/thumbnails/4.jpg)
What is Convergence?
(Uni)Discipline
Multidisciplinary
Interdisciplinary
Transdisciplinary
Source: Hall, 2014
![Page 5: Convergence Research Paradigm: A Powerful Approach to Enable … · 2019-08-07 · Multidisciplinarity: juxtaposition of two or more disciplines on a ... Computer Science Engineering](https://reader033.vdocument.in/reader033/viewer/2022050403/5f808daae95a3372a7394c88/html5/thumbnails/5.jpg)
Disciplines and Multidisciplinary
Discipline: particular branch of learning or body of knowledge
Multidisciplinarity: juxtaposition of two or more disciplines on a question, problem, topic, or theme.
• Juxtaposition of disciplines that remain separate• Individuals work separately, results typically published
separately or compiled, but not synthesized.
Source: Hall, 2014
![Page 6: Convergence Research Paradigm: A Powerful Approach to Enable … · 2019-08-07 · Multidisciplinarity: juxtaposition of two or more disciplines on a ... Computer Science Engineering](https://reader033.vdocument.in/reader033/viewer/2022050403/5f808daae95a3372a7394c88/html5/thumbnails/6.jpg)
Interdisciplinary
Interdisciplinary: integration of information, data, methods, tools, concepts, and/or theories from two or more disciplines
○ Key defining concept: integration○ Individuals may work alone, but increasingly research is
team-based. ○ Collaboration introduces social integration, project
management and communication.
Source: Hall, 2014
![Page 7: Convergence Research Paradigm: A Powerful Approach to Enable … · 2019-08-07 · Multidisciplinarity: juxtaposition of two or more disciplines on a ... Computer Science Engineering](https://reader033.vdocument.in/reader033/viewer/2022050403/5f808daae95a3372a7394c88/html5/thumbnails/7.jpg)
Transdisciplinary
Transdisciplinary: transcend disciplinary approaches through comprehensive frameworks and paradigms
• Problem-oriented research that crosses the boundaries of both academic and public and private spheres.
• Mutual learning, joint work, and knowledge integration are key to solving “real-world” problems.
• Beyond interdisciplinary combinations to foster new worldviews or domains.
Source: Hall, 2014
![Page 8: Convergence Research Paradigm: A Powerful Approach to Enable … · 2019-08-07 · Multidisciplinarity: juxtaposition of two or more disciplines on a ... Computer Science Engineering](https://reader033.vdocument.in/reader033/viewer/2022050403/5f808daae95a3372a7394c88/html5/thumbnails/8.jpg)
Convergence: Recent Reports and Initiatives
![Page 9: Convergence Research Paradigm: A Powerful Approach to Enable … · 2019-08-07 · Multidisciplinarity: juxtaposition of two or more disciplines on a ... Computer Science Engineering](https://reader033.vdocument.in/reader033/viewer/2022050403/5f808daae95a3372a7394c88/html5/thumbnails/9.jpg)
MIT 2016
![Page 10: Convergence Research Paradigm: A Powerful Approach to Enable … · 2019-08-07 · Multidisciplinarity: juxtaposition of two or more disciplines on a ... Computer Science Engineering](https://reader033.vdocument.in/reader033/viewer/2022050403/5f808daae95a3372a7394c88/html5/thumbnails/10.jpg)
MIT Report - Convergence: Future of Health
“Convergence as applied to health … integrates expertise from life sciences with physical, mathematical, and computational sciences, as well as engineering, to form comprehensiveframeworks … “
“… convergence goes beyond collaboration … involves integration of historically distinct disciplines and technologies into a unified whole … integration … offers potentially revolutionary change for biomedical sciences.”
Sharp et al 2016, Science, Capitalizing on convergence for health care
![Page 11: Convergence Research Paradigm: A Powerful Approach to Enable … · 2019-08-07 · Multidisciplinarity: juxtaposition of two or more disciplines on a ... Computer Science Engineering](https://reader033.vdocument.in/reader033/viewer/2022050403/5f808daae95a3372a7394c88/html5/thumbnails/11.jpg)
NRC 2014
![Page 12: Convergence Research Paradigm: A Powerful Approach to Enable … · 2019-08-07 · Multidisciplinarity: juxtaposition of two or more disciplines on a ... Computer Science Engineering](https://reader033.vdocument.in/reader033/viewer/2022050403/5f808daae95a3372a7394c88/html5/thumbnails/12.jpg)
NRC Report on Convergence
Convergence is an approach to problem solving … integratesknowledge, tools, and ways of thinking .. a comprehensive synthetic framework for tackling scientific andsocietal challenges ...
Two closely related but distinct properties:
• convergence of expertise• formation of the web of partnerships.
Source: Convergence: Facilitating Transdisciplinary Integration of Life Sciences, Physical Sciences, Engineering, and Beyond, NRC, 2014
![Page 13: Convergence Research Paradigm: A Powerful Approach to Enable … · 2019-08-07 · Multidisciplinarity: juxtaposition of two or more disciplines on a ... Computer Science Engineering](https://reader033.vdocument.in/reader033/viewer/2022050403/5f808daae95a3372a7394c88/html5/thumbnails/13.jpg)
Four Key Pillars
● People
● Organization
● Culture
● Ecosystem
Source: Convergence: Facilitating Transdisciplinary Integration of Life Sciences, Physical Sciences, Engineering, and Beyond, NRC, 2014
![Page 14: Convergence Research Paradigm: A Powerful Approach to Enable … · 2019-08-07 · Multidisciplinarity: juxtaposition of two or more disciplines on a ... Computer Science Engineering](https://reader033.vdocument.in/reader033/viewer/2022050403/5f808daae95a3372a7394c88/html5/thumbnails/14.jpg)
NSF’s 10 Big Ideas: Growing Convergence Research
![Page 15: Convergence Research Paradigm: A Powerful Approach to Enable … · 2019-08-07 · Multidisciplinarity: juxtaposition of two or more disciplines on a ... Computer Science Engineering](https://reader033.vdocument.in/reader033/viewer/2022050403/5f808daae95a3372a7394c88/html5/thumbnails/15.jpg)
Growing Convergence Research at NSF
Convergence Research has two primary characteristics:
A. Research driven by a specific and compelling problem: Need to address a specific challenge or opportunity, From deep scientific questions or pressing societal needs.
B. Deep integration across disciplines: Knowledge, theories, methods, data, research communities and languages intermingled or integrated. New frameworks, paradigms or disciplines from sustained interactions …
https://www.nsf.gov/pubs/2018/nsf18058/nsf18058.jsp?WT.mc_id=USNSF_25&WT.mc_ev=click
![Page 16: Convergence Research Paradigm: A Powerful Approach to Enable … · 2019-08-07 · Multidisciplinarity: juxtaposition of two or more disciplines on a ... Computer Science Engineering](https://reader033.vdocument.in/reader033/viewer/2022050403/5f808daae95a3372a7394c88/html5/thumbnails/16.jpg)
Convergence on Biomedical Challenges
![Page 17: Convergence Research Paradigm: A Powerful Approach to Enable … · 2019-08-07 · Multidisciplinarity: juxtaposition of two or more disciplines on a ... Computer Science Engineering](https://reader033.vdocument.in/reader033/viewer/2022050403/5f808daae95a3372a7394c88/html5/thumbnails/17.jpg)
Science, June 2016, pp. 1522-1524
![Page 18: Convergence Research Paradigm: A Powerful Approach to Enable … · 2019-08-07 · Multidisciplinarity: juxtaposition of two or more disciplines on a ... Computer Science Engineering](https://reader033.vdocument.in/reader033/viewer/2022050403/5f808daae95a3372a7394c88/html5/thumbnails/18.jpg)
Example Themes in the MIT Report
Imaging
Nanotechnology
Regenerative engineering and medicine
Big data, machine learning for health
![Page 19: Convergence Research Paradigm: A Powerful Approach to Enable … · 2019-08-07 · Multidisciplinarity: juxtaposition of two or more disciplines on a ... Computer Science Engineering](https://reader033.vdocument.in/reader033/viewer/2022050403/5f808daae95a3372a7394c88/html5/thumbnails/19.jpg)
Convergence and Team Science at UCI
![Page 20: Convergence Research Paradigm: A Powerful Approach to Enable … · 2019-08-07 · Multidisciplinarity: juxtaposition of two or more disciplines on a ... Computer Science Engineering](https://reader033.vdocument.in/reader033/viewer/2022050403/5f808daae95a3372a7394c88/html5/thumbnails/20.jpg)
UCI Center for Complex Biological Systems
Biological SciencesMedicineMathematicsPhysicsComputer ScienceEngineeringStatisticsPhilosophy of Science
Biological Systems
Research and Education
![Page 21: Convergence Research Paradigm: A Powerful Approach to Enable … · 2019-08-07 · Multidisciplinarity: juxtaposition of two or more disciplines on a ... Computer Science Engineering](https://reader033.vdocument.in/reader033/viewer/2022050403/5f808daae95a3372a7394c88/html5/thumbnails/21.jpg)
NCI Cancer Systems Biology Center
NIH National Center for Systems Biology
NSF/Simons Center for Multiscale Cell Fate Research
Mathematical, Computational & Systems Biology Training Program
NIH Short Course in Systems Biology:
Foundation for Interdisciplinary Careers
Southern California Regional Conference in Systems Biology
International Outreach
COSMOS
Big Data
Mathematical Modeling
![Page 22: Convergence Research Paradigm: A Powerful Approach to Enable … · 2019-08-07 · Multidisciplinarity: juxtaposition of two or more disciplines on a ... Computer Science Engineering](https://reader033.vdocument.in/reader033/viewer/2022050403/5f808daae95a3372a7394c88/html5/thumbnails/22.jpg)
Complexity, Cooperation and Community in CancerCancer is a disease of relationships, among the cells of a tumor, between tumor cells and the tissues in which they grow, and between tumor cells of the immune system.
Life SciencesMedicineMathematicsPhysicsComputer ScienceEngineeringStatistics
Supporting interdisciplinary approaches to cancer research
UCI Seed Funding
Competitive Award (2016)
![Page 23: Convergence Research Paradigm: A Powerful Approach to Enable … · 2019-08-07 · Multidisciplinarity: juxtaposition of two or more disciplines on a ... Computer Science Engineering](https://reader033.vdocument.in/reader033/viewer/2022050403/5f808daae95a3372a7394c88/html5/thumbnails/23.jpg)
OrganizationProject I: Patterned Heterogeneity in Colon Cancer
Project II: Understanding the Cellular Origins of Melanoma
Project III: Modeling Malignant Myelopoiesis: Increasing Targeted Leukemia Therapy Effectiveness
Core: Outreach
Seminars, Short courses, Youth Programs,Retreat, Interest groups, Workshops, Conferences,..
Core: Single cell sequencing
S. Sandmeyer
Pilot Grants: Two types
Mechanism-1: Students/postdocs3 awarded in 2018
Mechanism-2: Faculty3 awarded in 2018 (+cost share)
Core: Administration
Organizational framework, Logistical Support, Pilot grant program, Oversight, Communication
Administrative supplement: Validating sc transcriptomics
E. GrattonW. Zhao
![Page 24: Convergence Research Paradigm: A Powerful Approach to Enable … · 2019-08-07 · Multidisciplinarity: juxtaposition of two or more disciplines on a ... Computer Science Engineering](https://reader033.vdocument.in/reader033/viewer/2022050403/5f808daae95a3372a7394c88/html5/thumbnails/24.jpg)
• One of the four national centers on mathematics of complex biological systems jointly funded by NSF and The Simons Foundation ($10M)
• 18 core center faculty members, 13 center graduate fellows, and 6 postdoctoral center fellows from five schools of UCI
• Director and PI: Qing Nie (Mathematics and Developmental & Cell Biology); Associate directors: Arthur Lander (Developmental & Cell Biology) and John Lowengrub(Mathematics)
NSF-Simons Center for Multiscale Cell Fate ResearchUC Irvine
CMCF
![Page 25: Convergence Research Paradigm: A Powerful Approach to Enable … · 2019-08-07 · Multidisciplinarity: juxtaposition of two or more disciplines on a ... Computer Science Engineering](https://reader033.vdocument.in/reader033/viewer/2022050403/5f808daae95a3372a7394c88/html5/thumbnails/25.jpg)
Convergence and Team Research
![Page 26: Convergence Research Paradigm: A Powerful Approach to Enable … · 2019-08-07 · Multidisciplinarity: juxtaposition of two or more disciplines on a ... Computer Science Engineering](https://reader033.vdocument.in/reader033/viewer/2022050403/5f808daae95a3372a7394c88/html5/thumbnails/26.jpg)
Advancing Team Science at UCI: Team Science Accelerator Lab (TSAL)
Judith Olson
Gary Olson
Maritza Salazar
Dan Stokols
Convener: Pramod P. Khargonekar
![Page 27: Convergence Research Paradigm: A Powerful Approach to Enable … · 2019-08-07 · Multidisciplinarity: juxtaposition of two or more disciplines on a ... Computer Science Engineering](https://reader033.vdocument.in/reader033/viewer/2022050403/5f808daae95a3372a7394c88/html5/thumbnails/27.jpg)
Stokols, 2018
Influences on Convergent Science Beyond the Team and its
Immediate and Institutional Environments
Institutional Multi-Team System in which the Team
(T1) is Embedded
Team’s Immediate Environment
Individual Team Members
Physical-Spatial, Social, Organizational-Institutional,
Technological Features
T4Private Sector
T3
T2
T1
NGOs
GovernmentPolicies
Funding Agencies
![Page 28: Convergence Research Paradigm: A Powerful Approach to Enable … · 2019-08-07 · Multidisciplinarity: juxtaposition of two or more disciplines on a ... Computer Science Engineering](https://reader033.vdocument.in/reader033/viewer/2022050403/5f808daae95a3372a7394c88/html5/thumbnails/28.jpg)
Dimensions of Team Science
• Diversity of team members
• Disciplinary integration
• Team size
• Goal alignment
• Permeable boundaries
• Geographic proximity
• Task interdependence
Source: Enhancing Effectiveness of Team Science, NRC, 2015
a new interdisciplinary field . . . aims to better understand … team-based research and practice and to identify the unique outcomes of these approaches ... (Stokols et al.)
![Page 29: Convergence Research Paradigm: A Powerful Approach to Enable … · 2019-08-07 · Multidisciplinarity: juxtaposition of two or more disciplines on a ... Computer Science Engineering](https://reader033.vdocument.in/reader033/viewer/2022050403/5f808daae95a3372a7394c88/html5/thumbnails/29.jpg)
Improving Team Research Effectiveness
• Team processes
• Team composition
• Team professional development
• Leadership for team science
• Support for virtual collaboration
• Organizational support for team research
Source: Enhancing Effectiveness of Team Science, NRC, 2015
![Page 30: Convergence Research Paradigm: A Powerful Approach to Enable … · 2019-08-07 · Multidisciplinarity: juxtaposition of two or more disciplines on a ... Computer Science Engineering](https://reader033.vdocument.in/reader033/viewer/2022050403/5f808daae95a3372a7394c88/html5/thumbnails/30.jpg)
https://www.teamsciencetoolkit.cancer.gov
https://ccrod.cancer.gov/confluence/display/NIHOMBUD/Home
http://www.teamscience.net
http://www.scienceofteamscience.org/scits-a-team-science-resources
Training Resources for Team Science
![Page 31: Convergence Research Paradigm: A Powerful Approach to Enable … · 2019-08-07 · Multidisciplinarity: juxtaposition of two or more disciplines on a ... Computer Science Engineering](https://reader033.vdocument.in/reader033/viewer/2022050403/5f808daae95a3372a7394c88/html5/thumbnails/31.jpg)
Recognizing Individual Contributions to Team Science in Promotion and Tenure Reviews
![Page 32: Convergence Research Paradigm: A Powerful Approach to Enable … · 2019-08-07 · Multidisciplinarity: juxtaposition of two or more disciplines on a ... Computer Science Engineering](https://reader033.vdocument.in/reader033/viewer/2022050403/5f808daae95a3372a7394c88/html5/thumbnails/32.jpg)
204,750 SQ ft. includes laboratory support space, conference and collaboration spaces
Interdisciplinary Science and Engineering Building
![Page 33: Convergence Research Paradigm: A Powerful Approach to Enable … · 2019-08-07 · Multidisciplinarity: juxtaposition of two or more disciplines on a ... Computer Science Engineering](https://reader033.vdocument.in/reader033/viewer/2022050403/5f808daae95a3372a7394c88/html5/thumbnails/33.jpg)
Inclusion and Diversity in Convergence
“A central hypothesis of convergence is that diverse teams are able to generate innovative solutions ...
… an environment where opinions - especially dissentingopinions - are openly expressed, where diversity is valued, and opposing ideas are respectfully communicated may be vital to the success ….”
Source: Convergence, NRC, 2016
![Page 34: Convergence Research Paradigm: A Powerful Approach to Enable … · 2019-08-07 · Multidisciplinarity: juxtaposition of two or more disciplines on a ... Computer Science Engineering](https://reader033.vdocument.in/reader033/viewer/2022050403/5f808daae95a3372a7394c88/html5/thumbnails/34.jpg)
Types of Diversity and ImplicationsDiversity
Problem-solving approaches (functional)Demographic, cultural, and ethnic backgrounds (identity)
Relationship with team performance: Challenges in social integration and communication Perspective can mitigate and … reverse these effectsGreater creativity and satisfactionEnvironment with diverse views and perspectives can be uncomfortable. Inclusive attitudes, management strategies critical to success
Source: Convergence, NRC, 2016
![Page 35: Convergence Research Paradigm: A Powerful Approach to Enable … · 2019-08-07 · Multidisciplinarity: juxtaposition of two or more disciplines on a ... Computer Science Engineering](https://reader033.vdocument.in/reader033/viewer/2022050403/5f808daae95a3372a7394c88/html5/thumbnails/35.jpg)
Concluding Comments
Convergence is a powerful paradigm to address complex problems
Great potential for discovery and translation
Major attractor for diverse talents but
There are critical barriers to progress along this theme
Institutions have much work to do realize this potential