copyright © 2009 pearson education, inc. genomics, bioinformatics, and proteomics chapter 21...
TRANSCRIPT
![Page 1: Copyright © 2009 Pearson Education, Inc. Genomics, Bioinformatics, and Proteomics Chapter 21 Lecture Concepts of Genetics Tenth Edition](https://reader036.vdocument.in/reader036/viewer/2022062720/56649efc5503460f94c0f86d/html5/thumbnails/1.jpg)
Copyright © 2009 Pearson Education, Inc.
Genomics, Bioinformatics, and Proteomics
Chapter 21 Lecture
Concepts of GeneticsTenth Edition
![Page 2: Copyright © 2009 Pearson Education, Inc. Genomics, Bioinformatics, and Proteomics Chapter 21 Lecture Concepts of Genetics Tenth Edition](https://reader036.vdocument.in/reader036/viewer/2022062720/56649efc5503460f94c0f86d/html5/thumbnails/2.jpg)
Copyright © 2009 Pearson Education, Inc.
21.1 Whole-Genome Shotgun Sequencing Is a Widely Used Method for Sequencing and Assembling Entire Genomes
![Page 3: Copyright © 2009 Pearson Education, Inc. Genomics, Bioinformatics, and Proteomics Chapter 21 Lecture Concepts of Genetics Tenth Edition](https://reader036.vdocument.in/reader036/viewer/2022062720/56649efc5503460f94c0f86d/html5/thumbnails/3.jpg)
Copyright © 2009 Pearson Education, Inc. Figure 21.1
![Page 4: Copyright © 2009 Pearson Education, Inc. Genomics, Bioinformatics, and Proteomics Chapter 21 Lecture Concepts of Genetics Tenth Edition](https://reader036.vdocument.in/reader036/viewer/2022062720/56649efc5503460f94c0f86d/html5/thumbnails/4.jpg)
Copyright © 2009 Pearson Education, Inc.
21.1 Whole-Genome Shotgun Sequencing Is a Widely Used Method for Sequencing and Assembling Entire Genomes
21.1.1 High-Throughput Sequencing
![Page 5: Copyright © 2009 Pearson Education, Inc. Genomics, Bioinformatics, and Proteomics Chapter 21 Lecture Concepts of Genetics Tenth Edition](https://reader036.vdocument.in/reader036/viewer/2022062720/56649efc5503460f94c0f86d/html5/thumbnails/5.jpg)
Copyright © 2009 Pearson Education, Inc. Figure 21.2
![Page 6: Copyright © 2009 Pearson Education, Inc. Genomics, Bioinformatics, and Proteomics Chapter 21 Lecture Concepts of Genetics Tenth Edition](https://reader036.vdocument.in/reader036/viewer/2022062720/56649efc5503460f94c0f86d/html5/thumbnails/6.jpg)
Copyright © 2009 Pearson Education, Inc.
21.1 Whole-Genome Shotgun Sequencing Is a Widely Used Method for Sequencing and Assembling Entire Genomes
21.1.2 The Clone-by-Clone Approach
21.1.3 Draft Sequences and Checking for Errors
![Page 7: Copyright © 2009 Pearson Education, Inc. Genomics, Bioinformatics, and Proteomics Chapter 21 Lecture Concepts of Genetics Tenth Edition](https://reader036.vdocument.in/reader036/viewer/2022062720/56649efc5503460f94c0f86d/html5/thumbnails/7.jpg)
Copyright © 2009 Pearson Education, Inc. Figure 21.3
![Page 8: Copyright © 2009 Pearson Education, Inc. Genomics, Bioinformatics, and Proteomics Chapter 21 Lecture Concepts of Genetics Tenth Edition](https://reader036.vdocument.in/reader036/viewer/2022062720/56649efc5503460f94c0f86d/html5/thumbnails/8.jpg)
Copyright © 2009 Pearson Education, Inc.
21.2 DNA Sequence Analysis Relies on Bioinformatics Applications and Genome Databases
21.2.1 Annotation to Identify Gene Sequences
21.2.2 Hallmark Characteristics of a Gene Sequence Can Be Recognized During Annotation
![Page 9: Copyright © 2009 Pearson Education, Inc. Genomics, Bioinformatics, and Proteomics Chapter 21 Lecture Concepts of Genetics Tenth Edition](https://reader036.vdocument.in/reader036/viewer/2022062720/56649efc5503460f94c0f86d/html5/thumbnails/9.jpg)
Copyright © 2009 Pearson Education, Inc. Figure 21.4
![Page 10: Copyright © 2009 Pearson Education, Inc. Genomics, Bioinformatics, and Proteomics Chapter 21 Lecture Concepts of Genetics Tenth Edition](https://reader036.vdocument.in/reader036/viewer/2022062720/56649efc5503460f94c0f86d/html5/thumbnails/10.jpg)
Copyright © 2009 Pearson Education, Inc. Figure 21.5
![Page 11: Copyright © 2009 Pearson Education, Inc. Genomics, Bioinformatics, and Proteomics Chapter 21 Lecture Concepts of Genetics Tenth Edition](https://reader036.vdocument.in/reader036/viewer/2022062720/56649efc5503460f94c0f86d/html5/thumbnails/11.jpg)
Copyright © 2009 Pearson Education, Inc. Figure 21.6a
![Page 12: Copyright © 2009 Pearson Education, Inc. Genomics, Bioinformatics, and Proteomics Chapter 21 Lecture Concepts of Genetics Tenth Edition](https://reader036.vdocument.in/reader036/viewer/2022062720/56649efc5503460f94c0f86d/html5/thumbnails/12.jpg)
Copyright © 2009 Pearson Education, Inc. Figure 21.6b
![Page 13: Copyright © 2009 Pearson Education, Inc. Genomics, Bioinformatics, and Proteomics Chapter 21 Lecture Concepts of Genetics Tenth Edition](https://reader036.vdocument.in/reader036/viewer/2022062720/56649efc5503460f94c0f86d/html5/thumbnails/13.jpg)
Copyright © 2009 Pearson Education, Inc. Figure 21.6c
![Page 14: Copyright © 2009 Pearson Education, Inc. Genomics, Bioinformatics, and Proteomics Chapter 21 Lecture Concepts of Genetics Tenth Edition](https://reader036.vdocument.in/reader036/viewer/2022062720/56649efc5503460f94c0f86d/html5/thumbnails/14.jpg)
Copyright © 2009 Pearson Education, Inc. Figure 21.7
![Page 15: Copyright © 2009 Pearson Education, Inc. Genomics, Bioinformatics, and Proteomics Chapter 21 Lecture Concepts of Genetics Tenth Edition](https://reader036.vdocument.in/reader036/viewer/2022062720/56649efc5503460f94c0f86d/html5/thumbnails/15.jpg)
Copyright © 2009 Pearson Education, Inc.
21.3 Functional Genomics Attempts to Identify Potential Functions of Genes and Other Elements in a Genome
21.3.1 Predicting Gene and Protein Functions by Sequence Analysis
![Page 16: Copyright © 2009 Pearson Education, Inc. Genomics, Bioinformatics, and Proteomics Chapter 21 Lecture Concepts of Genetics Tenth Edition](https://reader036.vdocument.in/reader036/viewer/2022062720/56649efc5503460f94c0f86d/html5/thumbnails/16.jpg)
Copyright © 2009 Pearson Education, Inc. Figure 21.8
![Page 17: Copyright © 2009 Pearson Education, Inc. Genomics, Bioinformatics, and Proteomics Chapter 21 Lecture Concepts of Genetics Tenth Edition](https://reader036.vdocument.in/reader036/viewer/2022062720/56649efc5503460f94c0f86d/html5/thumbnails/17.jpg)
Copyright © 2009 Pearson Education, Inc. Figure 21.9
![Page 18: Copyright © 2009 Pearson Education, Inc. Genomics, Bioinformatics, and Proteomics Chapter 21 Lecture Concepts of Genetics Tenth Edition](https://reader036.vdocument.in/reader036/viewer/2022062720/56649efc5503460f94c0f86d/html5/thumbnails/18.jpg)
Copyright © 2009 Pearson Education, Inc.
21.3 Functional Genomics Attempts to Identify Potential Functions of Genes and Other Elements in a Genome
21.3.2 Predicting Function from Structural Analysis of Protein Domains and Motifs
![Page 19: Copyright © 2009 Pearson Education, Inc. Genomics, Bioinformatics, and Proteomics Chapter 21 Lecture Concepts of Genetics Tenth Edition](https://reader036.vdocument.in/reader036/viewer/2022062720/56649efc5503460f94c0f86d/html5/thumbnails/19.jpg)
Copyright © 2009 Pearson Education, Inc.
21.4 The Human Genome Project Revealed Many Important Aspects of Genome Organization in Humans
21.4.1 Origins of the Project
21.4.2 Major Features of the Human Genome
![Page 20: Copyright © 2009 Pearson Education, Inc. Genomics, Bioinformatics, and Proteomics Chapter 21 Lecture Concepts of Genetics Tenth Edition](https://reader036.vdocument.in/reader036/viewer/2022062720/56649efc5503460f94c0f86d/html5/thumbnails/20.jpg)
Copyright © 2009 Pearson Education, Inc.
![Page 21: Copyright © 2009 Pearson Education, Inc. Genomics, Bioinformatics, and Proteomics Chapter 21 Lecture Concepts of Genetics Tenth Edition](https://reader036.vdocument.in/reader036/viewer/2022062720/56649efc5503460f94c0f86d/html5/thumbnails/21.jpg)
© 2012 Pearson Education, Inc. Table 21.1
![Page 22: Copyright © 2009 Pearson Education, Inc. Genomics, Bioinformatics, and Proteomics Chapter 21 Lecture Concepts of Genetics Tenth Edition](https://reader036.vdocument.in/reader036/viewer/2022062720/56649efc5503460f94c0f86d/html5/thumbnails/22.jpg)
© 2012 Pearson Education, Inc. Table 21.1
![Page 23: Copyright © 2009 Pearson Education, Inc. Genomics, Bioinformatics, and Proteomics Chapter 21 Lecture Concepts of Genetics Tenth Edition](https://reader036.vdocument.in/reader036/viewer/2022062720/56649efc5503460f94c0f86d/html5/thumbnails/23.jpg)
Copyright © 2009 Pearson Education, Inc.
![Page 24: Copyright © 2009 Pearson Education, Inc. Genomics, Bioinformatics, and Proteomics Chapter 21 Lecture Concepts of Genetics Tenth Edition](https://reader036.vdocument.in/reader036/viewer/2022062720/56649efc5503460f94c0f86d/html5/thumbnails/24.jpg)
Copyright © 2009 Pearson Education, Inc. Figure 21.11
![Page 25: Copyright © 2009 Pearson Education, Inc. Genomics, Bioinformatics, and Proteomics Chapter 21 Lecture Concepts of Genetics Tenth Edition](https://reader036.vdocument.in/reader036/viewer/2022062720/56649efc5503460f94c0f86d/html5/thumbnails/25.jpg)
Copyright © 2009 Pearson Education, Inc. Figure 21.12a
![Page 26: Copyright © 2009 Pearson Education, Inc. Genomics, Bioinformatics, and Proteomics Chapter 21 Lecture Concepts of Genetics Tenth Edition](https://reader036.vdocument.in/reader036/viewer/2022062720/56649efc5503460f94c0f86d/html5/thumbnails/26.jpg)
Copyright © 2009 Pearson Education, Inc. Figure 21.12b
![Page 27: Copyright © 2009 Pearson Education, Inc. Genomics, Bioinformatics, and Proteomics Chapter 21 Lecture Concepts of Genetics Tenth Edition](https://reader036.vdocument.in/reader036/viewer/2022062720/56649efc5503460f94c0f86d/html5/thumbnails/27.jpg)
Copyright © 2009 Pearson Education, Inc.
21.5 The “Omics” Revolution Has Created a New Era of Biological Research Methods
![Page 28: Copyright © 2009 Pearson Education, Inc. Genomics, Bioinformatics, and Proteomics Chapter 21 Lecture Concepts of Genetics Tenth Edition](https://reader036.vdocument.in/reader036/viewer/2022062720/56649efc5503460f94c0f86d/html5/thumbnails/28.jpg)
© 2012 Pearson Education, Inc. Figure 21.13
![Page 29: Copyright © 2009 Pearson Education, Inc. Genomics, Bioinformatics, and Proteomics Chapter 21 Lecture Concepts of Genetics Tenth Edition](https://reader036.vdocument.in/reader036/viewer/2022062720/56649efc5503460f94c0f86d/html5/thumbnails/29.jpg)
© 2012 Pearson Education, Inc.
Personal Genomics
The Human Microbiome Project
No Genome Left Behind—10K genomes in 5 years
![Page 30: Copyright © 2009 Pearson Education, Inc. Genomics, Bioinformatics, and Proteomics Chapter 21 Lecture Concepts of Genetics Tenth Edition](https://reader036.vdocument.in/reader036/viewer/2022062720/56649efc5503460f94c0f86d/html5/thumbnails/30.jpg)
Copyright © 2009 Pearson Education, Inc.
21.6 Comparative Genomics Analyzes and Compares Genomes from Different Organisms
![Page 31: Copyright © 2009 Pearson Education, Inc. Genomics, Bioinformatics, and Proteomics Chapter 21 Lecture Concepts of Genetics Tenth Edition](https://reader036.vdocument.in/reader036/viewer/2022062720/56649efc5503460f94c0f86d/html5/thumbnails/31.jpg)
Copyright © 2009 Pearson Education, Inc. Table 21.2
![Page 32: Copyright © 2009 Pearson Education, Inc. Genomics, Bioinformatics, and Proteomics Chapter 21 Lecture Concepts of Genetics Tenth Edition](https://reader036.vdocument.in/reader036/viewer/2022062720/56649efc5503460f94c0f86d/html5/thumbnails/32.jpg)
Copyright © 2009 Pearson Education, Inc. Table 21.3
![Page 33: Copyright © 2009 Pearson Education, Inc. Genomics, Bioinformatics, and Proteomics Chapter 21 Lecture Concepts of Genetics Tenth Edition](https://reader036.vdocument.in/reader036/viewer/2022062720/56649efc5503460f94c0f86d/html5/thumbnails/33.jpg)
Copyright © 2009 Pearson Education, Inc. Figure 21.12
![Page 34: Copyright © 2009 Pearson Education, Inc. Genomics, Bioinformatics, and Proteomics Chapter 21 Lecture Concepts of Genetics Tenth Edition](https://reader036.vdocument.in/reader036/viewer/2022062720/56649efc5503460f94c0f86d/html5/thumbnails/34.jpg)
© 2012 Pearson Education, Inc. Table 21.3
![Page 35: Copyright © 2009 Pearson Education, Inc. Genomics, Bioinformatics, and Proteomics Chapter 21 Lecture Concepts of Genetics Tenth Edition](https://reader036.vdocument.in/reader036/viewer/2022062720/56649efc5503460f94c0f86d/html5/thumbnails/35.jpg)
Copyright © 2009 Pearson Education, Inc.Figure 20-8 Copyright © 2006 Pearson Prentice Hall, Inc.
![Page 36: Copyright © 2009 Pearson Education, Inc. Genomics, Bioinformatics, and Proteomics Chapter 21 Lecture Concepts of Genetics Tenth Edition](https://reader036.vdocument.in/reader036/viewer/2022062720/56649efc5503460f94c0f86d/html5/thumbnails/36.jpg)
Copyright © 2009 Pearson Education, Inc. Figure 21.15
![Page 37: Copyright © 2009 Pearson Education, Inc. Genomics, Bioinformatics, and Proteomics Chapter 21 Lecture Concepts of Genetics Tenth Edition](https://reader036.vdocument.in/reader036/viewer/2022062720/56649efc5503460f94c0f86d/html5/thumbnails/37.jpg)
Copyright © 2009 Pearson Education, Inc. Table 21.4
![Page 38: Copyright © 2009 Pearson Education, Inc. Genomics, Bioinformatics, and Proteomics Chapter 21 Lecture Concepts of Genetics Tenth Edition](https://reader036.vdocument.in/reader036/viewer/2022062720/56649efc5503460f94c0f86d/html5/thumbnails/38.jpg)
Copyright © 2009 Pearson Education, Inc.
21.6 Comparative Genomics Analyzes and Compares Genomes from Different Organisms
The Rhesus Monkey Genome
The Sea Urchin Genome
The Neanderthal Genome
Evolution of Multigene Families
![Page 39: Copyright © 2009 Pearson Education, Inc. Genomics, Bioinformatics, and Proteomics Chapter 21 Lecture Concepts of Genetics Tenth Edition](https://reader036.vdocument.in/reader036/viewer/2022062720/56649efc5503460f94c0f86d/html5/thumbnails/39.jpg)
Copyright © 2009 Pearson Education, Inc. Figure 21.16
![Page 40: Copyright © 2009 Pearson Education, Inc. Genomics, Bioinformatics, and Proteomics Chapter 21 Lecture Concepts of Genetics Tenth Edition](https://reader036.vdocument.in/reader036/viewer/2022062720/56649efc5503460f94c0f86d/html5/thumbnails/40.jpg)
Copyright © 2009 Pearson Education, Inc. Figure 21.17
![Page 41: Copyright © 2009 Pearson Education, Inc. Genomics, Bioinformatics, and Proteomics Chapter 21 Lecture Concepts of Genetics Tenth Edition](https://reader036.vdocument.in/reader036/viewer/2022062720/56649efc5503460f94c0f86d/html5/thumbnails/41.jpg)
Copyright © 2009 Pearson Education, Inc. Figure 21.18
![Page 42: Copyright © 2009 Pearson Education, Inc. Genomics, Bioinformatics, and Proteomics Chapter 21 Lecture Concepts of Genetics Tenth Edition](https://reader036.vdocument.in/reader036/viewer/2022062720/56649efc5503460f94c0f86d/html5/thumbnails/42.jpg)
Copyright © 2009 Pearson Education, Inc.
21.8 Transcriptome Analysis Reveals Profiles of Expressed Genes in Cells and Tissues
![Page 43: Copyright © 2009 Pearson Education, Inc. Genomics, Bioinformatics, and Proteomics Chapter 21 Lecture Concepts of Genetics Tenth Edition](https://reader036.vdocument.in/reader036/viewer/2022062720/56649efc5503460f94c0f86d/html5/thumbnails/43.jpg)
Copyright © 2009 Pearson Education, Inc. Figure 21.21
![Page 44: Copyright © 2009 Pearson Education, Inc. Genomics, Bioinformatics, and Proteomics Chapter 21 Lecture Concepts of Genetics Tenth Edition](https://reader036.vdocument.in/reader036/viewer/2022062720/56649efc5503460f94c0f86d/html5/thumbnails/44.jpg)
Copyright © 2009 Pearson Education, Inc. Figure 21.22
![Page 45: Copyright © 2009 Pearson Education, Inc. Genomics, Bioinformatics, and Proteomics Chapter 21 Lecture Concepts of Genetics Tenth Edition](https://reader036.vdocument.in/reader036/viewer/2022062720/56649efc5503460f94c0f86d/html5/thumbnails/45.jpg)
Copyright © 2009 Pearson Education, Inc. Figure 21.22a
![Page 46: Copyright © 2009 Pearson Education, Inc. Genomics, Bioinformatics, and Proteomics Chapter 21 Lecture Concepts of Genetics Tenth Edition](https://reader036.vdocument.in/reader036/viewer/2022062720/56649efc5503460f94c0f86d/html5/thumbnails/46.jpg)
Copyright © 2009 Pearson Education, Inc. Figure 21.22b
![Page 47: Copyright © 2009 Pearson Education, Inc. Genomics, Bioinformatics, and Proteomics Chapter 21 Lecture Concepts of Genetics Tenth Edition](https://reader036.vdocument.in/reader036/viewer/2022062720/56649efc5503460f94c0f86d/html5/thumbnails/47.jpg)
Copyright © 2009 Pearson Education, Inc.
21.9 Proteomics Identifies and Analyzes the Protein Composition of Cells
Reconciling the Number of Genes and the Number of Proteins Expressed by a Cell or Tissue
Proteomics Technologies: Two-Dimensional Gel Electrophoresis for Separating Proteins
![Page 48: Copyright © 2009 Pearson Education, Inc. Genomics, Bioinformatics, and Proteomics Chapter 21 Lecture Concepts of Genetics Tenth Edition](https://reader036.vdocument.in/reader036/viewer/2022062720/56649efc5503460f94c0f86d/html5/thumbnails/48.jpg)
Copyright © 2009 Pearson Education, Inc. Figure 21.24
![Page 49: Copyright © 2009 Pearson Education, Inc. Genomics, Bioinformatics, and Proteomics Chapter 21 Lecture Concepts of Genetics Tenth Edition](https://reader036.vdocument.in/reader036/viewer/2022062720/56649efc5503460f94c0f86d/html5/thumbnails/49.jpg)
Copyright © 2009 Pearson Education, Inc. Figure 21.25
![Page 50: Copyright © 2009 Pearson Education, Inc. Genomics, Bioinformatics, and Proteomics Chapter 21 Lecture Concepts of Genetics Tenth Edition](https://reader036.vdocument.in/reader036/viewer/2022062720/56649efc5503460f94c0f86d/html5/thumbnails/50.jpg)
Copyright © 2009 Pearson Education, Inc.
21.9 Proteomics Identifies and Analyzes the Protein Composition of Cells
Proteomics Technologies: Mass Spectrometry for Protein Identification
![Page 51: Copyright © 2009 Pearson Education, Inc. Genomics, Bioinformatics, and Proteomics Chapter 21 Lecture Concepts of Genetics Tenth Edition](https://reader036.vdocument.in/reader036/viewer/2022062720/56649efc5503460f94c0f86d/html5/thumbnails/51.jpg)
Copyright © 2009 Pearson Education, Inc. Figure 21.26
![Page 52: Copyright © 2009 Pearson Education, Inc. Genomics, Bioinformatics, and Proteomics Chapter 21 Lecture Concepts of Genetics Tenth Edition](https://reader036.vdocument.in/reader036/viewer/2022062720/56649efc5503460f94c0f86d/html5/thumbnails/52.jpg)
Copyright © 2009 Pearson Education, Inc. Figure 21.27
![Page 53: Copyright © 2009 Pearson Education, Inc. Genomics, Bioinformatics, and Proteomics Chapter 21 Lecture Concepts of Genetics Tenth Edition](https://reader036.vdocument.in/reader036/viewer/2022062720/56649efc5503460f94c0f86d/html5/thumbnails/53.jpg)
Copyright © 2009 Pearson Education, Inc.
21.10 Systems Biology Is an Integrated Approach to Studying Interactions of All Components of an Organism’s Cells
![Page 54: Copyright © 2009 Pearson Education, Inc. Genomics, Bioinformatics, and Proteomics Chapter 21 Lecture Concepts of Genetics Tenth Edition](https://reader036.vdocument.in/reader036/viewer/2022062720/56649efc5503460f94c0f86d/html5/thumbnails/54.jpg)
© 2012 Pearson Education, Inc. Figure 21.29