Aesculap, Inc.Aesculap Implant Systems, LLC

Corporate Brochure

Our CompanyProducts

Advances in health care are made from a willingness to face change with innovative

solutions which shape the future of medicine. This means taking responsibility for

recognizing opportunities in the marketplace and identifying the customers needs. As a

leading healthcare company, Aesculap is fully aware of this responsibility. The brand

promise, Sharing Expertise stands for the continual exchange of knowledge and

experience in medicine. We contribute to medical advancements from the perspective

of the healthcare professional and the patientthrough innovation, efficiency and

sustainability. We are an independent family-owned business that embraces the

opportunities presented by the global marketplace.

Customers

ServiceEnvironment

People

OURRESPONSIBILITIES

WHO WE ARE

AESCULAP AGTuttlingen, Germany

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C O N T E N T S

The B. Braun Group of Companies _______________________ 6

History ____________________________________________ 8

Surgical Technologies ________________________________ 10

Neurosurgery ______________________________________ 12

Power Systems _____________________________________ 14

Closure Technologies ________________________________ 16

Service Systems ____________________________________ 18

Aesculap Implant Systems ____________________________ 20

Spine ____________________________________________ 22

Orthopaedics ______________________________________ 24

Aesculap Academy __________________________________ 26

Aesculap, Inc.Phone: 1-800-258-1946Fax: 610-791-6880www.aesculapusa.com

For Surgical Technologies, Neurosurgery, Power Systems and Closure Technologiesproduct and service literature, visit www.aicliterature.com.

Aesculap Implant Systems, LLCPhone: 1-800-234-9179Fax: 610-984-9096www.aesculapimplantsystems.com

For Spine and Orthopaedic product and service literature, visitwww.aisliterature.com.

B. Braun Melsungen AGCorporate Headquarters

OUR VISIONThrough collaborative excellence we will improve the quality of a patients life and meet the needs of the changing healthcare environment.

OUR MISSIONWe are committed to achieving collaborative excellence, through a culture of Sharing Expertise among our employees, partners,providers and patients. We take responsibility as an organizationand as individuals to create a climate of trust, ethics and accountability.

We are part of a global, family owned organization with a proud heritage that is passionately committed to providing high quality, innovative products and services to all surgical disciplines, with particular focus in the fields of General, Neuro, Spine and Orthopaedics.

We are committed to a long term perspective of sustainablegrowth. Our growth is financed by our internal resources and innovative strength, and our commitment is to uphold this directivefor the future generations of our employees, healthcare partnersand through them, our patients.

OUR VALUESOur values are the foundation upon which our culture is built. They are the standard that every employee is held to, regardless oftitle, job function or responsibility. Embodying these values, in our everyday work lives, is the key to fostering a culture of collaboration and ensuring our long term success as a company. Integrity and Honesty Accountability Quality and Efficiency Innovation Responsibility to Our Employees Sustainability

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B. Braun is dedicated to supplying healthcare markets all over the world. B. Braun offers

products and services for hospitals, general practitioners, home care and extracorporeal

blood treatment. Aesculap, Inc. is a member of the B. Braun group of companies.

Aesculap is the worlds largest manufacturer of surgical instrumentation in addition to

providing innovative products in the areas of Power Systems, Closure Technologies and

neurosurgery.

The Hospital Care division providesproducts and services for general medical treatment and comprehensivetherapy concepts in anesthesia, intensive medicine and infusion therapy.

Our core businesses:IV-Sets and AccessoriesIV-CathetersParenterals, large and small volumeClinical NutritionPlasma Volume ReplacementInfusion Systems

B. Braun Hospital Care

The Outpatient Market (OPM) divisionis oriented towards general practitioners and the outpatient andinpatient care sector.

Our core businesses:Ambulatory Infusion TherapyClinical NutritionHome CareStoma CareSkin and Wound Care Management

B. Braun OPM

B. Braun Avitum offers patients withchronic kidney or metabolic disordersthe prospect for a better quality oflife. The product program containstreatment system for acute dialysis,hemodialysis and apheresis.

Our core businesses:Dialysis MachinesDialyzers and Consumables for

Hemodialysis

B. Braun Avitum

Members of the B. Braun Group of Companies

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Aesculap Implant Systems offers a complete line of high-tech implant systems and

instrumentation for both the Spine and Orthopaedic markets. The primary goal of

Aesculap and Aesculap Implant Systems is to exceed the expectations of the medical

professionals who depend upon Aesculap products to provide healthcare to their

patients in the United States.

The Aesculap division focuses on products and services for all the coreprocesses in surgery.

Our core businesses:Surgical TechnologiesNeurosurgeryPower SystemsClosure TechnologiesServices

Aesculap, Inc.

The Aesculap Implant Systems divisionfocuses on manufacturing implants, instruments and innovative systemsfor the treatment of the spine andtotal joint market.

Our core businesses:Spine SurgeryOrthopaedics

Aesculap Implant Systems, LLC

The Aesculap Academy focuses on delivery of the B. Braun brand promiseof Sharing Expertise through seminars,workshops and forums to further educate medical practitioners, hospitalpersonnel and hospital management.

Aesculap Academy

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The name Aesculap comes from Asclepius, the Greek God of medicine, who is often

depicted with his serpent entwined staff. Aesculap began as a manufacturer of classical

surgical instruments in Tuttlingen, Germany in 1867. Founded by Gottfried Jetter, the

Aesculap manufacturing plant quickly grew, and by 1900, a new factory was built to

hold 600 employees. The city of Tuttlingen is now the cradle of surgical instrument

manufacturing for the world.

History

OLD WORLD TRADIT ION

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Aesculap continues to grow and expand its production capabilities. In 2001, the

Benchmark Factory, one of the most modern implant factories in Europe, opened and

houses 200 production machines covering over 120,000 square feet of space.

B. Braun/Aesculap operates in 50 countries around the world. Today, Aesculaps U.S.

headquarters is located in Center Valley, PA with a distribution center located in

Hazelwood, MO and R&D facilities in Breinigsville, PA.

NOTABLE

Today Aesculap employs more than 580 people in the U.S.

Annual sales of the Aesculap U.S. division exceed 210 million dollars.

With a sales force of 250 and a distribution center centrally located inMissouri, Aesculap can easily service allof its U.S. and Canadian customers.

THE TRADIT ION CONTINUES

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As the worlds largest surgical instrument manufacturer, Aesculap designs and produces

surgical instruments for both classical and minimally invasive surgery for many surgical

specialities including neurosurgery, gynecology, urology, cardiovascular, thoracic, ENT,

plastic and reconstructive surgery.

Surgical Technologies

THINK INSTRUMENTS. THINK AESCULAP.

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Today, modern technology blends with Aesculap old world tradition to provide healthcare

professionals with the widest array of surgical instrumentation available from a single

manufacturer. When Aesculap introduced the first SterilContainer, it revolutionized the

sterile processing work flow. Today, Aesculap is the worldwide leader in both instruments

and sterilization containers.

NOTABLE

Aesculap manufactures over 20,000 different products for surgery.

The Aesculap division employs 3,800 skilled craftsmen in the art of instrument manufacturing in 15 different locations, over three continents.

SterilContainer System supports hospitals green initiatives.

The manufacturing of instruments in Tuttlingen is based on a long-lasting tradition in producing cutlery.

THINK QUALITY. THINK AESCULAP.

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Surgeries of the brain and spine are among the most delicate and demanding

procedures in the field of medicine. As a neurosurgeon, you expect excellence from the

instruments and devices you use to treat your patients. Aesculaps exacting standards

and commitment to quality have made us a trusted choice for neurosurgeons

worldwide. From initial incision to complete closure, our treatment solutions will help

you to provide outstanding patient care.

Neurosurgery

FROM OUR SKILLED HANDS TO YOURS

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In 1968, Aesculap helped to revolutionize the world of neurosurgery by introducing the

first aneurysm clip designed for use under the surgical microscope. Since then, our

unwavering commitment to developing innovative technology has kept us at the

forefront of the field. Products such as the ground-breaking KAIRISON and proGAV

shunt raise the bar on superior patient care, minimize valuable minutes spent in surgery,

and increase the ease with which you can perform even the most intricate procedures.

NOTABLE

Over 200 employees in the Aesculap division are solely dedicated to researchand development.

Aesculap introduces 800-1,000 newproducts every year.

Aesculap YASARGIL Aneurysm Clips arethe first choice for thousands of neurosurgeons worldwide.

HISTORY OF INNOVATION

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As a pioneer in power systems, Aesculap continues to drive innovation in this area. As

one of the first companies to introduce an electric surgical motor in 1935, a pneumatic

system in 1960, a flexible cable system in 1970, and battery powered motors in 1980,

Aesculap continues to expand the boundaries of innovation.

Power Systems

PIONEERS IN POWER

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21st century Aesculap focuses on meeting all the needs of our customers. From electric

and pneumatic high speed neuro, spine and small bone surgery to battery-driven large

bone orthopaedics, Aesculap can standardize our customers across all power disciplines.

Power, speed and reliability are at the heart of Aesculap Power Systems.

NOTABLE

Aesculaps latest high-speed electric system, the microspeed uni, combines the mostpowerful motor technology with the most compact design on the market.

The HiLAN XS offers maximum power along with the quietest pneumatic motoravailable.

The ACCULAN 3Ti battery-operated, large bone system provides an award-winningergonomic design for weight and balance.

The BoneScalpel uses ultrasonic energy to cut bone while sparing soft tissue.

TECHNOLOGY OF TODAY

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Every wound must be closed in order for it to heal. The B. Braun Closure Technologies

line of products closes that wound so the healing process can begin. Our complete line

of absorbable and non-absorbable sutures will meet your every need for wound closure.

B. Braun Closure Technologies is focused on becoming the clear alternative for sutures

that stresses high quality, superior service and value for all customers.

Closure Technologies

WOUND CLOSURE

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Simple to use and effective, Histoacryl Topical Skin Adhesive is the proven choice for

wound closure of the skin with less scarring. This skin adhesive delivers rapid closure in

a single layer application that sets in just 30 seconds. Histoacryl features one of the

highest bond strengths of all topical skin adhesives on the market and is the only product

available in two formulations (optically clear and blue).

NOTABLE

In 2008, B. Braun celebrated its 100th anniversary of suture expertise.

Our first suture produced was an absorbable suture made from sheep intestines.

Histoacryl tissue adhesive has been used by surgeons worldwide for more than 40 years and has been cited in over 1,000 clinical publications.

BEYOND SUTURE

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Consulting SolutionsEverything starts with transparency

IT SolutionsOrganization and documentation

Technical SolutionsQuality instruments deserve quality repair

Supply Solutions0% investment, 100% functionality

Service Systems

THINK SOLUTIONS. THINK AESCULAP.

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Through Intelligent Quality Solutions, we are able to share the expertise we have gained

through decades of experience. It is our tradition of excellence and our commitment to

sharing knowledge that has made Aesculap the partner of choice for top hospitals

throughout the world. Let Aesculap help design an individual solution to meet your

instrument management needs in the Sterile Processing Department and the O.R.

NOTABLE

Aesculap was the first company to introduce an instrument tracking system in 1986.

Aesculap has been managing Sterile Processing Departments since 1982.

500 inventory audits have been performed by our expert consultants.

200,000 pay-per-use procedures annually

THINK EFF IC IENCY. THINK AESCULAP.

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Aesculap Implant Systems, LLC focuses on the spine and orthopaedic markets with the

objective of improving operative procedures and patient outcomes to ensure a better

quality of life. We accomplish this objective by developing innovative products that

meet the needs of our surgeons and their patients.

Aesculap Implant Systems

A CUSTOMER NEED

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In 2007, Aesculap established a Spine R&D center in the United States in order to meet

the needs of this diverse and large market. Aesculap has also grown to become one of

the largest orthopedic implant companies in the world and is the pioneer in CT-free

navigation. Aesculap will continue to invest in new technologies and products that allow

surgeons to achieve superior clinical results and improve the lives of their patients.

AN AESCULAP SOLUTION

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With the introduction of the industrys first dynamic cervical plate (ABC) in 1999,

Aesculap established itself as one of the most innovative spinal implant companies in

the world. Aesculap added the lowest profile posterior lumbar system (S4) in 2004 and

continued to expand its product line with the addition of a complete line of interbody

spacers, trauma products to treat spinal fractures, posterior cervical products and

innovative instrumentation to correct vertebral body instability.

Spine

ADVANCEMENTS IN SP INE

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In 2005, Aesculap entered the fast growing motion preservation market with the launch

in Europe of activL artificial lumbar disc*. This was the first of the second generation of

artificial discs launched in Europe, keeping Aesculap true to its heritage of offering

innovative products to help improve clinical results and patients quality of life. activL is

currently undergoing a clinical trial in the U.S. It is one of the first studies to compare

different artificial disc designs.

NOTABLE

Aesculaps advanced implant technologyfor stabilizing the cervical and thoracolumbar spine, and preserving mobility of the spinal column, is basedon years of clinical experience and research and development.

Aesculaps S4 Spinal System is one ofthe most innovative pedicle screw systems due to its small size and exceptional biomechanical strength.

Aesculaps Caspar Cervical Retractor System, introduced in 1980, is still theindustrys gold standard.

* The activL artificial lumbar disc is an investigational device. It is limited by U.S. law to investigational use.

IMPROVEMENTS IN MOTION

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Aesculap entered the orthopaedic market in 1972 with the launch of knee and hip

implants. In the following decades, Aesculap developed into a top 10 global player in

orthopaedics through highly innovative implants and technologies that drive

outstanding outcomes and patient satisfaction.

Orthopaedics

INNOVATIVE IMPLANTS

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For nearly 15 years, OrthoPilot has been leading the navigation market. As a pioneer in

this technology, we are committed to quality and evidence based medicine with more

than 300 publications in the field of computer-assisted surgery. We address all surgeon

and patient needs with our expansive orthopaedic portfolio in knee and hip arthroplasty

and sports medicine.

NOTABLE

Pioneer in CT free navigation since 1997.

More than 140,000 orthopaedic procedures have been navigated with OrthoPilot.

Aesculaps Plasmapore coating, the most innovative titanium spray in the marketplace, was first implanted in 1986.

Hip and knee implants are produced in the Benchmark Factory, which reflects thehighest standards in manufacturing.

PATIENT SATISFACTION

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Seminars and workshops of the Aesculap Academy keep medical practitioners, hospital

personnel and hospital management fit for the future. Since 1995, Aesculap Academy

has contributed to the interdisciplinary communication and dialogue in medicine

through a wide range of course offerings.

Aesculap Academy

PILLARS OF LEARNING

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The Aesculap Academy is the response to the growing need for further training in

medicine. Used in many different ways as a forum for training and further education, the

Aesculap Academy is dedicated to the propagation of knowledgetrue to its ancient

divinity from which it takes its name.

NOTABLE

The Aesculap Academy has local headquarters in more than 40 countriesspanning the globe.

In 2010, more than 66,000 people attended over 1,400 Aesculap Academyevents worldwide.

20,000 people attended online coursesoffered by the Aesculap Academy.

Consecutive winner 2005, 2006 and2007 of Frost & Sullivans Global MedicalProfessional Education Institution of theYear.

HORIZONS OF KNOWLEDGE

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For Surgical, Neurosurgery, Power Systems and Closure Technology product and service literature, visit www.aicliterature.com.For Spine and Orthopaedic product and service literature, visit www.aisliterature.com.

General Instrument CatalogDOC373 Rev B

Hyrdolift Data SheetDOC907

Aesculap Spine Product Overview BrochureDOC922

Laparoscopic Suturing BrochureDOC460 Rev B

Heart XS Retraction System BrochureDOC941

SecureSpan Laminoplasty Sales BrochureDOC945

CS2 Acetabular Cup System Data SheetDOC959, REV. A

CranioFix Absorbable Product OverviewDOC968

DOC969-Reusable Trocar System BrochureDOC969

DOC836 Rev. A 7.5M 6/11

All rights reserved. Technical alterations are possible. This leaflet may be used for no other purposes than offering, buying and selling of our products. No part may be copied or reproduced in any form. In the case of misuse we retain the rights to recall our catalogs and price lists and to take legal actions.

2011 AESCULAP. ALL RIGHTS RESERVED. PRINTED IN THE USA.Aesculap is an equal opportunity employer

Aesculap, Inc. | 3773 Corporate Parkway | Center Valley, PA | 18034Phone 800-282-9000 | Fax 610-791-6886 | www.aesculapusa.com

Aesculap Implant Systems, LLC | 3773 Corporate Parkway | Center Valley, PA | 18034Phone 866-229-3002 | Fax 610-984-9096 | www.aesculapimplantsystems.com

Aesculap, Inc. - a B. Braun company