course syllabus scps 666: neuromuscular exercise physiology
TRANSCRIPT
ภาควิชาสรีรวิทยา คณะวิทยาศาสตร มหาวิทยาลัยมหดิล
DEPARTMENT OF PHYSIOLOGY, FACULTY OF SCIENCE, MAHIDOL UNIVERSITY
Course Syllabus
SCPS 666: Neuromuscular Exercise Physiology
Credit Hour: 2(2-0-4)
Semester I, Academic Year: 2021
August 9th – December 3rd
2
TABLE OF CONTENTS
Page
I. Course Description 3
II. Course Objectives 3
III. Expected Learning Outcome 4
IV. Teaching method 4
V. Student Assessment 4
VI. Recommended Textbooks 4
VII. Course Coordinators & Lecturers 4
VIII. Course Schedule 5
IX. Lesson Plan 6
3
Course Syllabus and Lesson
SCPS 666: Neuromuscular Exercise Physiology
Semester I, Academic Year: 2021
Course Title: Neuromuscular Exercise Physiology
สรีรวิทยาการออกกําลังกายของระบบประสาทและกลามเน้ือ
Course Code: SCPS 666
Credit: 2 (2-0-4)
Prerequisite: None
Course Description: The neural control of the body movement; mechanism of muscle contraction and its
regulation; adaptations of skeletal muscle to weight training, disuse, aging and injury.
การควบคมุการเคลื่อนไหวของรางกายโดยระบบประสาท การปรับตัวของระบบประสาทตอการฝกออกกําลังกาย กลไกการหดตัวของ
กลามเน้ือและการควบคุม การปรับตัวของกลามเน้ือลายตอการฝกออกกําลังกายโดยใชนํ้าหนัก การไมใชงาน สภาวะชราภาพ และการ
บาดเจ็บ
Course Objectives: After completing this course the student should be able to:
1. Understand how resting and action potential is generated
2. Explain how synapse occur at the neuromuscular junction
3. Understand basic principles of nervous system
4. Explain the process of the voluntary and local control of body movement
5. Describe the principals of neural adaptation
6. Describe the mechanisms underlying skeletal muscle contraction and its regulation
7. Describe factors affecting muscular performance during exercise
8. Describe the mechanisms of muscular fatigue
9. Discuss the adaptive changes in skeletal muscle to resistance training and endurance training
10. Describe genetic influence on muscular performance
4
Expected Learning Outcome (ELO)
Instruction Time:
Place: Department of Physiology, Faculty of Science, Mahidol University
Student Assessment: Grading for this class is based on:
i. Two in-class essay exams 60 pts (70%)
ii. Class participation & discussion 40 pts (30%)
Total 100 pts (100%)
Textbook:
1. Powers SK and Howley ET. Exercise physiology: Theory and application to fitness and performance, 10th ed., 2018.
2. McArdle WD, Katch FI, Katch VL. Exercise physiology: Energy, Nutrition and Human performance. 8th ed., 2015. 3. Gardiner PE. Advanced Neuromuscular Exercise Physiology. Human Kinetics, 2011.
4. ACSM’s Advanced Exercise Physiology. Tipton CM. Ed. Lippincott Williams & Wilkins, Philadelphia, 2006, p.
41–94.
5. Boron WF, Boulpaep EL. Eds. Medical Physiology. Elsevier, Philadelphia, 2005, p. 257–279.
Course co-ordinator E-mail Room Tel.
Dr. Ioannis Papadimiriou [email protected] B.522 5616
Course Lecturers
Physiology, Faculty of Science E-mail Room Tel.
Dr. Ioannis Papadimiriou [email protected] B.522 5616
Asst. Prof. Nattapon Panupinthu [email protected] Pr.409 5629
Dr Ratchaneevan Aeimlapa [email protected] Pr.522/2 5500
Asst. Prof. Witchuda Saengsawang [email protected] Pr.416 5616
Asst. Prof. Ratchakrit Srikuea [email protected] B.502/2 5518
ELO Teaching and Learning
Approach Assessment
ELO1 Apply the proper
knowledge in exercise
physiology with ethical
mindset
1) Lecture/Self-study
2) Discussion
3) Assignment
4) Presentation
1) Essay exam
2) Class participation and discussion
3) Quality of report
4) Quality of presentation (Rubrics)
5
Department of Physiology, Faculty of Science, Mahidol University
Neuromuscular Exercise Physiology (SCPS 666) Semester 1/2021 2(2-0-4)
Course coordinator: Ioannis Papadimitriou, Ph.D.
Tel: 02-201-5616
Date Time Topics h Instructor
Tue 10 Aug 9:00-9:30 Course orientation 0.5 IP
Wed 11 Aug 9:30-10:30 L1: Homeostasis 1 NP
Fri 13 Aug 9:00-10:30 L2: Membrane potential and nerve physiology 1.5 RA
Fri 13 Aug 13:00-16:00 L3: Fundamental knowledge of nervous system 3 WS
Mon 16 Aug 9:00-11:00 L4: Control of body movement 2 IP
Wed 18 Aug 9:00-11:00 L5: Neural adaptation 2 IP
Thu 19 Aug 9:00-11:00 Group discussion 1: Nervous system 2 IP
Mon 23 Aug 13:00-16:00 Exam 1 IP
Tue 24 Aug 9:00-11:00 L6: Fundamental knowledge of muscle physiology 2 RS
Wed 25 Aug 9:00-11:00 L7: Factors affecting muscular performance during exercise 2 RS
Thu 26 Aug 9:00-11:00 L8: Exercise and muscle fatigue 2 RS
Fri 27 Aug 9:00-11:00 L9: Muscle adaptations to resistance training 2 RS
13:00-15:00 L10: Muscle adaptations to endurance/concurrent training 2 RS
Mon 30 Aug 9:00-11:00 L11: Influence of genetics on muscular performance 2 IP
Wed 1 Sep 9:00-11:00 Group discussion 2: Protein supplementation and muscle
hypertrophy after resistance training
2 RS
Fri 3 Sep 9:00-11:00 Group discussion 3: Skeletal muscle adaptability 2 RS
Mon 6 Sep 9:00-11:00 Student Presentation: Sarcopenia and Response to Exercise
Training
2 RS
Wed 8 Sep 9:00-12:00 Exam 2 IP
Total 30
6
Lecture 1: Homeostasis: The Foundation of Physiology
Lecturer: Assistant Professor Nattapon Panupinthu, Ph.D., M.D.
Learning Objectives:
Students are able to
1. Identify and discuss the significance of internal environment of an organism
2. Explain the concept of homeostasis and how it is achieved
3. List factors of the internal environment that must be maintained at the steady state
4. Identify types of the control system and explain how the system functions
Content Outlines:
1. The external and internal environment of the body
2. The concept of homeostasis, a dynamic steady state in the internal environment
3. Contributions of the body systems to homeostasis
4. Control systems for maintenance of the homeostasis
5. Disruption of homeostasis and the consequences
Learning Organization:
1. Study the suggested reading material before the lecture
2. Listen to 50-minute lecture using visual presentation
3. Participate in 10-minute question and answer session
Learning Materials:
1. Lesson plan including learning objectives and content outlines
2. Handout of the lecture presentation
3. Suggested reading materials
Suggested reading materials:
1. Sherwood (2013) Human Physiology: From Cells to Systems, 8th Edition, Chapter 1: Introduction to Physiology
and Homeostasis, pp. 1 - 20, Brooks/Cole Cengage Learning.
2. Boron and Boulpaep (2012) Medical Physiology, Updated 2nd Edition, Chapter 1: Foundations of physiology, pp.
3 - 6, Elsevier Saunders.
Student Assessment:
Assay Exam
7
Lecture 2: Membrane potential and nerve physiology
Lecturer: Ratchaneevan Aeimlapa, Ph.D.
Department of Physiology, Faculty of Science ([email protected])
Background & synopsis Membrane potential is a potential difference between interior and exterior of cell membrane that is
important to determine cellular function. Ionic flow across membrane involves in generation of resting membrane
potential and action potential which in turn regulating excitability of excitable cells such as neurons. Propagation of
electrical signal along nerve fiber is essential for communication between adjacent cells through synaptic
transmission.
Learning Objectives:
Students are able to
1. Describe the equilibrium potential and predict the direction of ion flow in any given situations using Nernst
equation
2. Describe importance of resting membrane potential and mechanisms generating resting membrane potential
3. Describe the difference between the local response and action potential
4. Describe mechanisms of action potential generation and propagation
5. Discuss the difference of electrical propagation in myelinated vs. unmyelinated axons
6. Describe mechanisms of synaptic transmission
Content Outline:
1. Membrane potential
2. Mechanisms generating resting membrane potential
2.1 Contribution of ionic gradient across plasma membrane
2.2 Permeability of ion across plasma membrane
2.3 Contribution of Na+-K+ ATPases activity
2.4 Gibbs-Donnan equilibrium
3. Electrical responses in excitable cells
3.1 Subthreshold response
3.2 Action potential
4. Ionic mechanisms of action potential
5. Factors affecting action potential propagation
6. Synaptic transmission
6.1 Chemical vs. electrical synapse
6.2 Excitatory postsynaptic potential (EPSP) vs. inhibitory postsynaptic potential (IPSP)
6.3 Spatial vs. temporal summation
Learning Organization:
1. Study the learning material provided before attending the lecture
2. Lecture 80 min
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3. Questions and answers 10 min
Learning Materials:
1. Handout of lecture
2. Textbook
References:
1. Sherwood Human Physiology: From Cells to Systems, 9th edition, 2015, Brooks/Cole Cengage Learning.
2. Berne & Levy Physiology. Koeppen, B.M., Stanton, B.A. 6th edition, 2009, Mosby/Elsevier
Student Assessment:
Written exam
9
Lecture 3 Fundamental knowledge of nervous system
Instructor Assistant Professor Witchuda Saengsawang, Ph.D.
Department of Physiology, Faculty of Science, ([email protected])
Learning objectives
At the completion of this topic, students should be able to
1. Explain basic principles of sensory system
2. Explain basic principles of motor system
3. Explain basic principles of autonomic nervous system
4. Explain basic principles of higher brain functions
Lecture outline:
1. Somatosensory system
2. Special sensory system
3. Motor system
4. Autonomic nervous system
5. Higher brain function
Learning organization
1. Self-study of suggested reading materials before class
2. 2 sessions of 50-minute lecture using visual presentation
3. 10 minutes questions and answers
Learning materials
1. Lesson plan, including the behavioral objectives
2. Handout of the lecture presentation
Suggested readings
1. Boron WF, and Boulpaep EL. Medical Physiology, 2nd ed., Elsevier, 2009.
2. Guyton AC and Hall JE, Textbook of Medical Physiology, 12th ed., Elsevier, 2011
Student assessment:
Written exam
10
Lecture 4 Control of body movement
Instructor Ioannis Papadimitriou, Ph.D.
Department of Physiology, Faculty of Science, ([email protected])
Background & synopsis
Body movement depends on a coordination of voluntary actions controlled by higher brain centers and
involuntary reflexes coordinated by the spinal cord, which ultimately regulate contraction of muscles. Spinal cord
reflex are motor responses to specific kinds of stimuli, which occur within the neuronal circuit called the reflex arc.
Posture and movement are also controlled by several descending motor pathways.
Learning objectives:
Students should be able to
1. Describe basic principles of neural control of body movement
2. Describe the components and mechanisms of the reflexes
3. Explain physiology of pyramidal and extrapyramidal systems
4. Describe the roles of motor cortex, brain stem, cerebellum and basal ganglia in controlling
body movement
Lecture outline
1. Reflex and control of reflex
2. Fundamental concept of pyramidal and extrapyramidal systems
3. Cortical and brain stem control of motor function
4. Cerebellum and Basal ganglia control of motor function
Learning organization
1. Self-study of suggested reading materials before class
2. 2 sessions of 50-minute lecture using visual presentation
3. 10 minutes questions and answers
Learning materials
1. Lesson plan, including the behavioral objectives
2. Handout of the lecture presentation
Suggested readings
1. Boron WF, and Boulpaep EL. Medical Physiology, 2nd ed., Elsevier, 2009.
2. Guyton AC and Hall JE, Textbook of Medical Physiology, 12th ed., Elsevier, 2011
Student assessment:
Written exam
11
Lecture 5 Locomotion and neural adaptation
Instructor Dr Ioannis Papadimitriou, Ph.D.
Department of Physiology, Faculty of Science, ([email protected])
Background & synopsis
Posture and locomotion are tightly controlled by the nervous system. Adaptation of the nervous system is
required in response to training. Students will also be introduced to some disorders related to motor impairment.
Learning objectives:
After completion of this topic, students should be able to:
1. Explain the spinal control of posture and locomotion.
2. Explain the functions of motor cortex and motor fatigue.
3. Explain the process of muscle atrophy.
4. Explain the changes in the nervous system in response to training.
Lecture outline:
1. Spinal control of posture and locomotion
2. Motor cortex and motor fatigue
3. Muscle atrophy
4. Changes in the nervous system in response to training
Learning organization
1. Self-study of suggested reading materials before class
2. 2 sessions of 50-minute lecture using visual presentation
3. 10 minutes questions and answers
Learning materials
1. Lesson plan, including the behavioral objectives
2. Handout of the lecture presentation
Suggested readings
1. ACSM’s Advanced Exercise Physiology. Tipton CM. Ed. Lippincott Williams & Wilkins, Philadelphia, 2006,
p. 41–94.
2. Medical Physiology. Boron WF, Boulpaep EL. Eds. Elsevier, Philadelphia, 2005, p. 257–279.
Student assessment:
Written exam
12
Group Discussion 1: Nervous system
Lecturer Ioannis Papadimitriou, Ph.D.
Department of Physiology, Faculty of Science ([email protected])
Students M.Sc. Students (Exercise Physiology)
Objectives:
Students should be able to:
1. Discuss about fundamental knowledge of nervous system 2. Discuss about control of body movement 3. Discuss about neural adaptation to exercise
Learning organization 1. Self-study of the assigned contents before class 2. Group discussion on the assigned contents 3. Questions and answers
Learning materials 1. Lesson plan, including the behavioral objectives 2. Assigned contents
Suggested reading 1. ACSM’s Advanced Exercise Physiology. Tipton CM. Ed. Lippincott Williams & Wilkins, Philadelphia, 2006.
Student assessment: Class participation during group discussion
Lecture 6: Fundamental knowledge of muscle physiology
13
Lecturer Assistant Professor Ratchakrit Srikuea, Ph.D.
Department of Physiology, Faculty of Science ([email protected])
Students M.Sc. Students (Exercise Physiology)
Background & synopsis Fundamental knowledge of muscle physiology is an essential content to understand the physiological properties of three different types of muscle including skeletal muscle, cardiac muscle, and smooth muscle. These basic concepts are mandatory for studying the exercise physiology related contents.
Objectives: Students should be able to: 1. Describe physiological properties and the factors that regulate functions of skeletal muscle, cardiac
muscle, and smooth muscle 2. Explain the essential concepts of basic muscle physiology that can be applied to exercise physiology
Lecture outline
1. Physiological properties of skeletal muscle, cardiac muscle, and smooth muscle 2. Factors that regulate functions of skeletal muscle, cardiac muscle, and smooth muscle
Learning organization
1. Self-study of suggested reading materials before class 2. 2 sessions of 50-minute lecture using visual presentation 3. 10 minutes questions and answers
Learning materials 1. Lesson plan, including the behavioral objectives 2. Handout of the lecture presentation
Suggested readings 1. Koeppen BM, Stanton BA. BERNE & LEVY Physiology. 7th ed., 2018. 2. Marieb EN, Hoehn K. Human Anatomy & Physiology. 9th ed., 2013.
Student assessment: Essay writing
14
Lecture 7: Factors affecting muscular performance during exercise
Lecturer Assistant Professor Ratchakrit Srikuea, Ph.D.
Department of Physiology, Faculty of Science ([email protected])
Students M.Sc. Students (Exercise Physiology)
Background & synopsis Muscular performance during exercise is relied on the power and capacity of skeletal muscle to exert force to match the physical demand. Hence, understanding the factors that affect muscular performance and the underlying mechanisms are crucial for exercise physiology knowledge.
Objectives: Students should be able to: 1. Describe the effect of warm-up on muscular performance 2. Explain the underlying mechanisms of exercise-associated muscle cramps 3. Explain the events of delayed onset of muscle soreness after exercise 4. Explain the contribution of muscle fiber type composition on muscular performance
Lecture outline 1. Impact of warm-up sessions 2. Exercise-associated muscle cramps 3. Delayed onset of muscle soreness 4. Influence of muscle fiber type composition
Learning organization 1. Self-study of suggested reading materials before class 2. 2 sessions of 50-minute lecture using visual presentation 3. 10 minutes questions and answers
Learning materials 1. Lesson plan, including the behavioral objectives 2. Handout of the lecture presentation
Suggested readings 1. Powers SK and Howley ET. Exercise physiology: Theory and application to fitness and performance, 10th
ed., 2018. 2. McArdle WD, Katch FI, Katch VL. Essential of exercise physiology: Nutrition, Energy, and Human
performance. 8th ed., 2015. Student assessment:
Essay writing
15
Lecture 8: Exercise and muscle fatigue
Lecturer Assistant Professor Ratchakrit Srikuea, Ph.D.
Department of Physiology, Faculty of Science ([email protected])
Students M.Sc. Students (Exercise Physiology)
Background & synopsis Muscle fatigue is the phenomenon that deficit of muscle force occurs during physical exertion, i.e., exercise. Both central and peripheral contributions on muscle fatigue have been reported. Numerous underlying mechanisms have been proposed to date to explain how muscle fatigue developed during intense and prolonged exercise.
Objectives: Students should be able to: 1. Explain the concept of muscle fatigue during exercise 2. Describe the contributions of central and peripheral mechanisms of muscle fatigue during exercise 3. Describe the underlying mechanisms of muscle fatigue during intense vs. prolonged exercise
Lecture outline 1. Definition of muscle fatigue 2. Central and peripheral mechanisms of muscle fatigue 3. Muscle fatigue during intense vs. prolonged exercise
Learning organization 1. Self-study of suggested reading materials before class 2. 2 sessions of 50-minute lecture using visual presentation 3. 10 minutes questions and answers
Learning materials 1. Lesson plan, including the behavioral objectives 2. Handout of the lecture presentation
Suggested readings 1. Farrell PA, Joyner MJ, Caiozzo VJ. ACSM’s Advanced Exercise Physiology, 2nd ed., 2012.
Student assessment: Essay writing
Lecture 9: Muscle adaptations to resistance training
16
Lecturer Assistant Professor Ratchakrit Srikuea, Ph.D.
Department of Physiology, Faculty of Science ([email protected])
Students M.Sc. Students (Exercise Physiology)
Background & synopsis
Resistance training is a type of training that routinely apply as exercise regimen to increase muscle mass and strength. Adaptation of skeletal muscle to the external resistance are involves both neural and muscular adaptations. Resistance training induces changes of physiological responses, up-regulation of growth factors, and activation of skeletal muscle stem cell to play role in skeletal muscle hypertrophic process.
Objectives: Students should be able to: 1. Describe the impact on resistance training on neural and muscular adaptation 2. Explain the functions of skeletal muscle stem cell and myonuclear domain hypothesis 3. Define the growth factors that contribute to skeletal muscle hypertrophic process
Lecture outline 1. Resistance training and skeletal muscle adaptation 2. Myonuclear domain hypothesis 3. Growth factors mediate muscle hypertrophy 4. Sarcopenia and resistance training
Learning organization 1. Self-study of suggested reading materials before class 2. 2 sessions of 50-minute lecture using visual presentation 3. 10 minutes questions and answers
Learning materials 1. Lesson plan, including the behavioral objectives 2. Handout of the lecture presentation
Suggested readings 1. Powers SK and Howley ET. Exercise physiology: Theory and application to fitness and performance, 10th
ed., 2018. 2. McArdle WD, Katch FI, Katch VL. Essential of exercise physiology: Nutrition, Energy, and Human
performance. 8th ed., 2015. Student assessment:
Essay writing
17
Lecture 10: Muscle adaptations to endurance/concurrent training
Lecturer Assistant Professor Ratchakrit Srikuea, Ph.D.
Department of Physiology, Faculty of Science ([email protected])
Students M.Sc. Students (Exercise Physiology)
Background & synopsis
Endurance training is a type of training that regularly use to improve cardiorespiratory fitness. The effect of endurance training mainly involves angiogenesis and mitochondrial synthesis to increase oxygen delivery and oxygen extraction of the working muscle during exercise. In contrast to endurance training, concurrent training is the combination of resistance and endurance training to mimic various types of sports that require both strength and endurance performance.
Objectives: Students should be able to: 1. Describe the effects of endurance and concurrent training on muscular adaptation 2. Compare and contrast the effects of endurance and concurrent training to resistance training on skeletal
muscle adaptation Lecture outline
1. Endurance training and skeletal muscle adaptation 2. Concurrent training and skeletal muscle adaptation 3. Sarcopenia and endurance training
Learning organization 1. Self-study of suggested reading materials before class 2. 2 sessions of 50-minute lecture using visual presentation 3. 10 minutes questions and answers
Learning materials 1. Lesson plan, including the behavioral objectives 2. Handout of the lecture presentation
Suggested readings 1. Powers SK and Howley ET. Exercise physiology: Theory and application to fitness and performance, 10th
ed., 2018. 2. McArdle WD, Katch FI, Katch VL. Essential of exercise physiology: Nutrition, Energy, and Human
performance. 8th ed., 2015. Student assessment:
Essay writing
18
Lecture 11: Influence of genetics on muscular performance
Lecturer Dr Ioannis Papadimitriou, Ph.D.
Department of Physiology, Faculty of Science ([email protected])
Students M.Sc. Students (Exercise Physiology)
Background & synopsis Athletic performance is a complex trait that is influenced by both genetic and environmental factors. Studies focused on similarities and differences in athletic performance within families, including between twins, suggest that genetic factors underlie 30% to 80% of the differences among individuals in traits related to athletic performance. Many studies have investigated variations in specific genes thought to be involved in these traits, involving athletes and non-athletes. Some gene polymorphisms have been linked with exercise performance. Changes in our genome can influence speed, strength and endurance performance as well.
Objectives: Students should be able to: 1. Describe the influence of genetics on exercise performance 2. Define the major candidate genes and its effect on muscular performance
Lecture outline 1. Human genome and exercise performance 2. Candidate gene analysis on muscular performance 3. Single Nucleotide Polymorphisms (SNPs)
Learning organization 1. Self-study of suggested reading materials before class 2. 2 sessions of 50-minute lecture using visual presentation 3. 10 minutes questions and answers
Learning materials 1. Lesson plan, including the behavioral objectives 2. Handout of the lecture presentation
Suggested readings 1. Bray et al. The human gene map for performance and health-related fitness phenotypes: the 2006-2007
update. Med Sci Sports Exerc. 2009;41(1):35-73. 2. Malcolm Collins, Genetics Med Sport Sci. Basel, Karger, 2016 3. I. Papadimitriou, A. Lucia, Y. Pitsiladis, V. Pushkarev, D. Dyatlov, E. Orekhov, J. Guilherme, A. Lancha, V.
Ginevičien, P. Cieszczyk, A. Karlowska, M. Sawczuk, C. Muniesa, A. Kouvatsi, M. Massidda, C. Calò, F. Garton, G. Wang, K. Austin, V. Charlton, E. Morrison, A. Druzhevskaya, I. Astratenkova, I. Ahmetov ACTN3 R577X and ACE I/D gene variants influence specific performance phenotypes in elite sprinters: A study involved ten cohorts of Caucasian and African athletes, European Journal of Human Genetics Vol 23, p 336 June (2016)
Student assessment: Essay writing
19
Group Discussion 2: Protein supplementation and skeletal muscle hypertrophy after resistance training
Lecturer Assistant Professor Ratchakrit Srikuea, Ph.D.
Department of Physiology, Faculty of Science ([email protected])
Students M.Sc. Students (Exercise Physiology)
Background & synopsis Protein supplementation is recommended to apply during resistance training in trained men to enhance muscle hypertrophy. To support this notion, whey protein has been widely used in the bodybuilder. However, whether whey protein supplementation affect muscle hypertrophy in untrained men is remained unknown.
Objectives: Students should be able to: 1. Describe the impact of protein supplementation on skeletal muscle hypertrophy after resistance training 2. Explain the contribution of mTOR signaling in response to whey protein supplementation after resistance
training Learning organization
1. Self-study of the assigned papers before class 2. Group discussion on the assigned papers 3. Questions and answers
Learning materials 1. Lesson plan, including the behavioral objectives 2. Assigned papers
Suggested reading 1. Hulmi JJ, Lockwood CM, Stout JR. Effect of protein/essential amino acids and resistance training on
skeletal muscle hypertrophy: A case for whey protein. Nutr Metab 7: 51, 2010. Assigned Paper
1. Kakigi R, Yoshihara T, Ozaki H, Ogura Y, Ichinoseki-Sekine N, Kobayashi H, et al. Whey protein intake after resistance exercise activates mTOR signaling in a dose-dependent manner in human skeletal muscle. Eur J Appl Physiol, Apr;114(4):735-42, 2014.
Student assessment: Class participation during group discussion
20
Group Discussion 3: Skeletal muscle adaptability
Lecturer Assistant Professor Ratchakrit Srikuea, Ph.D.
Department of Physiology, Faculty of Science ([email protected])
Students M.Sc. Students (Exercise Physiology)
Background & synopsis Skeletal muscles are heterogeneous, composing of different fiber types including slow, fast oxidative, and fast glycolytic. Each of which is characterized by a set of contractile and molecular properties. One of the remarkable features of skeletal muscle is its adaptability. The adaptation of skeletal muscle is diverse and the magnitude of change is depended on many factors such as activity pattern, age, and muscle fiber type composition.
Objectives: Students should be able to: 1. Describe the concepts of skeletal muscle adaptation 2. Compare and contrast the adaptation of human skeletal muscle between unloading vs. aging
Learning organization 1. Self-study of the assigned contents before class 2. Group discussion on the assigned contents 3. Questions and answers
Learning materials 1. Lesson plan, including the behavioral objectives 2. Assigned contents
Suggested reading 1. Schiaffino and Reggiani. Fiber types in mammalian skeletal muscles. Physiol Rev 91: 1447–1531, 2011. 2. Wisdom et al. Use it or lose it: multiscale skeletal muscle adaptation to mechanical stimuli. Biomech
Model Mechanobiol. 14(2):195-215, 2015. Student assessment:
Class participation during group discussion
21
Student Presentation: Topic “Sarcopenia and Response to Exercise Training”
Lecturer Assistant Professor Ratchakrit Srikuea, Ph.D.
Department of Physiology, Faculty of Science ([email protected])
Students M.Sc. Students (Exercise Physiology)
Background & synopsis
Sarcopenia is the condition that muscle mass and strength are declined during aging. The impairment of
muscular performance in elderly can be alleviated with exercise training. Therefore, understanding the effects of
resistance and endurance exercise training on aged muscle will help to design the appropriate training regimens to
improve the quality of life in elderly.
Objectives: Students should be able to: 1. Explain the impact of sarcopenia on muscular performance 2. Describe the effects of resistance, endurance, and concurrent training on muscular adaptation in
elderly Learning organization
1. Self-study on the assigned paper before class 2. Students prepare the presentation using PowerPoint on the assigned topic 3. Questions and answers
Learning materials 1. Lesson plan, including the behavioral objectives 2. Assigned paper
Assigned Paper 1. Cadore at el. Strength and endurance training prescription in healthy and frail elderly. Aging Dis. Jun;5(3):
183–195, 2014. Student assessment:
Student presentation with PowerPoint