creating possiblegrapeseed.bio/wp-content/uploads/2017/08/sample_short... · 2017. 9. 1. ·...
TRANSCRIPT
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CREATING POSSIBLE
Aaron Wolfe, CEO | Adam Blanden, CSO
Presentation version 5.6
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Company at a glanceManagement: Aaron Wolfe (CEO), Adam Blanden (CSO)
Raise: $350k seed round
Current Funding: $297,500
Summary: recombiPure is a streamlined solution to protein chemistry
Market: $2.3B/year opportunity
Stage: Seed stage
Entity Type: Delaware C corp.
Founded: Q1 2017
Strategic Partnerships: 8,400 ft2
wet lab/office (through Ichor Therapeutics)
IP status: 3 pending patents (1 exclusive license from SUNY Upstate, 2 intramural), rep. by Dorsey & Whitney, LLP
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MBP Tag
6his Tag
Bead
A CB
D
A. Fluorescent antibody
B. Purification/labeling tag
C. Column resin
D. Solubility tag
Requires multiple vendors, lacks shelf-life, and high prices!
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Protein chemistry is not streamlined
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$10 billion1 in annual waste▪ Complicated, unreliable technologies
▪ Data is often not reproducible
▪ Required boutique solutions are:
- non-interchangeable
- expensive
- fragile
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1Weller. Quality Issues of Research Antibodies. Analytical Chemistry Insights 2016:11 21–27 doi:10.4137/ACI.S31614.
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The basis of our technology is a robust two-part protein tag
▪ Stable (extremophile origin)
▪ Soluble (expression enhancer)
▪ Inexpensive to produce (up to 1/1000th of the cost)
▪ Strong (antibody level affinity)
▪ Small (less bulky)
▪ Flexibility (diverse applications)
▪ Proprietary
RP-tag (large)
RP-tag (small)
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We can use these tags tostreamline protein chemistry tools
RP-tag (large)
RP-tag (small)
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F
Bead
Bead
F
Plate orSPR chip
Plate orSPR chip
Mix&
Match
RP-tag (large) RP-tag (small)
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RP-tag (large) RP-tag (small)
Mix&
match
F
Bead
Bead
F
Plate orSPR chip
Plate orSPR chip
Alone or in combination, these pieces offer a
functionally superior and streamlined solutionto replace existing products/kits used in every life
science lab in the world…
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Just a few examples…▪ Affinity chromatography (shown here)
▪ IP/pulldown kit
▪ ELISA kit
▪ Western blot kit
▪ Immunocytochemistry
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The RP system binds tighter than antibodies and is target specific
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The RP system is robust enoughto survive repeat boiling
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• RP system• 6xhis antibody
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Beta testers and clients (current)
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$200k(seed)
2016 2017 2018
$97,500(pre-seed)
Proof-of-concept
- Solubility tag- Genetic engineering of
RP(large) and RP(small)- Patent licensing
Product development
- Optimize RP tags- Develop kit prototypes- Patent filing (x2)- Beta testing- Identify market strategy- Secure distributors- Online store soft launch
Distribution
- Product extension- International distribution- Execute market strategy
Development summary
$350k(add. seed)
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Ready for testing:• IP/Pulldown
4-6 weeks:• Affinity Chromatography• ELISA
8-16 weeks:• Western Blot• Immunocytochemistry
Next step: beta test
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Meet the teamExecutive team
Research support
Justin ApplegateJustin Cox
Ashleigh CrawfordConnor McGuiganJacob MontalvanMeegan Sleeper
A rowdy group of aspiring scientists trying to make a change in the
world of antibodies… one protein interaction at a time.
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CEO Aaron J Wolfe
Co-Founder
PhD candidate, SU (ABD)
VP Marketing – DCN, Ltd.
VC Biotech Consultant
5 peer-reviewed papers
2 licensed patents
CSO Adam R. Blanden
Co-Founder
MD/PhD candidate, Upstate
NIH Fellow, biophysics
10 licensed patents
10 peer-reviewed papers
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Contact
Aaron Wolfe, CEO
2521 US Route 11 LaFayette, NY 13084
(315) 380-4700 | [email protected]
Website (under construction)
www.recombipure.com
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