crrt: quality management...
TRANSCRIPT
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CRRT: QUALITY MANAGEMENT SYSTEMS
Javier A. Neyra, MD, MSCS
Director, Acute Care Nephrology & CRRT ProgramUniversity of Kentucky Medical Center
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Disclosures and Funding
Disclosures
Funding
• Consulting agreement with Baxter Healthcare Inc.• No stock or income from CRRT-related activities
• ASN Foundation for Kidney Research (Ben J. Lipps Research Fellowship)
• Charles and Jane Pak Center of Mineral Metabolism and Clinical Research (UT Southwestern)
• Early Career Pilot Program (CCTS, University of Kentucky)• Clinical trials/registry support: STARRT-AKI, CRRTnet• Industry support for clinical trials: Prismocitrate (no COI)
USMP/MG230/18-0006 3/18
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Outline
CRRT deliverables that need improvement
How to optimize CRRT deliverables in the ICU?
Clinical informatics and CRRT deliverables
USMP/MG230/18-0006 3/18
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• Timing of CRRT initiation• Iterative changes in CRRT prescription and goals of
therapy in the context of critical illness, fluid overload and multi-organ failure
• Assessment of renal recovery and effective RRT de-escalation
• Risk-stratification of recurrent AKI and incident or progressive CKD or de novo ESRD
• Post-AKI outpatient care
CRRT deliverables that need improvement
USMP/MG230/18-0006 3/18
AKI, acute kidney injury; CKD, chronic kidney disease; CRRT, continuous renal replacement therapy; ESRD; end-stage renal disease; RRT, renal replacement therapy
Neyra JA and Goldstein SL. Clin Nephrol. 2018. In press
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• Average filter life = 12.7 hours• Average time for restart > 6 hours• Delivered dose < 70% of prescribed dose• Preventable significant errors ~ 1 per month• Average number of filter changes per day > 7• No standards • No tracking of quality parameters
Do we provide optimal CRRT care (1999-2002)?
USMP/MG230/18-0006 3/18CRRT, continuous renal replacement therapy
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Early sepsisMAP <55
SVV >20%collapsible IVC
AKI on CRRT, UF zero
8:00 AM
Three essential elements
1. Multidisciplinary team work dynamics2. Iterative assessment and adjustment of RRT goals3. Quality management systems
How to optimize CRRT deliverables in the ICU?
Late sepsiss/p 5L IVF, on pressors
MAP ~60SVV <10%
distended IVCAKI on CRRT, UF -50 ml/hr
8:00 PM
USMP/MG230/18-0006 3/18
AKI, acute kidney injury; CRRT, continuous renal replacement therapy; ICU, intensive care unit; IVC, inferior vena cava; IVF, intravenous fluid; MAP, mean arterial pressure; RRT, renal replacement therapy; s/p, status post; SVV, stroke volume variability; UF, ultrafiltration
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Multidisciplinary teams
• Intensivists• Nephrologists• Pharmacists• Nurses• Nutritionists• PT/OT• Data analysts• Computer scientists
How to optimize CRRT deliverables in the ICU?
COMMUNICATION
USMP/MG230/18-0006 3/18
CRRT, continuous renal replacement therapy; ICU, intensive care unit; OT, occupational therapy; PT, physical therapy
Askenazi DJ, et al. Blood Purif. 2017;43:68–77 Ronco C, Bellomo R, Kellum JA (eds): Acute Kidney Injury. Contrib Nephrol. Basel, Karger, 2007
Bagshaw SM, et al. Can J Kidney Health Dis. 2016;3:5
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Iterative assessment/adjustment of CRRT goals• Electronic Health Record Tools (some data points from CRRT machine)
– Customized order set (monitor prescription)– Customized flowsheets (monitor RRT deliverables: dosing, solutions,
fluid removal, access/return pressures, TMP, filter pressure drop, filtration fraction, etc.)
• Who, When and How? (integration of machine and patient data)
• Solute clearance and fluid regulation need – Monitoring of clinical status of the patient – Static/functional/respiratory variation tests/POCUS to guide
fluid therapy
How to optimize CRRT deliverables in the ICU?
USMP/MG230/18-0006 3/18
CRRT, continuous renal replacement therapy; ICU, intensive care unit; RRT, renal replacement therapy; TMP, transmembrane pressure; POCUS, point of care ultrasound Clark WR, et al. Int J Artif Organs. 2016;39:399–406
Jambeith R, et al. Crit Care Res Pract. 2017;2017:359–392
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Quality management systems
How to optimize CRRT deliverables in the ICU?
Standardization Protocols (dynamic)
Problem identification
monitoring (effective and sustainable), reporting *quality metrics
Improvement in CRRT deliverables Innovation
USMP/MG230/18-0006 3/18CRRT, continuous renal replacement therapy; ICU, intensive care unit Askenazi DJ, et al. Blood Purif. 2017;43:68–77
Neyra JA and Goldstein SL. Clin Nephrol. 2018. In press
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2
3
Quality management systems in CRRT
Metrics for CRRT
deliverables
Quality Management:
Assurance and Control
ProblemSolving
1
RRT in the ICU Standard Processes• Engaged and
Multidisciplinary CRRT Team
• Clear Roles and Responsibilities• Continuous Education• Leadership Support
4
5
Problem Identification
Process Improvement
USMP/MG230/18-0006 3/18 Adapted from: Neyra JA and Goldstein SL. Clin Nephrol. 2018. In press
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Development of quality metrics for CRRT
• Dose• Modality• Anticoagulation• Filter life• Downtime• Fluid removal• Access/return alarms
How to optimize CRRT deliverables in the ICU?
USMP/MG230/18-0006 3/18CRRT, continuous renal replacement therapy; ICU, intensive care unit Clark WR, et al. Int J Artif Organs. 2016;39:399–406
Rewa O, et al. Curr Opin Crit Care. 2015, 21:490–499
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Clinical informatics and CRRT deliverables
USMP/MG230/18-0006 3/18
• You can’t provide timely and effective therapy
“If you can’t measure it…”
• You can’t manage it
• You can’t improve it
CRRT, continuous renal replacement therapyAskenazi DJ, et al. Blood Purif. 2017;43:68–77
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Clinical informatics and CRRT deliverables
USMP/MG230/18-0006 3/18
It is not only about data, but clinical informatics development
CRRT, continuous renal replacement therapy
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Clinical Informatics
• The application of informatics and information technology to deliver safe, efficient, effective, timely, patient-centered, and equitable healthcare services
• Getting the right information, to the right health care team, at the right time to support effective patient care
Clinical informatics and CRRT deliverables
USMP/MG230/18-0006 3/18
Gardner RM, et al. J Am Med Inform Assoc. 2009;16:153–157 O’Connor AM, et al. BMJ. 2003;327:736–740 CRRT, continuous renal replacement therapy
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Domains of Clinical Informatics
Clinical informatics and CRRT deliverables
Clinical Care
The Health System
Information & Communications
Technology
Clinical Informatics
USMP/MG230/18-0006 3/18CRRT, continuous renal replacement therapy
Gardner RM, et al. J Am Med Inform Assoc. 2009;16:153–157
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Clinical informatics and CRRT deliverables
USMP/MG230/18-0006 3/18CRRT, continuous renal replacement therapy
Wisdom
Understanding
Knowledge
Information
Data
Information
Knowledge
Information
Herr TM, et al. J Pathol Inform. 2015;6:46
OPTIMAL PATIENT CARE
Knowledge
Information
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Clinical informatics and CRRT deliverables
CRRT-centric model
KnowledgeData
(machine + patient)
Information
Data integration
tools
Quality management systemsClinical decision support
USMP/MG230/18-0006 3/18Sim I, et al. J Am Med Inform Assoc. 2001;8:527–534
Askenazi DJ, et al. Blood Purif. 2017;43:68–77 CRRT, continuous renal replacement therapy
PATIENT CARE
Improve patient careImprove patient safetyDecrease medical errors
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Quality metrics: Tripartite data
University of Kentucky CRRT Quality Management System
USMP/MG230/18-0006 3/18
MACHINE OUTCOME
CRRT, continuous renal replacement therapyData and Key Parameters Incorporated – University of Kentucky Medical Center
PATIENT
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Example of machine data
• Programmatic Data– Filter/circuit life– Time on machine/treatment lost– Complications: access, clotting
• Therapy Data– CRRT dose: prescribed vs. delivered– Daily fluid goals: prescribed vs. achieved
CRRT Quality Management System
USMP/MG230/18-0006 3/18CRRT, continuous renal replacement therapy
Clark WR, et al. Int J Artif Organs. 2016;39:399–406
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• What is the average filter life?– Why are we changing filters?– How many filters do we lose due to clotting?– What is the cost of replacing filters?
• Filter costs • Nursing time • Waste• How much treatment time is lost?
– On machine time loss– Downtime
• How are we tracking toward our dosing target?• How much fluid was removed per treatment day?• How many access return alarms do we have?
Machine Data: Quality Metrics
USMP/MG230/18-0006 3/18 Clark WR, et al. Int J Artif Organs. 2016;39:399–406
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• CRRT modality• CRRT dose• Fluid removal• Filter life• Downtime
Machine Data: Quality Metrics
USMP/MG230/18-0006 3/18 Clark WR, et al. Int J Artif Organs. 2016;39:399–406 CRRT, continuous renal replacement therapy
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USMP/MG230/18-0006 3/18
CRRT modality: UK experience
September 2016
• CRRT protocol review and update• CRRT order set modifications to accommodate CVVHDF• Development of a comprehensive CRRT flowsheet in the EHR• CRRT education• CRRT machine management for data card access
January 2018
CRRT, continuous renal replacement therapy; CVVH, continuous veno-venous hemofiltration; CVVHDF, continuous veno-venous hemodiafiltration; EHR, electronic health record; UK, University of Kentucky
Case Study – University of Kentucky Medical Center
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CRRT dose: UK experience
September 2016 January 2018
• CRRT protocol review and update, recommended effluent dose ~30 ml/kg/h• Development of a comprehensive CRRT flowsheet in the EHR• CRRT education
USMP/MG230/18-0006 3/18CRRT, continuous renal replacement therapy; EHR, electronic health record; UK, University of Kentucky
Case Study – University of Kentucky Medical Center
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CRRT dose: prescribed vs delivered
• CRRT protocol review and update, recommended effluent dose ~30 ml/kg/h• Development of a comprehensive CRRT flowsheet in the EHR• CRRT education
USMP/MG230/18-0006 3/18CRRT, continuous renal replacement therapy; EHR, electronic health record; UK, University of Kentucky
Case Study – University of Kentucky Medical Center
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• CRRT and FO/fluid regulation education• ICU standardized daily weights• Automated CRRT flowsheet for hourly
suggested fluid removal based on UF goal
Fluid removal: UK experience
September 2016
January 2018
USMP/MG230/18-0006 3/18
CRRT, continuous renal replacement therapy; FO, fluid overload; ICU, intensive care unit; UF, ultrafiltration; UK, University of Kentucky
Case Study – University of Kentucky Medical Center
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Filter life: UK experience
June 2017
September 2016
Why are we changing filters?• Clotting issues *performance• Treatment interruption
*education/recirculation• Treatment ended• Other
USMP/MG230/18-0006 3/18CRRT, continuous renal replacement therapy; EHR, electronic health record; UK, University of Kentucky
• CRRT protocol review and update• CRRT new order set• Development of CRRT flowsheet in the EHR• CRRT education• Citrate anticoagulation education
Case Study – University of Kentucky Medical Center
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Downtime: UK experience
September 2016
June 2017
What events account for time lost?• Bag change/recirculation *performance• Filter change *performance• Patient time off• Access/return/other alarms
*performance
USMP/MG230/18-0006 3/18CRRT, continuous renal replacement therapy; EHR, electronic health record; UK, University of Kentucky
• CRRT protocol review and update• CRRT new order set• Development of CRRT flowsheet in the EHR• CRRT education• Right internal jugular preferred access
Case Study – University of Kentucky Medical Center
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MACHINE
Quality metrics: Tripartite Data
University of Kentucky CRRT Quality Management System
MACHINE
USMP/MG230/18-0006 3/18 Data and Key Parameters Incorporated – University of Kentucky Medical CenterCRRT, continuous renal replacement therapy; UK, University of Kentucky
OUTCOMEPATIENT
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• Integrates utilization, technical, machine data and patient’s outcomes
• ~40-50 patients per month• 60-75% utilization of
CRRT machines• Identified 3 machines to be
replaced (technical issues)
UK-CRRT Quality Management System
52.9%34.6%
12.5%
Hospital deathAlive at dischargeHospice
USMP/MG230/18-0006 3/18Case Study – University of Kentucky Medical CenterCRRT, continuous renal replacement therapy; UK, University of Kentucky
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Conclusions
It is critical to measure key CRRT deliverables that can be improved: delivered dose, achieved fluid removal and resource utilization
The use of clinical informatics is readily available to be implemented in our CRRT practice: integration of machine and patient data in the EHR is the first step!
It is important to develop effective (multidisciplinary) quality management systems: what we are doing and how we can do it better!
Clark WR, et al. Int J Artif Organs. 2016;39:399–406 Rewa O, et al. Curr Opin Crit Care. 2015, 21:490–499
Neyra JA and Goldstein SL. Clin Nephrol. 2018. In pressCRRT, continuous renal replacement therapy; EHR, electronic health recordUSMP/MG230/18-0006 3/18