CTRF Leadership MeetingMarch 4, 2002

Institutional Partners

Develop Infrastructure and Intellectual Property that

Enhances the Competitiveness of the Partners for Clinical and

Extramural Funds

Principle Objective

Evaluate gene expression (and genetic changes) in human brain, ovarian, breast and hematopoetic cancers

Link gene expression (and genetic changes) to clinical findings and clinical laboratory findings (including histopathological diagnoses) in a common database

Evaluate linked data using bioinformatics

Research Objective

ChandhokeGrant

ChristensenFryxell

Jamison

Torr (Central Admin)GinderGarrettBuck

Guiseppe-ElieAbraham

Cooper

Year 1 Year 1 Year 1$325,000 $582,000 $93,000

Total (3 yrs) Total (3 yrs) Total (3 yrs)$975,000 $1,734,603 $290,397

Funding From CTRF

CTRF Funding - Monitoring Expenses

$ Have identified all ledger 5 accounts$ Have identified 2 of the cost share

accounts$ Developing format for monthly

reports$ Automating data acquisition

remains major challenge

Reminder - Cost Share Form (VCU)

CTRF Funding - GMU

CTRF CG Administrative Assistant (Jo Ann Breaux) is developing the mechanisms to monitor VCU ledger 5 and cost share accounts.

Plan is to create regular feedback to project PIs in future.

Cost share expenditures not paid from cost share linked ledger 4 account must be documented using ‘In Kind/3rd Party Cost Share form’ obtained from Margie Booker’s office.

CTRF Funding

Establish Focus Groups to address each of the basic tasks.

Each Focus Group to consist of professionals associated with the CTRF Project with special expertise or knowledge in one or more areas required to address basic tasks.

Structure work within Focus Groups to deal with interrelatedness of basic tasks.

General Approach to Achieve Objectives

Tissue Bank Clinical and Pathology Laboratory Data Database Design Data Analysis Quality Assurance in Microarray

Analysis (Chip Fabrication - proposed)

Focus Group

Focus Group Leaders

G MU

G e rald in e G ran t ( G M U)S u h a il N as im ( V C U )B a rr ie C o o k ( I n o va)

Tissue Bank

L yn ne P en b e rth y (V C U )S u h a il N as im ( VC U )

J a m e s C o op e r ( I n o va)J a m e s B u rg e ss ( I n o va)

B a rr ie C o o k ( I n o va)

ClinP ath

C u rtis J am ison ( G M U)L yn ne P en b e rth y (V C U )

G re g M ille r (V C U )M ike S h e r id e n ( I no va)

D B D esign

V ik a s C h an d h ok e ( G M U)G re g B u ck ( V C U)

D ataA nalysis

A la n C hr is ten s en ( G M U )A n d re a F e rre ira - G o n zale z (V C U)

Q A/ LQ C

VCU I nova

Focus Group Leaders

• Tissue Acquisition System (TAS) Protocol Completed

• Approved by MCC Protocol Review & Monitoring Comm

• Contents– Tissue Handling

• residual sample• obtained after pathology review

– IC - Obtain prior to & following surgery

– Primary Data Collection• Submitted to VCU IRB• Meeting in March at INOVA to

review and assist in establishment of Tissue Bank procedures

• Tissue Bank Staff Activities (Cynthia Losco)– Improving current tissue

storage system– Meeting with pathologists

and MCC faculty• tissue handling• breast clinic scheduler

– Developing expertise at cutting frozen section and microdissection

– developing database fields necessary for Tissue Bank

CTRF - Tissue Bank

GMU Test Installation of GeneX up and Running Created And Instantiated A Schema For A Row-modeled Clinical

Database Creating A Linking Table To Span The Two Databases

VCU MCC - Cancer Registry Being Transferred to ODBC Compliant

Format MCC - Transferring Current Fox Pro to SQL 2000 Pathology Shadow DB (SQL 2000)

operational contains AP Surg Path Reports (text)

Categorization of AP Data identify categories (complete) evaluate accuracy of SNOMED coding (in progress) evaluate procedure to automate categorization from AP text reports

Database Design/Clinical Info

Developing a document to address issues related to QA/QC

Set up meetings with QA/QC Focus Group members Identifying a ‘standard’ RNA from cultured leukemic or

breast cancer cell lines to be examined by all platforms

GMU - Exploring “Terabyte” Database and associated analysis tools

VCU/GMU - GeneX database - has associated analysis tools Set up at both institutions

QA/QC

Data Analysis

Establish Standing Weekly or Biweekly Meeting Dates and TimesComplete the Milestone UpdatesDocument Discussions and Progress Using Listservs

CG-TISBK: Tissue Bank CG-CLNDT: Clinical and Pathology Data CG-DBDSN: Database Design CG-ANLDT: Analyze Data (Data Analysis) CG-QAQC: QAQC CG-LDRPI: Focus Group Leaders and PIs CG-MEMBS: All Members

Communication Amongst Members and

Focus Groups

Address messages to: listname@VENUS.VCU.EDU

Unsubscribe to the listserv by submitting a message with the words SIGNOFF listname to: LISTSERV@VENUS.VCU.EDU

Subscribe to the listserv by asking the PI with whom you work to submit your name and E-mail address to the Program Director (C.Garrett)

USE the listserv(s) to inform members of your activity or to seek advice from the members.

LISTSERVS

Website Update Framework for site has been

started URL is in process of being issued

http://ctrf_cagenomics.vcu.edu Annual Report being used; more

content is still needed Will be completed by mid April

Intellectual property reporting - licenses, patents, etcPublicationsNew applications identified - CTRF Administrative office

will search for new funding opportunities (SPIN)will collect CVs, other support, facilities, interest documentsgoal - 4 - 8 million in d.c. from CTRF CG Project

Any other discoveriesFederal money leveragedPrivate research money leveragedAdvancement of technology and economic development in VA

CTRF - Specific Reportables

Old Business

New Business

MondayApril 1, 2002

9:30 A.M.