CTSA Imaging Working CTSA Imaging Working GroupGroup

Coordinated by:Coordinated by:RSNA (Radiologic Society of North RSNA (Radiologic Society of North

America)America)DTRI (Duke Translational Research DTRI (Duke Translational Research

Institute)Institute)

Rationale for RSNA Rationale for RSNA Interest and InvolvementInterest and Involvement

RSNA Strategic Plan GoalsRSNA Strategic Plan Goals

1.1. Conduct activities to meet the educational and continuing Conduct activities to meet the educational and continuing professional development needs of RSNA members.professional development needs of RSNA members.

2.2. Promote high quality science and research in radiology, Promote high quality science and research in radiology, radiation oncology, and radiologic physics.radiation oncology, and radiologic physics.

3.3. Maintain the preeminence of the annual meeting as a Maintain the preeminence of the annual meeting as a scientific and educational forum.scientific and educational forum.

4.4. Pursue excellence in publications and communications to Pursue excellence in publications and communications to advance radiologic science and education.advance radiologic science and education.

5.5. Foster productive relationships with other organizations and Foster productive relationships with other organizations and corporate entities for the purpose of strengthening radiology.corporate entities for the purpose of strengthening radiology.

6.6. Foster relationships with international physicians and Foster relationships with international physicians and societies in recognition of an increasingly international societies in recognition of an increasingly international radiologic community.radiologic community.

7.7. Govern and manage RSNA in an effective, efficient, and Govern and manage RSNA in an effective, efficient, and fiscally responsible manner. fiscally responsible manner.

RSNA Strategic Plan GoalsRSNA Strategic Plan Goals

1.1. Conduct activities to meet the educational and continuing Conduct activities to meet the educational and continuing professional development needs of RSNA members.professional development needs of RSNA members.

2.2. Promote high quality science and research in radiology, Promote high quality science and research in radiology, radiation oncology, and radiologic physics.radiation oncology, and radiologic physics.

3.3. Maintain the preeminence of the annual meeting as a Maintain the preeminence of the annual meeting as a scientific and educational forum.scientific and educational forum.

4.4. Pursue excellence in publications and communications to Pursue excellence in publications and communications to advance radiologic science and education.advance radiologic science and education.

5.5. Foster productive relationships with other organizations and Foster productive relationships with other organizations and corporate entities for the purpose of strengthening radiology.corporate entities for the purpose of strengthening radiology.

6.6. Foster relationships with international physicians and Foster relationships with international physicians and societies in recognition of an increasingly international societies in recognition of an increasingly international radiologic community.radiologic community.

7.7. Govern and manage RSNA in an effective, efficient, and Govern and manage RSNA in an effective, efficient, and fiscally responsible manner.fiscally responsible manner.

Goal 2: Promote high quality science and Goal 2: Promote high quality science and research in radiology, radiation oncology, and research in radiology, radiation oncology, and radiologic physics.radiologic physics.

• 2.1 Facilitate successful applications for funding from NIH and 2.1 Facilitate successful applications for funding from NIH and other sources.other sources.

• 2.2 Increase awareness of cutting edge developments and 2.2 Increase awareness of cutting edge developments and research opportunities vital to the future of radiology.research opportunities vital to the future of radiology.

• 2.3 Stimulate the pursuit of cutting edge developments and 2.3 Stimulate the pursuit of cutting edge developments and research opportunities vital to the future of radiology.research opportunities vital to the future of radiology.

• 2.4 Identify, stimulate and support research opportunities in 2.4 Identify, stimulate and support research opportunities in residency and fellowship training.residency and fellowship training.

• 2.5 Enhance the readiness and capability of the radiologic 2.5 Enhance the readiness and capability of the radiologic community to conduct research.community to conduct research.

• 2.6 Prepare professionals in radiologic sciences for an 2.6 Prepare professionals in radiologic sciences for an increasingly quantitative future.increasingly quantitative future.

• 2.7 Increase the Research and Education Foundation 2.7 Increase the Research and Education Foundation resources.resources.

Goal 2: Promote high quality science and Goal 2: Promote high quality science and research in radiology, radiation oncology, and research in radiology, radiation oncology, and radiologic physics.radiologic physics.

• 2.1 Facilitate successful applications for funding from NIH and 2.1 Facilitate successful applications for funding from NIH and other sources.other sources.

• 2.2 Increase awareness of cutting edge developments and 2.2 Increase awareness of cutting edge developments and research opportunities vital to the future of radiology.research opportunities vital to the future of radiology.

• 2.3 Stimulate the pursuit of cutting edge developments and 2.3 Stimulate the pursuit of cutting edge developments and research opportunities vital to the future of radiology.research opportunities vital to the future of radiology.

• 2.4 Identify, stimulate and support research opportunities in 2.4 Identify, stimulate and support research opportunities in residency and fellowship training.residency and fellowship training.

• 2.5 Enhance the readiness and capability of the radiologic 2.5 Enhance the readiness and capability of the radiologic community to conduct research.community to conduct research.

• 2.6 Prepare professionals in radiologic sciences for an 2.6 Prepare professionals in radiologic sciences for an increasingly quantitative future.increasingly quantitative future.

• 2.7 Increase the Research and Education Foundation 2.7 Increase the Research and Education Foundation resources.resources.

CTSAs and IRATsCTSAs and IRATs

• RSNA coordination of CTSA RSNA coordination of CTSA Imaging Working Group is modeled Imaging Working Group is modeled after AACI (American Association of after AACI (American Association of Cancer Institutes) coordination of Cancer Institutes) coordination of NCI-funded Image Response NCI-funded Image Response Assessment Teams (IRATs)Assessment Teams (IRATs)

• Significant overlap of investigators Significant overlap of investigators in IRATs and imaging components in IRATs and imaging components of CTSAsof CTSAs

How is it funded?How is it funded?

• RSNA provides administrative and RSNA provides administrative and logistical support from the operating logistical support from the operating budget of its Scientific Division, headed budget of its Scientific Division, headed by Dr. Linda Bresolin.by Dr. Linda Bresolin.

• RSNA contracts with Duke University RSNA contracts with Duke University for a percentage of Dr. Sullivan’s time.for a percentage of Dr. Sullivan’s time.

• Dr. Reynolds’ time is included as part Dr. Reynolds’ time is included as part of his duties as Project Leader of the of his duties as Project Leader of the Imaging Core under DTRI.Imaging Core under DTRI.

Emory Emory CenterCenter

for Systems for Systems Imaging Imaging

4 Pillar Themes4 Pillar Themes

Education/Training

(Hu/Meltzer)Computation &

Image Processing

(Votaw)

Molecular Tracer

Development(Goodman)

ImagingInstrumentation/

Methodology(Hu)

Emory Center for Systems Imaging (CSI)

4 Pillar Themes

Oncology

Cardiovascular

Transplantation/Regenerative

Vaccines/InflammationCro

ss-C

utt

ing

Sci

enti

fic

Pro

gra

ms

Neuroscience

Common themes among CTSA Common themes among CTSA imaging programs imaging programs

1.1. Inventory both imaging resources and imaging trialsInventory both imaging resources and imaging trials2.2. Create an imaging Core or centralized imaging Create an imaging Core or centralized imaging

resource – some virtual, some physicalresource – some virtual, some physical3.3. Increase accessibility to information, expertise Increase accessibility to information, expertise

(possibly consultative) and equipment related to (possibly consultative) and equipment related to imaging imaging

4.4. Utilize/Integrate imaging in translational researchUtilize/Integrate imaging in translational research5.5. Increase knowledge of imaging biomarkers and their Increase knowledge of imaging biomarkers and their

use as endpoints in clinical trialsuse as endpoints in clinical trials6.6. Implement or improve image storage and analysis – Implement or improve image storage and analysis –

PACS and analytical toolsPACS and analytical tools7.7. Develop mechanisms for data sharingDevelop mechanisms for data sharing

8.8. Provide training in translational researchProvide training in translational research to new and to new and established investigatorsestablished investigators

9.9. Develop innovations in imagingDevelop innovations in imaging

RSNA-Duke Role in Developing an RSNA-Duke Role in Developing an Imaging Working Group within the CTSA Imaging Working Group within the CTSA

programprogram

• Organizational meeting, Chicago, Nov Organizational meeting, Chicago, Nov 27, 200727, 2007– Requests for regular conference Requests for regular conference

calls, wiki, periodic meetingscalls, wiki, periodic meetings

• Conference call with NCRR & NIBIB Conference call with NCRR & NIBIB staff Jan 2008staff Jan 2008

RSNA-Duke Role in Developing an RSNA-Duke Role in Developing an Imaging Working Group within the CTSA Imaging Working Group within the CTSA

programprogram

• Conference calls with grantees, Feb Conference calls with grantees, Feb 12 & Apr 11 200812 & Apr 11 2008

• Requests for subcommitteesRequests for subcommittees on: on: – Core resourcesCore resources– Imaging InformaticsImaging Informatics– Clinical TrialsClinical Trials– EducationEducation– QuantificationQuantification

ParticipationParticipation

• Participation in this Imaging Working Participation in this Imaging Working Group and Subgroups is open to all Group and Subgroups is open to all interested people.interested people.

• (Modeled after the NCI-funded caBIG (Modeled after the NCI-funded caBIG Workspaces).Workspaces).

IWG Subcommittees in IWG Subcommittees in development:development:

• Core ResourcesCore Resources– Brian Reynolds, PhD, DukeBrian Reynolds, PhD, Duke

• Imaging InformaticsImaging Informatics– Brad Erickson, MD, PhD, MayoBrad Erickson, MD, PhD, Mayo

• Clinical TrialsClinical Trials– Gary Dorfman, MD, CornellGary Dorfman, MD, Cornell

• EducationEducation– Katarzyna Macura, MD, PhD, HopkinsKatarzyna Macura, MD, PhD, Hopkins

Core Resources SubcommitteeCore Resources Subcommittee

• Share information about organization, Share information about organization, management, finances for core management, finances for core resourcesresources

• Promulgate “best practices”Promulgate “best practices”

• Provide “support group” for non-Provide “support group” for non-faculty-member Core Managers (e.g., faculty-member Core Managers (e.g., career development issues, etc.)career development issues, etc.)

Imaging Informatics Project Group

• Goal: Develop an inter-operable imaging informatics infrastructure that enables maximal sharing of image-derived data and information from research that can be widely deployed to CTSA sites, IRAT sites, Cancer Centers and other major research facilities employing medical imaging.

• Methods:1. Monthly (TBD) teleconferences in which participants discuss

what and how to achieve goal2. Participate in CTSA Informatics activities and Imaging

Informatics activities in other venues3. Establish task groups focused on components of the larger

plan4. Consider arranging/participating in a workshop on imaging

informatics needs / available tools for research5. Develop proposals and plans for prototypes / test

installations

Clinical Trials SubcommitteeClinical Trials Subcommittee

• Develop UPICT (Uniform Protocols for Develop UPICT (Uniform Protocols for Imaging in Clinical Trials)Imaging in Clinical Trials)

• Help CTSA imaging groups establish Help CTSA imaging groups establish procedures for imaging involvement in procedures for imaging involvement in development of and review of clinical trial development of and review of clinical trial protocols at their institutionsprotocols at their institutions

• Develop a proposal for a multi-site Develop a proposal for a multi-site demonstration project related to imaging in demonstration project related to imaging in clinical trials (e.g., a validation study of an clinical trials (e.g., a validation study of an imaging biomarker).imaging biomarker).

Education SubcommitteeEducation Subcommittee

• Inventory resources available to Inventory resources available to imagers and users of imaging to imagers and users of imaging to educate them about appropriate educate them about appropriate methodology for clinical trials.methodology for clinical trials.

• Develop educational activities or Develop educational activities or resources to fill gaps identified by resources to fill gaps identified by above inventory.above inventory.

Future PlansFuture Plans

• Full conference calls q 2 mosFull conference calls q 2 mos• Subgroup conference calls TBD, maybe Subgroup conference calls TBD, maybe

monthlymonthly• Face-to-face meetings:Face-to-face meetings:

– October 2, 2008, Pentagon City, VA, all day (with October 2, 2008, Pentagon City, VA, all day (with ACRIN meeting)ACRIN meeting)

– December 2, 2008, Chicago, 3 to 5 PM (with RSNA December 2, 2008, Chicago, 3 to 5 PM (with RSNA meeting)meeting)

– 2009, TBD, 1.5 days (with IRATs)2009, TBD, 1.5 days (with IRATs)• Google group establishedGoogle group established• Web site under developmentWeb site under development

Future PlansFuture Plans

• Determine appropriate interactions with Determine appropriate interactions with Translational Steering Committee, and Translational Steering Committee, and other Steering Committeesother Steering Committees

• Determine appropriate interactions with Determine appropriate interactions with other relevant subcommittees, task other relevant subcommittees, task forces, etc.forces, etc.

Questions?Questions?

Thank you.Thank you.