cure of colitis by cd4 + cd25 + regulatory t cells barrette kathleen – dreesen erwin mottet c,...
TRANSCRIPT
Cure of Colitis by CD4+CD25+ Regulatory T Cells
Barrette Kathleen – Dreesen Erwin
Mottet C, Uhlig HH, Powrie F
CD4+
CD45RBlow CD45RBhigh
CD4-
CD25+ CD25-
CD4+
CD45RBlow CD45RBhigh
CD4-
CD25+ CD25-
As therapeutic agents?
Conditions
- Inhibit ongoing T cell responses
- Reverse established pathology
Experimental protocol
Experimental protocol
Experimental protocol
Experimental protocol
Experimental protocol
Experimental protocol
CD4+CD25+ TR cells reverse wasting disease
CD4+CD25+ TR cells reverse wasting disease
CD4+CD25+ TR cells reverse wasting disease
CD4+CD25+ TR cells reverse wasting disease
CD4+CD25+ TR cells reverse wasting disease
CD4+CD25+ TR cells reverse wasting disease
CD4+CD25+ TR cells reverse wasting disease
CD4+CD25+ TR cells reverse colitis
CD4+CD25+ TR cells reverse colitis
CD4+CD25+ TR cells reverse colitis
CD4+CD25+ TR cells reverse colitis
CD4+CD25+ TR cells reverse colitis
CD4+CD25+ TR cells reverse wasting disease & colitis
CD4+CD25+ T cells home to the MLN & colon
* P < 0,05
*
CD4+CD25+ T cells home to the MLN & colon
The progeny of CD4+CD25+ T cellsproliferate in MLN & colon
The progeny of CD4+CD25+ T cellsproliferate in MLN & colon
CD4+CD25+ T cells are in contact withCD11c+ cells and CD4+ T cells in vivo
