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CURRICULUM VITAE (March, 2008)

Personal Data

Name: Anthony R. Caggiula

Address: 100 Denniston St. #20

Home: Pittsburgh, PA. 15206

Professional: Department of Psychology, 3131 Sennott Square

University of Pittsburgh, Pittsburgh, PA 15260

History: Born on March 3, 1941, in Philadelphia, PA.

Education

1958-62 B.S. in Psychology, St. Joseph's College

1962-64 M.S. in Psychology, University of Delaware

1964-66 M.A. and Ph.D. in Psychology, Princeton University

1966-68 Postdoctoral Fellow, Brain Research Laboratory, University of Michigan

Professional History

1962-64 Research Fellow, Center for Research on Social Behavior,

University of Delaware

1963-64 Research Assistant, Small Crew Effectiveness Division,

Behavioral Sciences Department, Naval Medical Research

Institute, Bethesda, Maryland

1964-65 Research Assistant in Physiological Psychology, Department of

Psychology, Princeton University

1965-66 N.I.H. Predoctoral Fellow, Department of Psychology, Princeton

University

1966-68 N.I.H. Postdoctoral Fellow, Brain Research Laboratory,

Department of Psychology, University of Michigan

1967-68 Lecturer, Department of Psychology, University of Michigan

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1968- Assistant - Full Professor of Psychology, University of Pittsburgh

1968-73 Assistant Professor (Secondary) of Pharmacology, University of

Pittsburgh School of Medicine

1986-89 Associate Professor (Secondary) of Behavioral Neuroscience,

University of Pittsburgh

1990-96 Chair, Biopsychology Graduate Training Program, Department of

Psychology, University of Pittsburgh

1996-97 Acting Chair, Health Psychology Graduate Training Program, Department

of Psychology, University of Pittsburgh

1991- Member, University of Pittsburgh Cancer Institute

1994- Associate - Full Professor (Secondary) of Psychiatry, University of

Pittsburgh School of Medicine

1997 Acting Chair, Department of Psychology, University of Pittsburgh

1998 Chair, Department of Psychology, University of Pittsburgh

Professional Organizations

American Association for the Advancement of Science

American Psychological Society

International Society for Psychoneuroendocrinology

International Society for Neuroimmunomodulation

New York Academy of Sciences

Society for Behavioral Medicine

Society for Neuroscience

Society for Research on Nicotine and Tobacco

College on Problems of Drug Addiction

Awards

Ph.D. Dissertation: honorable mention in Creative Talents Awards Program 1967,

American Institutes for Research

External Grant Support

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A. Prior Support

1969 Peripheral determinants of sexual- NIMH

aggressive behavior (P.I.)

1972-1973 Sexual behavior and brain biogenic amines NIMH

(P.I.)

1969-1981 Neurophysiological correlates of sexual NIMH

behavior (P.I.)

1986-1988 The effects of housing (number of mice/ ONR

cage) on immunologic competence

(Co-Investigator)

1987-1990 CHD risk, behavioral stress, and NHLBI

reproductive hormones (Co-P.I.)

1989-1992 Environmental control over chronic toler- NSF

ance to nicotine (P.I.)

1990-1992 Stress-induced time dependent sensitization NIAAA

and ethanol consumption (Co-P.I.)

1991-1993 Ovarian hormones, stress and immunologic NIMH

responsiveness (P.I.)

1991-1994 Long-term sensitization after acute NIMH

stressors (Co-P.I.)

1994-1996 Ovarian hormones, stress and immunologic NIMH

responsiveness (P.I.)

1992-1996 Conditioned tolerance to nicotine (P.I.) NIDA

1994-1997 On-off effects of cocaine on dopamine efflux NIDA

(Co-P.I.)

1994-1997 The Immunologic Effects of Nicotine (Co-P.I.) NIDA

1997-2000 Conditioned tolerance to nicotine (P.I.) NIDA

TDC(IndC): $351,778(155,137)

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1997-2000 Effects of self-administered vs noncontingent NIDA

nicotine (P.I.)

TDC(IndC): $351,430(155,907)

1997-2002 Smoking, stress and immune function (P.I - 1997 NIDA

to 2000; Co-P.I. - 2000 to 2002)

TDC(IndC): $862,713(411,506)

2000-2004 Effects of self-administered vs noncontingent NIDA

nicotine (P.I.)

TDC(IndC):$600,000 ($277,565).

2000-2004 (Co-P.I.) Sex differences in nicotine reinforcement: NIDA

Human/Animal (Ken Perkins .P.I.)

TDC (IndC): $900,000 ($421,575)

B. Current Support

2004-2008 (P.I.) Effects of self-administered vs noncontingent NIDA

nicotine

TDC (IndC):$800,000 ($$378,300).

2004-2007 (Co-I.) Extinction in smokers: Renewal and spontaneous NIDA

Recovery (Cynthia Conklin P.I.)

TDC (IndC) $450,000 ($218,250)

2005-2010 (Co- I.) Pharmacology of cue-induced nicotine relapse NIDA

(Xiu Liu P.I.)

TDC (IndC) $$900,000 ($436,500)

Administrative Experience: Departmental

Departmental Executive Committee

Student-Faculty Liason Committee (Ch.)

Colloquium Committee (Ch.)

Animal Care Committee (Ch.)

Chair, Psychobiology Program

Psychobiology Training Grant Executive Committee

Director, Psychobiology Graduate Student Teacher-Training Program

Long Range Planning Committee

Graduate Education Council

Chair, Biopsychology Program

Search Committee for Departmental Chair

Acting Chair, Health Psychology Program

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Acting Chair, Department of Psychology

Chair, Department of Psychology

Administrative Experience: University

Faculty of Arts and Sciences Representative to University Animal

Resources Committee

College of Arts and Sciences Curriculum Reform Committee

College of Arts and Sciences Curriculum Review Committee

Faculty of Arts and Sciences Graduate Council

Clinical Research Center for Affective Disorders Seed Money

Review Committee

Advisory Board on Science Education for the Non-Specialist

Natural Sciences Council

Chair, Natural Sciences Council (1999-2000)

Planning Committee, New Department Chairs Orientation Meeting

Numerous ad hoc committees

Additional Professional Functions

1) Reviewer for Physiology and Behavior; Science;

Psychopharmacology; Brain Research Bulletin;

Behavioral Biology; Pharmacology, Biochemistry & Behavior;

Hormones & Behavior; Physiological Psychology; Behavioral and Brain

Sciences; Journal of Applied Biobehavioral Research,

Neuropsychopharmacology,

International Journal of Psychopharmacology, Drug and Alcohol Dependence

2) Member of NSF Grant Review Panel (Integrative and Motor Processes). 1983-

1986

3) Book reviewer for Prentice Hall, William C. Brown Co.,

Allyn & Bacon Inc.

4) Study section member, NIAAA review of RFA on nicotine and alcohol; ad hoc

member of several NIH study sections

5) Member, Technical Advisory Committee, Tobacco and Health Research Institute;

1998-2002

6) Consultant, Minneapolis Medical Research Foundation, Hennepin County

Medical Center and University of Minnesota, Minneapolis, MN. 2000-2003

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Teaching

Introduction to Psychology (Undergrad.)

Introduction to Psychology as a Natural Science (Undergrad.)

Introduction to Biopsychology (Undergrad.)

Biopsychology of Health (Undergrad. honors)

Behavioral Endocrinology (Undergrad. and Graduate)

Psychoneuroimmunology (Undergrad. and Graduate)

Seminar in Behavioral Pharmacology (Graduate)

Seminar in Behavioral Medicine: Stress and Drugs (Graduate)

Seminar on Sexual Differentiation (Graduate)

Research Methods in Biopsychology (Graduate)

Biological Basis of Psychopathology (Graduate)

Ph.D. Dissertations Directed

Szechtman, H. Systematic, surgical isolation of the preoptic area with a microknife: A

neuroanatomical and behavioral analysis of the disruption of sexual behavior in male rats 1975

Booth, Jr., A.M. Nervous control of penile erection and copulatory behavior in the rat 1976

Clark, T.K. The region of the ascending dorsal noradrenergic bundle of the locus coeruleus in

relation to male copulatory behavior 1979

Bradshaw, W.G. The effects of testosterone and 5alpha-reduced androgens on male copulatory

behavior in the rat. 1980

Chiodo, L.A. Studies on the regulation of the responsiveness of substantia nigra dopamine

neurons to sensory stimuli 1981

Ostrowski, N.L. Morphine-dopamine interactions: behavioral and electrophysiological studies

1984

Donny, E.C. Nicotine self-administration in male and female rats: sex differences and estrous

cycle effects. 1999

McCallum, S.E. The effects of injection regimen and competitive or non-competitive blockade

on tolerance and nicotine-induced receptor upregulation in rats. 1999

Chaudhri, N. Complex interactions between nicotine and nonpharmacological stimuli reveal a

novel role for nicotine in reinforcement 2005

Publications: Refereed Articles

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1. Wheeler, L. and Caggiula, A.R. The contagion of aggression. Journal of Experimental

Social Psychology, 1966, 2, 1-10.

2. Caggiula, A.R. and Hoebel, B.G. Copulation-reward site in the posterior hypothalamus.

Science, 1966, 153, 1284-1285.

3. Caggiula, A.R. and Eibergen, R. Copulation of virgin male rats evoked by painful

peripheral stimulation. Journal of Comparative and Physiological Psychology, 1969, 69,

414-419.

4. Caggiula, A.R. Analysis of the copulation-reward properties of posterior hypothalamic

stimulation in male rats. Journal of Comparative and Physiological Psychology, 1970,

70, 399-412.

5. Caggiula, A.R. and Szechtman, H. Hypothalamic stimulation: A biphasic influence on

copulation of the male rat. Behavioral Biology, 1972, 7, 591-598.

6. Caggiula, A.R. Shock-elicited copulation and aggression. Journal of Comparative and

Physiological Psychology, 1972, 80, 393-397.

7. Caggiula, A.R., Antelman, S., & Zigmond, M.J. Disruption of copulation in male rats

after hypothalamic lesions: A behavioral, anatomical and neurochemical analysis. Brain

Research, 1973, 59, 273-287.

8. Eibergen, R.D. and Caggiula, A.R. Ventral midbrain involvement in copulatory behavior

of the male rat. Physiology and Behavior, 1973, 10, 435-441.

9. Caggiula, A.R., Antelman, S., & Zigmond, M.J. Ineffectiveness of sexually arousing

stimulation after hypothalamic lesions in the male rat. Physiology and Behavior, 1974,

12, 313-316.

10. Caggiula, A.R. and Vlahoulis, M. Modifications in the copulatory performance of male

rats by repeated peripheral shock. Behavioral Biology, 1974, 11, 269-274.

11. Szechtman, H., Lambrou, P.J., Caggiula, A.R., & Redgate, E.S. Plasma corticosterone

levels during sexual behavior in male rats. Hormones & Behavior, 1974, 5, 191-200.

12. Caggiula, A.R., Gay, V., Antelman, S.M., & Leggens, J. Disruption of copulatory

behavior in male rats after hypothalamic lesions: A neuroendocrine analysis.

Neuroendocrinology, 1975, 17, 193-202.

13. Eibergen, R. and Caggiula, A.R. Acceleration and pacing of copulatory performance of

male rats by repeated, aversive brain stimulation. Physiology and Behavior, 1975, 15,

253-258.

14. Clark, T.K., Caggiula, A.R., McConnell, R.A., & Antelman, S.M. Sexual inhibition is

reduced by rostral midbrain lesions in the male rat. Science, 1975, 190, 169-171.

15. Antelman, S.M., Herndon, J.G., Jr., Caggiula, A.R., & Shaw, D.H. Dopamine-receptor

blockade: Prevention of shock-activated sexual behavior in naive rats.

Psychopharmacological Bulletin, 1975, 11, 45-46.

16. Caggiula, A.R., Shaw, D.H., Antelman, S.M. & Edwards, D.J. Interactive effects of brain

catecholamines and variations in sexual and non-sexual arousal on copulatory behavior of

male rats. Brain Research, 1976, 111, 321-336.

17. Antelman, S.M. and Caggiula, A.R. Norepinephrine-dopamine interactions and behavior.

Science, 1977, 195, 646-653.

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18. Herndon, J.G., Jr., Caggiula, A.R., Sharp, D., Ellis, D., & Redgate, E.S. Selective

enhancement of the lordotic component of female sexual behavior in rats following

destruction of central catecholamine-containing systems. Brain Research, 1978, 141,

137-151.

19. Szechtman, H., Caggiula, A.R.. & Wulkan, D. Preoptic knife cuts and sexual behavior in

male rats. Brain Research, 1978, 150, 569-591.

20. Antelman, S.M., Caggiula, A.R., Black, C., & Edwards, D.J. Stress reverses the anorexia

induced by amphetamine and methylphenidate, but not fenfluramine. Brain Research,

1978, 143, 580-585.

21. Caggiula, A.R., Herndon, J.G., Jr., Scanlon, R., Greenstone, D., Bradshaw, W., & Sharp,

D. Dissociation of active from immobility components of sexual behavior in female rats

by central 6-hydroxydopamine: Implications for CA involvement in sexual behavior and

sensorimotor responsiveness. Brain Research, 1979, 172, 505-520.

22. Pang, S.F., Caggiula, A.R., Gay, V.L., Goodman, R.L., & Pang, C.S.F. Serum

concentrations of testosterone, oestrogens, luteinizing hormone and follicle-stimulating

hormone in male and female rats during the critical period of neuronal sexual

differentiation. J. Endocr., 1979, 80, 103-110.

23. Chiodo, L.A., Caggiula, A.R., & Saller, C.F. Estrogen increases both spirperone-induced

catalepsy and brain levels of 3H-spirperone in the rat. Brain Research, 1979, 172, 360-

366.

24. Chiodo, L.A., Caggiula, A.R., Antelman, S.M., & Lineberry, C.G. Reciprocal influences

of activating and immobilizing stimuli on the activity of nigrostriatal dopamine neurons.

Brain Research, 1979, 176, 385-390.

25. Chiodo, L.A., Antelman, S.M., Caggiula, A.R., & Lineberry, C.G. Sensory stimuli alter

the discharge rate of dopamine (DA) neurons: Evidence for two functional types of DA

cells in the substantia nigra. Brain Research, 1980, 189, 544-549.

26. Chiodo, L.A. & Caggiula, A.R. Alterations in basal firing rate and autoreceptor

sensitivity of dopamine neurons in the substantia nigra following acute and extended

exposure to estrogen. European Journal of Pharmacology, 1980, 67, 165-166.

27. Chiodo, L.A., Caggiula, A.R., & Saller, C.F. Estrogen potentiates the stereotypy

produced by dopamine agonists in the rat. Life Sciences, 1981, 28, 827-835.

28. Ostrowski, N.L., Hatfield, C.B., & Caggiula, A.R. The effects of low doses of morphine

on the activity of dopamine-containing cells and on behavior. Life Sciences, 1982, 31,

2347-2350.

29. Chiodo, L.A. & Caggiula, A.R. Substantia nigra dopamine neurons: Alterations in basal

discharge rates and autoreceptor sensitivity induced by estrogen. J. of

Neuropharmacology, 1983, 22, 593-599.

30. Rabin, B.S., Lyte, M., Epstein, L.H., & Caggiula, A.R. Alteration of immune

competency by number of mice housed per cage. Ann. N.Y. Academy of Science, 1987,

496, 492-500.

31. Lysle, D.T., Cunnick, J.E., Wu, R., Caggiula, A.R., Wood, P.G. & Rabin, B.S. 2-deoxy-

D-glucose modulation of T-lymphocyte reactivity: differential effects on lymphoid

compartments. Brain, Behavior and Immunity, 1988, 2: 212-221

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32. Epstein, L.H., Caggiula, A.R. & Stiller, R.L. Environment - specific tolerance to nicotine

Psychopharmacology, 1989, 97: 235-237

33. Caggiula, A.R., Antelman, S.M. Aul, E., Knopf, S. & Edwards, D.J. Prior stress

attenuates the analgesic response but sensitizes the corticosterone and cortical dopamine

response to stress 10 days later Psychopharmacology, 1989, 99: 233-237

34. Caggiula, A.R., Epstein, L.H. and Stiller, R.L. Changing environmental cues reduces

tolerance to nicotine-induced anorexia Psychopharmacology, 1989, 99: 389-392

35. Stoney, C.M., Owens, J., Matthews, K.A., Davis, M.C. and Caggiula, A. Influence of the

normal menstrual cycle on physiologic functioning during behavioral stress

Psychophysiology 1990, 27(2): 125-135

36. Caggiula, A.R., Stoney, K., Owens, J., Matthews, K.A. and Rabin, B. T-lymphocyte

reactivity during the menstrual cycle in women Clin Immunology and Immunopath 1990,

56(1): 130-134

37. Antelman, S.M., Cunnick, J.E., Lysle, D.T., Caggiula, A.R., Knopf, S., Kocan, D.J.,

Rabin, B.S., and Edwards, D.J. Immobilization 12 days (but not one hour) earlier

enhanced 2-deoxy-d-glucose-induced immunosuppression: evidence for stressor-induced

time-dependent sensitization of the immune system Progress in Neuro-

psychopharmacology and Biological Psychiatry 1990, 14: 579-590

38. Matthews, K.A., Davis, M.C., Stoney, C.M., Owens, J.F. and Caggiula, A.R. Does the

gender relevance of the stressor influence sex differences in psychophysiological

responses? Health Psychology 1991 10(2):112-120

39. Ostrowski, N.L. and Caggiula, A.R. Correlation between locomotor stimulation and the

electrophysiological effects of low doses of morphine on substantia nigra dopamine

neurons: I. Acute drug administration. J Pharmacol Exp Ther 1991 257(1):72-81

40. Epstein, L.H., Caggiula, A.R., Perkins, K.A., Bennett, S.M. & Smith, J. Context-

dependent tolerance to the heart rate effects of smoking Pharmacol Biochem Behav 1991

39:15-19

41. Caggiula, A.R., Epstein, L.H., Antelman, S.M., Saylor, S.S., Perkins, K.A., Knopf, S. and

Stiller, R. Conditioned tolerance to the anorectic and corticosterone-elevating effects of

nicotine Pharmacol Biochem Behav 1991 40:53-59

42. Antelman, S.M., Caggiula, A.R., Kocan, D., Knopf, S., Meyer, D., Edwards, D. and

Barry III, H. One Experience with "lower" or "higher" intensity stressors, respectively

enhances or diminishes responsiveness to haloperidol weeks later: Implications for

understanding drug variability Brain Research 1991 566:276-283

43. Epstein, L.H., Bulik, C.M., Perkins, K.A., Caggiula, A.R. and Rodefer, J. Behavioral

economic analysis of smoking: Money and food as alternatives 1991 Pharmacol Biochem

Behav 38: 715-721

44. Antelman, S.M., Caggiula, A.R., Knopf, S., Kocan, D. J. and Edwards, D.J.

Amphetamine or haloperidol two weeks earlier antagonized the plasma corticosterone

response to amphetamine; evidence for the stressful/foreign nature of drugs

Psychopharmacology 1992 107(2-3): 331-336

45. Antelman, S.M., Kocan D., Knopf, S., Edwards, D.J. and Caggiula, A.R. One brief

exposure to a psychological stressor induces long-lasting, time-dependent sensitization of

both the cataleptic and neurochemical response to haloperidol Life Sci 1992 51:261-266

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46. Perkins, K.A., Grobe, J.E., Epstein, L.H., Caggiula, A.R. and Stiller, R.L. Subjective

effects of nicotine may be dependent on baseline subjective state J Substance Abuse 1992

4:131-141

47. Caggiula, A.R., McAllister, C.M., Epstein, L.H., Antelman, S.M., Knopf, S., Saylor, S

and Perkins, K.A.. Nicotine suppresses the proliferative response of peripheral blood

lymphocytes in rats Drug Development Research 1992 26(4): 473-479

48. Epstein, L.H., Caggiula, A.R., Perkins, K.A., Mitchell, S. and Roedefer, J. Abstenence

from smoking decreases habituation to food cues Physiol Behav 1992 52:641-646

49. Epstein, L.H., Rodefer, J.S., Wisniewski, L. and Caggiula, A.R. Habituation and

dishabituation of the human salivary response Pharmacol Biochem Behav 1992 51(5):

945-950

50. Wisniewski, L., Epstein, L.H. and Caggiula, A.R. The effects of food change on

consumption hedonics and salivation in non-deprived subjects Physiol Behav 1992

Physiol Behav 1992 52:21-26

51. Epstein, L.H., Mitchell, S.L. and Caggiula, A.R. The effect of subjective and

physiological arousal on dishabituation of salivation Physiol Behav 1993 53:593-597

52. Perkins, K.A., Grobe, J.E., Epstein, L.H., Caggiula, A.R., Stiller, R.L. and Jacobs, R.G.

Chronic and acute tolerance to subjective effects of nicotine Pharmacol Biochem Behav

1993 45:375-381

53. Epstein, L.H., Caggiula, A.R., Rodefer, J.S., Wisniewski, L., and Mitchell, S.L. The

effects of calories and taste on habituation of the human salivary response. Addictive

Behav 1993 18: 179-185

54. Caggiula, A.R., Epstein, L.H., Antelman, S.M., Saylor, S., Knopf, S., Perkins, K.A. and

Stiller, R.L. Acute stress or corticosterone administration reduces responsiveness to

nicotine: Implications for a mechanism of conditioned tolerance Psychopharmacology

1993 111: 499-507

55. McAllister, C.G., Caggiula, A.R., Knopf, S., Epstein, L.H., Miller, A.L., Antelman, S.M.

and Perkins, K.A. Immunological effects of acute and chronic nicotine administration in

rats. J Neuroimmunology 1994 50: 43-49

56. Perkins, K.A., Grobe, J.E., Stiller, R.L., Scierka, A., Fonte, C., Goettler, J., Reynolds,

W.A., Caggiula, A.R. and Jacobs, R.G. Chronic and acute tolerance to the subjective,

cardiovascular and behavioral effects of nicotine in humans J Pharmacol Exp Ther 1994

270:628-638

57. Antelman, S.M., Caggiula, A.R., Kiss, S., Edwards, D.J., Kocan, D. and Stiller, R.

Neurochemical and physiological effects of cocaine oscillate with sequential drug

treatment: possibly a major factor in drug variability Neuropsychopharmacology 1995

12: 297-306

58. Caggiula, A.R., McAllister, C.G., Matthews, K.A., Berga, S.L., Owens, J.F. and Miller,

A.L. Psychological stress and immunological responsiveness in normally cycling,

follicular-stage women J Neuroimmunology 1995 59: 103-111

59. Matthews, K.A., Caggiula, A.R., McAllister, C.G., Berga, S.L., Owens, J.F., Flory, J.D.

and Miller, A.L. Sympathetic reactivity to acute stress and immune response in women

Psychosomatic Med. 1995 57: 564-571

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60. Caggiula, A.R., Epstein, L.H., Perkins, K.A. and Saylor, S. Different methods of

assessing nicotine-induced antinociception may engage somewhat different neural

mechanisms Psychopharmacology 1995 122: 301-306

61. Donny, E., Caggiula, A.R., Knopf, S. and Brown, C. Nicotine self-administration in rats

Psychopharmacology 1995 122: 390-394.

62. Perkins, K.A., Grobe, J.E., Mitchell, S.L., Goettler, J., Caggiula, A.R., Stiller, R.L. and

Scierka, A. Acute tolerance to nicotine in smokers: lack of dissipation within 2 hours.

Psychopharmacology 1995 118: 164-170

63. Antelman, S.M. and Caggiula, A.R. Oscillation follows drug sensitization: Implications.

Crit. Reviews in Neurobiology 1996, 10(1): 101-117

64. Caggiula, A.R., Antelman, S.M., Palmer, A., Kiss, S., Edwards, D.J., and Kocan, D. The

effects of ethanol on striatal dopamine and frontal cortical D-[3H]aspartate efflux

oscillate with repeated ethanol treatment: Relevance to individual differences in drug

variability Neuropsychopharmacology 1996 15(2): 125-132

65. Perkins, K.A., Grobe, J.E., Weiss, D, Fonte, C and Caggiula, A.R. Nicotine preference in

smokers as a function of smoking abstinence Pharmacol. Biochem. Behav. 1996 55(2)

257-263

66. Perkins, K.A., Grobe, J.E. and Caggiula, A.R. Acute reinforcing effects of low-dose

nicotine nasal spray in humans. Pharmacol. Biochem. Behav. 1997 56(2): 235-241

67. Robinson-Vanderwerf, T.M., DiPirro, J.M., Caggiula, A.R. and Kristal, M.B. The

analgesia-enhancing property of ingested amniotic fluid does not affect nicotine-induced

antinociception in naltrexone-treated rats. Pharmacol. Biochem. Behav. 1997 58(1) 147-

151.

68. Donny, E.C., Caggiula, A.R., Mielke, M.M., Jacobs, K.S., Rose, C.A. and Sved, A.F.

Acquisition of nicotine self-administration in rats: The effects of dose, feeding schedule

and drug contingency Psychopharmacol 1998 136(1): 83-90

69. Caggiula, A.R., Antelman, S.M., Kucinski, B., Fowler, H., Edwards, D.J., Austin, M.C.,

Samuel Gershon and Stiller, R. Oscillatory-sensitization model of repeated drug

exposure: Cocaine's effects on shock-induced hypoalgesia Prog. in Neuro-

Psychopharmacol. & Biol. Psychiat. 1998 22: 511-521

70. Antelman, S.M., Caggiula, A.R., Kucinski, B.J., Fowler, H., Gershon, S., Edwards, D.J.,

Austin, M.C., Stiller, R., Kiss, S., and Kocan, D. The effects of lithium on a potential

cycling model of bipolar disorder Prog. in Neuro-Psychopharmacol. & Biol. Psychiat.

1998 22: 495-519

71. Kucinski, B.J., Antelman, S.M., Caggiula, A.R., Fowler, H., Gershon, S, Edwards, D.J.

and Austin, M.C. The oscillatory effects of repeated morphine on shock-induced

hypoalgesia and β-endorphin Synapse 1998 30: 30-37

72. McCallum, S.E., Caggiula, A.R., Epstein, L.H., Saylor, S., Ploskina, T., and Sved, A.F.

Mecamylamine blocks the development of tolerance to nicotine in rats: implications for

the mechanisms of tolerance Psychopharmacol 1999 141(3): 332-338.

73. Kucinski, B.J., Antelman, S.M., Caggiula, A.R., Fowler, H., Gershon, S, Edwards, D.J.

Cocaine-induced oscillation is conditionable Pharmacol. Biochem. Behav. 1999 63(3):

449-455

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74. Donny, E.C., Caggiula, A.R., Mielke, M.M., Booth, S., Gharib, M.A., Hoffman, A.,

Maldovan, V., Shupenko, C. and McCallum, S. Nicotine self-administration in rats on a

progressive ratio schedule of reinforcement Psychopharmacol1999 147: 135-142

75. Antelman, S.M., Caggiula, A.R., Edwards, D.J., Gershon, S., Kucinski, B., Kiss, S. and

Kocan, D. Long-term oscillation of corticosterone following intermittent cocaine. J.

Neural Transmission 2000 107(3): 369-375

76. McCallum, S.E., Caggiula, A.R., Booth, S., Breese, C., Lee, M.J., Donny, E.C., Leonard,

S. and Sved, A.F. Mecamylamine prevents tolerance but enhances whole brain

[3H]epibatidine binding in response to repeated nicotine administration in rats

Psychopharmacol 2000 150:1-8

77. Donny, E.C., Caggiula, A.R., Rowell, P, Maldovan, V., Booth, S., Gharib, M.A., Mielke,

M.M., Hoffman, A. and McCallum, S. Nicotine self-administration: Estrous cycle effects,

sex differences and nicotinic receptor binding Psychopharmacol 2000 151:392-405

78. Donny, E.C., Caggiula, A.R., Rose, C.A., Jacobs, K.S., Mielke, M.M. and Sved, S.F.

Differential hormonal effects of response contingent and response independent nicotine

in rats European J Phamacol 2000 402: 231-240

79. Caggiula, A.R., Donny, E.C., White, A.R., Chaudhri, N., Booth, S., Gharib, M.A.,

Hoffman, A., Perkins, K.A. and Sved, A.F. Cue-dependency of nicotine self-

administration and smoking Pharmacol Biochem Behav (Special issue on nicotine) 2001

70: 515-530

80. Caggiula, A.R., Donny, E.C., White, A.R., Chaudhri, N., , Booth, S., Gharib, M.A., ,

Hoffman, A., Perkins, K.A., & Sved, A.F. Environmental stimuli promote the acquisition

of nicotine self-administration in rats Psychopharmacol. 2002 163: 230-237

81. Flory, J.D., Matthews, K.A., Sistilli, C.G., Caggiula, A.R., Berga, S.L. and Owens, J.F.

Short-term suppression of ovarian hormones and immune function in women.

Psychoneuroendocrinology 2002 27(6): 749-768

82. Perkins, K.A., Jacobs, L., Pelayo, E., Sanders, M. & Caggiula, A.R. Sex differences in

the subjective and reinforcing effects of cigarette nicotine dose. Psychopharmacology

2002 163: 194-201

83. Caggiula, A.R.; Donny, E.C.; Chaudhri, N.; Booth, S.; Gharib, M.; Hoffman, A.;

Clemens, L.; Perkins, K.A.; Evans-Martin, F.F. and Sved, A.F. Importance of non-

pharmacological factors in nicotine self-administration Physiol. Behav. 2002 77: 683-687

84. Donny, E.C., Chaudhri, N., Caggiula, A.R., Booth, S., Gharib, M.A., Evans-Martin, F.F.,

Clements, L.A. and Sved, A.F. Operant responding for a visual reinforcer in rats is

enhanced by non-contingent nicotine: Implications for nicotine self-administration and

reinforcement Psychopharmacology (2003) 169(1): 68-76

85. Perkins, K.A., Ciccocioppo, M., Jacobs, L., Doyle, T., Caggiula, A. (2003) The

subjective and reinforcing effects of visual and olfactory stimuli in alcohol drinking. Exp.

Clin Psychopharmacology 11(4) 269-275

86. Donny, E.C., Lanza, S.T., Balster, R.L., Collins, L.M., Caggiula, A.R. and Rowell, P.

(2004) Using growth models to relate acquisition of nicotine self-administration to break

point and nicotine receptor binding. Drug and Alcohol Dependence 75(1), 23-35

13

87. Perkins, K.A., Jacobs, L., Ciccocioppo, M., Conklin, C., Sayette, M., Caggiula, A. (2004)

The influence of instructions and nicotine dose on the subjective and reinforcing effects

of smoking. Exp. Clin Psychopharmacology 12(2) 91-101

88. Chaudhri, N., Caggiula, A.R., Donny, E.C., Booth, S., Gharib, M.A., Craven, L.A.,

Allen, S.S., Sved, A.F., Perkins, K.A. (2005) Sex Differences in the contribution of

nicotine and nonpharmacological stimuli to nicotine self-administration in rats.

Psychopharmacology 180(2) 258-266.

89. Liu X, Caggiula AR, Yee SK, Nobuta H, Poland RE, Pechnick RN. (2006) Reinstatement

of nicotine-seeking behavior by drug-associated stimuli after extinction in rats

Psychopharmacology 184 (3-4), 417-425.

90. Perkins KA, Doyle T, Ciccocioppo M, Conklin C, Sayette M, Caggiula A. (2006) Sex

differences in the influence of nicotine dose instructions on the reinforcing and self-

reported rewarding effects of smoking Psychopharmacology 184 (3-4), 600-607

91. Palmatier M , Evans-Martin FF, Hoffman A, Caggiula AR, Chaudhri N, Donny EC, Liu

X, Booth S, Gharib M, Craven L, Sved, A. (2006) Dissociating the primary reinforcing

and reinforcement enhancing effects of nicotine using a rat self-administration paradigm

with concurrently available drug and environmental reinforcers Psychopharmacology

184(3-4), 391-400

92. Chaudhri N, Caggiula AR, Donny EC, Booth S, Gharib MA, Craven LA, Sved AF.(2006) Operant responding for conditioned and unconditioned reinforcers in rats is differentially

enhanced by the primary reinforcing and reinforcement-enhancing effects of nicotine

Psychopharmacology (189(1) 27-36

93. Chaudhri N, Caggiula AR, Donny EC, Palmatier MI, Booth S, Gharib MA, Craven LA,

Sved AF. (2007) Self-administered and noncontingent nicotine enhance operant

responding for a visual stimulus in rats: the impact of dose and reinforcement-schedule

Psychopharmacology 190(3) 353-362

94. Liu X, Caggiula AR, Yee SK, Nobuta H, Sved AF, Pechnick RN, Poland RE (2007)

Mecamylamine attenuates cue-induced reinstatement of nicotine-seeking behavior in rats.

Neuropsychopharmacology Mar;32(3):710-8.

95. Palmitier MI, Liu X, Caggiula AR, Donny EC, Booth S, Gahrib M, Craven L, Sved AF

(2007) The role of nicotinic acetylcholine receptors in the primary reinforcing and

reinforcement enhancing effects of nicotine Neuropsychopharmacology 32: 1098-1108

96. Palmatier MI, Matteson GL, Black JJ, Liu X, Caggiula AR, Sved AF (2007). The

reinforcement enhancing effects of nicotine depend on the incentive value of non-drug

reinforcers and increase with repeated drug injections. Drug and Alcohol Dependence.

Jun 15;89(1):52-9.

97. Liu X, Caggiula AR, Palmitier, MI, Donny EC, Booth S, Gahrib M, Craven L (2007)

Reinforcement enhancing effects of nicotine and its attenuation by nicotinic antagonists

in rats Psychopharmacology Nov;194(4):463-73.

98. Palmatier MI, Liu X, Matteson G, Caggiula AR, Donny EC, Sved AF (2007)

Conditioned reinforcement established with self-administered nicotine and enhanced by

non-contingent nicotine. Psychopharmacology 195 (2): 235-243

14

99. Liu X, Caggiula A, Palmatier M, Donny E, Sved A. (2007) Cue-induced reinstatement of

nicotine-seeking behavior in rats: effect of bupropion, persistence over repeated tests and

its dependence on training dose Psychopharmacology Oct 12; [Epub ahead of print]

100. Palmatier MI, Liu X, Donny EC, Caggiula AR, Sved AF Metabotropic glutamate 5

receptor (mGluR5) antagonists decrease nicotine seeking, but do not affect the

reinforcement enhancing effects of nicotine Neurosychopharmacology (in Press)

Publications: Invited Articles, Reviews, Book Chapters and Books

1. Caggiula, A.R. Stability of behavior produced by electrical stimulation of the rat

hypothalamus. Brain, Behavior and Evolution, 1969, 2, 343-358.

2. Antelman, S.M. & Caggiula, A.R. Tails of stress-related behavior: A

neuropharmacological model. In I. Hanin & E. Usdin (Eds.): Animal Models in

Psychiatry & Neurology, 1977, Pergamon Press, N.Y., 227-245.

3. Caggiula, A.R., Antelman, S.M., Chiodo, L.A., & Lineberry,C.G. Brain dopamine &

sexual behavior: Psychopharmacological and electrophysiological evidence for a

dissociation between active and passive components. In E. Usdin, I.J. Kopin & J.

Barchas (Eds.): Catecholamines: Basic and Clinical Frontiers 1979 Pergamon Press.

1765-1767

4. Antelman, S.M., Caggiula, A.R., Eichler, A.J., & Lucik, R.R. The importance of stress in

assessing the effects of anorectic drugs. Current Medical Research & Opinion, 1979, b

Suppl. 73-82.

5. Antelman, S.M. & Caggiula, A.R. Stress-induced behavior: Chemotherapy without

drugs. In J.M. Davidson and R.J. Davidson (Eds.): The Psychobiology of Consciousness

1980, Plenum Press.

6. Ostrowski, N.L., Chiodo, L.A., Keller, R., and Caggiula, A.R. Morphine produces

different effects on subtypes of mesencephalic dopamine systems. In: H. Takagi & E.J.

Simon (Eds.): Advances in Endogenous and Exogenous Opioids 1982, Elsevier,

Amsterdam.

7. Antelman, S.M., Knopf, S., Caggiula, A.R., Kocan, D., Lysle, D.T. & Edwards, D.J.

Stress and enhanced dopamine utilization in the frontal cortex: The myth and the reality.

In P.W. Kalivas and C.B. Nemeroff (Eds.) The Mesocortical Dopamine System Ann.

N.Y. Academy of Sciences 1988, 537:262-272

8. Caggiula, A.R. & Frieze, I. Sex differences. In H. Tierney (Ed.) The Women's Studies

Encyclopedia, Vol.I: Views from the Sciences 1989, Greenwood Press.

9. Antelman, S.M. and Caggiula, A.R. Mechanisms of stimulant and stress sensitization:

Where to look. Clin. Neuropharm. 1990, 13(Suppl 2), 585-586

10. Antelman, S.M. and Caggiula, A.R. The effects of acute stressors and drugs grow with

the passage of time. In A. Oliviero and S. Puglisi-Allegra (Eds.) Psychobiology of Stress,

1990, Kluwer:Dordrecht, 161-170.

11. Antelman, S.M. and Caggiula, A.R. Norepinephrine-dopamine interactions; one step

beyond. In M. Briley and M. Marien (Eds.) Noradrenergic Mechanisms in Parkinson's

Disease 1994, CRC Press, pp.127-138

15

12. Caggiula, A.R., Epstein, L.H, Antelman, S.M., Knopf, S., Perkins, K.A., Saylor, S.,

Donny, E. and Stiller, R. Conditioned tolerance to nicotine in rats. In P.B.S. Clarke, M.

Quik, F. Adlkofer and K. Thurau (Eds.) The Effects of Nicotine on Biological Systems II

1995, Birkhäuser Verlag (Basel-Boston-Berlin), 101-107

13. Antelman, S.M., Caggiula, A.R., Gershon, S., Edwards, D.J., Austin, M.C., Kiss, S. and

Kocan, D. Stressor-induced oscillation: A possible model of the bidirectional symptoms

of PTSD Ann. NY Acad. Sci. 1997.

14. Caggiula, A.R., Donny, E.C., Epstein, L.H., Sved, A.F., Knopf, S., Rose, C.A.,

McAllister, C.G., Antelman, S.M. and Perkins, K.A. The role of corticosteroids in

nicotine’s physiological and behavioral effects Psychoneuroendocrinol. 1998 23(2): 143-

159

15. McAllister-Sistilli, C.G., Caggiula, A.R., Knopf, S., Rose, C.A., Miller, A.L. and Donny,

E.C. The effects of nicotine on the immune system Psychoneuroendocrinol. 1998 23(2):

175-187

16. Perkins, K.A., Donny, E. and Caggiula, A.R. Sex differences in nicotine effects and self-

administration: human and animal evidence Nicotine and Tobacco Research 1999 1: 301-

315.

17. Antelman, S.M., Levine, J., Gershon, S. Caggiula, A.R. and Edwards, D.J. Cyclic and

oscillatory behaviors in biological systems: A relevant model for bipolar disorders? In

J.C. Soares and S. Gershon (Eds.) Bipolar Disorders: Basic Mechanisms and Therapuetic

Implications 2000 Marcel Dekker, Inc. NY 49-58

18. Perkins, K., Sayette, M., Conklin, C. and Caggiula, A. Placebo effects of tobacco

smoking and other nicotine intake. Nicotine and Tobacco Research 2003 5(5): 695-709

19. Donny, E.C., Chaudhri, N., Caggiula, A.R., Sved, A.F. (2003) Multiple effects of

nicotine on behavior: A reply to Frenk and Dar Psychopharmacology 171(4) 474-476

20. Chaudhri, N., Caggiula, A.R., Donny, E.C., Palmatier, M.I., Lui, X., and Sved, A.F.

(2006) Complex interactions between nicotine and nonpharmacological stimuli reveal

multiple roles for nicotine in reinforcement Psychopharmacology 184 (3-4), 353-366

(Invited theoretical paper)

21. Matta, S.G., Balfour, D.J., Benowitz, N.L., Boyd, R.T., Buccafusco, J.J., Caggiula, A.R.,

Craig,C.R., Collins, A.C., Corrigall, W.A., Damaj, M.I., Donny, E.C., Gardiner, P.S.,

Grady, S.R., Heberlein, U., Leonard, S.S., Levin, E.D., Lukas, R.J., Markou, A, Marks,

M.J., McCallum, S.E., Parameswaran, N., Perkins, K.A., Picciotto, M.R., Quik, M, Rose,

J.E., Rothenfluh, A, Schafer, W.R., Stolerman, I.P., Tyndale, R.F., Wehner, J.M., Zirger,

J.M. (2007) Guidelines for nicotine dose selection for in vivo research: theoretical

underpinnings Psychopharmacology 190(3) 269-319 (Invited theoretical paper)

22. Caggiula A.R., Donny E.C., Palmatier, M.I., Liu, X., Chaudhri, N and Sved, A.F. The

role of nicotine in smoking: A dual reinforcement model. In Bivins, R.A. and Caggiula,

A.R. (Eds) The 55th

Nebraska Symposium on Motivation: The Motivational Impact of

Nicotine and It’s Role in Tobacco Use (Springer, in press)

23. Bivins, R.A. and Caggiula, A.R. (Eds) The 55th

Nebraska Symposium on Motivation:

The Motivational Impact of Nicotine and It’s Role in Tobacco Use (Springer, in press)

16

Presentations

Caggiula, A.R. Copulation-reward site in the posterior hypothalamus. Eastern Psychological

Assn, New York, 1966.

Caggiula, A.R. Specificity of copulation-reward systems in the posterior hypothalamus.

American Psychologycal Assn, Washington, D.C., 1967.

Caggiula, A.R. Stability of copulation-reward effects from posterior hypothalamic electrodes. In

symposium: Motivation, emotion and behavior elicited by activation of central nervous system

sites. Americal Psychological Assn, 1969, Washington, D.C.

Caggiula, A.R. Copulation of virgin male rats evoked by painful peripheral stimulation. Eastern

Psychological Assn, 1969, Philadelphia, Pennsylvania.

Caggiula, A.R. Stability of behavior from electrical stimulation of the rat hypothalamus. In

workshop held at the Third Annual Winter Conference on Brain Research, 1970, Snowmass-at-

Aspen, Colorado.

Caggiula, A.R. The effects on copulation of stimulating either end of a male rat. Given at the

1970 Eastern Regional Conference on Reproductive Behavior, 1970, Boca Raton, Florida.

Caggiula, A.R. Shock-elicited copulation and aggression. Eastern Psychological Association,

1971, New York.

Caggiula, A.R., Antelman, S.M., & Zigmond, M.J. Disruption of copulatory behavior in the

male rat by posterior hypothalamic lesions. The Society of Neurosciences First Annual Meeting,

Washington, D.C., 1971.

Caggiula, A.R. Discussant, Workshop on Neural Mechanisms of Motivation. Winter conference

on Brain Research, Vail, Colorado, 1972.

Caggiula, A.R. & Eibergen, R. Ventral midbrain involvement in the control of copulatory

behavior of the male rat. Eastern Psychological Association, Boston, Massachusetts, 1972.

Caggiula, A.R. The effects of hypothalamic and brain stem lesions on the copulatory behavior of

male rats. Eastern Regional Conference on Reproductive Behavior, New Orleans, Louisiana,

1972.

Caggiula, A.R., Antelman, S.M., & Zigmond, M.J. Ineffectiveness of sexually arousing

stimulation after hypothalamic lesions in male rats. A.P.A., 1974, Philadelphia, Pennsylvania.

Caggiula, A.R. Discussant, in Workshop on Research Methods in Sex Research. Eastern

Regional Conference on Reproductive Behavior, 1974, Atlanta, Georgia.

17

Caggiula, A.R. Neural control of sexual behavior in male rats. Talk given to Department of

Psychology, Purdue University, 1974.

Caggiula, A.R. & Antelman, S.M. Organizers and discussants of workshop on

Neuropharmacology of Mating Behavior. Eastern Regional Conference on Reproductive

Behavior, Nags Head, North Carolina,1975.

Caggiula, A.R. The medial preoptic-medial forebrain bundle "continuum" and sexual behavior in

male rats: An anatomical, neurochemical, and behavior dissection approach. Invited workshop

on Brain Control of Sociosexual Behavior. Winter Conference on Brain Research, Steamboat

Springs, Colorado, 1975.

Caggiula, A.R., Herndon, J.G., Jr., Antelman, S.M., Sharp, D., Scanlon, R., Greenstone, D. &

Bradshaw, W. Brain catecholamines and copulatory behavior of male and female rats. Paper

presented at Eastern Conference on Reproductive Behavior, Storrs, Connecticut, June, 1977.

Caggiula, A.R. Invited speaker in round table discussion "The relevance of animal studies to

problems of human reproductive behavior" organized by L. Aronson & M. Cooper at Eastern

Conference on Reproductive Behavior. Storrs, Connecticut, June, 1977.

Caggiula, A.R., Herndon, J.G., Jr., Scanlon, R., Greenstone, D., Bradshaw, W. & Sharp, D.

Dissociation of active from passive components of sexual behavior in female rats by destruction

of brain catecholamine-containing pathways. Society for Neuroscience, 1977, Anaheim,

California.

Caggiula, A.R. Invited colloquium presentation at the University of Buffalo, Department of

Psychology, February, 1977

Caggiula, A.R. Invited colloquium presentation at the University of Pennsylvania, Department of

Biology, December, 1977.

Caggiula, A.R. & Antelman, S.M. Brain catecholamines and sexual behavior. Winter

Conference on Brain Research, January, 1978.

Caggiula, A.R. Brain catecholamines and sexually dimorphic patterns of copulatory behavior:

A new perspective. Fourth International Catecholamine Symposium. Asilomar, California,

September, 1978.

Caggiula, A.R., Chiodo, L.A., Antelman, S.M. & Lineberry, C.G. Tail pinch-stress activates

nigrostriatal DA neurons and behavior: The reversal of both effects by cervical probing. Society

for Neuroscience, 1978. Abstract #44.21.

Caggiula, A.R. Invited colloquium presentation at the Mental Health Research Institute,

University of Michigan, February, 1979.

18

Caggiula, A.R. & Chiodo, L.A. Brain dopamine and sexual behavior: Paper presented at

Eastern Conference on Reproductive Behavior, New Orleans, 1979.

Caggiula, A.R. & Chiodo, L.A. An immobilizing stimulus significantly attenuates both

amphetamine and apomorphine-induced stereotypies. Society for Neuroscience, Atlanta, 1979.

Caggiula, A.R. Invited to participate in roundtable discussion on "Nonsteroidal factors in

reproductive behavior." Eastern Conference on Reproductive Behavior, New York, New York,

June, 1980.

Caggiula, A.R. Invited colloquium presentation at Neurotoxicology Section, NINCDS-NIH,

Bethesda, Maryland, August, 1980.

Caggiula, A.R. Invited colloquium presentation at Department of Psychology, Skidmore College,

Saratoga Springs, New York, December, 1980.

Caggiula, A.R. Invited colloquium presentation at Department of Behavioral Sciences,

University of Chicago, Illinois, February, 1981.

Caggiula, A.R. & Chiodo, L.A. Estrogen's influence on brain DA containing systems:

Electrophysiological and behavioral evidence. European Winter Conference on Brain Research,

Vars, France, March, 1981.

Caggiula, A.R. Invited colloquium presentation at Department of Psychology, University of

Buffalo, May, 1981.

Caggiula, A.R. Organizer of a Roundtable entitled: Hormonal modulation of neurotransmitter

function: Neurophysiological, behavioral and clinical effects. Winter Conference on Brain

Research, Steamboat Springs, Colorado, January, 1982.

Caggiula, A.R. & Chiodo, L.A. Estrogen-induced alterations in brain dopamine function:

Behavioral and electrophysiological evidence. Winter Conference on Brain Research, Steamboat

Springs, Colorado, January, 1982.

Caggiula, A.R. Invited colloquium presentation of Department of Anatomy, University of

Rochester, School of Medicine, June, 1984.

Caggiula, A.R., Antelman, S.M. Aul, E., Knopf, S. & Edwards, D.J. Prior stress attenuates the

analgesic response but sensitizes the corticosterone and cortical dopamine response to stress 10

days later Soc. for Neuroscience, Toronto, Canada, 1988

Caggiula, A.R. Both immediate and historical environmental factors modulate reactivity to drugs

and stress. Invited colloquium, Department of Psychology, University of Buffalo. April, 1989

19

Caggiula, A.R. Both immediate and historical environmental factors modulate reactivity to drugs

and stress. Invited colloquium, Department of Psychology, Allegheny College, May, 1989

Caggiula, A.R., Epstein, L.H., Antelman, S.M., Saylor, S. and Perkins, K.A. Changing

environmental cues uniquely associated with drug delivery reduces tolerance to nicotine-induced

anorexia and corticosterone release. Soc. for Neuroscience, St. Louis, MO, 1990

Caggiula, A.R. Drugs and Stress: The role of environmental context in modifications of

reactivity. Fourth Annual I. Ralph Hyatt Leadership Lecture. St. Joseph's University March,

1990

Caggiula, A.R., Epstein, L.H., Antelman, S.M., Knopf, S., Saylor, S., and Perkins, K.A.

Corticosterone accelerates the development of tolerance to nicotine-induced analgesia in rats

Soc. for Neuroscience, New Orleans, LA, 1991

Caggiula, A.R. Invited Colloquium, Department of Psychology, Allegheny College, 1991

Caggiula, A.R. (organizer and presenter) Symposium: The role of conditioning in chronic drug

effects: Implications for theories of drug abuse and therepeutic drug efficacy. Society for

Behavioral Medicine, New York, March, 1992

Antelman, S.M., Caggiula, A.R. (Speaker), Edwards, D.J., Kiss, S., Kocan D. and Barry III, H.

Acute stress or ethanol (ETOH) can have a very long lasting influence on in vitro dopamine

(DA) release from striatal slices. Soc. for Neuroscience Anaheim, CA, Nov., 1992.

Caggiula, A.R., McAllister, C.G., Matthews, K.A., Berga, S.A., and Owens J.F. Stress, ovarian

hormones and immunologic responsiveness in normally cycling women Society for Behavioral

Medicine, San Francisco, CA, March, 1993.

Caggiula, A.R. Invited colloquium, Department of Psychology, Princeton University. October,

1993

Caggiula, A.R., Epstein, L.H., Antelman, S.M., Knopf, S., Perkins, K.A., Saylor, S., Donny, E.,

and Stiller, R. Conditioned tolerance to nicotine in rats. Invited talk at International Symposium

on Nicotine, Montreal, Canada, July, 1994

Caggiula, A.R., Epstein, L.H., Perkins, K.A., and Saylor, S. Different methods of assessing

nicotine-induced antinociception may engage somewhat different neural mechanisms. Poster at

International Symposium on Nicotine, Montreal, Canada, July, 1994

S. Knopf, A. R. Caggiula, C. G. McAllister, L. H. Epstein, S. M. Antelman, K. A. Perkins, S.

Saylor, and R. Stiller. The effects of cholinergic and ß-adrenergic antagonists on nicotine-

induced suppression of blood and spleen leukocytes in rats. Poster at International Symposium

on Nicotine, Montreal, Canada, July, 1994

20

Caggiula, A.R., Antelman, S.M., Edwards, D.J., Kiss, S., Kocan D., and Stiller, R.

Oscillatory effects of cocaine on dopamine efflux in rat Soc. for Neuroscience Miami, Fla.,

November, 1994

Donny, E, Caggiula, A.R. and Knopf, S. Nicotine self-administration in rats. Poster presented at

Society for Research on Nicotine and Tobacco, San Diego, CA March 24-25, 1995

Donny, E.C., Caggiula, A.R. and Knopf, S. Nicotine self-administration in rats. Soc for

Neuroscience (1995) San Diego, CA Nov 11-16, 1995

Knopf, S., Caggiula, A.R., Sved, A.F., Schreihofer, A.M., & McAllister, C.G. Selective central

or peripheral nicotinic antagonism by chlorisondamine. Soc for Neuroscience San Diego, CA

Nov 11-16, 1995

Knopf, S., Sved, A.F., McAllister, C.G. and Caggiula, A.R. Selective central or peripheral

nicotine antagonism by chlorisondamine blocks nicotine's immunological effects. Soc. for

Research on Nicotine and Tobacco Washington, DC March 15-17, 1996

Donny, E.C., Caggiula, A.R., Knopf, S., Rose, C., McAllister, C.G., Sved, A and Perkins, K.A.

Does self-administered nicotine produce the same effects as experimenter-administered nicotine?

Soc. for Research on Nicotine and Tobacco Washington, DC March 15-17, 1996

Donny, E.C., Caggiula, A.R., Jacobs, K.S., Shaida, P. and Mielke, M.M. The role of dose and

feeding schedule in the acquisition of IV nicotine self-administration. Soc. for Research on

Nicotine and Tobacco Washington, DC March 15-17, 1996

Caggiula, A.R. The role of corticosterone in nicotine’s behavioral and physiological effects.

Invited presentation at the Nicotine Roundtable of the American Society of Addiction Medicine

Meetings, Washington, DC November 14, 1996.

S.E. Strong, S.E., Caggiula, A.R., Saylor, S. and Ploskina, T.M. Time course of the selective

peripheral antagonism of nicotine by chlorisondamine Society for Neuroscience, New Orleans,

La. Oct. 25-30, 1997

Caggiula, A.R., Antelman, S.M., Kucinski, B.J., Fowler, H., Gershon, S., Edwards, D.J., Austin,

M.C., Stiller, R., Kiss, S. and Kocan, D. Oscillatory-sensitization model of repeated drug

exposure: induction by cocaine and blockade by lithium Society for Neuroscience, New Orleans,

La. Oct. 25-30, 1997

Kucinski, B.J., Antelman, S.M., Caggiula, A.R., Fowler, H., Gershon, S., Edwards, D.J., Austin,

M.C., Kiss, S. and Kocan, D. Oscillatory-sensitization effects are produced by repeated

morphine pre-exposures and are blocked by chronic lithium treatments Society for Neuroscience,

New Orleans, La.Oct. 25-30, 1997

21

Donny, E.C., Caggiula, A.R., Mielke, M.M., Strong, S.E., Rose, C., Ploskina, T.M., Jacobs, K.S.

and Shupanko, C.D. Use of progressive ratio schedules in nicotine self-administration. Society

for Neuroscience, New Orleans, La.Oct. 25-30, 1997

Donny, E.C., Caggiula, A.R., Rose, C., Jacobs, K.S., Mielke, M.M. and Strong, S. Nicotine self-

administration using a progressive ratio schedule of reinforcement. Society for Research on

Nicotine and Tobacco Nashville, TN June 13-14, 1997

McCallum, S.E., Caggiula, A.R., Epstein, L.H., Saylor, S., Ploskina, T. and Sved, A.F.

Mecamylamine blocks tolerance to nicotine in rats: Implications for the mechanisms of

tolerance. College on Problems of Drug Dependence Scottsdale, AZ June 13-18, 1998

Donny, E.D., Caggiula, A.R., Shupenko, C.D., Mielke, M.M., Booth, S., Hoffmna, A.S., Imerito,

C.A., Rose, C., McCallum, S.E. and Perkins, K. Effect of dose, extinction, and drug-paired cues

on nicotine self-administration under a progressive ratio. College on Problems of Drug

Dependence Scottsdale, AZ June 13-18, 1998

Donny, E.C., Caggiula, A.R.,Shupanko, C.D., Mielke, M.M., Booth, S., Hoffman, A.S., Imerito,

C.A., Rose, McCallum, S.E. Nicotine self-administration in male and female rats on fixed and

progressive ratio schedules of reinforcement. Society for Neuroscience, Los Angeles, CA

November 7-12, 1998

Kucinski, B.J., Antelman, S.M., Caggiula, A.R., Fowler, H., Gershon, S, Edwards, D.J.

Cocaine-induced oscillation is conditionable Society for Neuroscience Los Angeles, CA

November 7-12, 1998

Antelman, S.M., Edwards, D.J., Caggiula, A.R., Gershon, S., Kocan, D. and Kiss, S. Inositol

prevents cycling in a possible animal model of bipolar disorder: A challenge to the inositol-

depletion hypothesis of lithium action. American College of Neuropsychopharmacology San

Juan, PR. December, 1998

Caggiula, A.R. The psychology of nicotine pharmacology. Invited colloquium, University of

Kentucky, May, 1999

Caggiula, A.R. Pharmacological and non-pharmacological factors in nicotine reinforcement.

Invited Colloquium, University of Minnesota, April 7, 2000

Caggiula, A.R., Donny, E.C., White, A.R., Sved, A., Gharib, M, Maldovan, V., Booth, S and

Chaudhri, N. The role of environmental cues in the acquisition, extinction and reinstatement of

nicotine self-administration in rats. Society for Neuroscience New Orleans, LA 2000

Donny, E.C., Caggiula, A.R., Rowell, P.P., Gharib, M.A., Maldovan, V., Booth, S, Hoffman,

A., Mielke, M.M., McCallum, S. Nicotinic receptor binding and plasma and brain nicotine levels

22

following nicotine self-administration in male and female rats. Society for Neuroscience New

Orleans, LA 2000

Caggiula, A.R., Donny, E.C., White, A.R., Sved, A.F., Gharib, M., Booth, S., Chaudhri, N. The

role of environmental cues in the acquisition, extinction and reinstatement of nicotine self-

administration. Society for Research on Nicotine and Tobacco, Seattle, WA 2001

White, R., Chaudhri, N., Caggiula, A.R., Donny, E.C., Gharib, M, Booth, S., Sved, A.F.

Contingently-presented environmental stimuli enhance nicotine self-administration in rats

Society for Neuroscience Meetings, San Diego, 2001

Caggiula, A.R., Donny, E.C., White, R., Chaudhri, N., Gharib, M., Booth, S., Sved, A.F. Non-

contingent nicotine enhances responding maintained by behaviorally contingent environmental

cues. Society for Neuroscience Meetings, San Diego, 2001

Donny, E.C. and Caggiula, A.R. Sex differences in the behavioral and reinforcing effects of

nicotine in rats. Invited presentation, Symposium on “The effects of hormones on nicotine

dependence” Society for Research on Nicotine and Tobacco Meetings, March., 2001. (Eric

Donny gave the presentation in my stead).

Donny, E.C. and Caggiula, A.R. The role of environmental stimuli and response-contingency in

the acquisition of nicotine self-administration in rats. Invited presentation at the ISGIDAR

Meetings in Scotsdale, AZ, June, 2001 (Eric Donny gave the presentation because I had a

scheduling conflict).

Caggiula, A.R. Cue dependence of nicotine self-administration and smoking. Invited

presentation at the Treatment Research Center, Department of Psychiatry, University of

Pennsylvania. September 17, 2001

Caggiula, A.R. The role of environmental stimuli in the acquisition, maintenance and

reinstatement of nicotine self-administration. Invited presentation at the Society for Research on

Nicotine and Tobacco, Savannah, GA February, 23, 2002

Caggiula, A.R. Gender differences in nicotine reinforcement using an animal self-administration

model. Invited presentation at the Winter Conference on Neurochemistry, Solden, Austria, April

5, 2003

Chaudhri, N., Caggiula, A.R. Donny, E.C., Perkins, K.A. & Sved, A.F. Sex differences and

nicotine reinforcement in humans and animals. Invitation to A.R. Caggiula to provide a female

post-doc or graduate student to present our research in a symposium sponsored by American

Society of Pharmacology and Experimental Therapeutics at the Experimental Biology Meetings,

April 14, 2003, San Diego, CA

Caggiula, A.R. “From sex to drugs to ....” Invited presentation in the Department of Psychology,

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Princeton University, November, 2003

Perkins, K.A., Jacobs, L., Conklin, C., Sayette, M., Caggiula, A.R. The influence of instructions

and nicotine dose on the subjective and reinforcing effects of smoking. Poster at Society for

Research on Nicotine and Tobacco New Orleans, LA February, 2003

Chaudhri, N., Caggiula, A.R., Donny, E.C., Gharib, M.A., Booth, S., Clements, L.A., Perkins, K.A.

Sved, A.F. Dissociating the primary reinforcing and reward-enhancing effects of nicotine: analysis

of sex, dose and drug contingency on operant responding in rats. Poster at College on Problems of

Drug Dependence, Miami Beach, FL June, 2003

Chaudhri, N., Caggiula, A.R., Donny, E.C., Gharib, M.A., Booth, S., Clements, L.A., Perkins, K.A.

Sved, A.F. Enhancement of reinforced operant responding by nicotine and cocaine in rats: analysis

of dose and drug-contingency. Poster at Society for Neuroscience meeting, New Orleans, LA Nov,

2003

Chaudhri, N, Evans-Martin, F., Caggiula, A.R., Donny, E.C., Sved, A.F., Booth, S., Gharib, M.A.,

Craven, L.A. Evidence for dual actions of nicotine on reinforced behavior. Paper given at the

Society for Research on Nicotine and Tobacco Scottsdale, AZ February 19, 2004

Caggiula, A.R., Chaudhri, N., Donny, E.C. and Sved, A.F. Dual reinforcement model of nicotine.

Poster at Society for Neurochemistry meeting in Solden, Austria. April, 2004

Palmatier M, Evans-Martin FF, Hoffman A, Caggiula AR, Chaudhri N, Sved AF. Self-

administration of nicotine and environmental cues under concurrent schedules of reinforcement.

Paper given at the Winter Conference on Animal Learning and Behavior Winter Park, Colorado

February 7 - 11, 2004

Caggiula, AR Dual Reinforcement model of nicotine self-administration and smoking. Research

Institute on Addictions, Buffalo, NY November, 2004

Caggiula, AR Dual Reinforcement model of nicotine self-administration and smoking. Duke

Conference on Nicotine and Smoking. Durham, NC October, 2004

Chaudhri N, Caggiula AR, Donny EC, Sved AF. A Dual Role for Nicotine in Reinforcement: The

interaction between nicotine and non-drug cues. Invited presentation at NIDA Frontiers of

Addiction Symposium. San Diego, CA October, 2004 (given by N Chaudhri in my absence)

Perkins KA, Jacobs L, Conklin C, Sayette M, Caggiula AR The influence of instructions and

nicotine dose on the subjective and reinforcing effects of smoking. International Study Group

Investigating Drugs as Reinforcers Orlando, FL June, 2005

Palmitier M, Evans-Martin FF, Hoffman A, Caggiula AR, Chaudhri N, Sved AF. Nicotine

enhances responding for a visual reinforcer in a novel self-administration paradigm. Paper given at

24

the Society for Research on Nicotine and Tobacco Prague, CZ March, 2005

Caggiula AR, Chaudhri N, Donny EC, Palmatier MI, Liu X, Sved AF (2005). Nicotine enhances

responding for nonpharmacological stimuli: impact of dose and reinforcement schedule. 35th

Annual Meeting of Society for Neuroscience.

Chaudhri N, Caggiula AR, Donny EC, Palmatier MI, Liu X, Sved AF (2005). Dissociable

behavioral actions of nicotine in reinforcement. 35th Annual Meeting of Society for Neuroscience.

Liu X, Caggiula AR, Palmatier MI, Booth S, Gharib M, Craven L, Donny EC, Sved AF (2006).

Reinforcement enhancing effect of nicotine and its attenuation by nicotinic and dopaminergic

antagonists. 12th Annual Meeting of the Society for Research on Nicotine and Tobacco.

Liu X, Caggiula AR, Palmatier MI, Donny EC, Chaudhri N, Sved AF (2005). Reinforcement

enhancing effect of nicotine depends on the reinforcement valence of non-drug stimulus. 35th

Annual Meeting of Society for Neuroscience.

Palmatier MI, Liu X, Caggiula AR, Donny EC, and Sved AF (2006). A pharmacological

dissociation of the primary reinforcing and reinforcment enhancing effects of nicotine. 12th Annual

Meeting of the Society for Research on Nicotine and Tobacco.

Palmatier MI, Evans-Martin FF, Hoffman A, Caggiula AR, Chaudhri N, Donny EC, Liu X, and

Sved AF (2005). Self-administered nicotine enhances responding for a concurrently available visual

reinforcer. 35th Annual Meeting of Society for Neuroscience.

Palmatier MI, Evans-Martin FF, Hoffman A, Caggiula AR, Chaudhri N, and Sved AF (2005).

Nicotine enhances responding for a visual reinforcer in a novel self-administration paradigm. 11th

Annual Meeting of the Society for Research on Nicotine and Tobacco.

Matteson GL, Palmatier MI, Liu X, Chaudhri N, Caggiula AR, Donny EC, Sved AF (2006). The

reinforcement enhancing effect of nicotine depends on the incentive value of a nonpharmacological

reinforcer. 12th Annual Meeting of the Society for Research on Nicotine and Tobacco.

Thiels E, Palmatier MI, Shiflett MW, Caggiula AR, Sved AF (2005). ERK activation during drug-

primed reinstatement of nicotine self-administration. 35th Annual Meeting of Society for

Neuroscience

Caggiula AR. (2006) Human and animal approaches to discover the bases of nicotine

reinforcement: Associative and non-associative mechanisms" Invited presentation at the Presidential

Symposium, Eastern Psychological Association, Baltimore, MD

Caggiula AR (2005) Dual reinforcement model of nicotine reinforcement in rats. Invited

symposium presentation. Society for Research on Nicotine and Tobacco, Prague, CZ

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Caggiula AR (2005) (discussant) Novartis Foundation Symposium: Understanding nicotine and

tobacco addiction, London UK

Caggiula AR (2005) Human and animal approaches to discover the bases of nicotine reinforcement.

Novartis Foundation Symposium: Understanding nicotine and tobacco addiction. Invited

presentation at the Open Meeting. London, UK

Caggiula AR (2005) A dual reinforcement model of nicotine. Invited symposium presentation.

European Behavioral Pharmacology Society, Barcelona, Spain,

Caggiula AR (2005) A dual reinforcement model of nicotine self-administration and smoking.

Invited presentation at the Center for the Neural Basis of Cognition Retreat, Hidden Valley, PA

Caggiula AR (2006) A dual reinforcement model of nicotine self-administration and smoking.

Invited presentation at the National Institute on Drug Abuse Intramural Program, Baltimore, MD

Matteson G, Palmatier MI, Liu X, Caggiula AR, Black JJ, Gaily L, Donny EC, Sved AF (2006) The

reinforcement enhancing effects of nicotine depend on the incentive value of non-drug reinforcers

and the acute action of nicotine. 36th Annual Meeting of the Society for Neuroscience, Atlanta, GA

M.I. Palmatier MI, Liu X, Caggiula AR, Donny EC, Sved AF. (2006) Nicotine self-administration

in rats: Response-rates match outcome-value when nicotine infusions and a visual reinforcer are

contingent upon separate operants. 36th Annual Meeting of the Society for Neuroscience, Atlanta,

GA

Liu X, Palmatier MI, A.R. Caggiula AR, E.C. Donny EC, A.F. Sved

AF. (2006) Cue-induced reinstatement of nicotine-seeking behavior

in rats: effects of training dose and delay of extinction. 36th

Annual Meeting of the Society for Neuroscience, Atlanta, GA

Caggiula AR (2006) Human and animal approaches to discover the bases of nicotine reinforcement:

Associative and non-associative mechanisms Invited presentation at the Presidential Symposium, Eastern

Psychological Association, Baltimore, MD

Caggiula AR, Palmatier MI, Liu X, Donny EC, Sved AF. (2006)

Pharmacological properties of the primary reinforcing and

reinforcement enhancing effects of nicotine. Annual meeting of the College on

Problems of Drug Dependence, Scottsdale, AZ

Caggiula AR (2006) Nonpharmacological stimuli in nicotine reinforcement. Invited presentation at the

European Society for Research on Nicotine and Tobacco, Kusadasi, Turkey

Caggiula AR (2006) Multiple roles for nicotine in self-administration and smoking. Invited presentation

at the European Society for Research on Nicotine and Tobacco, Kusadasi, Turkey

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Caggiula AR (2006) What is the role of nicotine in smoking: a perspective from animal research? Invited

presentation at the Department of Psychiatry, University of Pennsylvania School of Medicine

Philadelphia, PA

Caggiula AR (2007) What is the role of nicotine in smoking: a perspective from animal research? Invited

Plenary Pre-Clinical Theme Lecture, Annual Meeting of the Society for Research on Nicotine and

Tobacco, Austin Texas

Caggiula AR (2007) What is the role of nicotine in smoking? A perspective from animal research.

Invited presentation, Nebraska Symposium on Motivation, University of Nebraska, Lincoln NE

Palmatier MI, Donny EC, Liu X, Matteson GL, Caggiula AR, Sved AF (2007) Conditioned

reinforcement established with self-administered nicotine: Motivational effects of stimuli associated with

different unit nicotine doses. Society for Neuroscience. Society for Neuroscience, San Diego.

Kara L. Mays, Melissa E. Levin, Kasia M. Bak, Matthew I. Palmatier, Xiu Liu, Anthony R. Caggiula,

Eric C. Donny, Alan F. Sved (2007) Nicotine and bupropion have similar effects on responding for

reinforcing non-drug stimuli. 13th Annual Meeting of the Society for Research on Nicotine and Tobacco,

Austin, TX.

Palmatier MI, Matteson GL, Liu X, Caggiula AR, Donny EC, Sved AF (2007) Conditioned

reinforcement is established with self-administered nicotine. 13th Annual Meeting of the Society for

Research on Nicotine and Tobacco, Austin, TX.