curriculum vitae€¦ · chandan mandal, avijit dutta, asish mallick, sarmila chandra, laxminarain...

CURRICULUM VITAE 1. Name: Dr. Chandan Mandal

2. Designation: Administrator of I3T Advance Diagnostic Center and Principal Scientist

3. Job responsibility: Smooth running of advance diagnostic center which includes Hematology, Clinical

Biochemistry, Serology, Histopathology, Cytogentics, Flow cytometry, Molecular genetics (Real time

PCR and Nextgen sequencing) in NABL standard work flow and Drug development, Translational

Glycoimmunology, Proteomics and Glycomics mainly in cancer and infectious disease as Principle

Scientist

4. Place of work: International Institute of Innovation and Technology, Kolkata

5. Record of Achievement

SL

NO

Subject Institute

1 COVID-19: Operational Planning Guidelines

and COVID-19 Partners Platform to support

country preparedness and response

World Health Organization (WHO) and Health

Emergencies Programme

2 Health Cluster Coordination (Global Health

Cluster)


Cluster

3 Decontamination and sterilization of medical

devices



4 Standard precautions: Environmental cleaning

& disinfection



5 Standard precautions: Waste management World Health Organization (WHO) and Health


6 Introduction to the Principles and Practice of

Clinical Research

National Institutes of Health (NIH) and

Department of Health and human service-USA

6. Academics:

Research Institution Year

Scientist C Tata Medical Center, Kolkata June 2016-Dec2019

Special Appointed Researcher (Post Doctorate)

Immunoglycobiology Division, IFReC, Osaka University, Japan

2014-Aug to 2016 June

Post Doctorate Indian Institute of Chemical biology, CSIR, India 2009-2014 (Aug)

Ph. D.* (Life Science.) Jadavpur University, West Bengal, and Indian Institute of Chemical biology, CSIR, India 2009

M. Sc. (Organic. Chem.) CSJMU, Kanpur, India 2002

Member of National Society: Member of Association of Carbohydrate Chemist Technologists (India)

Life Member: Kolkata Gynecological Oncology Trials and Translational Research, Kolkata

List of Publications

1. Chowdhury S, Bhattacharya K, Mandal Chandan, Mondal S, Sarkar S, Chandra S, Banerjee S, Mandal C.A

Glycomic Approach Towards Identification of Signature Molecules in CD34+ Haematopoietic Stem Cells

from Umbilical Cord Blood. Adv ExpMed Biol. 2018; 1112:309-318. doi: 10.1007/978-981-13-3065-0_21.

https://www.ncbi.nlm.nih.gov/pubmed/30637706

2. Satyavarapu EM, Das R, Mandal Chandan, Mukhopadhyay A, Mandal C. Autophagy-independent induction

of LC3B through oxidative stress reveals its non-canonical role in anoikis of ovarian cancer cells. Cell Death

Dis. 2018 Sep 17;9(10):934. doi: 10.1038/s41419-018-0989-8.


3. Sarkar Bhattacharya S*, Mandal Chandan*, Albiez RS, Samanta SK, Mandal C. Mahanine drives pancreatic

adenocarcinoma cells into endoplasmic reticular stress-mediated apoptosis through modulating sialylation

process and Ca2+-signaling. SciRep. 2018 Mar 2;8(1):3911. doi: 10.1038/s41598-018-22143-w. *Equal

contribution https://www.ncbi.nlm.nih.gov/pubmed/29500369

4. Chandan Mandal, Sayantani Sarkar, Reinhart SA, Mandal C. GD3 synthaseoverexpression inhibits survival

and angiogenesis of pancreatic cancer cells through S-phase arrest and disruption of β1 integrin-mediated

anchorage. Int J Bio Cell Bio. 2014, 53:162-73, ISSN: 1357-2725

http://www.ncbi.nlm.nih.gov/pubmed/24842107 (Citedby 10)

5. Chandan Mandal, Chhabinath Mandal, Sarmila Chandra, Roland Schauer and ChitraMandal. Regulation of

O-acetylation of sialic acids by sialate-O-acetyltransferase and sialate-O-acetylesterase activities in

childhood acute lymphoblastic leukemia. Glycobiology. 2012, 22, 70-83 (Cited by 7)

http://www.ncbi.nlm.nih.gov/pubmed/21803834 (Cited by 10)

6. Chandan Mandal, Cristina Tringali, Susmita Mondal, Leugi Anastasia, Sarmila Chandra,Venerando Burno

and Chitra Mandal. Down-regulation of membrane-bound Neu3 is negatively correlated with disease

progression and associated with apoptosis suppression of lymphoblasts in childhood acute lymphoblastic

leukemia. International J Cancer. 2010, 126:337-349 (Cited by 40)

http://www.ncbi.nlm.nih.gov/pubmed/19588508

7. Chandan Mandal, G. Vinayaga Srinivasan, Suchandra Chowdhury, Sarmila Chandra,Chhabinath Mandal,

Roland Schauer, and Chitra Mandal. High Level of Sialate-O-acetyltransferase Activity in Lymphoblasts of

Childhood Acute Lymphoblastic Leukaemia (ALL): Enzyme Characterization and Correlation with Disease

Status. Glycoconjugate Journal. 2009, 26, 57-73 (Cited by 20)


8. Chandan Mandal, Avijit Dutta, Asish Mallick, Sarmila Chandra, Laxminarain Misra,Rajender Sangwan, and

Chitra Mandal. Withaferin A induces apoptosis by activating p38 mitogen-activated protein kinase signaling

cascade in leukemic cells of lymphoid and myeloid origin in a transcription-dependent manner through

mitochondrial death cascade. Apoptosis. 2008, 13, 1450-1464 (Cited by 133)










9. Susmita Mondal, Chandan Mandal, Chandra S, Mandal C. Upregulated alfa2,6 sialyltransferases in

association with reduced Neu3 promotes cell survival in pediatric leukemia. Exp. Cell Res. 2020

(communicated)

10. Sayantani Sarkar, Chandan Mandal, Sangwan R, Mandal C. Coupling G2/M arrest to the Wnt/β-catenin

pathway restrains pancreatic adenocarcinoma. Endo.Rel.Cancer 2014, 21(1):113-25


11. Chowdhury S, Chandan Mandal et. al. Mobilization of lymphoblasts from bone marrow to peripheral blood

in childhood acute lymphoblastic leukaemia: Role of 9-O-acetylated sialoglycoproteins. Leukemia Research.

2012 Feb;36(2):146-55 http://www.ncbi.nlm.nih.gov/pubmed/22078066

12. Khatua B, Ghoshal A, Bhattacharya K, Chandan Mandal, Saha B, Crocker PR, Mandal C. Sialic acids acquired

by Pseudomonas aeruginosa are involved in reduced complement deposition and siglec mediated host-cell

recognition. FEBS Lett. 2010, 584, 555-61. (Cited by 36) http://www.ncbi.nlm.nih.gov/pubmed/19945458

13. Susmita Mondal, Chandan Mandal, Sangwan R, Chandra S, Mandal C. Withanolide D induces apoptosis in

leukemia by targeting the activation of neutral sphingomyelinase-ceramide cascade mediated by synergistic

activation of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase. Mol Cancer. 2010, 9, 239.

(Cited by 45) http://www.ncbi.nlm.nih.gov/pubmed/20836852

14. Kankana Mukherjee, Anil Kumar Chava, Chandan Mandal, Sailendra Nath Dey, Bernhard Kniep, Sarmila

Chandra, Chitra Mandal. O-acetylation of GD3 prevents its apoptotic effect and promotes survival of

lymphoblasts in childhood acute lymphoblastic leukaemia. J. Cell biochem, 2008, 105, 724-34 (Cited by 19)


15. Chowdhury S, Bandyopadhyay S, Chandan Mandal, Chandra S, Mandal C. Flow-cytometric monitoring of

disease-associated expression of 9-O-acetylated sialoglycoproteins in combination with known CD antigens,

as an index for MRD in children with acute lymphoblastic leukaemia: a two-year longitudinal follow-up study

BMC Cancer, 2008, 8, 40 (Cited by 12) http://www.ncbi.nlm.nih.gov/pubmed/18241334

16. Mukherjee, K Chowdhury S, Mondal, S, Chandan Mandal, Chandra S, Bhadra RK and Mandal C 9-O-

acetylated GD3 triggers programmed cell death in mature erythrocytes. Biochemical and Biophysical

Research Communications, 2007, 362, 651-657 (Cited by 13)


Chapter in Book Series 1. Chandan Mandal and Chitra Mandal. Identification and analysis of O-acetylatedsialoglycoproteins. “Methods

in Molecular Biology” Chapter 6, Human Press, Springer publishing group, USA, 2013 981:57-93


2. Kankana Mukherjee, Suchandra Chowdhury, Susmita Mondal, Chandan Mandal, Sarmila Chandra, and Chitra

Mandal 9-O-Acetyl GD3 in lymphoid and erythroid cells, MICC-3 book, Publisher Springer, NY, USA, Adv Exp

Med Biol 2011 705, 317-334. http://www.ncbi.nlm.nih.gov/pubmed/21618115

Poster Presentation International Conference

1. Poster presentation titled “High Level of Sialate-O-acetyltransferase Activity in Lymphoblasts of Childhood

Acute Lymphoblastic Leukaemia (ALL): Enzyme

Characterization and Correlation with Disease Status” in International symposium on cell surface

macromolecule, held on January, 2005 at Puri, India










2. 1st prize in poster presentation titled “Evaluation of membrane bound Neu3 in childhood acute

lymphoblastic leukemia” in International symposium named Glycan 2006, in Indian institute of science,

Bangalore, India

3. Poster presentation titled, Withaferin A induces apoptosis by activating p38 mitogen-activated protein

kinase signaling cascade in leukemic cells of lymphoid and myeloid origin in a transcription-dependent

manner through mitochondrial death cascade” in International symposium on cell surface macromolecule,

held on January, 2008 at Centre for Cellular and Molecular Biology, Hyderabad, India

4. International symposium named, International symposium on Chemical Biology, held on March, 2007 at

Indian Institute Chemical Biology, Kolkata, India

5. Oral presentation on “Down regulation of membrane-bound Neu3 constitutes a new potential marker for

childhood acute lymphoblastic leukemia and induces apoptosis suppression of neoplastic cells” in the

conference of Society for Biological chemist held at Digha 2009

6. Poster Presentation on “Regulation of O-acetylation of sialic acids by sialate-O-acetyltransferase and

sialate-O-acetylesterase activities in acute lymphoblastic leukemia” in International symposium named

“Sialoglyco2010” held at Potsdam, Germany dated Aug. 2010.

7. Poster presentation on “Elevated level of GD3-induced program cell death in pancreatic cancer” in

International symposium “SIGNALING NETWORK AND CANCER” held at IICB, Kolkata, dated Feb. 2011.

8. 1st Annual meeting of Kolkata Gynecological Oncology Trials and TranslationalResearch, Kolkata,

Biswabangla Convention center

Techniques known

Analytical tools: Thin layer Chromatography (TLC), High performance TLC (HPTLC), GelFiltration, Affinity

Purification, Ion exchange chromatography, High performance liquid chromatography (HPLC), Radio HPLC,

Fluorimetric HPLC, MALDI-TOF, Nano-HPLC-ESI-QTOF,

Imaging: Fluorescence activated cell shorting (FACS) and analysis. Fluorescence Microscopy, Confocal

microscopy. Ratiometric confocal microscopy, Transmission Electron Microscopy (TEM), Scanning Electron

Microscopy (SEM) Histopathology.

Molecular genetics: RNA isolation, Real Time PCR, Gene micro-array, Recombinant DNA Technology, CRISPR-

Cas9 system, GECKO library, Haploid genetic screening, Split protein technology etc.

Biobank: Primary culture and Cell line development, Organoid development. Primary tissue storage for whole

genome, transcriptome and proteomics analysis

Animal work: Animal handling (mice, Rat, Rabbit) (feeding, injection, blood collection,spleen cell

isolation, peritoneal macrophage isolation etc for mice.), pharmacokinetics, tumor formation in NUDE mice.

Protein & Lipid characterization: Protein purification, Electrophoresis (1D &2D), Proteinsequencing,

Enzyme characterization, Radio Immuno assay, Western blotting, Immuno-precipitation, Lipid purification and

analysis by TLC.

Exposure to various instruments

(a) HPLC (b) MALDI-TOF (c) LC-MS (d) FACS (e) TEM (f) Confocal Microscopy.

Development of new ELISA method for sialate-O-acetyltransferase activity Mandal et.al. Glycobiology. 2012, 22, 70-83

Doctorate details

Title of Ph.D. Thesis : Enzymatic modulation of sialic acid in childhood acute lymphoblastic leukemia

Research Supervisor: Chitra Mandal, PhD.

FTWAS, F.N.A.,F.A.Sc, F.N.A.Sc, Sir J.C. Bose National Fellow Head, Cancer and Cell Biology Division Outstanding Scientist, Sct-H CSIR-Indian Institute of Chemical Biology, Kolkata Email : [email protected], [email protected] Tel :91-33-2473-3491 Mob : +919831036964

Brief outline of Doctoral research Research Work : [I] Regulation of O-acetylation of sialic acids by sialate-O-acetyltransferase and sialate-O-acetylesterase

activities in childhood acute lymphoblastic leukemia.

[ii] High Level of Sialate-O-acetyltransferase Activity in Lymphoblasts of Childhood Acute Lymphoblastic

Leukaemia (ALL).

[iii] Down-regulation of membrane-bound Neu3 is negatively correlated with disease progression and

associated with apoptosis suppression of lymphoblasts in childhood acute lymphoblastic leukemia.

[iv] Down-regulation of membrane-bound Neu3 is negatively correlated with high Sialate-O-

acetyltransferase Activity in Lymphoblasts of Childhood Acute Lymphoblastic Leukaemia.

[v] Withaferin A induces apoptosis by activating p38 mitogen-activated protein kinase signaling cascade in

leukemic cells of lymphoid and myeloid origin in a transcription-dependent manner through

mitochondrial death cascade.

Brief outline of 1st Post-doctoral research work:

[i] GD3 induce program cell death in pancreatic cancer.

[ii] It induces S-phase cell cycle arrest in pancreatic cancer.

[iii] It disrupts integrin-beta 1 signaling pathway.

[iv] GD3 inhibit the tumor angiogenesis

Brief outline of 2nd Post-doctoral research work:

[i] VAPs modulate the membrane contact sites organisation.

Visit abroad:

Visiting Research Associate

Charite Universitatmedizin,

Berlin, Germany

Aug 2012 to Nov 2012

Identification sialoglycoproteins by Mass Spectrometry and Cellular proteome analysis by MALDI-TOF and, Nano-HPLC-ESI-QTOF in cancer

Visiting Research Fellow

DKFZ, Heidelberg, Germany

2010 Glyco-immunology, Tumor angiogenesis

(Sialo-enzymes)

Special Appointed Immunoglycobiology 2014-Aug to Regulation Lipid and Calcium

Researcher Division, IFReC, 2016 June transfer through membrane

Osaka University, contact sites

Japan

mailto:[email protected]

Reference:

Dr. Chitra Mandal, F.N.A.,F.A.Sc,F.N.A.Sc.,

Director.Distinguished Biotechnology research Professor

Cancer Biology & Inflammatory Disorder CSIR-Indian

Institute of Chemical Biology, Kolkata Email:

[email protected], [email protected] Tel :91-33-

2473-3491

Dr. Sib Sankar Roy

Principle scientist, CSIR-IICB, Kolkata

Cell Biology & Physiology

Email: [email protected]

Phone: 9433414568

Family details

Father’s name: Basudev Mandal

Mother’s name: Sibani Mandal

Date of birth: 15th September, 1978

Sex: Male

Marital status: Married

Nationality : Indian

Email:[email protected];

Phone: 9433128906

Permanent address: At-Putputia, Tamluk, Purbamedinipur, West Bengal India, Pin-721651



curriculum vitae€¦ · chandan mandal, avijit dutta, asish mallick, sarmila chandra, laxminarain...

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